Eif2b5 (eukaryotic translation initiation factor 2B subunit epsilon) - Rat Genome Database

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Gene: Eif2b5 (eukaryotic translation initiation factor 2B subunit epsilon) Rattus norvegicus
Analyze
Symbol: Eif2b5
Name: eukaryotic translation initiation factor 2B subunit epsilon
RGD ID: 708380
Description: Enables translation initiation factor binding activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including hippocampus development; positive regulation of translation; and response to glucose. Part of eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter and leukoencephalopathy with vanishing white matter 5. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon); PARTICIPATES IN translation initiation pathway; RNA transport pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eIF-2B GDP-GTP exchange factor subunit epsilon; eIF2B GDP-GTP exchange factor subunit epsilon; eukaryotic translation initiation factor 2B subunit 5; eukaryotic translation initiation factor 2B subunit 5 epsilon; eukaryotic translation initiation factor 2B, subunit 5 epsilon; initiation factor eIF-2Be; LOC192234; translation initiation factor eIF-2B subunit epsilon; translation initiation factor eIF2B subunit epsilon
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,898,814 - 93,909,431 (-)NCBIGRCr8
mRatBN7.21180,394,433 - 80,404,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,394,433 - 80,404,419 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,116,870 - 89,126,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,770,291 - 81,780,275 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,831,361 - 80,841,345 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,080,273 - 84,090,259 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,080,273 - 84,090,259 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,151,639 - 87,161,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,634,006 - 82,643,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,691,594 - 82,701,581 (-)NCBI
Celera1179,234,453 - 79,244,439 (-)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation. Anthony TG, etal., Biochim Biophys Acta. 2000 Jun 21;1492(1):56-62.
2. Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B. Bosetti F, etal., Neurosci Lett. 2002 Jul 12;327(1):71-3.
3. Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. Fabian JR, etal., J Biol Chem. 1997 May 9;272(19):12359-65.
4. Reconstitution and purification of eukaryotic initiation factor 2B (eIF2B) expressed in Sf21 insect cells. Fabian JR, etal., Protein Expr Purif. 1998 Jun;13(1):16-22.
5. Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B. Flowers KM, etal., Biochim Biophys Acta 1996 Jul 17;1307(3):318-24.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans. Gilligan M, etal., J Biol Chem. 1996 Jan 26;271(4):2121-5.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. The mechanism of eukaryotic translation initiation: new insights and challenges. Hinnebusch AG and Lorsch JR, Cold Spring Harb Perspect Biol. 2012 Oct 1;4(10). pii: a011544. doi: 10.1101/cshperspect.a011544.
10. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
11. Developmental changes of eukaryotic initiation factor 2B subunits in rat hippocampus. Inamura N, etal., Neurosci Lett. 2003 Jul 31;346(1-2):117-9.
12. Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats. Karinch AM, etal., Am J Physiol. 1993 Jan;264(1 Pt 1):E101-8.
13. Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B. Kashiwagi K, etal., J Struct Funct Genomics. 2016 Mar;17(1):33-8. doi: 10.1007/s10969-016-9203-3. Epub 2016 Mar 29.
14. Assessment of biomarkers of protein anabolism in skeletal muscle during the life span of the rat: sarcopenia despite elevated protein synthesis. Kimball SR, etal., Am J Physiol Endocrinol Metab. 2004 Oct;287(4):E772-80. Epub 2004 Jun 8.
15. Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B. Kimball SR, etal., J Biol Chem. 1998 Jan 30;273(5):3039-44.
16. Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b. Kimball SR, etal., J Biol Chem. 1998 May 22;273(21):12841-5.
17. Subunits of the translation initiation factor eIF2B are mutant in leukoencephalopathy with vanishing white matter. Leegwater PA, etal., Nat Genet 2001 Dec;29(4):383-8.
18. Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. Martin de la Vega C, etal., Biochem J. 2001 Aug 1;357(Pt 3):819-26.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway. Pap M and Cooper GM, Mol Cell Biol 2002 Jan;22(2):578-86.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Effect of CCK and intracellular calcium to regulate eIF2B and protein synthesis in rat pancreatic acinar cells. Sans MD, etal., Am J Physiol Gastrointest Liver Physiol. 2002 Feb;282(2):G267-76.
27. Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells. Scheper GC, etal., J Biol Chem. 1997 Oct 24;272(43):26850-6.
28. Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis. Tuckow AP, etal., Am J Physiol Endocrinol Metab. 2010 Aug;299(2):E241-8. doi: 10.1152/ajpendo.00151.2010. Epub 2010 May 18.
29. Phosphorylation of eukaryotic initiation factor eIF2Bepsilon in skeletal muscle during sepsis. Vary TC, etal., Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E1032-9.
30. Eukaryotic initiation factor 2B: identification of multiple phosphorylation sites in the epsilon-subunit and their functions in vivo. Wang X, etal., EMBO J. 2001 Aug 15;20(16):4349-59.
Additional References at PubMed
PMID:8626696   PMID:11323413   PMID:12388085   PMID:12426392   PMID:12477932   PMID:12624094   PMID:14566705   PMID:15054402   PMID:15060152   PMID:15217090   PMID:15489334   PMID:15507143  
PMID:15591312   PMID:15723074   PMID:16041584   PMID:16289705   PMID:16396499   PMID:18556237   PMID:19023445   PMID:23707720  


Genomics

Comparative Map Data
Eif2b5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81193,898,814 - 93,909,431 (-)NCBIGRCr8
mRatBN7.21180,394,433 - 80,404,468 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1180,394,433 - 80,404,419 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1189,116,870 - 89,126,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01181,770,291 - 81,780,275 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01180,831,361 - 80,841,345 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01184,080,273 - 84,090,259 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1184,080,273 - 84,090,259 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01187,151,639 - 87,161,625 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41182,634,006 - 82,643,992 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11182,691,594 - 82,701,581 (-)NCBI
Celera1179,234,453 - 79,244,439 (-)NCBICelera
Cytogenetic Map11q23NCBI
EIF2B5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383184,135,358 - 184,145,311 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3184,135,038 - 184,146,127 (+)EnsemblGRCh38hg38GRCh38
GRCh373183,853,146 - 183,863,099 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363185,335,504 - 185,345,793 (+)NCBINCBI36Build 36hg18NCBI36
Build 343185,335,825 - 185,345,792NCBI
Celera3182,295,251 - 182,305,538 (+)NCBICelera
Cytogenetic Map3q27.1NCBI
HuRef3181,260,682 - 181,271,225 (+)NCBIHuRef
CHM1_13183,817,213 - 183,827,502 (+)NCBICHM1_1
T2T-CHM13v2.03186,944,907 - 186,954,859 (+)NCBIT2T-CHM13v2.0
Eif2b5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391620,317,544 - 20,328,073 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1620,317,567 - 20,328,073 (+)EnsemblGRCm39 Ensembl
GRCm381620,498,795 - 20,509,325 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1620,498,817 - 20,509,323 (+)EnsemblGRCm38mm10GRCm38
MGSCv371620,498,890 - 20,509,398 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361620,412,371 - 20,422,866 (+)NCBIMGSCv36mm8
Celera1621,062,563 - 21,073,067 (+)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1612.45NCBI
Eif2b5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542023,309,378 - 23,322,698 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542023,313,405 - 23,322,748 (-)NCBIChiLan1.0ChiLan1.0
EIF2B5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22182,006,857 - 182,017,041 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13182,011,761 - 182,021,758 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03181,170,806 - 181,180,923 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13189,652,675 - 189,663,132 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3189,652,554 - 189,665,528 (+)Ensemblpanpan1.1panPan2
EIF2B5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13417,038,163 - 17,047,390 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3417,038,203 - 17,046,928 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3421,125,466 - 21,134,700 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03416,946,336 - 16,955,570 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3416,946,379 - 16,955,125 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13416,983,667 - 16,992,900 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03416,979,604 - 16,988,841 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03417,209,816 - 17,219,064 (+)NCBIUU_Cfam_GSD_1.0
Eif2b5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602119,624,479 - 119,633,010 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365785,715,512 - 5,725,096 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365785,716,333 - 5,724,869 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2B5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13122,060,473 - 122,070,304 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113122,060,408 - 122,070,327 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213131,370,853 - 131,377,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2B5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1155,278,759 - 5,289,422 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl155,278,749 - 5,289,030 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606314,059,084 - 14,070,350 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2b5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473072,417,856 - 72,428,093 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473072,417,069 - 72,428,194 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2b5
9 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:413
Count of miRNA genes:241
Interacting mature miRNAs:275
Transcripts:ENSRNOT00000002321
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat
1354656Bvd3Brain ventricular dilatation QTL 33.640.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116944607082846715Rat
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)117695713183051965Rat

Markers in Region
AW528025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,395,292 - 80,395,595 (+)MAPPERmRatBN7.2
Rnor_6.01184,081,133 - 84,081,435NCBIRnor6.0
Rnor_5.01187,152,499 - 87,152,801UniSTSRnor5.0
RGSC_v3.41182,634,866 - 82,635,168UniSTSRGSC3.4
Celera1179,235,313 - 79,235,615UniSTS
RH 3.4 Map11657.2UniSTS
Cytogenetic Map11q23UniSTS
AI716564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21180,394,672 - 80,394,763 (+)MAPPERmRatBN7.2
Rnor_6.01184,080,513 - 84,080,603NCBIRnor6.0
Rnor_5.01187,151,879 - 87,151,969UniSTSRnor5.0
RGSC_v3.41182,634,246 - 82,634,336UniSTSRGSC3.4
Celera1179,234,693 - 79,234,783UniSTS
RH 3.4 Map11656.0UniSTS
Cytogenetic Map11q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002321   ⟹   ENSRNOP00000002321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1180,394,433 - 80,404,419 (-)Ensembl
Rnor_6.0 Ensembl1184,080,273 - 84,090,259 (-)Ensembl
RefSeq Acc Id: NM_138866   ⟹   NP_620221
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,898,814 - 93,908,800 (-)NCBI
mRatBN7.21180,394,433 - 80,404,419 (-)NCBI
Rnor_6.01184,080,273 - 84,090,259 (-)NCBI
Rnor_5.01187,151,639 - 87,161,625 (-)NCBI
RGSC_v3.41182,634,006 - 82,643,992 (-)RGD
Celera1179,234,453 - 79,244,439 (-)RGD
Sequence:
RefSeq Acc Id: XM_039087951   ⟹   XP_038943879
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,903,439 - 93,909,431 (-)NCBI
mRatBN7.21180,399,058 - 80,404,468 (-)NCBI
RefSeq Acc Id: XM_039087952   ⟹   XP_038943880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81193,903,530 - 93,909,431 (-)NCBI
mRatBN7.21180,399,149 - 80,404,468 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_620221   ⟸   NM_138866
- UniProtKB: Q5RKL3 (UniProtKB/Swiss-Prot),   Q64350 (UniProtKB/Swiss-Prot),   A6JSB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002321   ⟸   ENSRNOT00000002321
RefSeq Acc Id: XP_038943879   ⟸   XM_039087951
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038943880   ⟸   XM_039087952
- Peptide Label: isoform X2
Protein Domains
W2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64350-F1-model_v2 AlphaFold Q64350 1-716 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698281
Promoter ID:EPDNEW_R8805
Type:initiation region
Name:Eif2b5_1
Description:eukaryotic translation initiation factor 2B subunit epsilon
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01184,090,246 - 84,090,306EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708380 AgrOrtholog
BioCyc Gene G2FUF-20729 BioCyc
Ensembl Genes ENSRNOG00000038160 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055004929 UniProtKB/Swiss-Prot
  ENSRNOG00060012025 UniProtKB/Swiss-Prot
  ENSRNOG00065004327 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000002321 ENTREZGENE
  ENSRNOT00000002321.4 UniProtKB/Swiss-Prot
  ENSRNOT00055007862 UniProtKB/Swiss-Prot
  ENSRNOT00060020385 UniProtKB/Swiss-Prot
  ENSRNOT00065006306 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.180 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hexapeptide repeat proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193458 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  eIF-2B_epsilon_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trimer_LpxA-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  W2_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  W2_eIF2B_epsilon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:192234 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93170 IMAGE-MGC_LOAD
NCBI Gene 192234 ENTREZGENE
PANTHER TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON UniProtKB/Swiss-Prot
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON UniProtKB/Swiss-Prot
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON UniProtKB/TrEMBL
  TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON UniProtKB/TrEMBL
Pfam PF02020 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2b5 PhenoGen
PROSITE PS51363 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000038160 RatGTEx
  ENSRNOG00055004929 RatGTEx
  ENSRNOG00060012025 RatGTEx
  ENSRNOG00065004327 RatGTEx
SMART eIF5C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP ARM repeat UniProtKB/TrEMBL
  Nucleotide-diphospho-sugar transferases UniProtKB/TrEMBL
  SSF48371 UniProtKB/Swiss-Prot
  SSF51161 UniProtKB/Swiss-Prot
  SSF53448 UniProtKB/Swiss-Prot
  Trimeric LpxA-like enzymes UniProtKB/TrEMBL
UniProt A6JSB3 ENTREZGENE, UniProtKB/TrEMBL
  EI2BE_RAT UniProtKB/Swiss-Prot
  Q5RKL3 ENTREZGENE
  Q64350 ENTREZGENE
UniProt Secondary Q5RKL3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 Eif2b5  eukaryotic translation initiation factor 2B subunit epsilon  Eif2b5  eukaryotic translation initiation factor 2B subunit 5 epsilon  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-26 Eif2b5  eukaryotic translation initiation factor 2B subunit 5 epsilon  Eif2b5  eukaryotic translation initiation factor 2B subunit 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-25 Eif2b5  eukaryotic translation initiation factor 2B subunit 5  Eif2b5  eukaryotic translation initiation factor 2B, subunit 5 epsilon  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Eif2b5  eukaryotic translation initiation factor 2B, subunit 5 epsilon  LOC192234  initiation factor eIF-2Be  Symbol and Name updated 1299863 APPROVED