Lgals3 (galectin 3) - Rat Genome Database

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Gene: Lgals3 (galectin 3) Rattus norvegicus
Analyze
Symbol: Lgals3
Name: galectin 3
RGD ID: 69356
Description: Enables several functions, including Fc-gamma receptor I complex binding activity; IgE binding activity; and advanced glycation end-product receptor activity. Involved in several processes, including negative regulation of cell proliferation in bone marrow; positive regulation of serotonin secretion; and response to quercetin. Located in cell surface; extracellular matrix; and extracellular space. Biomarker of several diseases, including acute kidney failure; attention deficit hyperactivity disorder; brain ischemia; colon cancer; and congestive heart failure. Human ortholog(s) of this gene implicated in asthma. Orthologous to human LGALS3 (galectin 3); PARTICIPATES IN Hedgehog signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 35 kDa lectin; AGE-R3; carbohydrate-binding protein 35; CBP 35; CBP30; epsilon BP; gal-3; galactose-specific lectin 3; galectin-3; IgE binding protein; L-34; laminin-binding protein; lectin galactoside-binding soluble 3 protein; lectin L-29; lectin, galactose binding, soluble 3; lectin, galactoside-binding, soluble, 3; mac-2 antigen; MGC105387
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Lgals3em1Dfult
Genetic Models: SD-Lgals3em1Dfult
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81523,099,795 - 23,111,731 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1523,086,841 - 23,111,737 (+)EnsemblGRCr8
mRatBN7.21520,620,083 - 20,632,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,607,692 - 20,632,025 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1523,400,729 - 23,412,663 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,358,692 - 24,370,626 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,609,201 - 22,621,133 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01524,153,602 - 24,165,537 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1524,141,651 - 24,165,537 (+)Ensemblrn6Rnor6.0
Rnor_5.01528,094,344 - 28,106,281 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41523,327,071 - 23,339,006NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1521,014,742 - 21,026,522 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,4-dichlorobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dimethoxyphenol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium sulfate (anhydrous)  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bucladesine  (ISO)
buspirone  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium dichloride  (EXP)
calcitriol  (ISO)
calyculin A  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chloroform  (EXP)
choline  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythromycin estolate  (EXP)
etoposide  (ISO)
fenamidone  (ISO)
ferric oxide  (EXP)
flurbiprofen  (ISO)
folic acid  (EXP,ISO)
furfural  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
GSK-J4  (ISO)
hexadecanoic acid  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lactose  (ISO)
leflunomide  (ISO)
lipoteichoic acid  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methimazole  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (EXP)
mitomycin C  (ISO)
monocrotaline  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetylsphingosine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naloxone  (EXP)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
Nonylphenol  (ISO)
Nutlin-3  (ISO)
ochratoxin A  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenacetin  (EXP)
phenobarbital  (EXP,ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
quinoline  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
theophylline  (EXP)
thioacetamide  (EXP,ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc oxide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell differentiation  (IEA)
eosinophil chemotaxis  (IBA,IEA,ISO)
epithelial cell differentiation  (IEA,ISO)
extracellular matrix organization  (ISO)
immune system process  (IEA)
innate immune response  (IEA)
macrophage chemotaxis  (IBA,IEA,ISO)
maintenance of protein location  (ISO)
monocyte chemotaxis  (IBA,IEA,ISO)
mononuclear cell migration  (IEA,ISO)
mRNA processing  (IEA)
negative regulation of apoptotic process  (IDA)
negative regulation of cell proliferation in bone marrow  (IDA)
negative regulation of endocytosis  (IBA,IEA,ISO)
negative regulation of extrinsic apoptotic signaling pathway  (IBA,IEA,ISO)
negative regulation of immunological synapse formation  (ISO)
negative regulation of NK T cell activation  (IEA,ISO)
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
neutrophil chemotaxis  (IBA,IEA,ISO)
positive chemotaxis  (IBA,IEA,ISO)
positive regulation of angiogenesis  (IMP)
positive regulation of calcium ion import  (IBA,IEA,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of dendritic cell differentiation  (ISO)
positive regulation of mononuclear cell migration  (IEA,ISO)
positive regulation of protein localization to plasma membrane  (IEA,ISO)
positive regulation of protein-containing complex assembly  (IEA,ISO)
positive regulation of serotonin secretion  (IDA)
regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
regulation of T cell apoptotic process  (IEA,ISO)
regulation of T cell proliferation  (IEA,ISO)
response to quercetin  (IEP)
RNA splicing  (IEA)
skeletal system development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer Ahmed HH, etal., Asian Pac J Cancer Prev. 2016 Nov 1;17(11):4991-4998. doi: 10.22034/APJCP.2016.17.11.4991.
2. An IgE-binding protein with a distinctive repetitive sequence and homology with an IgG receptor. Albrandt K, etal., Proc Natl Acad Sci U S A 1987 Oct;84(19):6859-63.
3. Galectin-3 gene (LGALS3) expression in experimental atherosclerosis and cultured smooth muscle cells. Arar C, etal., FEBS Lett. 1998 Jul 3;430(3):307-11.
4. Gene and protein expression of galectin-3 and galectin-9 in experimental pneumococcal meningitis. Bellac CL, etal., Neurobiol Dis. 2007 Nov;28(2):175-83. Epub 2007 Jul 10.
5. Galectin-3 in preneoplastic lesions of glioma. Binh NH, etal., J Neurooncol. 2013 Jan;111(2):123-32. doi: 10.1007/s11060-012-1005-2. Epub 2012 Nov 23.
6. Galectin-3 mediates aldosterone-induced vascular fibrosis. Calvier L, etal., Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):67-75. doi: 10.1161/ATVBAHA.112.300569. Epub 2012 Nov 1.
7. Galectin-3 as a potential prognostic biomarker of severe COVID-19 in SARS-CoV-2 infected patients. Cervantes-Alvarez E, etal., Sci Rep. 2022 Feb 3;12(1):1856. doi: 10.1038/s41598-022-05968-4.
8. Epsilon BP, a beta-galactoside-binding animal lectin, recognizes IgE receptor (Fc epsilon RI) and activates mast cells. Frigeri LG, etal., Biochemistry. 1993 Aug 3;32(30):7644-9.
9. Expression of biologically active recombinant rat IgE-binding protein in Escherichia coli. Frigeri LG, etal., J Biol Chem. 1990 Dec 5;265(34):20763-9.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Inflammation-induced modulation of cellular galectin-1 and -3 expression in a model of rat peritonitis. Gil CD, etal., Inflamm Res. 2006 Mar;55(3):99-107.
12. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPa (signal regulatory protein-a) on phagocytes. Gitik M, etal., J Neuroinflammation. 2011 Mar 15;8:24. doi: 10.1186/1742-2094-8-24.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Henderson NC, etal., Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5060-5. Epub 2006 Mar 20.
15. Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3. Hikita C, etal., J Cell Biol. 2000 Dec 11;151(6):1235-46.
16. Enhanced expression of lymphomagenesis-related genes in peripheral blood B cells of chronic hepatitis C patients. Ito M, etal., Clin Immunol. 2010 Jun;135(3):459-65. doi: 10.1016/j.clim.2010.02.002. Epub 2010 Mar 1.
17. Immune-mediated beta-cell destruction in vitro and in vivo-A pivotal role for galectin-3. Karlsen AE, etal., Biochem Biophys Res Commun. 2006 May 26;344(1):406-15. Epub 2006 Mar 29.
18. Galectin-3 inhibits granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven rat bone marrow cell proliferation and GM-CSF-induced gene transcription. Krugluger W, etal., Immunobiology. 1997 Jun;197(1):97-109.
19. Identification of an IgE-binding protein by molecular cloning. Liu FT, etal., Proc Natl Acad Sci U S A 1985 Jun;82(12):4100-4.
20. Inhibition of chronic airway inflammation and remodeling by galectin-3 gene therapy in a murine model. Lopez E, etal., J Immunol. 2006 Feb 1;176(3):1943-50.
21. Stimulation of proliferation of rat hepatic stellate cells by galectin-1 and galectin-3 through different intracellular signaling pathways. Maeda N, etal., J Biol Chem. 2003 May 23;278(21):18938-44. Epub 2003 Mar 19.
22. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Up-regulation of galectin-3 in acute renal failure of the rat. Nishiyama J, etal., Am J Pathol. 2000 Sep;157(3):815-23.
25. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction. Sharma UC, etal., Circulation. 2004 Nov 9;110(19):3121-8. Epub 2004 Nov 1.
30. Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model. Shou J, etal., Arthritis Res Ther. 2006;8(1):R28. Epub 2006 Jan 10.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Multi-modal proteomic analysis of retinal protein expression alterations in a rat model of diabetic retinopathy. VanGuilder HD, etal., PLoS One. 2011 Jan 13;6(1):e16271. doi: 10.1371/journal.pone.0016271.
33. Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex. Vlassara H, etal., Mol Med. 1995 Sep;1(6):634-46.
34. Galectin-3 is upregulated in microglial cells in response to ischemic brain lesions, but not to facial nerve axotomy. Walther M, etal., J Neurosci Res. 2000 Aug 15;61(4):430-5.
35. A novel function of microRNA let-7d in regulation of galectin-3 expression in attention deficit hyperactivity disorder rat brain. Wu L, etal., Brain Pathol. 2010 Nov;20(6):1042-54. doi: 10.1111/j.1750-3639.2010.00410.x. Epub 2010 Jun 14.
36. Galectin-3 mediates post-ischemic tissue remodeling. Yan YP, etal., Brain Res. 2009 Sep 8;1288:116-24. doi: 10.1016/j.brainres.2009.06.073. Epub 2009 Jun 30.
Additional References at PubMed
PMID:2261464   PMID:2402511   PMID:2605254   PMID:7682704   PMID:8253805   PMID:8692888   PMID:9447709   PMID:10745073   PMID:10925302   PMID:11532191   PMID:11856751   PMID:12477932  
PMID:12615069   PMID:14622091   PMID:14961764   PMID:15265923   PMID:15489334   PMID:15646023   PMID:15729693   PMID:15800063   PMID:16116184   PMID:16131647   PMID:16691442   PMID:16982911  
PMID:17202886   PMID:17592963   PMID:19015643   PMID:19016746   PMID:19056867   PMID:19199708   PMID:19706535   PMID:19785949   PMID:19946888   PMID:20551380   PMID:20826656   PMID:20865664  
PMID:20980634   PMID:21188523   PMID:21435650   PMID:21472689   PMID:21492153   PMID:21566659   PMID:21670307   PMID:22658674   PMID:22664934   PMID:22761016   PMID:23376485   PMID:23460747  
PMID:23533145   PMID:23576987   PMID:23580065   PMID:24006456   PMID:24846175   PMID:25481849   PMID:25489662   PMID:26875907   PMID:27010252   PMID:27068509   PMID:27559042   PMID:27836669  
PMID:27870162   PMID:28255782   PMID:28360193   PMID:28431936   PMID:28500071   PMID:28758988   PMID:28826890   PMID:28858976   PMID:29286090   PMID:30463073   PMID:30724100   PMID:30795916  
PMID:31763668   PMID:32090685   PMID:32311288   PMID:32667865   PMID:33275526   PMID:34225083   PMID:37926077   PMID:38561725   PMID:38728287   PMID:38989572  


Genomics

Comparative Map Data
Lgals3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81523,099,795 - 23,111,731 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1523,086,841 - 23,111,737 (+)EnsemblGRCr8
mRatBN7.21520,620,083 - 20,632,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,607,692 - 20,632,025 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1523,400,729 - 23,412,663 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,358,692 - 24,370,626 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,609,201 - 22,621,133 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01524,153,602 - 24,165,537 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1524,141,651 - 24,165,537 (+)Ensemblrn6Rnor6.0
Rnor_5.01528,094,344 - 28,106,281 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41523,327,071 - 23,339,006NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1521,014,742 - 21,026,522 (+)NCBICelera
Cytogenetic Map15p14NCBI
LGALS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381455,129,252 - 55,145,430 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1455,121,352 - 55,148,022 (+)Ensemblhg38GRCh38
GRCh371455,595,970 - 55,612,148 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,665,625 - 54,681,901 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341454,665,757 - 54,681,881NCBI
Celera1435,645,428 - 35,661,641 (+)NCBICelera
Cytogenetic Map14q22.3NCBI
HuRef1435,758,537 - 35,774,750 (+)NCBIHuRef
CHM1_11455,534,573 - 55,550,756 (+)NCBICHM1_1
T2T-CHM13v2.01449,334,442 - 49,350,620 (+)NCBIT2T-CHM13v2.0
Lgals3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,611,317 - 47,623,624 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,605,208 - 47,623,617 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381447,373,860 - 47,386,167 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,367,751 - 47,386,160 (+)Ensemblmm10GRCm38
MGSCv371447,993,535 - 48,005,842 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361446,295,795 - 46,308,037 (+)NCBIMGSCv36mm8
Celera1443,562,063 - 43,575,064 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
Lgals3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,447,774 - 8,452,438 (-)Ensembl
ChiLan1.0NW_0049554098,448,120 - 8,452,437 (-)NCBIChiLan1.0ChiLan1.0
LGALS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21556,250,524 - 56,266,924 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,467,032 - 55,483,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,715,850 - 35,732,263 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,990,023 - 54,006,412 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,990,023 - 54,006,412 (+)EnsemblpanPan2panpan1.1
LGALS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,977,438 - 30,994,711 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,983,633 - 30,994,705 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha830,752,177 - 30,763,224 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0831,236,480 - 31,254,738 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl831,236,550 - 31,254,723 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,846,505 - 30,857,542 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,923,589 - 30,934,646 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0831,288,737 - 31,299,778 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lgals3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,252,712 - 74,264,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493669727,145 - 38,586 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493669720,861 - 38,568 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LGALS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1184,478,710 - 184,497,951 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11184,478,639 - 184,496,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,956,478 - 204,974,108 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LGALS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,311,343 - 32,328,335 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,311,271 - 32,328,339 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605320,546,585 - 20,562,993 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lgals3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,298,201 - 14,304,637 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473114,300,138 - 14,307,843 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Lgals3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11275,660,981 - 75,673,725 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lgals3
146 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:116
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000014216
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15231575947315759Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15278592347785923Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15139411584Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15132342855Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15144836456Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15231575953331089Rat
10755503Bp391Blood pressure QTL 3912.37arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)152272835342072050Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151691152132439851Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152233635152597086Rat

Markers in Region
RH127694  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21520,630,850 - 20,631,876 (+)MAPPERmRatBN7.2
Rnor_6.01524,164,371 - 24,165,396NCBIRnor6.0
Rnor_5.01528,105,113 - 28,106,138UniSTSRnor5.0
RGSC_v3.41523,337,840 - 23,338,865UniSTSRGSC3.4
Celera1521,025,356 - 21,026,381UniSTS
RH 3.4 Map15143.2UniSTS
Cytogenetic Map15p14UniSTS
PMC263848P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21520,630,798 - 20,630,919 (+)MAPPERmRatBN7.2
Rnor_6.01524,164,319 - 24,164,439NCBIRnor6.0
Rnor_5.01528,105,061 - 28,105,181UniSTSRnor5.0
RGSC_v3.41523,337,788 - 23,337,908UniSTSRGSC3.4
Celera1521,025,304 - 21,025,424UniSTS
Cytogenetic Map15p14UniSTS


Genetic Models
This gene Lgals3 is modified in the following models/strains:
SD-Lgals3em1Dfult    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031832 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB183247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220215 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220224 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229266 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229280 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229348 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229494 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF639959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000014216   ⟹   ENSRNOP00000014216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1523,099,795 - 23,111,733 (+)Ensembl
mRatBN7.2 Ensembl1520,620,083 - 20,632,012 (+)Ensembl
Rnor_6.0 Ensembl1524,153,602 - 24,165,537 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082304   ⟹   ENSRNOP00000070344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1523,099,835 - 23,111,737 (+)Ensembl
mRatBN7.2 Ensembl1520,607,692 - 20,632,025 (+)Ensembl
Rnor_6.0 Ensembl1524,141,651 - 24,165,535 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082675   ⟹   ENSRNOP00000070203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1523,099,795 - 23,111,726 (+)Ensembl
mRatBN7.2 Ensembl1520,620,083 - 20,632,014 (+)Ensembl
Rnor_6.0 Ensembl1524,159,647 - 24,165,418 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106924   ⟹   ENSRNOP00000097784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1523,086,841 - 23,111,737 (+)Ensembl
mRatBN7.2 Ensembl1520,620,097 - 20,632,025 (+)Ensembl
RefSeq Acc Id: NM_031832   ⟹   NP_114020
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81523,099,795 - 23,111,729 (+)NCBI
mRatBN7.21520,620,083 - 20,632,017 (+)NCBI
Rnor_6.01524,153,602 - 24,165,537 (+)NCBI
Rnor_5.01528,094,344 - 28,106,281 (+)NCBI
RGSC_v3.41523,327,071 - 23,339,006 (+)RGD
Celera1521,014,742 - 21,026,522 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093700   ⟹   XP_038949628
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81523,100,043 - 23,111,731 (+)NCBI
mRatBN7.21520,620,331 - 20,632,019 (+)NCBI
RefSeq Acc Id: NP_114020   ⟸   NM_031832
- UniProtKB: V5QR27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070203   ⟸   ENSRNOT00000082675
Ensembl Acc Id: ENSRNOP00000070344   ⟸   ENSRNOT00000082304
Ensembl Acc Id: ENSRNOP00000014216   ⟸   ENSRNOT00000014216
RefSeq Acc Id: XP_038949628   ⟸   XM_039093700
- Peptide Label: isoform X1
- UniProtKB: P08699 (UniProtKB/Swiss-Prot),   V5QQP9 (UniProtKB/TrEMBL),   A6KE45 (UniProtKB/TrEMBL),   V5QR27 (UniProtKB/TrEMBL),   V5QRT4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097784   ⟸   ENSRNOT00000106924
Protein Domains
Galectin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08699-F1-model_v2 AlphaFold P08699 1-262 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699612
Promoter ID:EPDNEW_R10136
Type:multiple initiation site
Name:Lgals3_1
Description:galectin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01524,153,602 - 24,153,662EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69356 AgrOrtholog
BioCyc Gene G2FUF-14150 BioCyc
Ensembl Genes ENSRNOG00000010645 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014216 ENTREZGENE
  ENSRNOT00000014216.6 UniProtKB/Swiss-Prot
  ENSRNOT00000082675 ENTREZGENE
Gene3D-CATH 2.60.120.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7312891 IMAGE-MGC_LOAD
InterPro ConA-like_dom_sf UniProtKB/Swiss-Prot
  Galectin-like UniProtKB/Swiss-Prot
  Galectin_CRD UniProtKB/Swiss-Prot
KEGG Report rno:83781 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105387 IMAGE-MGC_LOAD
NCBI Gene 83781 ENTREZGENE
PANTHER PTHR11346 UniProtKB/Swiss-Prot
  PTHR11346:SF26 UniProtKB/Swiss-Prot
Pfam Gal-bind_lectin UniProtKB/Swiss-Prot
PhenoGen Lgals3 PhenoGen
PROSITE GALECTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010645 RatGTEx
SMART Gal-bind_lectin UniProtKB/Swiss-Prot
  GLECT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot
TIGR TC217069
UniProt A0A0G2JXB1_RAT UniProtKB/TrEMBL
  A0A0G2JXN6_RAT UniProtKB/TrEMBL
  A0A8I6ATC2_RAT UniProtKB/TrEMBL
  A6KE45 ENTREZGENE, UniProtKB/TrEMBL
  A6KE46_RAT UniProtKB/TrEMBL
  A6KE49_RAT UniProtKB/TrEMBL
  A6KE51_RAT UniProtKB/TrEMBL
  LEG3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  V5QQP9 ENTREZGENE
  V5QR27 ENTREZGENE, UniProtKB/TrEMBL
  V5QRT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-25 Lgals3  galectin 3  Lgals3  lectin, galactoside-binding, soluble, 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-30 Lgals3  lectin, galactoside-binding, soluble, 3  Lgals3  lectin, galactose binding, soluble 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lgals3  lectin, galactose binding, soluble 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Tyr-Pro-Gly-Pro/Gln-Ala/Thr-Pro/Ala-Pro-Gly-Ala repetive sequence in N-terminal and a domain with homology of that found in the lymphocyte/macrophage receptor for the Fc portion of IgG 68810