Inppl1 (inositol polyphosphate phosphatase-like 1) - Rat Genome Database

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Gene: Inppl1 (inositol polyphosphate phosphatase-like 1) Rattus norvegicus
Analyze
Symbol: Inppl1
Name: inositol polyphosphate phosphatase-like 1
RGD ID: 68396
Description: Enables inositol-polyphosphate 5-phosphatase activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in several processes, including inositol trisphosphate metabolic process; negative regulation of DNA replication; and negative regulation of signal transduction. Located in lamellipodium. Human ortholog(s) of this gene implicated in hypertension; obesity; and type 2 diabetes mellitus. Orthologous to human INPPL1 (inositol polyphosphate phosphatase like 1); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; phosphatidylinositol 3-kinase class I signaling pathway; phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 3-chloropropane-1,2-diol; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol polyphosphate phosphatase-like protein 1; INPPL-1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; SH2 domain-containing inositol 5'-phosphatase 2; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SH2-containing inositol phosphatase 2; SHIP-2; Ship2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,595,047 - 165,609,503 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,595,063 - 165,609,503 (-)EnsemblGRCr8
mRatBN7.21156,183,043 - 156,197,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,183,059 - 156,197,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1164,173,364 - 164,187,835 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,353,452 - 171,367,925 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,230,970 - 164,245,436 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,898,177 - 166,912,524 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,899,894 - 166,912,524 (-)Ensemblrn6Rnor6.0
Rnor_5.01173,087,891 - 173,102,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41159,278,131 - 159,292,740 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1154,261,664 - 154,276,489 (-)NCBICelera
RGSC_v3.11159,357,146 - 159,371,757 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
carmustine  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
fipronil  (EXP)
folic acid  (ISO)
glycidyl methacrylate  (ISO)
indometacin  (ISO)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methamphetamine  (ISO)
methidathion  (ISO)
methoxychlor  (EXP)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
Tanshinone I  (ISO)
temozolomide  (ISO)
testosterone enanthate  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basal plasma membrane  (IEA,ISO,ISS)
cytoplasm  (IEA,ISO)
cytoskeleton  (IEA)
cytosol  (IBA,IEA,ISO)
filopodium  (IEA)
lamellipodium  (IDA,IEA)
membrane  (IEA)
nuclear speck  (IEA,ISO,ISS)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
spindle pole  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. Aoki K, etal., J Cell Biol. 2007 Jun 4;177(5):817-27. Epub 2007 May 29.
2. PPAR-gamma inhibits ANG II-induced cell growth via SHIP2 and 4E-BP1. Benkirane K, etal., Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H390-7. Epub 2005 Sep 9.
3. Reversal of denervation-induced insulin resistance by SHIP2 protein synthesis blockade. Bertelli DF, etal., Am J Physiol Endocrinol Metab. 2003 Apr;284(4):E679-87. Epub 2002 Nov 26.
4. Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome. Buettner R, etal., Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1871-8. Epub 2007 Feb 27.
5. The lipid phosphatase SHIP2 controls insulin sensitivity. Clement S, etal., Nature 2001 Jan 4;409(6816):92-7.
6. Metabolic switching of PI3K-dependent lipid signals. Downes CP, etal., Biochem Soc Trans. 2007 Apr;35(Pt 2):188-92.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Molecular cloning of rat SH2-containing inositol phosphatase 2 (SHIP2) and its role in the regulation of insulin signaling. Ishihara H, etal., Biochem Biophys Res Commun 1999 Jun 24;260(1):265-72.
10. Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. Kaisaki PJ, etal., Diabetes. 2004 Jul;53(7):1900-4.
11. Localization of mRNA for SHIP2, SH2 domain-containing inositol polyphosphate 5-phosphatase, in the brain of developing and mature rats. Kudo M, etal., Brain Res Mol Brain Res 2000 Jan 10;75(1):172-7.
12. The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man. Marion E, etal., Diabetes 2002 Jul;51(7):2012-7.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes. Sasaoka T, etal., Diabetologia. 2001 Oct;44(10):1258-67.
22. Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells. Sasaoka T, etal., Endocrinology. 2003 Sep;144(9):4204-14.
Additional References at PubMed
PMID:5668240   PMID:8889548   PMID:12847108   PMID:14502564   PMID:15654325   PMID:15668240   PMID:15983195   PMID:17893321   PMID:21624956   PMID:22247557   PMID:23273569  


Genomics

Comparative Map Data
Inppl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,595,047 - 165,609,503 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1165,595,063 - 165,609,503 (-)EnsemblGRCr8
mRatBN7.21156,183,043 - 156,197,500 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,183,059 - 156,197,500 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1164,173,364 - 164,187,835 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,353,452 - 171,367,925 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,230,970 - 164,245,436 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01166,898,177 - 166,912,524 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,899,894 - 166,912,524 (-)Ensemblrn6Rnor6.0
Rnor_5.01173,087,891 - 173,102,238 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41159,278,131 - 159,292,740 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1154,261,664 - 154,276,489 (-)NCBICelera
RGSC_v3.11159,357,146 - 159,371,757 (-)NCBI
Cytogenetic Map1q32NCBI
INPPL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381172,223,563 - 72,239,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1172,223,524 - 72,239,184 (+)Ensemblhg38GRCh38
GRCh371171,935,811 - 71,950,191 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,613,473 - 71,627,797 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341171,613,472 - 71,627,796NCBI
Celera1169,237,286 - 69,251,595 (+)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1168,229,043 - 68,243,351 (+)NCBIHuRef
CHM1_11171,819,333 - 71,833,642 (+)NCBICHM1_1
T2T-CHM13v2.01172,150,179 - 72,165,764 (+)NCBIT2T-CHM13v2.0
Inppl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,471,839 - 101,487,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7101,471,839 - 101,487,436 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387101,822,632 - 101,838,226 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,822,632 - 101,838,229 (-)Ensemblmm10GRCm38
MGSCv377108,971,146 - 108,986,740 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367101,696,482 - 101,711,897 (-)NCBIMGSCv36mm8
Celera7102,194,349 - 102,209,965 (-)NCBICelera
Cytogenetic Map7E2NCBI
cM Map754.67NCBI
Inppl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,145,432 - 19,163,923 (-)Ensembl
ChiLan1.0NW_00495541419,146,304 - 19,163,923 (-)NCBIChiLan1.0ChiLan1.0
INPPL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2973,170,486 - 73,186,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11174,213,883 - 74,229,609 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01167,302,066 - 67,317,785 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11170,527,525 - 70,540,623 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,527,017 - 70,540,846 (+)EnsemblpanPan2panpan1.1
INPPL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,900,308 - 25,914,527 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,900,900 - 25,915,577 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2125,670,004 - 25,684,057 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02126,108,942 - 26,122,997 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,108,951 - 26,124,170 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12125,900,410 - 25,914,476 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,116,609 - 26,130,663 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,018,164 - 26,032,213 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Inppl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,924,592 - 59,940,332 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364981,524,128 - 1,540,578 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364981,524,128 - 1,539,680 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INPPL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,793,069 - 6,808,028 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.196,793,971 - 6,807,286 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,554,374 - 7,570,176 (+)NCBISscrofa10.2Sscrofa10.2susScr3
INPPL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,443,819 - 63,459,067 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl163,444,713 - 63,459,776 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604362,425,383 - 62,440,788 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Inppl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248174,779,057 - 4,793,732 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248174,779,875 - 4,794,644 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Inppl1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12100,117,171 - 100,131,586 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Inppl1
166 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000066915
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1165278545168003898Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
X75014  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,182,774 - 156,182,957 (+)MAPPERmRatBN7.2
Rnor_6.01166,897,909 - 166,898,091NCBIRnor6.0
Rnor_5.01173,087,623 - 173,087,805UniSTSRnor5.0
RGSC_v3.41159,277,548 - 159,277,730UniSTSRGSC3.4
Celera1154,261,396 - 154,261,578UniSTS
Cytogenetic Map1q32UniSTS
RH128243  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,182,790 - 156,182,986 (+)MAPPERmRatBN7.2
Rnor_6.01166,897,925 - 166,898,120NCBIRnor6.0
Rnor_5.01173,087,639 - 173,087,834UniSTSRnor5.0
Celera1154,261,412 - 154,261,607UniSTS
RH 3.4 Map11272.9UniSTS
Cytogenetic Map1q32UniSTS
RH142431  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,182,775 - 156,182,987 (+)MAPPERmRatBN7.2
Rnor_6.01166,897,910 - 166,898,121NCBIRnor6.0
Rnor_5.01173,087,624 - 173,087,835UniSTSRnor5.0
Celera1154,261,397 - 154,261,608UniSTS
RH 3.4 Map11272.9UniSTS
Cytogenetic Map1q32UniSTS
Inppl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,196,343 - 156,197,699 (+)MAPPERmRatBN7.2
Rnor_6.01166,911,368 - 166,912,723NCBIRnor6.0
Rnor_5.01173,101,082 - 173,102,437UniSTSRnor5.0
RGSC_v3.41159,291,584 - 159,292,939UniSTSRGSC3.4
Celera1154,275,333 - 154,276,688UniSTS
Cytogenetic Map1q32UniSTS
Inppl1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81165,596,008 - 165,596,659 (+)Marker Load Pipeline
mRatBN7.21156,184,005 - 156,184,656 (+)MAPPERmRatBN7.2
Rnor_6.01166,899,140 - 166,899,790NCBIRnor6.0
Rnor_5.01173,088,854 - 173,089,504UniSTSRnor5.0
RGSC_v3.41159,278,814 - 159,279,464UniSTSRGSC3.4
Celera1154,262,627 - 154,263,277UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000066915   ⟹   ENSRNOP00000061371
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,595,063 - 165,608,673 (-)Ensembl
mRatBN7.2 Ensembl1156,183,059 - 156,196,670 (-)Ensembl
Rnor_6.0 Ensembl1166,899,894 - 166,911,694 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000092952   ⟹   ENSRNOP00000075945
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1165,595,063 - 165,609,503 (-)Ensembl
mRatBN7.2 Ensembl1156,183,059 - 156,197,500 (-)Ensembl
Rnor_6.0 Ensembl1166,900,001 - 166,912,524 (-)Ensembl
RefSeq Acc Id: NM_001270843   ⟹   NP_001257772
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,595,047 - 165,608,673 (-)NCBI
mRatBN7.21156,183,043 - 156,196,670 (-)NCBI
Rnor_6.01166,898,177 - 166,911,694 (-)NCBI
Rnor_5.01173,087,891 - 173,102,238 (-)NCBI
Celera1154,261,664 - 154,275,659 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022944   ⟹   NP_075233
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,595,047 - 165,609,503 (-)NCBI
mRatBN7.21156,183,043 - 156,197,500 (-)NCBI
Rnor_6.01166,898,177 - 166,912,524 (-)NCBI
Rnor_5.01173,087,891 - 173,102,238 (-)NCBI
RGSC_v3.41159,278,131 - 159,292,740 (-)RGD
Celera1154,261,664 - 154,276,489 (-)NCBI
Sequence:
RefSeq Acc Id: NP_075233   ⟸   NM_022944
- Peptide Label: isoform 1
- UniProtKB: Q9R1V2 (UniProtKB/Swiss-Prot),   Q9WVR3 (UniProtKB/Swiss-Prot),   A0A1B0GWM0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257772   ⟸   NM_001270843
- Peptide Label: isoform 2
- UniProtKB: A0A1B0GWM0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075945   ⟸   ENSRNOT00000092952
Ensembl Acc Id: ENSRNOP00000061371   ⟸   ENSRNOT00000066915
Protein Domains
Phosphatidylinositol 3,4,5-trisphosphate 5-   SAM   SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WVR3-F1-model_v2 AlphaFold Q9WVR3 1-1257 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690259
Promoter ID:EPDNEW_R784
Type:single initiation site
Name:Inppl1_2
Description:inositol polyphosphate phosphatase-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R785  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01166,911,677 - 166,911,737EPDNEW
RGD ID:13690262
Promoter ID:EPDNEW_R785
Type:initiation region
Name:Inppl1_1
Description:inositol polyphosphate phosphatase-like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R784  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01166,912,542 - 166,912,602EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68396 AgrOrtholog
BioCyc Gene G2FUF-58276 BioCyc
BioCyc Pathway PWY-6368 [3-phosphoinositide degradation] BioCyc
BioCyc Pathway Image PWY-6368 BioCyc
Ensembl Genes ENSRNOG00000019730 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000066915 ENTREZGENE
  ENSRNOT00000066915.4 UniProtKB/Swiss-Prot
  ENSRNOT00000092952 ENTREZGENE
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  3.60.10.10 UniProtKB/Swiss-Prot
InterPro Endo/exonu/phosph_ase_sf UniProtKB/Swiss-Prot
  IPPc UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SAM/pointed_sf UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:65038 UniProtKB/Swiss-Prot
NCBI Gene 65038 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 5-PHOSPHATASE 2 UniProtKB/Swiss-Prot
  SH2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam C2_SHIP1-2_2nd UniProtKB/Swiss-Prot
  C2_SHIP1-2_first UniProtKB/Swiss-Prot
  Exo_endo_phos2 UniProtKB/Swiss-Prot
  SAM_1 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Inppl1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SAM_DOMAIN UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019730 RatGTEx
SMART IPPc UniProtKB/Swiss-Prot
  SAM UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
  SSF56219 UniProtKB/Swiss-Prot
UniProt A0A1B0GWM0 ENTREZGENE, UniProtKB/TrEMBL
  A6I6V8_RAT UniProtKB/TrEMBL
  A6I6W0_RAT UniProtKB/TrEMBL
  A6I6W4_RAT UniProtKB/TrEMBL
  Q9R1V2 ENTREZGENE
  Q9WVR3 ENTREZGENE, UniProtKB/Swiss-Prot
  V9GZ88_RAT UniProtKB/TrEMBL
UniProt Secondary Q9R1V2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Inppl1  inositol polyphosphate phosphatase-like 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an amino-terminal SH2 domain, a central 5'-phosphoinositol phosphatase activity domain, and a phosphotyrosine binding (PTB) consensus sequence and a proline-rich region 68267