Cacnb1 (calcium voltage-gated channel auxiliary subunit beta 1) - Rat Genome Database

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Gene: Cacnb1 (calcium voltage-gated channel auxiliary subunit beta 1) Rattus norvegicus
Analyze
Symbol: Cacnb1
Name: calcium voltage-gated channel auxiliary subunit beta 1
RGD ID: 68382
Description: Enables several functions, including identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to voltage-gated calcium channel activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; neuromuscular junction development; and regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to act upstream of or within calcium ion transport and protein targeting to membrane. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: brain calcium channel beta 1 subunit; CAB1; calcium channel beta 1 subunit; calcium channel voltage-dependent beta 1 subunit; calcium channel voltage-dependent subunit beta 1; calcium channel, voltage-dependent, beta 1 subunit; voltage-dependent L-type calcium channel subunit beta-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,494,509 - 83,515,164 (-)NCBIGRCr8
mRatBN7.21082,998,182 - 83,018,838 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,946,204 - 87,966,793 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,444,288 - 87,464,877 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,836,918 - 82,857,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,954,138 - 85,974,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,954,138 - 85,974,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,742,631 - 85,763,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,764,283 - 86,784,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,778,652 - 86,799,161 (-)NCBI
Celera1081,751,498 - 81,772,006 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
arrhythmogenic right ventricular cardiomyopathy pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium transport pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
dilated cardiomyopathy pathway  (IEA)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
felodipine pharmacokinetics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
hypertrophic cardiomyopathy pathway  (IEA)
ibutilide pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway   (ISO)
mitogen activated protein kinase signaling pathway  (IEA)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway   (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation. Abiria SA and Colbran RJ, J Neurochem. 2010 Jan;112(1):150-61. doi: 10.1111/j.1471-4159.2009.06436.x. Epub 2009 Oct 15.
2. BARP suppresses voltage-gated calcium channel activity and Ca2+-evoked exocytosis. Beguin P, etal., J Cell Biol. 2014 Apr 28;205(2):233-49. doi: 10.1083/jcb.201304101. Epub 2014 Apr 21.
3. Voltage-gated calcium channels. Catterall WA Cold Spring Harb Perspect Biol. 2011 Aug 1;3(8):a003947. doi: 10.1101/cshperspect.a003947.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating. Gonzalez-Gutierrez G, etal., Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14198-203. doi: 10.1073/pnas.0806558105. Epub 2008 Sep 5.
7. Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. Grueter CE, etal., Biochemistry. 2008 Feb 12;47(6):1760-7. Epub 2008 Jan 19.
8. Integrin receptor activation triggers converging regulation of Cav1.2 calcium channels by c-Src and protein kinase A pathways. Gui P, etal., J Biol Chem. 2006 May 19;281(20):14015-25. Epub 2006 Mar 22.
9. Modulation of CaV2.1 channels by the neuronal calcium-binding protein visinin-like protein-2. Lautermilch NJ, etal., J Neurosci. 2005 Jul 27;25(30):7062-70.
10. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. Leroy J, etal., J Neurosci. 2005 Jul 27;25(30):6984-96.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons. Obermair GJ, etal., J Biol Chem. 2010 Feb 19;285(8):5776-91. doi: 10.1074/jbc.M109.044271. Epub 2009 Dec 8.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Cloning and tissue-specific expression of the brain calcium channel beta-subunit. Pragnell M, etal., FEBS Lett 1991 Oct 21;291(2):253-8.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:1370480   PMID:8943043   PMID:9929471   PMID:10328888   PMID:11160515   PMID:11756409   PMID:14760703   PMID:15750602   PMID:19953087   PMID:21883149  


Genomics

Comparative Map Data
Cacnb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81083,494,509 - 83,515,164 (-)NCBIGRCr8
mRatBN7.21082,998,182 - 83,018,838 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1087,946,204 - 87,966,793 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01087,444,288 - 87,464,877 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01082,836,918 - 82,857,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01085,954,138 - 85,974,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1085,954,138 - 85,974,651 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01085,742,631 - 85,763,268 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41086,764,283 - 86,784,791 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11086,778,652 - 86,799,161 (-)NCBI
Celera1081,751,498 - 81,772,006 (-)NCBICelera
Cytogenetic Map10q31NCBI
CACNB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381739,173,453 - 39,197,669 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1739,173,453 - 39,197,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371737,329,706 - 37,353,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361734,583,235 - 34,607,427 (-)NCBINCBI36Build 36hg18NCBI36
Build 341734,586,914 - 34,607,427NCBI
Celera1733,990,617 - 34,014,805 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1733,125,170 - 33,149,131 (-)NCBIHuRef
CHM1_11737,565,987 - 37,590,231 (-)NCBICHM1_1
T2T-CHM13v2.01740,037,330 - 40,061,546 (-)NCBIT2T-CHM13v2.0
Cacnb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391197,892,339 - 97,913,860 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1197,892,334 - 97,913,860 (-)EnsemblGRCm39 Ensembl
GRCm381198,001,508 - 98,023,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1198,001,508 - 98,023,034 (-)EnsemblGRCm38mm10GRCm38
MGSCv371197,864,215 - 97,883,941 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361197,818,991 - 97,839,113 (-)NCBIMGSCv36mm8
Celera11107,653,222 - 107,676,228 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1161.5NCBI
Cacnb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545114,038,668 - 14,059,848 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545114,041,848 - 14,059,740 (-)NCBIChiLan1.0ChiLan1.0
CACNB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21925,740,744 - 25,765,311 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11727,634,877 - 27,659,438 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01718,073,818 - 18,098,400 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11718,349,146 - 18,373,338 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1718,349,146 - 18,373,338 (+)Ensemblpanpan1.1panPan2
CACNB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1923,182,407 - 23,197,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl923,180,554 - 23,195,673 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha922,649,781 - 22,668,495 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0923,972,610 - 23,991,331 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl923,972,594 - 23,991,326 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1922,744,505 - 22,763,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0923,005,588 - 23,024,294 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0923,130,733 - 23,149,448 (+)NCBIUU_Cfam_GSD_1.0
Cacnb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560222,606,360 - 22,626,845 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649014,448,258 - 14,468,785 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649014,448,305 - 14,468,785 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,037,810 - 23,060,490 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11223,038,185 - 23,060,504 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21223,491,054 - 23,513,338 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11666,971,379 - 66,994,031 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1666,971,459 - 66,996,095 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607737,916,094 - 37,941,343 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacnb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247953,732,320 - 3,747,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247953,732,201 - 3,747,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacnb1
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:99
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000006098
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107437208484007272Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608584007272Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)107821062285220348Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)107981378985160854Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat

Markers in Region
D10Got128  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,004,425 - 83,004,668 (+)MAPPERmRatBN7.2
Rnor_6.01085,960,382 - 85,960,624NCBIRnor6.0
Rnor_5.01085,748,875 - 85,749,117UniSTSRnor5.0
RGSC_v3.41086,770,526 - 86,770,769RGDRGSC3.4
RGSC_v3.41086,770,527 - 86,770,769UniSTSRGSC3.4
RGSC_v3.11086,784,897 - 86,785,139RGD
Celera1081,757,742 - 81,757,984UniSTS
RH 3.4 Map10797.4UniSTS
RH 3.4 Map10797.4RGD
RH 2.0 Map10946.9RGD
Cytogenetic Map10q31UniSTS
D10Got122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,016,914 - 83,017,138 (+)MAPPERmRatBN7.2
Rnor_6.01085,972,867 - 85,973,088NCBIRnor6.0
Rnor_5.01085,761,360 - 85,761,581UniSTSRnor5.0
RGSC_v3.41086,783,013 - 86,783,235RGDRGSC3.4
RGSC_v3.41086,783,014 - 86,783,235UniSTSRGSC3.4
RGSC_v3.11086,797,383 - 86,797,605RGD
Celera1081,770,229 - 81,770,450UniSTS
Cytogenetic Map10q31UniSTS
G73122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,006,475 - 83,007,239 (+)MAPPERmRatBN7.2
Rnor_6.01085,962,432 - 85,963,195NCBIRnor6.0
Rnor_5.01085,750,925 - 85,751,688UniSTSRnor5.0
RGSC_v3.41086,772,577 - 86,773,340UniSTSRGSC3.4
Celera1081,759,792 - 81,760,555UniSTS
Cytogenetic Map10q31UniSTS
CACNB1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21083,001,957 - 83,002,450 (+)MAPPERmRatBN7.2
Rnor_6.01085,957,914 - 85,958,406NCBIRnor6.0
Rnor_5.01085,746,407 - 85,746,899UniSTSRnor5.0
RGSC_v3.41086,768,059 - 86,768,551UniSTSRGSC3.4
Celera1081,755,274 - 81,755,766UniSTS
Cytogenetic Map10q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 8 11 72 10 10 8
Low 3 27 22 8 17 8 2 22 30 11
Below cutoff 16 26 26 26 3 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000006098   ⟹   ENSRNOP00000006098
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)Ensembl
Rnor_6.0 Ensembl1085,954,138 - 85,974,644 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082974   ⟹   ENSRNOP00000073177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)Ensembl
Rnor_6.0 Ensembl1085,955,346 - 85,974,651 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095610   ⟹   ENSRNOP00000078981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000108528   ⟹   ENSRNOP00000091590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,998,182 - 83,014,742 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109621   ⟹   ENSRNOP00000085572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1082,998,182 - 83,018,694 (-)Ensembl
RefSeq Acc Id: NM_017346   ⟹   NP_059042
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,494,509 - 83,515,146 (-)NCBI
mRatBN7.21082,998,182 - 83,018,823 (-)NCBI
Rnor_6.01085,954,138 - 85,974,644 (-)NCBI
Rnor_5.01085,742,631 - 85,763,268 (-)NCBI
RGSC_v3.41086,764,283 - 86,784,791 (-)RGD
Celera1081,751,498 - 81,772,006 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247409   ⟹   XP_006247471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,494,516 - 83,515,164 (-)NCBI
mRatBN7.21082,998,187 - 83,018,838 (-)NCBI
Rnor_6.01085,954,145 - 85,974,764 (-)NCBI
Rnor_5.01085,742,631 - 85,763,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247410   ⟹   XP_006247472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,494,516 - 83,511,078 (-)NCBI
mRatBN7.21082,998,187 - 83,014,757 (-)NCBI
Rnor_6.01085,954,145 - 85,971,861 (-)NCBI
Rnor_5.01085,742,631 - 85,763,268 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086662   ⟹   XP_038942590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81083,494,516 - 83,505,160 (-)NCBI
mRatBN7.21082,998,187 - 83,008,833 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_059042   ⟸   NM_017346
- UniProtKB: P54283 (UniProtKB/Swiss-Prot),   G3V6K8 (UniProtKB/TrEMBL),   A6HIP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247471   ⟸   XM_006247409
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K4U4 (UniProtKB/TrEMBL),   A0A8I5ZLV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247472   ⟸   XM_006247410
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ASP4 (UniProtKB/TrEMBL),   A0A8I5ZLV2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073177   ⟸   ENSRNOT00000082974
RefSeq Acc Id: ENSRNOP00000006098   ⟸   ENSRNOT00000006098
RefSeq Acc Id: XP_038942590   ⟸   XM_039086662
- Peptide Label: isoform X3
- UniProtKB: A6HIP4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078981   ⟸   ENSRNOT00000095610
RefSeq Acc Id: ENSRNOP00000085572   ⟸   ENSRNOT00000109621
RefSeq Acc Id: ENSRNOP00000091590   ⟸   ENSRNOT00000108528
Protein Domains
Guanylate kinase/L-type calcium channel beta   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P54283-F1-model_v2 AlphaFold P54283 1-597 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68382 AgrOrtholog
BioCyc Gene G2FUF-23387 BioCyc
Ensembl Genes ENSRNOG00000004518 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006098 ENTREZGENE
  ENSRNOT00000006098.6 UniProtKB/TrEMBL
  ENSRNOT00000082974.2 UniProtKB/TrEMBL
  ENSRNOT00000095610.1 UniProtKB/TrEMBL
  ENSRNOT00000108528.1 UniProtKB/TrEMBL
  ENSRNOT00000109621.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CAB1-4_N_A-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GK/Ca_channel_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_b1su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_L_bsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:50688 UniProtKB/Swiss-Prot
NCBI Gene 50688 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Guanylate_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VGCC_beta4Aa_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacnb1 PhenoGen
PRINTS LCACHANNELB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LCACHANNELB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004518 RatGTEx
SMART GuKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221486
UniProt A0A0G2K4U4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZLV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A459_RAT UniProtKB/TrEMBL
  A0A8I6ASP4 ENTREZGENE, UniProtKB/TrEMBL
  A6HIP2 ENTREZGENE, UniProtKB/TrEMBL
  A6HIP4 ENTREZGENE, UniProtKB/TrEMBL
  A6HIP5_RAT UniProtKB/TrEMBL
  A6HIP6_RAT UniProtKB/TrEMBL
  A6HIP7_RAT UniProtKB/TrEMBL
  CACB1_RAT UniProtKB/Swiss-Prot
  G3V6K8 ENTREZGENE, UniProtKB/TrEMBL
  P54283 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Cacnb1  calcium voltage-gated channel auxiliary subunit beta 1  Cacnb1  calcium channel, voltage-dependent, beta 1 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-11 Cacnb1  calcium voltage-gated channel auxiliary subunit beta 1  Cacnb1  calcium voltage-gated channel auxiliary subunit beta 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cacnb1  calcium channel beta 1 subunit       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression displays high level of expression in the cerebral hemispheres and hippocampus with lower expression in cerebellum 68220