Myo7a (myosin VIIA) - Rat Genome Database

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Gene: Myo7a (myosin VIIA) Rattus norvegicus
Analyze
Symbol: Myo7a
Name: myosin VIIA
RGD ID: 628830
Description: Enables several functions, including adenyl ribonucleotide binding activity; calmodulin binding activity; and identical protein binding activity. Involved in actin filament-based movement. Located in upper tip-link density. Part of myosin VII complex. Used to study Usher syndrome. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)); myosin-VIIa; unconventional myosin-VIIa
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Myo7atnd/Hubr  
Genetic Models: W-Myo7atnd/Hubr
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,755,110 - 161,825,397 (-)NCBIGRCr8
mRatBN7.21152,342,611 - 152,414,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,344,448 - 152,414,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,331,375 - 160,401,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,511,561 - 167,581,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,385,070 - 160,454,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,001,313 - 163,071,545 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,001,875 - 163,071,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,206,150 - 169,276,706 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,292,620 - 155,362,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,371,025 - 155,441,104 (-)NCBI
Celera1150,435,342 - 150,505,024 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Reference
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Original Reference(s)
Myo7aRatcongenital nystagmus  ISOMYO7A (Homo sapiens)11537385associated with Leber Congenital Amaurosis and DNA:missense mutation:cds:c.578C>T (p.T193I)(human)RGD 
Myo7aRatCOVID-19  ISOMYO7A (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Myo7aRatDeafness  ISOMyo7a (Mus musculus)4892285DNA:mutations:cds:multiple (mouse)RGD 
Myo7aRatDeafness  IAGP 1581470DNA:nonsense mutation:cdsRGD 
Myo7aRatDeafness  ISOMyo7a (Mus musculus)8694136DNA:deletions:exonsRGD 
Myo7aRatLeber congenital amaurosis  ISOMYO7A (Homo sapiens)11537385DNA:missense mutation:cds:c.578C>T (p.T193I)(human)RGD 
Myo7aRatretinitis pigmentosa  ISOMYO7A (Homo sapiens)8547536 RGD 
Myo7aRatsensorineural hearing loss  ISOMYO7A (Homo sapiens)8694138DNA:missense mutation:exon:c.5660C>T (p.P1887L) (human)RGD 
Myo7aRatUsher syndrome  ISOMYO7A (Homo sapiens)8547536 RGD 
Myo7aRatUsher syndrome type 1  ISOMYO7A (Homo sapiens)8694152DNA:insertion:CDS:c.2663_2664insA (human)RGD 
Myo7aRatUsher Syndrome Type 1B  IAGP 1581470DNA:nonsense mutationRGD 
Myo7aRatUsher Syndrome Type 1B  ISOMYO7A (Homo sapiens)8694135DNA:mutations: :multipleRGD 
Myo7aRatUsher Syndrome Type 1B  ISOMYO7A (Homo sapiens)8694137DNA:mutations: :multipleRGD 
Myo7aRatUsher Syndrome Type 1B treatmentISOMYO7A (Homo sapiens)8694151 RGD 
Myo7aRatUsher Syndrome Type 1B  ISOMyo7a (Mus musculus)8694151 RGD 
Myo7aRatvestibular disease  ISOMyo7a (Mus musculus)4892285DNA:mutations:cds:multiple (mouse)RGD 
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Object Symbol
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Original Reference(s)
Myo7aRatAuditory Neuropathy  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Auditory neuropathyClinVar 
Myo7aRatautosomal dominant nonsyndromic deafness 11  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Deafness and autosomal dominant 11ClinVarPMID:10094549 more ...
Myo7aRatautosomal dominant nonsyndromic deafness 80  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Deafness and autosomal dominant 80ClinVarPMID:24033266 more ...
Myo7aRatautosomal recessive nonsyndromic deafness  ISOMYO7A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10094549 more ...
Myo7aRatautosomal recessive nonsyndromic deafness 2  ISOMYO7A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10094549 more ...
Myo7aRatautosomal recessive nonsyndromic deafness 7  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Deafness and autosomal recessive 7ClinVarPMID:16449806 more ...
Myo7aRatCohen syndrome  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Cohen syndromeClinVarPMID:24033266 more ...
Myo7aRatCutis Verticis Gyrata, Retinitis Pigmentosa, and Sensorineural Deafness  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Cutis verticis gyrata more ...ClinVarPMID:24033266 more ...
Myo7aRatDeafness  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: DeafnessClinVarPMID:22135276 more ...
Myo7aRatfundus dystrophy  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Retinal dystrophyClinVarPMID:10094549 more ...
Myo7aRatgenetic disease  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10094549 more ...
Myo7aRatHearing Loss  ISOMYO7A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10094549 more ...
Myo7aRathereditary breast ovarian cancer syndrome  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast and ovarian cancerClinVarPMID:21436283 more ...
Myo7aRatintellectual disability  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Myo7aRatMeniere's disease  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Meniere diseaseClinVarPMID:15221449 more ...
Myo7aRatnonsyndromic deafness  ISOMYO7A (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10094549 more ...
Myo7aRatNonsyndromic Sensorineural Hearing Loss  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Nonsyndromic Hearing Loss and DominantClinVarPMID:24033266 more ...
Myo7aRatoptic atrophy  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Optic atrophyClinVarPMID:24033266 more ...
Myo7aRatPendred syndrome  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Pendred syndromeClinVarPMID:24033266 more ...
Myo7aRatretinitis pigmentosa  ISOMYO7A (Homo sapiens)8554872ClinVar Annotator: match by term: Retinitis pigmentosaClinVarPMID:10094549 more ...
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Original Reference(s)
Myo7aRatautosomal dominant nonsyndromic deafness 11  ISOMYO7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Myo7aRatautosomal recessive nonsyndromic deafness 2  ISOMYO7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Myo7aRatmelanoma  ISOMYO7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22535842
Myo7aRatUsher syndrome  ISOMYO7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15965244
Myo7aRatUsher Syndrome Type 1B  ISOMYO7A (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Original Reference(s)
Myo7aRatautosomal recessive nonsyndromic deafness 2  ISSMyo7a (Mus musculus)13592920OMIM:600060MouseDO 
Myo7aRatUsher syndrome type 1  ISSMyo7a (Mus musculus)13592920OMIM:276900MouseDO 

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Original Reference(s)
Myo7aRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of MYO7A mRNA]CTDPMID:31150632
Myo7aRat1,1-dichloroethene increases expressionISOMyo7a (Mus musculus)6480464vinylidene chloride results in increased expression of MYO7A mRNACTDPMID:26682919
Myo7aRat1,2-dimethylhydrazine increases expressionISOMyo7a (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of MYO7A mRNACTDPMID:22206623
Myo7aRat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MYO7A mRNACTDPMID:32741896
Myo7aRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of MYO7A mRNACTDPMID:35192832
Myo7aRat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of MYO7A mRNACTDPMID:32741896
Myo7aRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMyo7a (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MYO7A mRNACTDPMID:19933214
Myo7aRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of MYO7A mRNACTDPMID:33387578 and PMID:34747641
Myo7aRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMyo7a (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MYO7A mRNACTDPMID:21570461
Myo7aRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of MYO7A mRNACTDPMID:21346803
Myo7aRat3,3',5,5'-tetrabromobisphenol A decreases expressionISOMyo7a (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of MYO7A mRNACTDPMID:25172293
Myo7aRat3-methylcholanthrene decreases expressionISOMyo7a (Mus musculus)6480464Methylcholanthrene results in decreased expression of MYO7A mRNACTDPMID:20713471
Myo7aRat4,4'-sulfonyldiphenol decreases methylationISOMyo7a (Mus musculus)6480464bisphenol S results in decreased methylation of MYO7A exonCTDPMID:33297965
Myo7aRat4-hydroxyphenyl retinamide increases expressionISOMyo7a (Mus musculus)6480464Fenretinide results in increased expression of MYO7A mRNACTDPMID:28973697
Myo7aRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of MYO7A mRNACTDPMID:24780913 and PMID:25825206
Myo7aRat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of MYO7A mRNACTDPMID:36843608
Myo7aRatacetamide increases expressionEXP 6480464acetamide results in increased expression of MYO7A mRNACTDPMID:31881176
Myo7aRataflatoxin B1 decreases expressionISOMYO7A (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of MYO7A mRNACTDPMID:22100608
Myo7aRataflatoxin B1 affects methylationISOMYO7A (Homo sapiens)6480464Aflatoxin B1 affects the methylation of MYO7A intronCTDPMID:30157460
Myo7aRatAflatoxin B2 alpha affects methylationISOMYO7A (Homo sapiens)6480464aflatoxin B2 affects the methylation of MYO7A intronCTDPMID:30157460

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Biological Process
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Original Reference(s)
Myo7aRatactin filament organization involved_inIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo7aRatactin filament-based movement involved_inISOMYO7A (Homo sapiens)1624291 PMID:21687988RGDPMID:21687988
Myo7aRatactin filament-based movement  IDA 633398 RGD 
Myo7aRatactin filament-based movement involved_inIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo7aRatactin filament-based movement involved_inIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatauditory receptor cell stereocilium organization acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1860092 more ...RGDPMID:11753415 more ...
Myo7aRatauditory receptor cell stereocilium organization acts_upstream_of_or_withinIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatcell projection organization acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1856716 more ...RGDPMID:9435277
Myo7aRatcell projection organization acts_upstream_of_or_withinIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatcochlea development acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1856716 PMID:13336002 more ...RGDMGI:63006 more ...
Myo7aRatcochlea development acts_upstream_of_or_withinIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatequilibrioception involved_inISOMYO7A (Homo sapiens)1624291 PMID:7870171RGDPMID:7870171
Myo7aRatequilibrioception involved_inIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatinner ear auditory receptor cell differentiation acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1860092 more ...RGDPMID:11753415 more ...
Myo7aRatinner ear auditory receptor cell differentiation acts_upstream_of_or_withinIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatinner ear development acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1856716 more ...RGDMGI:63006 more ...
Myo7aRatinner ear development acts_upstream_of_or_withinIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatinner ear morphogenesis acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1856716 more ...RGDPMID:11753415 more ...
Myo7aRatinner ear morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatinner ear receptor cell differentiation acts_upstream_of_or_withinISOMyo7a (Mus musculus)1624291MGI:1856716 more ...RGDPMID:9435277 and PMID:9680294
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Cellular Component
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Original Reference(s)
Myo7aRatactin cytoskeleton is_active_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo7aRatapical plasma membrane located_inISOMyo7a (Mus musculus)1624291 PMID:9620764RGDPMID:9620764
Myo7aRatapical plasma membrane located_inIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Myo7aRatcytoplasm located_inIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatcytoplasm located_inISOMyo7a (Mus musculus)1624291 PMID:11023859 more ...RGDPMID:11023859 more ...
Myo7aRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Myo7aRatcytoplasm located_inIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatcytoplasm is_active_inIBACGD:CAL0000199209 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo7aRatcytoplasm located_inISOMYO7A (Homo sapiens)1624291 PMID:23704327RGDPMID:23704327
Myo7aRatcytoskeleton located_inIEAInterPro:IPR000299 and InterPro:IPR0008571600115GO_REF:0000002InterProGO_REF:0000002
Myo7aRatcytosol located_inISOMYO7A (Homo sapiens)1624291 PMID:15300860RGDPMID:15300860
Myo7aRatcytosol located_inIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatlysosomal membrane located_inISOMYO7A (Homo sapiens)1624291 PMID:16001398RGDPMID:16001398
Myo7aRatlysosomal membrane located_inIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatmelanosome located_inISOMyo7a (Mus musculus)1624291 PMID:14978221 and PMID:15572405RGDPMID:14978221 and PMID:15572405
Myo7aRatmelanosome located_inIEAUniProtKB:P97479 and ensembl:ENSMUSP000001027441600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatmembrane is_active_inIBAFB:FBgn0262029 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo7aRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Myo7aRatmicrovillus is_active_inIBAFB:FBgn0000317 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function
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Original Reference(s)
Myo7aRatactin binding enablesIEAUniProtKB-KW:KW-00091600115GO_REF:0000043UniProtGO_REF:0000043
Myo7aRatactin binding  IDA 633398 RGD 
Myo7aRatactin filament binding enablesISOMYO7A (Homo sapiens)1624291 PMID:21687988RGDPMID:21687988
Myo7aRatactin filament binding enablesIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatactin filament binding enablesIBAFB:FBgn0011225 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Myo7aRatADP binding  IDA 633398 RGD 
Myo7aRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Myo7aRatATP binding  IDA 633398 RGD 
Myo7aRatATP binding enablesIEAInterPro:IPR0016091600115GO_REF:0000002InterProGO_REF:0000002
Myo7aRatATP binding enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myo7aRatcalmodulin binding enablesISOMYO7A (Homo sapiens)1624291 PMID:15300860RGDPMID:15300860
Myo7aRatcalmodulin binding  IDA 633398 RGD 
Myo7aRatcalmodulin binding enablesIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
Myo7aRatcytoskeletal motor activity enablesIEAInterPro:IPR0016091600115GO_REF:0000002InterProGO_REF:0000002
Myo7aRatcytoskeletal motor activity  IDA 633398 RGD 
Myo7aRatcytoskeletal motor activity enablesIEAUniRule:UR0006864691600115GO_REF:0000104UniProtGO_REF:0000104
Myo7aRatidentical protein binding  IPIMyo7a (Rattus norvegicus)633398homodimerizationRGD 
Myo7aRatmicrofilament motor activity enablesISOMYO7A (Homo sapiens)1624291 PMID:21687988RGDPMID:21687988
Myo7aRatmicrofilament motor activity  IDA 633398 RGD 
Myo7aRatmicrofilament motor activity enablesIEAUniProtKB:Q13402 and ensembl:ENSP000003863311600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
Myo7aRatabnormal auditory brainstem response  IAGP 1581470DNA:nonsense mutation:cdsRGD 
Myo7aRatabnormal cochlear hair cell stereociliary bundle morphology  IAGP 1581470DNA:nonsense mutation:cdsRGD 
Myo7aRatabnormal vestibular system physiology  IAGP 1581470DNA:nonsense mutation:cdsRGD 
Myo7aRatcircling  IAGP 1581470DNA:nonsense mutation:cdsRGD 
Myo7aRathyperactivity  IAGP 1581470DNA:nonsense mutation:cdsRGD 

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Reference Title
Reference Citation
1. Analysis of two Arab families reveals additional support for a DFNB2 nonsyndromic phenotype of MYO7A. Ben-Salem S, etal., Mol Biol Rep. 2014 Jan;41(1):193-200. doi: 10.1007/s11033-013-2851-5. Epub 2013 Nov 6.
2. Myosin VIIa, harmonin and cadherin 23, three Usher I gene products that cooperate to shape the sensory hair cell bundle. Boeda B, etal., EMBO J 2002 Dec 16;21(24):6689-99.
3. Myosin7a deficiency results in reduced retinal activity which is improved by gene therapy. Colella P, etal., PLoS One. 2013 Aug 26;8(8):e72027. doi: 10.1371/journal.pone.0072027. eCollection 2013.
4. Human Usher 1B/mouse shaker-1: the retinal phenotype discrepancy explained by the presence/absence of myosin VIIA in the photoreceptor cells. el-Amraoui A, etal., Hum Mol Genet. 1996 Aug;5(8):1171-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Myosin VIIa and sans localization at stereocilia upper tip-link density implicates these Usher syndrome proteins in mechanotransduction. Grati M and Kachar B, Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11476-81. doi: 10.1073/pnas.1104161108. Epub 2011 Jun 27.
9. Expression in cochlea and retina of myosin VIIa, the gene product defective in Usher syndrome type 1B. Hasson T, etal., Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9815-9.
10. Characterization of the motor activity of mammalian myosin VIIA. Inoue A and Ikebe M, J Biol Chem 2003 Feb 14;278(7):5478-87.
11. Sensing sound: molecules that orchestrate mechanotransduction by hair cells. Kazmierczak P and Muller U, Trends Neurosci. 2012 Apr;35(4):220-9. doi: 10.1016/j.tins.2011.10.007. Epub 2011 Dec 15.
12. Genetic analysis of a four generation Indian family with Usher syndrome: a novel insertion mutation in MYO7A. Kumar A, etal., Mol Vis. 2004 Nov 24;10:910-6.
13. Mutation analysis of the mouse myosin VIIA deafness gene. Mburu P, etal., Genes Funct. 1997 Jun;1(3):191-203.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Mutations in myosin VIIA (MYO7A) and usherin (USH2A) in Spanish patients with Usher syndrome types I and II, respectively. Najera C, etal., Hum Mutat. 2002 Jul;20(1):76-7.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Pruss H, etal., Brain Res Mol Brain Res. 2005 Sep 13;139(1):63-79.
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
1 to 20 of 26 rows
PMID:5795329   PMID:6627025   PMID:7870171   PMID:7870172   PMID:9435277   PMID:9620764   PMID:10414956   PMID:11023859   PMID:11162241   PMID:11222540   PMID:11398101   PMID:11753415  
PMID:11921171   PMID:11964381   PMID:12121736   PMID:12743369   PMID:13336002   PMID:14198707   PMID:14609561   PMID:14978221   PMID:15300860   PMID:15316067   PMID:15389316   PMID:15572405  
PMID:15590703   PMID:15657400   PMID:15905332   PMID:16001398   PMID:16481439   PMID:17050716   PMID:17329413   PMID:17567809   PMID:17666436   PMID:18339676   PMID:18796539   PMID:20016102  
PMID:21146598   PMID:21687988   PMID:23704327   PMID:25535395   PMID:26754646   PMID:27525485   PMID:30649248  



Myo7a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81161,755,110 - 161,825,397 (-)NCBIGRCr8
mRatBN7.21152,342,611 - 152,414,171 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,344,448 - 152,414,157 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,331,375 - 160,401,213 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,511,561 - 167,581,393 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,385,070 - 160,454,912 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,001,313 - 163,071,545 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,001,875 - 163,071,508 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,206,150 - 169,276,706 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,292,620 - 155,362,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,371,025 - 155,441,104 (-)NCBI
Celera1150,435,342 - 150,505,024 (-)NCBICelera
Cytogenetic Map1q32NCBI
MYO7A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,128,246 - 77,215,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,128,246 - 77,215,241 (+)EnsemblGRCh38hg38GRCh38
GRCh371176,839,292 - 76,926,286 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,516,964 - 76,603,932 (+)NCBINCBI36Build 36hg18NCBI36
Build 341176,516,957 - 76,603,931NCBI
Celera1174,146,794 - 74,233,913 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1173,136,682 - 73,224,253 (+)NCBIHuRef
CHM1_11176,722,561 - 76,809,502 (+)NCBICHM1_1
T2T-CHM13v2.01177,058,823 - 77,147,851 (+)NCBIT2T-CHM13v2.0
Myo7a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39797,700,261 - 97,768,730 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl797,700,267 - 97,768,731 (-)EnsemblGRCm39 Ensembl
GRCm38798,051,054 - 98,119,522 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,051,060 - 98,119,524 (-)EnsemblGRCm38mm10GRCm38
MGSCv377105,199,570 - 105,268,003 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36797,926,593 - 97,992,926 (-)NCBIMGSCv36mm8
Celera798,371,628 - 98,440,211 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.57NCBI
Myo7a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541414,576,356 - 14,647,500 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541414,576,356 - 14,647,500 (-)NCBIChiLan1.0ChiLan1.0
MYO7A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2978,045,811 - 78,134,539 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,093,985 - 79,182,922 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01172,187,024 - 72,265,931 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,834,409 - 75,908,297 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,834,185 - 75,907,752 (+)Ensemblpanpan1.1panPan2
MYO7A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12121,539,735 - 21,624,063 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2121,539,785 - 21,624,279 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2121,371,283 - 21,451,548 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02121,739,388 - 21,823,670 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2121,739,387 - 21,823,979 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12121,514,983 - 21,599,193 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02121,731,135 - 21,815,380 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02121,654,692 - 21,739,052 (-)NCBIUU_Cfam_GSD_1.0
Myo7a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494764,150,067 - 64,224,924 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364985,751,779 - 5,824,378 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364985,758,572 - 5,824,526 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO7A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl911,249,075 - 11,666,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1911,251,187 - 11,337,618 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2912,345,556 - 12,430,950 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYO7A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1168,334,781 - 68,423,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl168,350,598 - 68,425,625 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604357,352,101 - 57,439,357 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo7a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624863205,478 - 283,839 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624863205,468 - 283,840 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Myo7a
428 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
1 163045907 163045908 T G snv F344/NCrl (RGD) View more Information
1 163045909 163045910 A G snv F344/NCrl (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:39
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000019053
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 69 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat

1 to 10 of 69 rows
RH136948  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21152,416,290 - 152,416,441 (+)MAPPERmRatBN7.2
Rnor_6.01163,073,173 - 163,073,323NCBIRnor6.0
Rnor_5.01169,278,369 - 169,278,519UniSTSRnor5.0
RGSC_v3.41155,364,724 - 155,364,874UniSTSRGSC3.4
Celera1150,507,162 - 150,507,312UniSTS
RH 3.4 Map11166.1UniSTS
Cytogenetic Map1q32UniSTS


This gene Myo7a is modified in the following models/strains:
W-Myo7atnd/Hubr    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000019053   ⟹   ENSRNOP00000019053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1152,344,448 - 152,414,157 (-)Ensembl
Rnor_6.0 Ensembl1163,001,875 - 163,071,508 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103282   ⟹   ENSRNOP00000083122
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1152,344,448 - 152,407,422 (-)Ensembl
RefSeq Acc Id: NM_001414743   ⟹   NP_001401672
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,818,577 (-)NCBI
mRatBN7.21152,343,886 - 152,407,357 (-)NCBI
RefSeq Acc Id: NM_153473   ⟹   NP_703203
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,825,365 (-)NCBI
mRatBN7.21152,343,886 - 152,414,147 (-)NCBI
Rnor_6.01163,001,875 - 163,071,508 (-)NCBI
Rnor_5.01169,206,150 - 169,276,706 (-)NCBI
RGSC_v3.41155,292,620 - 155,362,698 (-)RGD
Celera1150,435,342 - 150,505,024 (-)RGD
Sequence:
RefSeq Acc Id: XM_006229742   ⟹   XP_006229804
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,819,225 (-)NCBI
mRatBN7.21152,342,611 - 152,407,989 (-)NCBI
Rnor_6.01163,001,313 - 163,065,331 (-)NCBI
Rnor_5.01169,206,150 - 169,276,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006229744   ⟹   XP_006229806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,825,397 (-)NCBI
mRatBN7.21152,342,611 - 152,414,171 (-)NCBI
Rnor_6.01163,001,877 - 163,071,545 (-)NCBI
Rnor_5.01169,206,150 - 169,276,706 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039102474   ⟹   XP_038958402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,818,078 (-)NCBI
mRatBN7.21152,342,611 - 152,406,858 (-)NCBI
RefSeq Acc Id: XM_039102483   ⟹   XP_038958411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,788,166 (-)NCBI
mRatBN7.21152,342,611 - 152,376,949 (-)NCBI
RefSeq Acc Id: XM_039102487   ⟹   XP_038958415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81161,755,110 - 161,795,099 (-)NCBI
mRatBN7.21152,342,611 - 152,383,879 (-)NCBI
RefSeq Acc Id: NP_703203   ⟸   NM_153473
- Peptide Label: isoform 2
- UniProtKB: Q8CJE3 (UniProtKB/TrEMBL),   D4AB24 (UniProtKB/TrEMBL),   A6I6C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229806   ⟸   XM_006229744
- Peptide Label: isoform X2
- UniProtKB: A0A8J8XYU9 (UniProtKB/TrEMBL),   A6I6C5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006229804   ⟸   XM_006229742
- Peptide Label: isoform X1
- UniProtKB: A6I6C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019053   ⟸   ENSRNOT00000019053
RefSeq Acc Id: XP_038958402   ⟸   XM_039102474
- Peptide Label: isoform X3
- UniProtKB: A6I6C5 (UniProtKB/TrEMBL)
FERM   Myosin motor   MyTH4   SH3

Name Modeler Protein Id AA Range Protein Structure
AF-Q8CJE3-F1-model_v2 AlphaFold Q8CJE3 1-2177 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690216
Promoter ID:EPDNEW_R741
Type:initiation region
Name:Myo7a_1
Description:myosin VIIA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01163,071,493 - 163,071,553EPDNEW


1 to 40 of 72 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-58430 BioCyc
Ensembl Genes ENSRNOG00000013641 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019053 ENTREZGENE
  ENSRNOT00000019053.7 UniProtKB/TrEMBL
  ENSRNOT00000103282 ENTREZGENE
  ENSRNOT00000103282.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  1.20.80.10 UniProtKB/TrEMBL
  1.25.40.530 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM/acyl-CoA_bd_prot_3-hlx UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  IQ_CaM_bd_region UniProtKB/TrEMBL
  IRS_PTB UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  MyoVII_FERM_C1 UniProtKB/TrEMBL
  MyoVII_FERM_C2 UniProtKB/TrEMBL
  MYSc_Myo7 UniProtKB/TrEMBL
  MyTH4_dom UniProtKB/TrEMBL
  MyTH4_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
  Unconventional_Myosin_ATPase UniProtKB/TrEMBL
NCBI Gene 266714 ENTREZGENE
PANTHER MYOSIN VII, XV UniProtKB/TrEMBL
  MYOSIN VIIA UniProtKB/TrEMBL
1 to 40 of 72 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Myo7a  myosin VIIA    myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))  Name updated 1299863 APPROVED
2003-02-27 Myo7a  myosin VIIA (Usher syndrome 1B (autosomal recessive, severe))      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_domains contains a motor domain, IQ domain, and the coiled-coil domain 633398