RGD Reference Report - Sensing sound: molecules that orchestrate mechanotransduction by hair cells. - Rat Genome Database

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Sensing sound: molecules that orchestrate mechanotransduction by hair cells.

Authors: Kazmierczak, P  Muller, U 
Citation: Kazmierczak P and Muller U, Trends Neurosci. 2012 Apr;35(4):220-9. doi: 10.1016/j.tins.2011.10.007. Epub 2011 Dec 15.
RGD ID: 8547671
Pubmed: PMID:22177415   (View Abstract at PubMed)
PMCID: PMC3310959   (View Article at PubMed Central)
DOI: DOI:10.1016/j.tins.2011.10.007   (Journal Full-text)

Animals use acoustic signals to communicate and to obtain information about their environment. The processing of acoustic signals is initiated at auditory sense organs, where mechanosensory hair cells convert sound-induced vibrations into electrical signals. Although the biophysical principles underlying the mechanotransduction process in hair cells have been characterized in much detail over the past 30 years, the molecular building-blocks of the mechanotransduction machinery have proved to be difficult to determine. We review here recent studies that have both identified some of these molecules and established the mechanisms by which they regulate the activity of the still-elusive mechanotransduction channel.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

Objects Annotated

Genes (Rattus norvegicus)
Cdh23  (cadherin-related 23)
Myo7a  (myosin VIIA)
Pcdh15  (protocadherin related 15)
Ush1c  (USH1 protein network component harmonin)
Ush1g  (USH1 protein network component sans)

Genes (Mus musculus)
Cdh23  (cadherin related 23 (otocadherin))
Myo7a  (myosin VIIA)
Pcdh15  (protocadherin 15)
Ush1c  (USH1 protein network component harmonin)
Ush1g  (USH1 protein network component sans)

Genes (Homo sapiens)
CDH23  (cadherin related 23)
MYO7A  (myosin VIIA)
PCDH15  (protocadherin related 15)
USH1C  (USH1 protein network component harmonin)
USH1G  (USH1 protein network component sans)


Additional Information