RGD Reference Report - Mechanotransduction by hair cells: models, molecules, and mechanisms. - Rat Genome Database

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Mechanotransduction by hair cells: models, molecules, and mechanisms.

Authors: Gillespie, PG  Muller, U 
Citation: Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
RGD ID: 8547667
Pubmed: PMID:19804752   (View Abstract at PubMed)
PMCID: PMC2888516   (View Article at PubMed Central)
DOI: DOI:10.1016/j.cell.2009.09.010   (Journal Full-text)

Mechanotransduction, the transformation of mechanical force into an electrical signal, allows living organisms to hear, register movement and gravity, detect touch, and sense changes in cell volume and shape. Hair cells in the inner ear are specialized mechanoreceptor cells that detect sound and head movement. The mechanotransduction machinery of hair cells is extraordinarily sensitive and responds to minute physical displacements on a submillisecond timescale. The recent discovery of several molecular constituents of the mechanotransduction machinery of hair cells provides a new framework for the interpretation of biophysical data and necessitates revision of prevailing models of mechanotransduction.

Objects Annotated

Genes (Rattus norvegicus)
Cdh23  (cadherin-related 23)
Espn  (espin)
Myo15a  (myosin XVA)
Myo1c  (myosin 1C)
Myo3a  (myosin IIIA)
Myo7a  (myosin VIIA)
Pcdh15  (protocadherin related 15)
Ush1c  (USH1 protein network component harmonin)
Whrn  (whirlin)

Genes (Mus musculus)
Cdh23  (cadherin related 23 (otocadherin))
Espn  (espin)
Myo15a  (myosin XVA)
Myo1c  (myosin IC)
Myo3a  (myosin IIIA)
Myo7a  (myosin VIIA)
Pcdh15  (protocadherin 15)
Ush1c  (USH1 protein network component harmonin)
Whrn  (whirlin)

Genes (Homo sapiens)
CDH23  (cadherin related 23)
ESPN  (espin)
MYO15A  (myosin XVA)
MYO1C  (myosin IC)
MYO3A  (myosin IIIA)
MYO7A  (myosin VIIA)
PCDH15  (protocadherin related 15)
USH1C  (USH1 protein network component harmonin)
WHRN  (whirlin)


Additional Information