Slc24a2 (solute carrier family 24 member 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Slc24a2 (solute carrier family 24 member 2) Rattus norvegicus
Analyze
Symbol: Slc24a2
Name: solute carrier family 24 member 2
RGD ID: 628650
Description: Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport and protein-containing complex assembly. Predicted to be located in membrane. Predicted to be active in plasma membrane; postsynapse; and presynapse. Orthologous to human SLC24A2 (solute carrier family 24 member 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; visual phototransduction pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: na(+)/K(+)/Ca(2+)-exchange protein 2; Nckx2; potassium-dependent sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; solute carrier family 24, member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,543,867 - 106,787,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5106,543,874 - 106,787,780 (-)EnsemblGRCr8
mRatBN7.25101,497,916 - 101,741,840 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5103,875,413 - 104,113,006 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05105,665,961 - 105,903,464 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05105,699,555 - 105,944,125 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05105,336,287 - 105,579,959 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,336,262 - 105,582,375 (-)Ensemblrn6Rnor6.0
Rnor_5.05109,323,070 - 109,564,102 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45106,295,254 - 106,537,714 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5101,349,538 - 101,587,410 (+)NCBICelera
RGSC_v3.15106,300,479 - 106,542,940 (-)NCBI
Cytogenetic Map5q32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO)
postsynapse  (IEA,ISO)
presynapse  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Na+/Ca2+-K+ exchangers (NCKX): functional properties and physiological roles. Altimimi HF and Schnetkamp PP, Channels (Austin). 2007 Mar-Apr;1(2):62-9. Epub 2007 Apr 30.
2. Topological studies of the rat brain K+-dependent Na+/Ca2+ exchanger NCKX2. Cai X, etal., Ann N Y Acad Sci 2002 Nov;976:90-3.
3. A novel topology and redox regulation of the rat brain K+-dependent Na+/Ca2+ exchanger, NCKX2. Cai X, etal., J Biol Chem 2002 Dec 13;277(50):48923-30.
4. Electrophysiological characterization and ionic stoichiometry of the rat brain K(+)-dependent NA(+)/CA(2+) exchanger, NCKX2. Dong H, etal., J Biol Chem. 2001 Jul 13;276(28):25919-28. Epub 2001 May 7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Preferential expression of plasmalemmal K-dependent Na+/Ca2+ exchangers in neurons versus astrocytes. Kiedrowski L, etal., Neuroreport 2002 Aug 27;13(12):1529-32.
7. K+-dependent Na+/Ca2+ exchange is a major Ca2+ clearance mechanism in axon terminals of rat neurohypophysis. Lee SH, etal., J Neurosci 2002 Aug 15;22(16):6891-9.
8. Na+/Ca2+ exchangers: three mammalian gene families control Ca2+ transport. Lytton J Biochem J. 2007 Sep 15;406(3):365-82.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning of a novel potassium-dependent sodium-calcium exchanger from rat brain. Tsoi M, etal., J Biol Chem 1998 Feb 13;273(7):4155-62.
12. Different cation sensitivities and binding site domains of Na+-Ca2+-K+ and Na+-Ca2+ exchangers. Uehara A, etal., J Cell Physiol. 2005 May;203(2):420-8.
Additional References at PubMed
PMID:10662833   PMID:16407245   PMID:17038313   PMID:18166528   PMID:22871113   PMID:26631410   PMID:32582988  


Genomics

Comparative Map Data
Slc24a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85106,543,867 - 106,787,810 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5106,543,874 - 106,787,780 (-)EnsemblGRCr8
mRatBN7.25101,497,916 - 101,741,840 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5103,875,413 - 104,113,006 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05105,665,961 - 105,903,464 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05105,699,555 - 105,944,125 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05105,336,287 - 105,579,959 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5105,336,262 - 105,582,375 (-)Ensemblrn6Rnor6.0
Rnor_5.05109,323,070 - 109,564,102 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45106,295,254 - 106,537,714 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5101,349,538 - 101,587,410 (+)NCBICelera
RGSC_v3.15106,300,479 - 106,542,940 (-)NCBI
Cytogenetic Map5q32NCBI
SLC24A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38919,507,455 - 20,307,892 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl919,507,452 - 19,789,119 (-)Ensemblhg38GRCh38
GRCh37919,507,453 - 19,789,035 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36919,505,978 - 19,776,926 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34919,505,977 - 19,776,926NCBI
Celera919,433,508 - 19,714,554 (-)NCBICelera
Cytogenetic Map9p22.1-p21.3NCBI
HuRef919,468,902 - 19,749,276 (-)NCBIHuRef
CHM1_1919,507,294 - 19,786,814 (-)NCBICHM1_1
T2T-CHM13v2.0919,520,160 - 20,321,675 (-)NCBIT2T-CHM13v2.0
Slc24a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39486,901,361 - 87,148,780 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl486,901,361 - 87,148,714 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38486,983,124 - 87,230,652 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl486,983,124 - 87,230,477 (-)Ensemblmm10GRCm38
MGSCv37486,629,028 - 86,876,444 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36486,461,003 - 86,701,654 (-)NCBIMGSCv36mm8
Celera485,505,583 - 85,755,220 (-)NCBICelera
Cytogenetic Map4C4NCBI
cM Map440.69NCBI
Slc24a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543421,873,091 - 22,091,177 (-)Ensembl
ChiLan1.0NW_00495543421,871,319 - 22,091,125 (-)NCBIChiLan1.0ChiLan1.0
SLC24A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211104,762,654 - 105,039,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19104,768,598 - 105,044,955 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0919,317,132 - 19,593,503 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1919,808,591 - 20,251,387 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl919,814,244 - 20,249,225 (-)EnsemblpanPan2panpan1.1
SLC24A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11139,273,285 - 39,521,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1139,278,370 - 39,519,222 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1137,927,494 - 38,178,882 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01140,203,164 - 40,454,628 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1140,209,212 - 40,454,579 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11138,895,568 - 39,147,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01138,693,264 - 38,938,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01139,327,164 - 39,578,919 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc24a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947153,700,301 - 153,916,436 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366521,378,045 - 1,583,403 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366521,375,292 - 1,585,718 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC24A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1203,059,588 - 203,333,781 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11203,059,563 - 203,336,442 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21226,912,944 - 226,979,819 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.21226,645,477 - 226,845,623 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC24A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11259,962,744 - 60,229,539 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1259,964,749 - 60,224,816 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603848,071,391 - 48,345,344 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc24a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473623,496,268 - 23,733,259 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473623,488,228 - 23,735,657 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc24a2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1166,791,134 - 67,016,689 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc24a2
2299 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:935
Count of miRNA genes:308
Interacting mature miRNAs:434
Transcripts:ENSRNOT00000010827
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)573779642118779642Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
2302381Bw84Body weight QTL 844.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
1357402Bw46Body weight QTL 464.47body mass (VT:0001259)body mass index (BMI) (CMO:0000105)573779642118779642Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
7394708Emca11Estrogen-induced mammary cancer QTL 11mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)573176602118176602Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)569474415114474415Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)564589016109589016Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2290005Mcs24Mammary carcinoma susceptibility QTL 24mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)569835120114835120Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
2312671Scl64Serum cholesterol level QTL 640.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)573779642118779642Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
D5Got28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,660,429 - 101,660,568 (+)MAPPERmRatBN7.2
Rnor_6.05105,500,674 - 105,500,812NCBIRnor6.0
Rnor_5.05109,485,162 - 109,485,300UniSTSRnor5.0
RGSC_v3.45106,457,416 - 106,457,554UniSTSRGSC3.4
RGSC_v3.45106,457,415 - 106,457,554RGDRGSC3.4
Celera5101,428,245 - 101,428,383UniSTS
RGSC_v3.15106,462,642 - 106,462,780RGD
RH 3.4 Map5738.9UniSTS
RH 3.4 Map5738.9RGD
RH 2.0 Map5657.6RGD
Cytogenetic Map5q32UniSTS
D5Got31  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,703,657 - 101,703,889 (+)MAPPERmRatBN7.2
Rnor_6.05105,544,278 - 105,544,509NCBIRnor6.0
Rnor_5.05109,528,421 - 109,528,652UniSTSRnor5.0
RGSC_v3.45106,502,033 - 106,502,264UniSTSRGSC3.4
RGSC_v3.45106,502,032 - 106,502,264RGDRGSC3.4
Celera5101,384,977 - 101,385,208UniSTS
RH 3.4 Map5745.4RGD
RH 3.4 Map5745.4UniSTS
Cytogenetic Map5q32UniSTS
D5Uwm23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85106,653,429 - 106,653,613 (+)Marker Load Pipeline
mRatBN7.25101,607,489 - 101,607,673 (+)MAPPERmRatBN7.2
Rnor_6.05105,444,977 - 105,445,160NCBIRnor6.0
Rnor_5.05109,431,760 - 109,431,943UniSTSRnor5.0
RGSC_v3.45106,403,190 - 106,403,373UniSTSRGSC3.4
Celera5101,479,696 - 101,479,879UniSTS
Cytogenetic Map5q32UniSTS
D5Wox41  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85106,548,152 - 106,548,326 (+)Marker Load Pipeline
mRatBN7.25101,502,201 - 101,502,377 (+)MAPPERmRatBN7.2
Rnor_6.05105,338,953 - 105,339,126NCBIRnor6.0
Rnor_5.05109,325,736 - 109,325,909UniSTSRnor5.0
RGSC_v3.45106,297,920 - 106,298,093UniSTSRGSC3.4
Celera5101,584,497 - 101,584,744UniSTS
Cytogenetic Map5q32UniSTS
AU047371  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,621,882 - 101,621,985 (+)MAPPERmRatBN7.2
Rnor_6.05105,461,768 - 105,461,870NCBIRnor6.0
Rnor_5.05109,446,256 - 109,446,358UniSTSRnor5.0
RGSC_v3.45106,418,860 - 106,418,962UniSTSRGSC3.4
Celera5101,466,670 - 101,466,742UniSTS
Cytogenetic Map5q32UniSTS
AI007603  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,505,317 - 101,505,509 (+)MAPPERmRatBN7.2
Rnor_6.05105,342,067 - 105,342,258NCBIRnor6.0
Rnor_5.05109,328,850 - 109,329,041UniSTSRnor5.0
RGSC_v3.45106,301,034 - 106,301,225UniSTSRGSC3.4
Celera5101,581,365 - 101,581,556UniSTS
RH 3.4 Map5741.6UniSTS
Cytogenetic Map5q32UniSTS
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
BE113849  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,543,131 - 101,543,342 (+)MAPPERmRatBN7.2
Rnor_6.05105,380,626 - 105,380,836NCBIRnor6.0
Rnor_5.05109,367,409 - 109,367,619UniSTSRnor5.0
RGSC_v3.45106,338,841 - 106,339,051UniSTSRGSC3.4
Celera5101,543,885 - 101,544,095UniSTS
RH 3.4 Map5742.0UniSTS
Cytogenetic Map5q32UniSTS
BF415948  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25101,704,072 - 101,704,264 (+)MAPPERmRatBN7.2
Rnor_6.05105,544,693 - 105,544,884NCBIRnor6.0
Rnor_5.05109,528,836 - 109,529,027UniSTSRnor5.0
RGSC_v3.45106,502,448 - 106,502,639UniSTSRGSC3.4
Celera5101,384,602 - 101,384,793UniSTS
RH 3.4 Map5739.4UniSTS
Cytogenetic Map5q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 52 158 67 66 35 42 35 6 226 122 7 139 52 70 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000010827   ⟹   ENSRNOP00000010827
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5106,543,874 - 106,787,780 (-)Ensembl
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)Ensembl
Rnor_6.0 Ensembl5105,336,262 - 105,579,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083373   ⟹   ENSRNOP00000074180
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5106,543,874 - 106,787,780 (-)Ensembl
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)Ensembl
Rnor_6.0 Ensembl5105,342,727 - 105,582,375 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114418   ⟹   ENSRNOP00000092960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5106,543,874 - 106,787,780 (-)Ensembl
mRatBN7.2 Ensembl5101,502,278 - 101,739,337 (-)Ensembl
RefSeq Acc Id: NM_031743   ⟹   NP_113931
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,867 - 106,787,780 (-)NCBI
mRatBN7.25101,497,916 - 101,741,840 (-)NCBI
Rnor_6.05105,336,287 - 105,579,959 (-)NCBI
Rnor_5.05109,323,070 - 109,564,102 (-)NCBI
RGSC_v3.45106,295,254 - 106,537,714 (-)RGD
Celera5101,349,538 - 101,587,410 (+)RGD
Sequence:
RefSeq Acc Id: XM_063288501   ⟹   XP_063144571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,809 (-)NCBI
RefSeq Acc Id: XM_063288502   ⟹   XP_063144572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,403 (-)NCBI
RefSeq Acc Id: XM_063288503   ⟹   XP_063144573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,426 (-)NCBI
RefSeq Acc Id: XM_063288504   ⟹   XP_063144574
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,040 (-)NCBI
RefSeq Acc Id: XM_063288505   ⟹   XP_063144575
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,810 (-)NCBI
RefSeq Acc Id: XM_063288506   ⟹   XP_063144576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,810 (-)NCBI
RefSeq Acc Id: XM_063288507   ⟹   XP_063144577
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,809 (-)NCBI
RefSeq Acc Id: XM_063288508   ⟹   XP_063144578
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,809 (-)NCBI
RefSeq Acc Id: XM_063288509   ⟹   XP_063144579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,787,426 (-)NCBI
RefSeq Acc Id: XM_063288510   ⟹   XP_063144580
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85106,543,869 - 106,650,382 (-)NCBI
RefSeq Acc Id: NP_113931   ⟸   NM_031743
- UniProtKB: O54706 (UniProtKB/Swiss-Prot),   O54701 (UniProtKB/Swiss-Prot),   A6KRB1 (UniProtKB/TrEMBL),   A0A8I6GKF7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074180   ⟸   ENSRNOT00000083373
Ensembl Acc Id: ENSRNOP00000010827   ⟸   ENSRNOT00000010827
Ensembl Acc Id: ENSRNOP00000092960   ⟸   ENSRNOT00000114418
RefSeq Acc Id: XP_063144576   ⟸   XM_063288506
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GKF7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144575   ⟸   XM_063288505
- Peptide Label: isoform X2
- UniProtKB: A0A8I6GKF7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144578   ⟸   XM_063288508
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKF7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144577   ⟸   XM_063288507
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKF7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144571   ⟸   XM_063288501
- Peptide Label: isoform X1
- UniProtKB: O54706 (UniProtKB/Swiss-Prot),   O54701 (UniProtKB/Swiss-Prot),   A0A8I6GKF7 (UniProtKB/TrEMBL),   A6KRB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144579   ⟸   XM_063288509
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GKF7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144573   ⟸   XM_063288503
- Peptide Label: isoform X1
- UniProtKB: O54706 (UniProtKB/Swiss-Prot),   O54701 (UniProtKB/Swiss-Prot),   A0A8I6GKF7 (UniProtKB/TrEMBL),   A6KRB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144572   ⟸   XM_063288502
- Peptide Label: isoform X1
- UniProtKB: O54706 (UniProtKB/Swiss-Prot),   O54701 (UniProtKB/Swiss-Prot),   A0A8I6GKF7 (UniProtKB/TrEMBL),   A6KRB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144574   ⟸   XM_063288504
- Peptide Label: isoform X1
- UniProtKB: O54706 (UniProtKB/Swiss-Prot),   O54701 (UniProtKB/Swiss-Prot),   A0A8I6GKF7 (UniProtKB/TrEMBL),   A6KRB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144580   ⟸   XM_063288510
- Peptide Label: isoform X4
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O54701-F1-model_v2 AlphaFold O54701 1-670 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693831
Promoter ID:EPDNEW_R4352
Type:single initiation site
Name:Slc24a2_1
Description:solute carrier family 24 member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05105,582,428 - 105,582,488EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628650 AgrOrtholog
BioCyc Gene G2FUF-40835 BioCyc
Ensembl Genes ENSRNOG00000008169 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010827 ENTREZGENE
  ENSRNOT00000010827.7 UniProtKB/Swiss-Prot
  ENSRNOT00000083373 ENTREZGENE
  ENSRNOT00000083373.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1420.30 UniProtKB/Swiss-Prot
InterPro K/Na/Ca-exchanger UniProtKB/Swiss-Prot
  NaCa_Exmemb UniProtKB/Swiss-Prot
  NCX_ion-bd_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:84550 UniProtKB/Swiss-Prot
NCBI Gene 84550 ENTREZGENE
PANTHER PTHR10846 UniProtKB/Swiss-Prot
  PTHR10846:SF41 UniProtKB/Swiss-Prot
Pfam Na_Ca_ex UniProtKB/Swiss-Prot
PhenoGen Slc24a2 PhenoGen
RatGTEx ENSRNOG00000008169 RatGTEx
UniProt A0A8I6GKF7 ENTREZGENE, UniProtKB/TrEMBL
  A6KRB1 ENTREZGENE, UniProtKB/TrEMBL
  NCKX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  O54706 ENTREZGENE
UniProt Secondary O54706 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc24a2  solute carrier family 24 member 2  Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-26 Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2      Symbol and Name status set to approved 625702 APPROVED
2003-02-27 Slc24a2  solute carrier family 24 (sodium/potassium/calcium exchanger), member 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain 625729
gene_process mediates K+-dependent Ca2+ clearance; may mediate 90% of Na+/Ca2+ exchanger activity in axon terminals of neurohypophysis 625729