Ppp3cc (protein phosphatase 3 catalytic subunit gamma) - Rat Genome Database

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Gene: Ppp3cc (protein phosphatase 3 catalytic subunit gamma) Rattus norvegicus
Analyze
Symbol: Ppp3cc
Name: protein phosphatase 3 catalytic subunit gamma
RGD ID: 621616
Description: Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in positive regulation of synaptic vesicle endocytosis. Located in presynapse. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; schizophrenia pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma); protein phosphatase 3, catalytic subunit, gamma; protein phosphatase 3, catalytic subunit, gamma isoform; protein phosphatase 3, catalytic subunit, gamma isozyme; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,699,586 - 51,771,763 (-)NCBIGRCr8
mRatBN7.21545,289,917 - 45,362,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,290,373 - 45,361,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,408,396 - 49,479,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,519,884 - 50,591,181 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,379,209 - 47,450,507 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,896,427 - 51,968,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,896,615 - 51,967,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,615,454 - 55,692,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,616,635 - 50,688,593 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,656,759 - 50,661,916 (-)NCBI
Celera1544,969,817 - 45,041,567 (-)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Altered Bad localization and interaction between Bad and Bcl-xL in the hippocampus after transient global ischemia. Abe T, etal., Brain Res. 2004 May 29;1009(1-2):159-68.
2. Calcineurin Agamma is a Functional Phosphatase That Modulates Synaptic Vesicle Endocytosis. Cottrell JR, etal., J Biol Chem. 2016 Jan 22;291(4):1948-56. doi: 10.1074/jbc.M115.705319. Epub 2015 Dec 1.
3. Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. Eastwood SL, etal., Biol Psychiatry. 2005 Apr 1;57(7):702-10. doi: 10.1016/j.biopsych.2004.12.029.
4. Differential expression of calcineurin A subunit mRNA isoforms during rat hippocampal and cerebellar development. Eastwood SL, etal., Eur J Neurosci. 2005 Dec;22(12):3017-24.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Gerber DJ, etal., Proc Natl Acad Sci U S A 2003 Jul 22;100(15):8993-8. Epub 2003 Jul 8.
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Calcineurin is not involved in some mitochondrial enzyme adaptations to endurance exercise training in rat skeletal muscle. Terada S, etal., Eur J Appl Physiol 2003 Sep;90(1-2):210-7.
13. Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells. Wadzinski BE, etal., J Biol Chem 1990 Dec 15;265(35):21504-8.
14. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
15. DARPP-32, Jack of All Trades... Master of Which? Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:12177418   PMID:12477932   PMID:17101875   PMID:19154138   PMID:23376485  


Genomics

Comparative Map Data
Ppp3cc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,699,586 - 51,771,763 (-)NCBIGRCr8
mRatBN7.21545,289,917 - 45,362,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1545,290,373 - 45,361,832 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1549,408,396 - 49,479,694 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,519,884 - 50,591,181 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01547,379,209 - 47,450,507 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,896,427 - 51,968,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,896,615 - 51,967,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,615,454 - 55,692,782 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,616,635 - 50,688,593 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,656,759 - 50,661,916 (-)NCBI
Celera1544,969,817 - 45,041,567 (-)NCBICelera
Cytogenetic Map15p11NCBI
PPP3CC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38822,441,078 - 22,541,125 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl822,440,819 - 22,541,142 (+)EnsemblGRCh38hg38GRCh38
GRCh37822,298,591 - 22,398,638 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,354,541 - 22,454,583 (+)NCBINCBI36Build 36hg18NCBI36
Build 34822,354,540 - 22,454,580NCBI
Celera821,260,229 - 21,360,247 (+)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef820,840,793 - 20,940,821 (+)NCBIHuRef
CHM1_1822,500,579 - 22,601,011 (+)NCBICHM1_1
T2T-CHM13v2.0822,714,907 - 22,814,982 (+)NCBIT2T-CHM13v2.0
Ppp3cc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,455,314 - 70,526,979 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,455,314 - 70,526,920 (-)EnsemblGRCm39 Ensembl
GRCm381470,217,864 - 70,289,536 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1470,217,865 - 70,289,471 (-)EnsemblGRCm38mm10GRCm38
MGSCv371470,617,705 - 70,689,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,952,978 - 69,024,529 (-)NCBIMGSCv36mm8
Celera1467,759,280 - 67,830,918 (-)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.3NCBI
Ppp3cc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540345,916,002 - 45,968,185 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540345,915,985 - 45,969,350 (+)NCBIChiLan1.0ChiLan1.0
PPP3CC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2740,947,495 - 41,048,202 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1816,672,682 - 16,773,433 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0821,690,598 - 21,791,335 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1818,629,269 - 18,732,041 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl818,629,261 - 18,729,995 (+)Ensemblpanpan1.1panPan2
PPP3CC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,732,268 - 34,839,743 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,725,226 - 34,838,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2535,321,911 - 35,428,700 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02534,941,741 - 35,049,609 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2534,938,993 - 35,049,662 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12534,888,109 - 34,995,583 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02534,742,194 - 34,849,641 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02534,897,774 - 34,979,730 (-)NCBIUU_Cfam_GSD_1.0
Ppp3cc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494312,287,521 - 12,333,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365556,236,464 - 6,283,012 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365556,216,202 - 6,283,012 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1820,522,829 - 20,621,445 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605221,606,011 - 21,707,786 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3cc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475817,969,705 - 18,049,904 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475817,969,777 - 18,048,476 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppp3cc
242 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000012993
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
D15Got229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,333,787 - 45,333,928 (+)MAPPERmRatBN7.2
Rnor_6.01551,939,856 - 51,939,996NCBIRnor6.0
Rnor_5.01555,664,901 - 55,665,041UniSTSRnor5.0
RGSC_v3.41550,660,921 - 50,661,061UniSTSRGSC3.4
Celera1545,013,683 - 45,013,823UniSTS
Cytogenetic Map15p11UniSTS
RH143458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X145,949,718 - 145,949,835 (+)MAPPERmRatBN7.2
Rnor_6.0X151,819,554 - 151,819,670NCBIRnor6.0
Rnor_5.0X151,809,605 - 151,809,721UniSTSRnor5.0
RGSC_v3.4X153,397,829 - 153,397,945UniSTSRGSC3.4
CeleraX141,796,043 - 141,796,159UniSTS
Cytogenetic Map15p16UniSTS
Cytogenetic Map15p11UniSTS
RH138866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21545,284,093 - 45,284,223 (+)MAPPERmRatBN7.2
Rnor_6.01551,890,168 - 51,890,297NCBIRnor6.0
Rnor_5.01555,616,295 - 55,616,424UniSTSRnor5.0
RGSC_v3.41550,610,443 - 50,610,572UniSTSRGSC3.4
Celera1544,963,373 - 44,963,502UniSTS
Cytogenetic Map15p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 13 141 113 53 65 53 36 45 240 104 145 57 24
Low 114 94 94 11
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_134367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770813 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063273953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC126842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC079027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473951 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ376198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ376199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ376200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000012993   ⟹   ENSRNOP00000012993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,290,541 - 45,338,966 (-)Ensembl
Rnor_6.0 Ensembl1551,896,818 - 51,967,806 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082505   ⟹   ENSRNOP00000075488
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,290,541 - 45,361,832 (-)Ensembl
Rnor_6.0 Ensembl1551,896,615 - 51,967,897 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084166   ⟹   ENSRNOP00000069433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,290,541 - 45,361,832 (-)Ensembl
Rnor_6.0 Ensembl1551,896,818 - 51,967,806 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091826   ⟹   ENSRNOP00000074438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,290,373 - 45,361,832 (-)Ensembl
Rnor_6.0 Ensembl1551,916,378 - 51,967,806 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100817   ⟹   ENSRNOP00000095864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1545,290,541 - 45,340,921 (-)Ensembl
RefSeq Acc Id: NM_134367   ⟹   NP_599194
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,700,252 - 51,771,538 (-)NCBI
mRatBN7.21545,290,538 - 45,361,832 (-)NCBI
Rnor_6.01551,896,612 - 51,967,897 (-)NCBI
Rnor_5.01555,615,454 - 55,692,782 (-)NCBI
RGSC_v3.41550,616,635 - 50,688,593 (-)RGD
Celera1544,969,817 - 45,041,567 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770813   ⟹   XP_008769035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,771,716 (-)NCBI
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
Rnor_6.01551,896,427 - 51,968,075 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770814   ⟹   XP_008769036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,771,716 (-)NCBI
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
Rnor_6.01551,896,427 - 51,968,074 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092973   ⟹   XP_038948901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,771,717 (-)NCBI
mRatBN7.21545,289,917 - 45,362,012 (-)NCBI
RefSeq Acc Id: XM_039092974   ⟹   XP_038948902
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,771,716 (-)NCBI
mRatBN7.21545,289,917 - 45,362,010 (-)NCBI
RefSeq Acc Id: XM_039092975   ⟹   XP_038948903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,771,714 (-)NCBI
mRatBN7.21545,290,538 - 45,362,009 (-)NCBI
RefSeq Acc Id: XM_039092976   ⟹   XP_038948904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,771,763 (-)NCBI
mRatBN7.21545,289,917 - 45,362,009 (-)NCBI
RefSeq Acc Id: XM_063273952   ⟹   XP_063130022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,699,586 - 51,758,477 (-)NCBI
RefSeq Acc Id: XM_063273953   ⟹   XP_063130023
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,725,795 - 51,771,713 (-)NCBI
RefSeq Acc Id: NP_599194   ⟸   NM_134367
- UniProtKB: Q6AYJ0 (UniProtKB/TrEMBL),   A0A8J8XJJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769035   ⟸   XM_008770813
- Peptide Label: isoform X1
- UniProtKB: E2CWF0 (UniProtKB/TrEMBL),   F1M7P9 (UniProtKB/TrEMBL),   A0A8J8XJJ2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769036   ⟸   XM_008770814
- Peptide Label: isoform X4
- UniProtKB: E2CWF1 (UniProtKB/TrEMBL),   A0A8J8XJJ2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075488   ⟸   ENSRNOT00000082505
Ensembl Acc Id: ENSRNOP00000012993   ⟸   ENSRNOT00000012993
Ensembl Acc Id: ENSRNOP00000069433   ⟸   ENSRNOT00000084166
Ensembl Acc Id: ENSRNOP00000074438   ⟸   ENSRNOT00000091826
RefSeq Acc Id: XP_038948901   ⟸   XM_039092973
- Peptide Label: isoform X2
- UniProtKB: A0A8J8XJJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948902   ⟸   XM_039092974
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K820 (UniProtKB/TrEMBL),   A0A8J8XJJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948904   ⟸   XM_039092976
- Peptide Label: isoform X6
- UniProtKB: A0A8J8XJJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948903   ⟸   XM_039092975
- Peptide Label: isoform X5
- UniProtKB: A0A8J8XJJ2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000095864   ⟸   ENSRNOT00000100817
RefSeq Acc Id: XP_063130022   ⟸   XM_063273952
- Peptide Label: isoform X5
- UniProtKB: A0A8J8XJJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130023   ⟸   XM_063273953
- Peptide Label: isoform X7
- UniProtKB: E2CWF2 (UniProtKB/TrEMBL)
Protein Domains
Serine/threonine specific protein phosphatases

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E2CWF0-F1-model_v2 AlphaFold E2CWF0 1-515 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621616 AgrOrtholog
BioCyc Gene G2FUF-13230 BioCyc
Ensembl Genes ENSRNOG00000009745 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012993.8 UniProtKB/TrEMBL
  ENSRNOT00000082505.2 UniProtKB/TrEMBL
  ENSRNOT00000084166.2 UniProtKB/TrEMBL
  ENSRNOT00000091826.2 UniProtKB/TrEMBL
  ENSRNOT00000100817.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7114037 IMAGE-MGC_LOAD
InterPro Metallo-depent_PP-like UniProtKB/TrEMBL
  Metallo_PEstase_dom UniProtKB/TrEMBL
  MPP_PP2B UniProtKB/TrEMBL
  PP2B UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/TrEMBL
KEGG Report rno:171378 UniProtKB/TrEMBL
MGC_CLONE MGC:93954 IMAGE-MGC_LOAD
NCBI Gene 171378 ENTREZGENE
PANTHER PTHR45673 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT GAMMA ISOFORM UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
PhenoGen Ppp3cc PhenoGen
PRINTS STPHPHTASE UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009745 RatGTEx
SMART PP2Ac UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/TrEMBL
UniProt A0A0G2K820 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLU2_RAT UniProtKB/TrEMBL
  A0A8J8XJJ2 ENTREZGENE, UniProtKB/TrEMBL
  A6HTJ7_RAT UniProtKB/TrEMBL
  A6HTJ8_RAT UniProtKB/TrEMBL
  A6HTJ9_RAT UniProtKB/TrEMBL
  E2CWF0 ENTREZGENE, UniProtKB/TrEMBL
  E2CWF1 ENTREZGENE, UniProtKB/TrEMBL
  E2CWF2 ENTREZGENE, UniProtKB/TrEMBL
  F1M7P9 ENTREZGENE
  Q6AYJ0 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M7P9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Ppp3cc  protein phosphatase 3 catalytic subunit gamma  Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isozyme  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-01-26 Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isozyme  Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isoform  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ppp3cc  protein phosphatase 3, catalytic subunit, gamma isoform    protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)  Name updated 1299863 APPROVED
2002-08-07 Ppp3cc  protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_process does not mediate mitochondrial enzyme adaptations to endurance exercise training 724651