Ppp1r15a (protein phosphatase 1, regulatory subunit 15A) - Rat Genome Database

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Gene: Ppp1r15a (protein phosphatase 1, regulatory subunit 15A) Rattus norvegicus
Analyze
Symbol: Ppp1r15a
Name: protein phosphatase 1, regulatory subunit 15A
RGD ID: 621526
Description: Enables protein phosphatase 1 binding activity. Involved in several processes, including cellular response to calcium ion starvation; cellular response to cordycepin; and cellular response to desipramine. Predicted to be located in Golgi apparatus; membrane; and mitochondrion. Predicted to be part of protein phosphatase type 1 complex. Predicted to be active in endoplasmic reticulum. Biomarker of brain ischemia and transient cerebral ischemia. Orthologous to human PPP1R15A (protein phosphatase 1 regulatory subunit 15A); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; (S)-colchicine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gadd34; growth arrest and DNA damage-inducible protein GADD34; Myd116; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116 homolog; Peg-3; progression elevated gene 3 protein; protein phosphatase 1 regulatory subunit 15A; protein phosphatase 1, regulatory (inhibitor) subunit 15A; RGD1624209
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,136,521 - 105,139,596 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,136,525 - 105,139,774 (-)EnsemblGRCr8
mRatBN7.2196,000,053 - 96,003,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,000,058 - 96,003,171 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,385,485 - 101,388,560 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,858,161 - 109,861,236 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,148,553 - 103,151,628 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,511,899 - 101,515,043 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,590,677 - 102,593,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,994,023 - 95,997,080 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,255,750 - 90,258,825 (-)NCBICelera
RGSC_v3.1196,072,182 - 96,074,782 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Azaspiracid  (ISO)
azathioprine  (ISO)
azoxystrobin  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
boric acid  (ISO)
boron nitride  (ISO)
bortezomib  (ISO)
brequinar  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
cefaloridine  (EXP)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
DDE  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl malate  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elesclomol  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenofibrate  (EXP,ISO)
fenthion  (ISO)
ferric oxide  (ISO)
fluoranthene  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
gliotoxin  (EXP)
glucose  (ISO)
glycidol  (EXP)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxychloroquine  (ISO)
ibuprofen  (ISO)
idarubicin  (ISO)
indometacin  (EXP,ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
L-glutamine  (EXP)
L-serine  (ISO)
lactacystin  (ISO)
leflunomide  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metacetamol  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
myristicin  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naled  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
NMS-873  (ISO)
Nodularin  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-menthan-3-ol  (ISO)
pamidronate  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
pentanal  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinoline yellow  (ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
salubrinal  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
sertraline  (ISO)
Shikonin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium hypochlorite  (ISO)
Soman  (EXP)
sorafenib  (ISO)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP,ISO)
VX nerve agent  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to antibiotic  (IEP)
cellular response to calcium ion starvation  (IEP)
cellular response to carbohydrate stimulus  (IEP)
cellular response to cordycepin  (IEP)
cellular response to desipramine  (IEP)
cellular response to gold(3+)  (IEP)
cellular response to hypoxia  (IEP)
cellular response to methamphetamine hydrochloride  (IEP)
cellular response to methyl methanesulfonate  (IEP)
cellular response to UV  (IEP)
cellular response to xenobiotic stimulus  (IEP)
endoplasmic reticulum unfolded protein response  (IEP,ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of protein processing  (IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of apoptotic process  (IDA,IMP)
positive regulation of gene expression  (ISO)
positive regulation of protein phosphorylation  (IDA)
positive regulation of signal transduction by p53 class mediator  (ISO)
positive regulation of transcription by RNA polymerase I  (ISO)
positive regulation of translational initiation in response to stress  (ISO)
protein localization to endoplasmic reticulum  (ISO)
regulation of angiogenesis  (IMP)
regulation of protein metabolic process  (IEA)
regulation of translation  (IEA)
regulation of translation in response to endoplasmic reticulum stress  (ISO)
regulation of translational initiation  (ISO)
regulation of translational initiation in response to stress  (ISO)
response to cocaine  (IEP)
response to endoplasmic reticulum stress  (IBA,IEP,ISO)
response to environmental enrichment  (IEP)
response to immobilization stress  (IEP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents. Amundson SA, etal., Oncogene. 1998 Oct 29;17(17):2149-54.
2. Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12. Badiola N, etal., Cell Death Dis. 2011 Apr 28;2:e149. doi: 10.1038/cddis.2011.31.
3. Involvement of dopamine receptors in binge methamphetamine-induced activation of endoplasmic reticulum and mitochondrial stress pathways. Beauvais G, etal., PLoS One. 2011;6(12):e28946. doi: 10.1371/journal.pone.0028946. Epub 2011 Dec 13.
4. D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis. Coustry F, etal., Am J Pathol. 2012 Feb;180(2):738-48. doi: 10.1016/j.ajpath.2011.10.033. Epub 2011 Dec 7.
5. Activation of MYD116 (gadd34) expression following transient forebrain ischemia of rat: implications for a role of disturbances of endoplasmic reticulum calcium homeostasis. Doutheil J, etal., Brain Res Mol Brain Res. 1999 Jan 8;63(2):225-32.
6. Regulatory proteins of eukaryotic initiation factor 2-alpha subunit (eIF2 alpha) phosphatase, under ischemic reperfusion and tolerance. Garcia-Bonilla L, etal., J Neurochem. 2007 Nov;103(4):1368-80. Epub 2007 Aug 30.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Level of activation of the unfolded protein response correlates with Paneth cell apoptosis in human small intestine exposed to ischemia/reperfusion. Grootjans J, etal., Gastroenterology. 2011 Feb;140(2):529-539.e3. doi: 10.1053/j.gastro.2010.10.040. Epub 2010 Oct 19.
9. Gadd34 functional domains involved in growth suppression and apoptosis. Hollander MC, etal., Oncogene. 2003 Jun 19;22(25):3827-32.
10. Reduced eIF2alpha phosphorylation and increased proapoptotic proteins in aging. Hussain SG and Ramaiah KV, Biochem Biophys Res Commun. 2007 Apr 6;355(2):365-70. Epub 2007 Feb 6.
11. GADD34 mediates cytoprotective autophagy in mutant huntingtin expressing cells via the mTOR pathway. Hyrskyluoto A, etal., Exp Cell Res. 2012 Jan 1;318(1):33-42. doi: 10.1016/j.yexcr.2011.08.020. Epub 2011 Sep 7.
12. Protein disulfide isomerase in ALS mouse glia links protein misfolding with NADPH oxidase-catalyzed superoxide production. Jaronen M, etal., Hum Mol Genet. 2013 Feb 15;22(4):646-55. doi: 10.1093/hmg/dds472. Epub 2012 Nov 1.
13. Methamphetamine induces dopamine D1 receptor-dependent endoplasmic reticulum stress-related molecular events in the rat striatum. Jayanthi S, etal., PLoS One. 2009 Jun 30;4(6):e6092. doi: 10.1371/journal.pone.0006092.
14. Acrolein induces endoplasmic reticulum stress and causes airspace enlargement. Kitaguchi Y, etal., PLoS One. 2012;7(5):e38038. doi: 10.1371/journal.pone.0038038. Epub 2012 May 31.
15. Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine. Kitamura M, etal., Cell Death Differ. 2011 Dec;18(12):1876-88. doi: 10.1038/cdd.2011.63. Epub 2011 May 20.
16. Novel mouse model of monocular amaurosis fugax. Lelong DC, etal., Stroke. 2007 Dec;38(12):3237-44. Epub 2007 Nov 1.
17. Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways. Lin MH, etal., Toxicology. 2014 Jan 6;315:24-37. doi: 10.1016/j.tox.2013.11.007. Epub 2013 Nov 28.
18. Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma. Lin W, etal., Am J Pathol. 2008 Nov;173(5):1508-17. doi: 10.2353/ajpath.2008.080449. Epub 2008 Sep 25.
19. Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma. Lum CT, etal., Int J Cancer. 2006 Mar 15;118(6):1527-38.
20. Desipramine induces apoptosis in rat glioma cells via endoplasmic reticulum stress-dependent CHOP pathway. Ma J, etal., J Neurooncol. 2011 Jan;101(1):41-8. doi: 10.1007/s11060-010-0237-2. Epub 2010 Jun 12.
21. Evolution of GADD34 expression after focal cerebral ischaemia. McCaig D, etal., Brain Res. 2005 Feb 9;1034(1-2):51-61.
22. Response of neurons to an irreversible inhibition of endoplasmic reticulum Ca(2+)-ATPase: relationship between global protein synthesis and expression and translation of individual genes. Mengesdorf T, etal., Biochem J. 2001 Jun 15;356(Pt 3):805-12.
23. Mode of action of S-methyl-N, N-diethylthiocarbamate sulfoxide (DETC-MeSO) as a novel therapy for stroke in a rat model. Mohammad-Gharibani P, etal., Mol Neurobiol. 2014 Oct;50(2):655-72. doi: 10.1007/s12035-014-8658-0. Epub 2014 Feb 28.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. GADD34 protein levels increase after transient ischemia in the cortex but not in the CA1 subfield: implications for post-ischemic recovery of protein synthesis in ischemia-resistant cells. Paschen W, etal., J Neurochem. 2004 Aug;90(3):694-701.
26. Psychological stress, cocaine and natural reward each induce endoplasmic reticulum stress genes in rat brain. Pavlovsky AA, etal., Neuroscience. 2013 Aug 29;246:160-9. doi: 10.1016/j.neuroscience.2013.04.057. Epub 2013 May 2.
27. Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response. Penas C, etal., J Neurochem. 2007 Aug;102(4):1242-55. Epub 2007 Jun 19.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. The dysregulation of endoplasmic reticulum stress response in acute-on-chronic liver failure patients caused by acute exacerbation of chronic hepatitis B. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes. Schug M, etal., Arch Toxicol. 2013 Feb;87(2):337-45. doi: 10.1007/s00204-012-0999-8. Epub 2012 Dec 29.
33. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
34. Potential molecular mechanism for rodent tumorigenesis: mutational generation of Progression Elevated Gene-3 (PEG-3). Su ZZ, etal., Oncogene. 2005 Mar 24;24(13):2247-55.
35. Subtraction hybridization identifies a transformation progression-associated gene PEG-3 with sequence homology to a growth arrest and DNA damage-inducible gene. Su ZZ, etal., Proc Natl Acad Sci U S A 1997 Aug 19;94(17):9125-30.
36. PEG-3, a nontransforming cancer progression gene, is a positive regulator of cancer aggressiveness and angiogenesis. Su ZZ, etal., Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15115-20.
37. Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim. Szegezdi E, etal., J Cell Mol Med. 2008 Dec;12(6A):2482-96. doi: 10.1111/j.1582-4934.2008.00268.x. Epub 2008 Feb 5.
38. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
Additional References at PubMed
PMID:11381086   PMID:11517336   PMID:11564868   PMID:12556489   PMID:14635196   PMID:15389539   PMID:15601821   PMID:16835242   PMID:19131336   PMID:21518769   PMID:34098025  


Genomics

Comparative Map Data
Ppp1r15a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,136,521 - 105,139,596 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,136,525 - 105,139,774 (-)EnsemblGRCr8
mRatBN7.2196,000,053 - 96,003,128 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,000,058 - 96,003,171 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,385,485 - 101,388,560 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,858,161 - 109,861,236 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,148,553 - 103,151,628 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,511,899 - 101,515,043 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)Ensemblrn6Rnor6.0
Rnor_5.01102,590,677 - 102,593,806 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4195,994,023 - 95,997,080 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,255,750 - 90,258,825 (-)NCBICelera
RGSC_v3.1196,072,182 - 96,074,782 (-)NCBI
Cytogenetic Map1q22NCBI
PPP1R15A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,872,421 - 48,876,058 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,872,212 - 48,876,291 (+)Ensemblhg38GRCh38
GRCh371949,375,678 - 49,379,315 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,067,461 - 54,071,131 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341954,067,489 - 54,071,126NCBI
Celera1946,243,013 - 46,246,683 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,752,093 - 45,755,763 (+)NCBIHuRef
CHM1_11949,377,516 - 49,381,187 (+)NCBICHM1_1
T2T-CHM13v2.01951,867,284 - 51,870,921 (+)NCBIT2T-CHM13v2.0
Ppp1r15a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,172,341 - 45,175,692 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,172,340 - 45,175,692 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38745,522,917 - 45,526,268 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,522,916 - 45,526,268 (-)Ensemblmm10GRCm38
MGSCv37752,778,287 - 52,781,638 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,390,962 - 45,394,255 (-)NCBIMGSCv36mm8
Celera740,979,415 - 40,982,766 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.34NCBI
Ppp1r15a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,750,168 - 1,753,629 (-)Ensembl
ChiLan1.0NW_0049555591,750,227 - 1,753,607 (-)NCBIChiLan1.0ChiLan1.0
PPP1R15A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22054,976,288 - 54,980,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,902,557 - 56,906,388 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,872,596 - 45,876,376 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,880,052 - 54,883,840 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,880,141 - 54,883,003 (-)EnsemblpanPan2panpan1.1
PPP1R15A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,486,399 - 107,490,151 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,486,438 - 107,489,222 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1107,009,025 - 107,012,774 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01108,011,176 - 108,014,925 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1108,011,176 - 108,014,910 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,678,133 - 107,681,882 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,324,992 - 107,328,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,160,618 - 108,164,367 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppp1r15a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,292,394 - 21,296,016 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366642,910,609 - 2,914,205 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP1R15A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,172,050 - 54,175,463 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1654,172,038 - 54,175,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2649,919,349 - 49,922,838 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP1R15A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366607321,992,307 - 21,996,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp1r15a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,103,072 - 5,107,801 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248325,103,251 - 5,107,751 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppp1r15a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12153,986,308 - 153,989,424 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppp1r15a
25 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:12
Count of miRNA genes:10
Interacting mature miRNAs:12
Transcripts:ENSRNOT00000044788
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
RH127458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,000,152 - 96,000,335 (+)MAPPERmRatBN7.2
Rnor_6.01101,511,999 - 101,512,181NCBIRnor6.0
Rnor_5.01102,590,777 - 102,590,959UniSTSRnor5.0
RGSC_v3.4195,994,123 - 95,994,305UniSTSRGSC3.4
Celera190,255,850 - 90,256,032UniSTS
RH 3.4 Map1909.29UniSTS
Cytogenetic Map1q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 92 59 6 356 192 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044788   ⟹   ENSRNOP00000048451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,136,525 - 105,139,774 (-)Ensembl
mRatBN7.2 Ensembl196,000,058 - 96,003,171 (-)Ensembl
Rnor_6.0 Ensembl1101,511,901 - 101,514,974 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079633   ⟹   ENSRNOP00000075192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1101,511,907 - 101,514,547 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000165396   ⟹   ENSRNOP00000101669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,136,529 - 105,139,169 (-)Ensembl
RefSeq Acc Id: NM_133546   ⟹   NP_598230
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,136,521 - 105,139,596 (-)NCBI
mRatBN7.2196,000,053 - 96,003,128 (-)NCBI
Rnor_6.01101,511,899 - 101,514,974 (-)NCBI
Rnor_5.01102,590,677 - 102,593,806 (-)NCBI
RGSC_v3.4195,994,023 - 95,997,080 (-)RGD
Celera190,255,750 - 90,258,825 (-)NCBI
Sequence:
RefSeq Acc Id: NP_598230   ⟸   NM_133546
- UniProtKB: Q7TQC2 (UniProtKB/Swiss-Prot),   O88344 (UniProtKB/Swiss-Prot),   Q6IN02 (UniProtKB/Swiss-Prot),   A0A0G2JSW4 (UniProtKB/TrEMBL),   A6JB49 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075192   ⟸   ENSRNOT00000079633
Ensembl Acc Id: ENSRNOP00000048451   ⟸   ENSRNOT00000044788
Ensembl Acc Id: ENSRNOP00000101669   ⟸   ENSRNOT00000165396
Protein Domains
Protein phosphatase 1 regulatory subunit 15A/B C-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IN02-F1-model_v2 AlphaFold Q6IN02 1-578 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690045
Promoter ID:EPDNEW_R569
Type:single initiation site
Name:Ppp1r15a_1
Description:protein phosphatase 1, regulatory subunit 15A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01101,514,984 - 101,515,044EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621526 AgrOrtholog
BioCyc Gene G2FUF-59678 BioCyc
Ensembl Genes ENSRNOG00000020938 Ensembl
IMAGE_CLONE IMAGE:7104357 IMAGE-MGC_LOAD
InterPro PPP1R15 UniProtKB/Swiss-Prot
  Prot_Pase1_reg-su15A/B_C UniProtKB/Swiss-Prot
KEGG Report rno:171071 UniProtKB/Swiss-Prot
MGC_CLONE MGC:91505 IMAGE-MGC_LOAD
NCBI Gene 171071 ENTREZGENE
PANTHER GH11727P UniProtKB/Swiss-Prot
  PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15A UniProtKB/Swiss-Prot
Pfam PP1c_bdg UniProtKB/Swiss-Prot
PhenoGen Ppp1r15a PhenoGen
RatGTEx ENSRNOG00000020938 RatGTEx
UniProt A0A0G2JSW4 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LB08_RAT UniProtKB/TrEMBL
  A6JB49 ENTREZGENE, UniProtKB/TrEMBL
  O88344 ENTREZGENE
  PR15A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TQC2 ENTREZGENE
UniProt Secondary O88344 UniProtKB/Swiss-Prot
  Q7TQC2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Ppp1r15a  protein phosphatase 1, regulatory subunit 15A  Ppp1r15a  protein phosphatase 1, regulatory (inhibitor) subunit 15A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Ppp1r15a  protein phosphatase 1, regulatory (inhibitor) subunit 15A  Myd116  myeloid differentiation primary response gene 116  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Myd116  myeloid differentiation primary response gene 116      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Myd116  myeloid differentiation primary response gene 116      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_product member of the gadd and Myd family 633491