Aoc3 (amine oxidase, copper containing 3) - Rat Genome Database

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Gene: Aoc3 (amine oxidase, copper containing 3) Rattus norvegicus
Analyze
Symbol: Aoc3
Name: amine oxidase, copper containing 3
RGD ID: 62058
Description: Enables identical protein binding activity and primary amine oxidase activity. Involved in several processes, including eating behavior; leukocyte migration involved in inflammatory response; and positive regulation of glucose transmembrane transport. Located in extracellular space. Used to study aortic aneurysm; obesity; type 2 diabetes mellitus; and uveitis. Biomarker of intracranial aneurysm. Orthologous to human AOC3 (amine oxidase copper containing 3); PARTICIPATES IN beta-alanine metabolic pathway; carnosinemia pathway; GABA aminotransferase deficiency pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: amine oxidase, copper containing 3 (vascular adhesion protein 1); copper amine oxidase; membrane primary amine oxidase; semicarbazide-sensitive amine oxidase; SSAO; VAP-1; vascular adhesion protein 1; VP97
RGD Orthologs
Human
Mouse
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,773,018 - 86,780,961 (+)NCBIGRCr8
mRatBN7.21086,272,757 - 86,280,702 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1091,310,347 - 91,318,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,785,046 - 90,792,989 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,178,338 - 86,186,282 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,251,370 - 89,259,313 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,251,370 - 89,259,313 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,049,333 - 89,057,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,357,094 - 90,365,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,371,458 - 90,372,508 (+)NCBI
Celera1084,990,891 - 84,998,741 (+)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Allylamine  (EXP,ISO)
amitrole  (EXP)
ammonia  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP,ISO)
iron dichloride  (ISO)
isoprenaline  (ISO)
lidocaine  (EXP)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylamine  (ISO)
mifepristone  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel atom  (ISO)
ochratoxin A  (EXP,ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
PhIP  (EXP)
pioglitazone  (ISO)
procarbazine  (EXP)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
semicarbazide  (EXP,ISO)
silicon dioxide  (ISO)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
versicolorin A  (ISO)
vinclozolin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO,ISS)
cytoplasm  (ISO)
early endosome  (IBA,ISO)
endoplasmic reticulum  (IBA,ISO)
extracellular space  (IDA)
Golgi apparatus  (IBA,ISO)
membrane  (ISO,ISS)
microvillus  (ISO)
plasma membrane  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 activity exerts an antidiabetic action in Goto-Kakizaki rats. Abella A, etal., Diabetes. 2003 Apr;52(4):1004-13.
2. Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats. Abella A, etal., J Physiol Biochem. 2003 Sep;59(3):153-60.
3. Plasma semicarbazide-sensitive amine oxidase (SSAO) is an independent prognostic marker for mortality in chronic heart failure. Boomsma F, etal., Eur Heart J. 2000 Nov;21(22):1859-63.
4. Age-related changes in the activities of the amine metabolizing enzymes of rat eye. Cao Danh H, etal., J Pharm Pharmacol. 1985 May;37(5):357-61.
5. Reduction of fat deposition by combined inhibition of monoamine oxidases and semicarbazide-sensitive amine oxidases in obese Zucker rats. Carpene C, etal., Pharmacol Res. 2007 Dec;56(6):522-30. Epub 2007 Sep 26.
6. Contribution of serum and cellular semicarbazide-sensitive amine oxidase to amine metabolism and cardiovascular toxicity. Conklin DJ, etal., Toxicol Sci. 1998 Dec;46(2):386-92.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Gong B, etal., Birth Defects Res A Clin Mol Teratol. 2006 Jan;76(1):29-38.
10. Follow-up of plasma semicarbazide-sensitive amine oxidase activity and retinopathy in Type 2 diabetes mellitus. Gronvall-Nordquist JL, etal., J Diabetes Complications. 2001 Sep-Oct;15(5):250-6.
11. Semicarbazide-sensitive amine oxidase activity in streptozotocin diabetic rats. Hayes BE and Clarke DE, Res Commun Chem Pathol Pharmacol. 1990 Jul;69(1):71-83.
12. Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia. Li HY, etal., Clin Chim Acta. 2009 Jun 27;404(2):149-53. Epub 2009 Mar 29.
13. Vascular amine oxidases are needed for leukocyte extravasation into inflamed joints in vivo. Marttila-Ichihara F, etal., Arthritis Rheum. 2006 Sep;54(9):2852-62.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Membrane amine oxidase cloning and identification as a major protein in the adipocyte plasma membrane. Morris NJ, etal., J Biol Chem 1997 Apr 4;272(14):9388-92.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Vascular adhesion protein-1 regulates leukocyte transmigration rate in the retina during diabetes. Noda K, etal., Exp Eye Res. 2009 Nov;89(5):774-81. Epub 2009 Jul 25.
18. Inhibition of vascular adhesion protein-1 suppresses endotoxin-induced uveitis. Noda K, etal., FASEB J. 2008 Apr;22(4):1094-103. Epub 2007 Nov 21.
19. Vascular adhesion protein-1 blockade suppresses choroidal neovascularization. Noda K, etal., FASEB J. 2008 Aug;22(8):2928-35. Epub 2008 Apr 24.
20. Semicarbazide-sensitive amine oxidase (SSAO) gene expression in alloxan-induced diabetes in mice. Nordquist JE, etal., Mol Med. 2002 Dec;8(12):824-9.
21. Anti-inflammatory effects of LJP 1586 [Z-3-fluoro-2-(4-methoxybenzyl)allylamine hydrochloride], an amine-based inhibitor of semicarbazide-sensitive amine oxidase activity. O'Rourke AM, etal., J Pharmacol Exp Ther. 2008 Feb;324(2):867-75. Epub 2007 Nov 9.
22. Evidence for existence of immobilization stress-inducible semicarbazide-sensitive amine oxidase inhibitor in rat brain cytosol. Obata T and Yamanaka Y, Neurosci Lett. 2000 Dec 15;296(1):58-60.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. GOA pipeline RGD automated data pipeline
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Insulin-regulated increase of soluble vascular adhesion protein-1 in diabetes. Salmi M, etal., Am J Pathol. 2002 Dec;161(6):2255-62.
28. Association between semicarbazide-sensitive amine oxidase, a regulator of the glucose transporter, and elastic lamellae thinning during experimental cerebral aneurysm development: laboratory investigation. Sibon I, etal., J Neurosurg. 2008 Mar;108(3):558-66.
29. Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. Smith DJ, etal., J Exp Med. 1998 Jul 6;188(1):17-27.
30. Semicarbazide-sensitive amine oxidase (SSAO) and its possible contribution to vascular damage in Alzheimer's disease. Unzeta M, etal., J Neural Transm. 2007;114(6):857-62. Epub 2007 Mar 29.
31. Hypotensive effect of hydroxylamine, an endogenous nitric oxide donor and SSAO inhibitor. Vidrio H and Medina M, J Neural Transm. 2007;114(6):863-5. Epub 2007 Mar 26.
32. Vascular adhesion protein-1 plays an important role in postischemic inflammation and neuropathology in diabetic, estrogen-treated ovariectomized female rats subjected to transient forebrain ischemia. Xu HL, etal., J Pharmacol Exp Ther. 2006 Apr;317(1):19-29. Epub 2005 Dec 8.
33. Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice. Yu PH, etal., Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E634-41. Epub 2003 Dec 2.
Additional References at PubMed
PMID:8520629   PMID:12477932   PMID:15489334   PMID:15744061   PMID:16046623   PMID:16524643   PMID:17431735   PMID:19764817   PMID:20686801   PMID:23349812   PMID:23474851   PMID:26886786  
PMID:28318627   PMID:28910971   PMID:29600311   PMID:32410850   PMID:36835077  


Genomics

Comparative Map Data
Aoc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,773,018 - 86,780,961 (+)NCBIGRCr8
mRatBN7.21086,272,757 - 86,280,702 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1091,310,347 - 91,318,078 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,785,046 - 90,792,989 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01086,178,338 - 86,186,282 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01089,251,370 - 89,259,313 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1089,251,370 - 89,259,313 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01089,049,333 - 89,057,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41090,357,094 - 90,365,040 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11090,371,458 - 90,372,508 (+)NCBI
Celera1084,990,891 - 84,998,741 (+)NCBICelera
Cytogenetic Map10q31NCBI
AOC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,851,199 - 42,858,124 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,851,184 - 42,858,130 (+)EnsemblGRCh38hg38GRCh38
GRCh371741,003,216 - 41,010,141 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,256,727 - 38,263,667 (+)NCBINCBI36Build 36hg18NCBI36
Build 341738,256,726 - 38,263,664NCBI
Celera1737,659,256 - 37,666,196 (+)NCBICelera
Cytogenetic Map17q21.31NCBI
HuRef1736,767,841 - 36,774,787 (+)NCBIHuRef
CHM1_11741,238,814 - 41,245,760 (+)NCBICHM1_1
T2T-CHM13v2.01743,708,339 - 43,715,264 (+)NCBIT2T-CHM13v2.0
Aoc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911101,221,432 - 101,230,256 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11101,221,431 - 101,232,764 (+)EnsemblGRCm39 Ensembl
GRCm3811101,330,606 - 101,339,430 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11101,330,605 - 101,341,938 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711101,191,920 - 101,200,744 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611102,109,647 - 102,118,471 (+)NCBIMGSCv36mm8
MGSCv3611101,146,696 - 101,155,514 (+)NCBIMGSCv36mm8
Cytogenetic Map11DNCBI
cM Map1164.72NCBI
AOC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,158,581 - 20,179,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,157,410 - 20,241,376 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha919,619,309 - 19,641,100 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0920,876,395 - 20,898,170 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl920,877,411 - 20,897,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1919,661,243 - 19,683,028 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0919,927,536 - 19,949,304 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,044,945 - 20,051,732 (-)NCBIUU_Cfam_GSD_1.0
UU_Cfam_GSD_1.0920,030,195 - 20,037,021 (-)NCBIUU_Cfam_GSD_1.0
LOC101973421
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,511,803 - 19,525,647 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493649017,549,836 - 17,564,867 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110256000
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11219,996,324 - 20,007,006 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AOC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,435,494 - 63,442,790 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,437,067 - 63,442,256 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,225,706 - 34,232,618 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Aoc3
42 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 16 10 4 6 9 18 11 6
Low 27 31 25 15 25 2 2 29 31 15 2
Below cutoff 16 16 16 45 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000076820   ⟹   ENSRNOP00000068449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1089,251,370 - 89,259,313 (+)Ensembl
RefSeq Acc Id: NM_031582   ⟹   NP_113770
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,773,018 - 86,780,961 (+)NCBI
mRatBN7.21086,272,757 - 86,280,702 (+)NCBI
Rnor_6.01089,251,370 - 89,259,313 (+)NCBI
Rnor_5.01089,049,333 - 89,057,276 (+)NCBI
RGSC_v3.41090,357,094 - 90,365,040 (+)RGD
Celera1084,990,891 - 84,998,741 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113770 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53189 (Get FASTA)   NCBI Sequence Viewer  
  AAI00614 (Get FASTA)   NCBI Sequence Viewer  
  BAD74047 (Get FASTA)   NCBI Sequence Viewer  
  EDM06115 (Get FASTA)   NCBI Sequence Viewer  
  O08590 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_113770   ⟸   NM_031582
- UniProtKB: Q497D2 (UniProtKB/Swiss-Prot),   Q5R1T5 (UniProtKB/Swiss-Prot),   O08590 (UniProtKB/Swiss-Prot),   A6HJB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000068449   ⟸   ENSRNOT00000076820
Protein Domains
Copper amine oxidase catalytic   Copper amine oxidase N3-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08590-F1-model_v2 AlphaFold O08590 1-763 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697755
Promoter ID:EPDNEW_R8280
Type:multiple initiation site
Name:Aoc3_1
Description:amine oxidase, copper containing 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01089,251,363 - 89,251,423EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62058 AgrOrtholog
BioCyc Gene G2FUF-23179 BioCyc
BioCyc Pathway 2PHENDEG-PWY [phenylethylamine degradation I] BioCyc
BioCyc Pathway Image 2PHENDEG-PWY BioCyc
Ensembl Genes ENSRNOG00000051307 Ensembl
Gene3D-CATH 2.70.98.20 UniProtKB/Swiss-Prot
  3.10.450.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Copper amine oxidase, catalytic domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598211 IMAGE-MGC_LOAD
InterPro Cu_amine_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_N-reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidase_N2 UniProtKB/Swiss-Prot
  Cu_amine_oxidase_N3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29473 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124520 IMAGE-MGC_LOAD
NCBI Gene 29473 ENTREZGENE
PANTHER COPPER AMINE OXIDASE UniProtKB/TrEMBL
  MEMBRANE PRIMARY AMINE OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10638 UniProtKB/Swiss-Prot
Pfam Cu_amine_oxid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cu_amine_oxidN2 UniProtKB/Swiss-Prot
  Cu_amine_oxidN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aoc3 PhenoGen
PRINTS CUDAOXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE COPPER_AMINE_OXID_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  COPPER_AMINE_OXID_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051307 RatGTEx
Superfamily-SCOP Amine oxidase catalytic domain UniProtKB/TrEMBL
  Amine oxidase N-terminal region UniProtKB/TrEMBL
  SSF49998 UniProtKB/Swiss-Prot
  SSF54416 UniProtKB/Swiss-Prot
UniProt A6HJB0 ENTREZGENE, UniProtKB/TrEMBL
  AOC3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q497D2 ENTREZGENE
  Q5R1T5 ENTREZGENE
UniProt Secondary Q497D2 UniProtKB/Swiss-Prot
  Q5R1T5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-15 Aoc3  amine oxidase, copper containing 3  Aoc3  amine oxidase, copper containing 3 (vascular adhesion protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Aoc3  amine oxidase, copper containing 3 (vascular adhesion protein 1)  Aoc3  amine oxidase, copper containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aoc3  amine oxidase, copper containing 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_protein 97 kDa 61537