RGD Reference Report - Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice. - Rat Genome Database

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Involvement of SSAO-mediated deamination in adipose glucose transport and weight gain in obese diabetic KKAy mice.

Authors: Yu, PH  Wang, M  Fan, H  Deng, Y  Gubisne-Haberle, D 
Citation: Yu PH, etal., Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E634-41. Epub 2003 Dec 2.
RGD ID: 2313822
Pubmed: PMID:14656718   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpendo.00272.2003   (Journal Full-text)

Semicarbazide-sensitive amine oxidase (SSAO) is located on outer surfaces of adipocytes and endothelial and vascular smooth muscle cells. This enzyme catalyzes deamination of methylamine and aminoacetone, leading to production of toxic formaldehyde and methylglyoxal, respectively, as well as hydrogen peroxide and ammonium. Several lines of evidence suggest that increased SSAO activity is related to chronic inflammation and vascular disorders related to diabetic complications. We found that a highly potent and selective SSAO inhibitor, (E)-2-(4-fluorophenethyl)-3-fluoroallylamine (FPFA), was capable of reducing numbers of atherosclerotic lesions as well as weight gain in obese KKAy mice fed an atherogenic diet. SSAO inhibitors cause a moderate and long-lasting hyperglycemia. Such an increase in serum glucose is a result of reduction of glucose uptake by adipocytes. SSAO-mediated deamination of endogenous methylamine substrates induces adipocyte glucose uptake and lipogenesis. Highly selective SSAO inhibitors can effectively block induced glucose uptake. The results suggest that increased SSAO-mediated deamination may be concomitantly related to obesity and vascular disorders associated with type 2 diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  ISOAoc3 (Mus musculus)2313822; 2313822 RGD 
type 2 diabetes mellitus  IMP 2313822 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aoc3  (amine oxidase, copper containing 3)

Genes (Mus musculus)
Aoc3  (amine oxidase, copper containing 3)

Genes (Homo sapiens)
AOC3  (amine oxidase copper containing 3)


Additional Information