RGD Reference Report - Vascular adhesion protein-1 blockade suppresses choroidal neovascularization. - Rat Genome Database

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Vascular adhesion protein-1 blockade suppresses choroidal neovascularization.

Authors: Noda, K  She, H  Nakazawa, T  Hisatomi, T  Nakao, S  Almulki, L  Zandi, S  Miyahara, S  Ito, Y  Thomas, KL  Garland, RC  Miller, JW  Gragoudas, ES  Mashima, Y  Hafezi-Moghadam, A 
Citation: Noda K, etal., FASEB J. 2008 Aug;22(8):2928-35. Epub 2008 Apr 24.
RGD ID: 2313908
Pubmed: PMID:18436961   (View Abstract at PubMed)
PMCID: PMC2493453   (View Article at PubMed Central)
DOI: DOI:10.1096/fj.07-105346   (Journal Full-text)

Vascular adhesion protein-1 (VAP-1) is an endothelial cell adhesion molecule involved in leukocyte recruitment. Leukocytes and, in particular, macrophages play an important role in the development of choroidal neovascularization (CNV), an integral component of age-related macular degeneration (AMD). Previously, we showed a role for VAP-1 in ocular inflammation. Here, we investigate the expression of VAP-1 in the choroid and its role in CNV development. VAP-1 was expressed in the choroid, exclusively in the vessels, and colocalized in the vessels of the CNV lesions. VAP-1 blockade with a novel and specific inhibitor significantly decreased CNV size, fluorescent angiographic leakage, and the accumulation of macrophages in the CNV lesions. Furthermore, VAP-1 blockade significantly reduced the expression of inflammation-associated molecules such as tumor necrosis factor (TNF) -alpha, monocyte chemoattractant protein (MCP) -1, and intercellular adhesion molecule (ICAM) -1. This work provides evidence for an important role of VAP-1 in the recruitment of macrophages to CNV lesions, establishing a novel link between VAP-1 and angiogenesis. Inhibition of VAP-1 may become a new therapeutic strategy in the treatment of AMD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Choroidal Neovascularization  ISOAoc3 (Rattus norvegicus)2313908; 2313908 RGD 
Choroidal Neovascularization  IMP 2313908 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aoc3  (amine oxidase, copper containing 3)

Genes (Mus musculus)
Aoc3  (amine oxidase, copper containing 3)

Genes (Homo sapiens)
AOC3  (amine oxidase copper containing 3)


Additional Information