Kl (Klotho) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Kl (Klotho) Rattus norvegicus
Analyze
Symbol: Kl
Name: Klotho
RGD ID: 620396
Description: Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in apical plasma membrane and extracellular region. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho); PARTICIPATES IN fibroblast growth factor signaling pathway; pentose and glucuronate interconversion pathway; starch and sucrose metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-methyladenine.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8125,326,003 - 5,367,016 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl125,325,959 - 5,367,015 (+)EnsemblGRCr8
mRatBN7.212490,402 - 531,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12490,399 - 530,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,064,277 - 1,103,820 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,586,514 - 1,626,063 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012486,601 - 526,810 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.012942,974 - 987,206 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)Ensemblrn6Rnor6.0
Rnor_5.012929,158 - 972,144 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera122,195,730 - 2,234,485 (+)NCBICelera
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Cytogenetic Map12p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(Z)-ligustilide  (ISO)
1,1-dichloroethene  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol 3-glucosiduronic acid  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acrylamide  (ISO)
amino acid  (ISO)
ammonium chloride  (EXP)
androsterone 3-glucosiduronic acid  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
berberine  (EXP)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calciol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
chlorophyllin  (ISO)
cisplatin  (EXP)
cocaine  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (EXP)
elemental selenium  (ISO)
estriol 3-O-(beta-D-glucuronide)  (ISO)
estrone 3-O-(beta-D-glucuronide)  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fosinopril  (EXP)
genistein  (ISO)
glycidol  (EXP)
glyphosate  (EXP)
guggulsterone  (ISO)
hypoxanthine  (ISO)
icariin  (ISO)
indoxyl sulfate  (EXP,ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
malonaldehyde  (ISO)
melatonin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
nitrates  (EXP)
okadaic acid  (ISO)
Osajin  (ISO)
paclitaxel  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phosphorus atom  (ISO)
phosphorus(.)  (ISO)
Pomiferin  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
potassium dichromate  (ISO)
propanal  (ISO)
puerarin  (ISO)
pyrrolidine dithiocarbamate  (ISO)
resveratrol  (EXP,ISO)
retinyl acetate  (ISO)
Rosavin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
selenium atom  (ISO)
SL-327  (ISO)
sodium arsenite  (EXP,ISO)
sodium chlorate  (ISO)
streptozocin  (EXP,ISO)
taurocholic acid  (ISO)
testosterone 17-glucosiduronic acid  (ISO)
titanium dioxide  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
valproic acid  (ISO)
valsartan  (EXP)
vancomycin  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Aizawa H, etal., Biochem Biophys Res Commun. 1998 Aug 28;249(3):865-71.
2. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Arking DE, etal., Circ Res. 2005 Mar 4;96(4):412-8. Epub 2005 Jan 27.
3. The parathyroid is a target organ for FGF23 in rats. Ben-Dov IZ, etal., J Clin Invest. 2007 Dec;117(12):4003-8.
4. Vitamin D-deficient diet rescues hearing loss in Klotho mice. Carpinelli MR, etal., Hear Res. 2011 May;275(1-2):105-9. doi: 10.1016/j.heares.2010.12.009. Epub 2010 Dec 16.
5. Fosinopril and valsartan intervention in gene expression of Klotho, MMP-9, TIMP-1, and PAI-1 in the kidney of spontaneously hypertensive rats. Cheng X, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Oct;35(10):1048-56. doi: 10.3969/j.issn.1672-7347.2010.10.004.
6. Retinitis Pigmentosa: over-expression of anti-ageing protein Klotho in degenerating photoreceptors. Farinelli P, etal., J Neurochem. 2013 Dec;127(6):868-79. doi: 10.1111/jnc.12353. Epub 2013 Jul 22.
7. Modulating fibroblast growth factor 21 in hyperphagic OLETF rats with daily exercise and caloric restriction. Fletcher JA, etal., Appl Physiol Nutr Metab. 2012 Dec;37(6):1054-62. doi: 10.1139/h2012-091. Epub 2012 Aug 15.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Increased parathyroid expression of klotho in uremic rats. Hofman-Bang J, etal., Kidney Int. 2010 Dec;78(11):1119-27. doi: 10.1038/ki.2010.215. Epub 2010 Jul 14.
11. Klotho deficiency causes vascular calcification in chronic kidney disease. Hu MC, etal., J Am Soc Nephrol. 2011 Jan;22(1):124-36. doi: 10.1681/ASN.2009121311. Epub 2010 Nov 29.
12. Rosiglitazone is effective to improve renal damage in type-1-like diabetic rats. Huang KC, etal., Horm Metab Res. 2014 Apr;46(4):240-4. doi: 10.1055/s-0033-1357161. Epub 2013 Oct 17.
13. Klotho gene polymorphism may be a genetic risk factor for atherosclerotic coronary artery disease but not for vasospastic angina in Japanese. Imamura A, etal., Clin Chim Acta. 2006 Sep;371(1-2):66-70. Epub 2006 Mar 6.
14. Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice. Inoue S, etal., Shock. 2013 Mar;39(3):311-6. doi: 10.1097/SHK.0b013e3182845445.
15. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Kim Y, etal., Neurosci Lett. 2006 Oct 30;407(3):189-94. Epub 2006 Sep 14.
16. Severely reduced production of klotho in human chronic renal failure kidney. Koh N, etal., Biochem Biophys Res Commun. 2001 Feb 2;280(4):1015-20.
17. Klotho upregulation contributes to the neuroprotection of ligustilide in an Alzheimer's disease mouse model. Kuang X, etal., Neurobiol Aging. 2014 Jan;35(1):169-78. doi: 10.1016/j.neurobiolaging.2013.07.019. Epub 2013 Aug 21.
18. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Kuro-o M, etal., Nature. 1997 Nov 6;390(6655):45-51.
19. Regulation of fibroblast growth factor-23 signaling by klotho. Kurosu H, etal., J Biol Chem. 2006 Mar 10;281(10):6120-3. Epub 2006 Jan 25.
20. [Klotho gene attenuates the progression of hypertension and heart damage in spontaneous hypertensive rats]. Li BS, etal., Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Dec;29(6):662-8. doi: 10.3760/cma.j.issn.1003-9406.2012.06.008.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Mitani H, etal., Hypertension 2002 Apr;39(4):838-43.
23. Endothelial dysfunction in the klotho mouse and downregulation of klotho gene expression in various animal models of vascular and metabolic diseases. Nagai R, etal., Cell Mol Life Sci. 2000 May;57(5):738-46.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Association of klotho gene polymorphism with bone density and spondylosis of the lumbar spine in postmenopausal women. Ogata N, etal., Bone. 2002 Jul;31(1):37-42.
26. Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Ohyama Y, etal., Biochem Biophys Res Commun 1998 Oct 29;251(3):920-5.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. The differential effects of age on the association of KLOTHO gene polymorphisms with coronary artery disease. Rhee EJ, etal., Metabolism. 2006 Oct;55(10):1344-51.
33. In vivo klotho gene delivery protects against endothelial dysfunction in multiple risk factor syndrome. Saito Y, etal., Biochem Biophys Res Commun. 2000 Sep 24;276(2):767-72.
34. N-acetylcysteine attenuates renal alterations induced by senescence in the rat. Shimizu MH, etal., Exp Gerontol. 2013 Feb;48(2):298-303. doi: 10.1016/j.exger.2012.11.006. Epub 2012 Nov 23.
35. Klotho reduces apoptosis in experimental ischaemic acute renal failure. Sugiura H, etal., Nephrol Dial Transplant. 2005 Dec;20(12):2636-45. Epub 2005 Oct 4.
36. Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expression. Takeshita K, etal., Circulation. 2004 Apr 13;109(14):1776-82. Epub 2004 Mar 22.
37. Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis. Thurston RD, etal., Gastroenterology. 2010 Apr;138(4):1384-94, 1394.e1-2. doi: 10.1053/j.gastro.2009.12.002. Epub 2009 Dec 11.
38. Association of KLOTHO gene polymorphisms with knee osteoarthritis in Greek population. Tsezou A, etal., J Orthop Res. 2008 Nov;26(11):1466-70. doi: 10.1002/jor.20634.
39. RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway. Wang X and Sun Z, Physiol Genomics. 2010 Apr 1;41(2):120-6. doi: 10.1152/physiolgenomics.00192.2009. Epub 2010 Jan 19.
40. Renal expression of FGF23 in progressive renal disease of diabetes and the effect of ACE inhibitor. Zanchi C, etal., PLoS One. 2013 Aug 14;8(8):e70775. doi: 10.1371/journal.pone.0070775. eCollection 2013.
Additional References at PubMed
PMID:10631108   PMID:11095966   PMID:11792841   PMID:12965205   PMID:15135068   PMID:17086194   PMID:18056631   PMID:18829467   PMID:19056867   PMID:19349416   PMID:19367378   PMID:19756714  
PMID:19955715   PMID:20360647   PMID:20625492   PMID:20830528   PMID:21038689   PMID:21209102   PMID:21276773   PMID:21311136   PMID:21389697   PMID:21646815   PMID:22285620   PMID:22551380  
PMID:23041151   PMID:23365232   PMID:23376485   PMID:23533145   PMID:23838326   PMID:24304882   PMID:24721634   PMID:24867139   PMID:24979306   PMID:25695625   PMID:26093264   PMID:26880455  
PMID:26970306   PMID:28515153   PMID:29187373   PMID:29226550   PMID:31001900   PMID:31422095   PMID:31578871   PMID:32438076   PMID:32699940   PMID:32869899   PMID:33737505   PMID:34050772  
PMID:34360633   PMID:34637700   PMID:34730891   PMID:35104732   PMID:35436879   PMID:35900650   PMID:36041714   PMID:36641458   PMID:36674721   PMID:37704925   PMID:37793463   PMID:38330925  
PMID:38589756   PMID:38904464   PMID:39264079  


Genomics

Comparative Map Data
Kl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8125,326,003 - 5,367,016 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl125,325,959 - 5,367,015 (+)EnsemblGRCr8
mRatBN7.212490,402 - 531,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl12490,399 - 530,080 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx121,064,277 - 1,103,820 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0121,586,514 - 1,626,063 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.012486,601 - 526,810 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.012942,974 - 987,206 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl12943,006 - 987,551 (+)Ensemblrn6Rnor6.0
Rnor_5.012929,158 - 972,144 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4123,732,712 - 3,772,371 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera122,195,730 - 2,234,485 (+)NCBICelera
RGSC_v3.1123,732,711 - 3,772,371 (-)NCBI
Cytogenetic Map12p12NCBI
KL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381333,016,243 - 33,066,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1333,016,423 - 33,066,143 (+)Ensemblhg38GRCh38
GRCh371333,590,561 - 33,640,280 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361332,488,571 - 32,538,279 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341332,488,570 - 32,538,279NCBI
Celera1314,657,386 - 14,707,106 (+)NCBICelera
Cytogenetic Map13q13.1NCBI
HuRef1314,401,659 - 14,452,070 (+)NCBIHuRef
CHM1_11333,558,119 - 33,607,832 (+)NCBICHM1_1
T2T-CHM13v2.01332,233,557 - 32,283,464 (+)NCBIT2T-CHM13v2.0
Kl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395150,876,072 - 150,917,282 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5150,876,072 - 150,917,282 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385150,952,607 - 150,993,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5150,952,607 - 150,993,817 (+)Ensemblmm10GRCm38
MGSCv375151,755,182 - 151,796,392 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365151,221,078 - 151,262,196 (+)NCBIMGSCv36mm8
Celera5148,957,067 - 148,998,277 (+)NCBICelera
Cytogenetic Map5G3NCBI
cM Map589.77NCBI
Kl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543112,782,846 - 12,833,215 (-)Ensembl
ChiLan1.0NW_00495543112,782,913 - 12,833,215 (-)NCBIChiLan1.0ChiLan1.0
KL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21432,579,481 - 32,629,284 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11323,685,802 - 23,735,607 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01314,272,463 - 14,321,122 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11332,697,381 - 32,752,578 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1332,702,336 - 32,751,458 (+)EnsemblpanPan2panpan1.1
KL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1257,154,359 - 7,201,744 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl257,156,620 - 7,199,558 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha257,190,325 - 7,236,623 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0257,256,203 - 7,302,574 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl257,255,966 - 7,302,141 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,155,694 - 7,201,964 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,148,224 - 7,195,654 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0257,211,791 - 7,258,193 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945168,294,810 - 168,347,489 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647227,604,517 - 27,650,086 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647227,604,681 - 27,649,613 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,427,037 - 9,479,228 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1119,427,236 - 9,479,251 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2119,357,470 - 9,390,509 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1311,755,015 - 11,799,537 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl311,755,016 - 11,797,596 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605732,549,747 - 32,594,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462491595,155 - 110,834 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kl
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v116502,564 - 543,043 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kl
562 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:146
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000001449
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12115486827Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)12129775522Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12124849755Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1357337Gluco3Glucose level QTL 30.0004adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)12116966671Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303568Bw88Body weight QTL 883body mass (VT:0001259)body weight (CMO:0000012)12128606299Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12133700600Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
61334Gluco17Glucose level QTL 176.3adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)12116966671Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12128133365Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)12128606299Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)12133700556Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12111869600Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 12 59 140 62 61 30 29 30 6 243 116 6 121 81 74 31 11 11

Sequence


Ensembl Acc Id: ENSRNOT00000001449   ⟹   ENSRNOP00000001449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl125,325,959 - 5,367,015 (+)Ensembl
mRatBN7.2 Ensembl12490,399 - 530,080 (+)Ensembl
Rnor_6.0 Ensembl12943,006 - 987,551 (+)Ensembl
RefSeq Acc Id: NM_031336   ⟹   NP_112626
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,326,003 - 5,365,679 (+)NCBI
mRatBN7.212490,402 - 530,080 (+)NCBI
Rnor_6.012942,974 - 987,206 (+)NCBI
Rnor_5.012929,158 - 972,144 (+)NCBI
RGSC_v3.4123,732,712 - 3,772,371 (-)RGD
Celera122,195,730 - 2,234,485 (+)RGD
Sequence:
RefSeq Acc Id: XM_039089809   ⟹   XP_038945737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8125,344,261 - 5,367,016 (+)NCBI
mRatBN7.212510,542 - 531,417 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112626 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945737 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA34740 (Get FASTA)   NCBI Sequence Viewer  
  EDL74914 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001449
  ENSRNOP00000001449.3
GenBank Protein Q9Z2Y9 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112626   ⟸   NM_031336
- Peptide Label: precursor
- UniProtKB: Q9Z2Y9 (UniProtKB/Swiss-Prot),   A6KSV6 (UniProtKB/TrEMBL),   A0A0H2UH96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001449   ⟸   ENSRNOT00000001449
RefSeq Acc Id: XP_038945737   ⟸   XM_039089809
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2Y9-F1-model_v2 AlphaFold Q9Z2Y9 1-1014 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698360
Promoter ID:EPDNEW_R8885
Type:multiple initiation site
Name:Kl_1
Description:Klotho
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.012942,995 - 943,055EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620396 AgrOrtholog
BioCyc Gene G2FUF-20507 BioCyc
Ensembl Genes ENSRNOG00000001092 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001449 ENTREZGENE
  ENSRNOT00000001449.5 UniProtKB/Swiss-Prot
Gene3D-CATH Glycosidases UniProtKB/Swiss-Prot
InterPro Glyco_hydro_1 UniProtKB/Swiss-Prot
  Glyco_hydro_1_N_CS UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
KEGG Report rno:83504 UniProtKB/Swiss-Prot
NCBI Gene 83504 ENTREZGENE
PANTHER LACTASE-LIKE PROTEIN UniProtKB/Swiss-Prot
  PTHR10353 UniProtKB/Swiss-Prot
Pfam Glyco_hydro_1 UniProtKB/Swiss-Prot
PhenoGen Kl PhenoGen
PRINTS GLHYDRLASE1 UniProtKB/Swiss-Prot
PROSITE GLYCOSYL_HYDROL_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001092 RatGTEx
Superfamily-SCOP SSF51445 UniProtKB/Swiss-Prot
UniProt A0A0H2UH96 ENTREZGENE, UniProtKB/TrEMBL
  A6KSV6 ENTREZGENE, UniProtKB/TrEMBL
  KLOT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kl  Klotho      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Kl  Klotho      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated in arteriosclerosis, osteoporosis, infertility, pulmonary emphysema 70544
gene_expression expressed in kidney 70544
gene_process has a role in protection against Ang II-induced renal damage 70544
gene_regulation downregulated by Ang II 70544
gene_regulation expression decreased by lipopolysaccharide 633145