Ppib (peptidylprolyl isomerase B) - Rat Genome Database

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Gene: Ppib (peptidylprolyl isomerase B) Rattus norvegicus
Analyze
Symbol: Ppib
Name: peptidylprolyl isomerase B
RGD ID: 620312
Description: Predicted to enable RNA polymerase binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in several processes, including host-mediated activation of viral genome replication; neutrophil chemotaxis; and protein stabilization. Located in smooth endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Orthologous to human PPIB (peptidylprolyl isomerase B); PARTICIPATES IN codeine and morphine pharmacodynamics pathway; codeine and morphine pharmacokinetics pathway; etoposide pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cyclophilin B; CYP-S1; CypB; peptidyl-prolyl cis-trans isomerase B; PPIase; PPIase B; rotamase; rotamase B; S-cyclophilin; S-cyclophylin; Scylp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,498,966 - 75,504,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl875,498,797 - 75,504,847 (+)EnsemblGRCr8
mRatBN7.2866,603,877 - 66,609,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,603,861 - 66,630,428 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx872,116,410 - 72,122,281 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,389,471 - 70,395,342 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,259,312 - 68,265,165 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,719,681 - 71,725,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,719,563 - 71,725,562 (+)Ensemblrn6Rnor6.0
Rnor_5.0871,388,620 - 71,394,477 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4870,343,463 - 70,349,320 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera865,993,837 - 65,999,694 (+)NCBICelera
RGSC_v3.1870,362,516 - 70,368,374 (+)NCBI
Cytogenetic Map8q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,6-dimethoxyphenol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethanol  (EXP)
fenthion  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
folpet  (ISO)
furfural  (ISO)
genistein  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
graphite  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
limonene  (EXP)
lipopolysaccharide  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
Propiverine  (EXP)
quinomethionate  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. An endoplasmic reticulum-specific cyclophilin. Hasel KW, etal., Mol Cell Biol 1991 Jul;11(7):3484-91.
4. An interaction map of endoplasmic reticulum chaperones and foldases. Jansen G, etal., Mol Cell Proteomics. 2012 Sep;11(9):710-23. doi: 10.1074/mcp.M111.016550. Epub 2012 Jun 4.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Role of cyclophilin B in prolactin signal transduction and nuclear retrotranslocation. Rycyzyn MA, etal., Mol Endocrinol 2000 Aug;14(8):1175-86.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1530944   PMID:2194066   PMID:10775569   PMID:12475965   PMID:15489334   PMID:15989969   PMID:16854843   PMID:18946027   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20089953  
PMID:20458337   PMID:20676357   PMID:21332552   PMID:21423176   PMID:21630459   PMID:21683784   PMID:22658674   PMID:22681889   PMID:23376485   PMID:23533145   PMID:29967478   PMID:32908452  


Genomics

Comparative Map Data
Ppib
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8875,498,966 - 75,504,823 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl875,498,797 - 75,504,847 (+)EnsemblGRCr8
mRatBN7.2866,603,877 - 66,609,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl866,603,861 - 66,630,428 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx872,116,410 - 72,122,281 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0870,389,471 - 70,395,342 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0868,259,312 - 68,265,165 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0871,719,681 - 71,725,538 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl871,719,563 - 71,725,562 (+)Ensemblrn6Rnor6.0
Rnor_5.0871,388,620 - 71,394,477 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4870,343,463 - 70,349,320 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera865,993,837 - 65,999,694 (+)NCBICelera
RGSC_v3.1870,362,516 - 70,368,374 (+)NCBI
Cytogenetic Map8q24NCBI
PPIB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381564,155,817 - 64,163,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1564,155,740 - 64,163,159 (-)Ensemblhg38GRCh38
GRCh371564,448,016 - 64,455,221 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,235,067 - 62,242,407 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341562,235,067 - 62,242,407NCBI
Celera1541,326,958 - 41,334,299 (-)NCBICelera
Cytogenetic Map15q22.31NCBI
HuRef1541,272,716 - 41,280,027 (-)NCBIHuRef
CHM1_11564,567,543 - 64,574,883 (-)NCBICHM1_1
T2T-CHM13v2.01561,962,993 - 61,970,198 (-)NCBIT2T-CHM13v2.0
Ppib
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39965,967,451 - 65,973,911 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl965,967,504 - 65,973,905 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38966,060,169 - 66,066,629 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl966,060,222 - 66,066,623 (+)Ensemblmm10GRCm38
MGSCv37965,907,976 - 65,914,436 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36965,858,175 - 65,864,635 (+)NCBIMGSCv36mm8
Celera963,295,684 - 63,302,172 (+)NCBICelera
Cytogenetic Map9CNCBI
cM Map935.69NCBI
Ppib
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545011,241,279 - 11,249,056 (+)Ensembl
ChiLan1.0NW_00495545011,241,279 - 11,246,628 (+)NCBIChiLan1.0ChiLan1.0
PPIB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21653,411,365 - 53,418,816 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11557,585,689 - 57,592,998 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01543,108,139 - 43,115,470 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11561,400,275 - 61,406,758 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1561,400,272 - 61,406,758 (-)EnsemblpanPan2panpan1.1
PPIB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13028,654,193 - 28,660,129 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3028,654,200 - 28,788,801 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3028,573,442 - 28,579,364 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03028,830,352 - 28,836,280 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3028,830,352 - 28,836,229 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13028,764,458 - 28,770,385 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03028,826,745 - 28,832,670 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03029,065,950 - 29,071,877 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ppib
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640106,785,707 - 106,792,093 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647124,632,311 - 24,640,316 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647124,633,769 - 24,640,246 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPIB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1107,886,658 - 107,893,253 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11107,886,663 - 107,893,155 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21118,800,893 - 118,806,498 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPIB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12619,380,496 - 19,399,596 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048122,005,937 - 122,012,943 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppib
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247818,402,430 - 8,411,003 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247818,402,518 - 8,407,950 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ppib
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1860,396,645 - 60,402,930 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ppib
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:43
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000022828
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83975280384752803Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)839106363103375781Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)85076395195763951Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83910625884106258Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)85158969999045312Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)839106363103375781Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)84447792689477926Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85899169791341052Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)839106258103375958Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83910625891341052Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)863404444108404444Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)84754141992541419Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83910625884106258Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83910625884106258Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)850763951107970527Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84444783789447837Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84961020494610204Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)839106363114525825Rat
1582254Kidm31Kidney mass QTL 313kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)84924517894245178Rat
724540Uae8Urinary albumin excretion QTL 85urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)839106258103375958Rat
10402857Bp380Blood pressure QTL 3800.95arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
1582243Bw66Body weight QTL 663.40.0048body mass (VT:0001259)body weight (CMO:0000012)84924517894245178Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85899169791341052Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)84447504389475043Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83910625891341052Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)862848139107848139Rat
1300177Cm2Cardiac mass QTL 23.65heart mass (VT:0007028)heart weight (CMO:0000017)863141536109261840Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)858337123103337123Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)862848139107848139Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83910625891341052Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)862970527107970527Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)862848139107848139Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)862848139107848139Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)862848139107848139Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)862848139107848139Rat
71120Niddm21Non-insulin dependent diabetes mellitus QTL 213.73blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)866992095111992095Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)860248093105248093Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85899169791341052Rat
2293697Bmd39Bone mineral density QTL 39femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)862848139107848139Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)855428416107963099Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)862963099107963099Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83910625891341052Rat
2301402Bp316Blood pressure QTL 3160.005arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)862848139107848139Rat
631664Hcar3Hepatocarcinoma resistance QTL 32.90.0005liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)862982864107982864Rat

Markers in Region
RH127700  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8875,503,785 - 75,504,643 (+)Marker Load Pipeline
mRatBN7.2866,608,696 - 66,609,554 (+)MAPPERmRatBN7.2
Rnor_6.0871,724,501 - 71,725,358NCBIRnor6.0
Rnor_5.0871,393,440 - 71,394,297UniSTSRnor5.0
RGSC_v3.4870,348,283 - 70,349,140UniSTSRGSC3.4
Celera865,998,657 - 65,999,514UniSTS
RH 3.4 Map8840.3UniSTS
Cytogenetic Map8q24UniSTS
RH132751  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2866,608,396 - 66,608,593 (+)MAPPERmRatBN7.2
Rnor_6.0871,724,201 - 71,724,397NCBIRnor6.0
Rnor_5.0871,393,140 - 71,393,336UniSTSRnor5.0
RGSC_v3.4870,347,983 - 70,348,179UniSTSRGSC3.4
Celera865,998,357 - 65,998,553UniSTS
RH 3.4 Map8839.1UniSTS
Cytogenetic Map8q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071225 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022828   ⟹   ENSRNOP00000022828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl875,498,797 - 75,504,847 (+)Ensembl
mRatBN7.2 Ensembl866,603,861 - 66,630,428 (+)Ensembl
Rnor_6.0 Ensembl871,719,563 - 71,725,562 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114298   ⟹   ENSRNOP00000088370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl866,603,867 - 66,609,636 (+)Ensembl
RefSeq Acc Id: NM_022536   ⟹   NP_071981
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8875,498,966 - 75,504,823 (+)NCBI
mRatBN7.2866,603,877 - 66,609,734 (+)NCBI
Rnor_6.0871,719,681 - 71,725,538 (+)NCBI
Rnor_5.0871,388,620 - 71,394,477 (+)NCBI
RGSC_v3.4870,343,463 - 70,349,320 (+)RGD
Celera865,993,837 - 65,999,694 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071981 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC25590 (Get FASTA)   NCBI Sequence Viewer  
  AAH61971 (Get FASTA)   NCBI Sequence Viewer  
  EDL95844 (Get FASTA)   NCBI Sequence Viewer  
  EDL95845 (Get FASTA)   NCBI Sequence Viewer  
  EDL95846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022828
  ENSRNOP00000022828.5
GenBank Protein P24368 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071981   ⟸   NM_022536
- Peptide Label: precursor
- UniProtKB: A0A8I6GG55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022828   ⟸   ENSRNOT00000022828
Ensembl Acc Id: ENSRNOP00000088370   ⟸   ENSRNOT00000114298
Protein Domains
PPIase cyclophilin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P24368-F1-model_v2 AlphaFold P24368 1-216 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696083
Promoter ID:EPDNEW_R6606
Type:initiation region
Name:Ppib_1
Description:peptidylprolyl isomerase B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0871,719,653 - 71,719,713EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620312 AgrOrtholog
BioCyc Gene G2FUF-30035 BioCyc
Ensembl Genes ENSRNOG00000016781 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022828 ENTREZGENE
  ENSRNOT00000022828.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.100.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623342 IMAGE-MGC_LOAD
InterPro Cyclophilin-like_dom_sf UniProtKB/Swiss-Prot
  Cyclophilin-type_PPIase_CS UniProtKB/Swiss-Prot
  Cyclophilin-type_PPIase_dom UniProtKB/Swiss-Prot
KEGG Report rno:64367 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72443 IMAGE-MGC_LOAD
NCBI Gene 64367 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/Swiss-Prot
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B UniProtKB/Swiss-Prot
Pfam Pro_isomerase UniProtKB/Swiss-Prot
PhenoGen Ppib PhenoGen
PRINTS CSAPPISMRASE UniProtKB/Swiss-Prot
PROSITE CSA_PPIASE_1 UniProtKB/Swiss-Prot
  CSA_PPIASE_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016781 RatGTEx
Superfamily-SCOP SSF50891 UniProtKB/Swiss-Prot
UniProt A0A8I6GG55 ENTREZGENE
  A6J5H1_RAT UniProtKB/TrEMBL
  A6J5H2_RAT UniProtKB/TrEMBL
  A6J5H3_RAT UniProtKB/TrEMBL
  P24368 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88541 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Ppib  peptidylprolyl isomerase B    cyclophilin B  Name updated 1299863 APPROVED
2002-08-07 Ppib  cyclophilin B      Symbol and Name status set to provisional 70820 PROVISIONAL