C1s (complement C1s) - Rat Genome Database

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Gene: C1s (complement C1s) Rattus norvegicus
Analyze
Symbol: C1s
Name: complement C1s
RGD ID: 619983
Description: Predicted to enable identical protein binding activity and serine-type endopeptidase activity. Involved in glial cell differentiation and response to cAMP. Located in extracellular region. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 2. Orthologous to human C1S (complement C1s); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C1 esterase; complement C1s subcomponent; complement component 1 subcomponent s; complement component 1, s subcomponent; r-gsp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Oia7
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,116,549 - 159,128,736 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,116,549 - 159,128,736 (-)EnsemblGRCr8
mRatBN7.24157,430,249 - 157,442,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,430,117 - 157,442,303 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,653,002 - 163,665,144 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,435,909 - 159,448,049 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,082,567 - 158,094,754 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,143,592 - 157,155,592 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,162,096 - 224,174,096 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,736,133 - 160,748,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,169,963 - 146,181,341 (-)NCBICelera
RGSC_v3.14160,981,068 - 160,993,073 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-aminothiophenol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroaniline  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
fenthion  (ISO)
ferric oxide  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
glucose  (ISO)
hexachlorobenzene  (EXP)
indometacin  (ISO)
isotretinoin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
naled  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
pyrogallol  (ISO)
quercetin  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
Tesaglitazar  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
troglitazone  (EXP,ISO)
undecane  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Increased expression and secretion of r-Gsp protein, rat counterpart of complement C1s precursor, during cyclic AMP-induced differentiation in rat C6 glioma cells. Nakagawa M, etal., Brain Res Mol Brain Res 2002 Oct 15;106(1-2):12-21.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Molecular cloning of a cDNA encoding a serine protease homologous to complement C1s precursor from rat C6 glial cells and its expression during glial differentiation. Sakai H, etal., Gene 1998 Mar 16;209(1-2):87-94.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:2387866   PMID:11527969   PMID:12788922   PMID:15489334   PMID:22516433   PMID:23376485  


Genomics

Comparative Map Data
C1s
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,116,549 - 159,128,736 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,116,549 - 159,128,736 (-)EnsemblGRCr8
mRatBN7.24157,430,249 - 157,442,438 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,430,117 - 157,442,303 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,653,002 - 163,665,144 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,435,909 - 159,448,049 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,082,567 - 158,094,754 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,143,592 - 157,155,592 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,162,096 - 224,174,096 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44160,736,133 - 160,748,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,169,963 - 146,181,341 (-)NCBICelera
RGSC_v3.14160,981,068 - 160,993,073 (-)NCBI
Cytogenetic Map4q42NCBI
C1S
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38127,060,718 - 7,071,032 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,988,259 - 7,071,281 (+)Ensemblhg38GRCh38
GRCh37127,168,022 - 7,178,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,038,278 - 7,048,597 (+)NCBIBuild 36Build 36hg18NCBI36
Celera128,790,867 - 8,801,223 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef127,028,290 - 7,038,646 (+)NCBIHuRef
CHM1_1127,166,966 - 7,177,322 (+)NCBICHM1_1
T2T-CHM13v2.0127,074,188 - 7,084,511 (+)NCBIT2T-CHM13v2.0
C1s1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,507,303 - 124,519,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,507,304 - 124,519,318 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,530,344 - 124,542,392 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,530,345 - 124,542,359 (-)Ensemblmm10GRCm38
MGSCv376124,480,362 - 124,492,377 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,495,964 - 124,507,900 (-)NCBIMGSCv36mm8
Celera6132,361,770 - 132,365,592 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
C1s
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,620,450 - 4,630,860 (+)Ensembl
ChiLan1.0NW_0049554134,620,450 - 4,630,860 (+)NCBIChiLan1.0ChiLan1.0
C1S
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,626,244 - 12,636,744 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,623,083 - 12,634,100 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0127,191,679 - 7,202,036 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1127,107,214 - 7,117,614 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl127,106,157 - 7,117,614 (+)EnsemblpanPan2panpan1.1
C1S
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12737,976,196 - 37,985,846 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2737,976,197 - 37,989,575 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,630,918 - 8,640,567 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,328,637 - 38,338,284 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,327,536 - 38,342,200 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,203,588 - 38,213,240 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,244,607 - 38,254,261 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0278,109,060 - 8,118,714 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
C1s
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,063,662 - 102,075,054 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936709731,165 - 742,686 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936709731,211 - 742,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C1S
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,670,312 - 63,708,214 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1563,670,309 - 63,681,466 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103218857
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,106,769 - 7,115,055 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,139,115 - 7,148,056 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl117,139,115 - 7,148,056 (+)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660631,100,303 - 1,110,870 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C1s
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,659,341 - 3,671,142 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248603,658,272 - 3,667,717 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
C1s
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1623,245,815 - 23,257,820 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in C1s
72 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:178
Count of miRNA genes:139
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000016330, ENSRNOT00000056058
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4150095743159267220Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
C1s  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,436,555 - 157,437,461 (+)MAPPERmRatBN7.2
Rnor_6.04157,149,897 - 157,150,802NCBIRnor6.0
Rnor_5.04224,168,401 - 224,169,306UniSTSRnor5.0
RGSC_v3.44160,366,950 - 160,367,086UniSTSRGSC3.4
RGSC_v3.44160,742,438 - 160,743,343UniSTSRGSC3.4
Celera4145,837,214 - 145,837,350UniSTS
Celera4146,175,646 - 146,176,551UniSTS
Cytogenetic Map4q42UniSTS
RH141407  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,059,101 - 157,059,317 (+)MAPPERmRatBN7.2
mRatBN7.24157,430,433 - 157,430,649 (+)MAPPERmRatBN7.2
Rnor_6.04157,143,777 - 157,143,992NCBIRnor6.0
Rnor_6.04156,728,380 - 156,728,595NCBIRnor6.0
Rnor_5.04224,162,281 - 224,162,496UniSTSRnor5.0
Rnor_5.04223,744,633 - 223,744,848UniSTSRnor5.0
RGSC_v3.44160,365,103 - 160,365,318UniSTSRGSC3.4
RGSC_v3.44160,736,318 - 160,736,533UniSTSRGSC3.4
Celera4145,835,367 - 145,835,582UniSTS
RH 3.4 Map41002.0UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 46 59 6 308 146 11 137 79 92 31 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000016330   ⟹   ENSRNOP00000016330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,116,549 - 159,128,736 (-)Ensembl
mRatBN7.2 Ensembl4157,430,117 - 157,442,260 (-)Ensembl
Rnor_6.0 Ensembl4157,143,592 - 157,155,609 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000056058   ⟹   ENSRNOP00000052910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,117,131 - 159,127,318 (-)Ensembl
mRatBN7.2 Ensembl4157,430,831 - 157,441,020 (-)Ensembl
Rnor_6.0 Ensembl4157,144,195 - 157,154,120 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112418   ⟹   ENSRNOP00000086080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,117,131 - 159,128,736 (-)Ensembl
mRatBN7.2 Ensembl4157,430,831 - 157,442,303 (-)Ensembl
RefSeq Acc Id: NM_138900   ⟹   NP_620255
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,116,549 - 159,128,736 (-)NCBI
mRatBN7.24157,430,249 - 157,442,438 (-)NCBI
Rnor_6.04157,143,592 - 157,155,592 (-)NCBI
Rnor_5.04224,162,096 - 224,174,096 (-)NCBI
RGSC_v3.44160,736,133 - 160,748,133 (-)RGD
Celera4146,169,963 - 146,181,341 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620255 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62042 (Get FASTA)   NCBI Sequence Viewer  
  BAA25797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016330
GenBank Protein Q6P6T1 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620255   ⟸   NM_138900
- Peptide Label: precursor
- UniProtKB: A6ILI8 (UniProtKB/TrEMBL),   G3V7L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016330   ⟸   ENSRNOT00000016330
Ensembl Acc Id: ENSRNOP00000052910   ⟸   ENSRNOT00000056058
Ensembl Acc Id: ENSRNOP00000086080   ⟸   ENSRNOT00000112418
Protein Domains
CUB   EGF-like   Peptidase S1   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6T1-F1-model_v2 AlphaFold Q6P6T1 1-688 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693382
Promoter ID:EPDNEW_R3907
Type:initiation region
Name:C1s_1
Description:complement C1s
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,155,601 - 157,155,661EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619983 AgrOrtholog
BioCyc Gene G2FUF-43092 BioCyc
Ensembl Genes ENSRNOG00000011971 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016330 ENTREZGENE
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot
  2.60.120.290 UniProtKB/Swiss-Prot
  Complement Module, domain 1 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598051 IMAGE-MGC_LOAD
InterPro CUB_dom UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/Swiss-Prot
  Peptidase_S1_PA UniProtKB/Swiss-Prot
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot
  Peptidase_S1A UniProtKB/Swiss-Prot
  Sperma_CUB_dom_sf UniProtKB/Swiss-Prot
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot
  Trypsin_dom UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
KEGG Report rno:192262 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72298 IMAGE-MGC_LOAD
NCBI Gene 192262 ENTREZGENE
PANTHER COMPLEMENT COMPONENT 1, S SUBCOMPONENT-RELATED UniProtKB/Swiss-Prot
  PTHR24255:SF18 UniProtKB/Swiss-Prot
Pfam CUB UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Sushi UniProtKB/Swiss-Prot
  Trypsin UniProtKB/Swiss-Prot
PhenoGen C1s PhenoGen
PIRSF C1r_C1s_MASP UniProtKB/Swiss-Prot
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  CUB UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  SUSHI UniProtKB/Swiss-Prot
  TRYPSIN_DOM UniProtKB/Swiss-Prot
  TRYPSIN_SER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011971 RatGTEx
SMART CCP UniProtKB/Swiss-Prot
  CUB UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  Tryp_SPc UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  SSF49854 UniProtKB/Swiss-Prot
  SSF50494 UniProtKB/Swiss-Prot
  SSF57535 UniProtKB/Swiss-Prot
UniProt A0A8I6A2W2_RAT UniProtKB/TrEMBL
  A6ILI8 ENTREZGENE, UniProtKB/TrEMBL
  C1S_RAT UniProtKB/Swiss-Prot
  D4A1S0_RAT UniProtKB/TrEMBL
  G3V7L3 ENTREZGENE, UniProtKB/TrEMBL
  Q6P6T1 ENTREZGENE
UniProt Secondary O70542 UniProtKB/Swiss-Prot
  Q8R099 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-18 C1s  complement C1s  C1s  complement component 1, s subcomponent  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 C1s  complement component 1, s subcomponent      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 C1s  complement component 1, s subcomponent      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein is secreted into medium 632360
gene_regulation expression is induced by dibutyryl cyclic AMP 632360