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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619983 Species: Rattus norvegicus RGD Object: Gene Symbol: C1s Name: complement component 1, s subcomponent

Acc ID: CHEBI:35549 Term: perfluorooctanoic acid Definition: A fluoroalkanoic acid that has formula C8HF15O2. CasRN: 335-67-1 Chemical ID: MESH:C023036

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:1620479	6480464	CTD	perfluorooctanoic acid affects the expression of C1S mRNA	PMID:19429403
decreases expression	ISO	RGD:1620479	6480464	CTD	perfluorooctanoic acid results in decreased expression of C1S mRNA	PMID:18467677
multiple interactions	ISO	RGD:1620479	6480464	CTD	PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C1S mRNA]	PMID:18467677
decreases expression	EXP		6480464	CTD	perfluorooctanoic acid results in decreased expression of C1S mRNA	PMID:19162173
decreases expression	ISO	RGD:1620479	6480464	CTD	perfluorooctanoic acid results in decreased expression of C1S mRNA	PMID:18467677 PMID:20936131