Vegfc (vascular endothelial growth factor C) - Rat Genome Database

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Gene: Vegfc (vascular endothelial growth factor C) Rattus norvegicus
Analyze
Symbol: Vegfc
Name: vascular endothelial growth factor C
RGD ID: 619800
Description: Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including positive regulation of blood vessel endothelial cell migration; positive regulation of protein secretion; and regulation of vascular endothelial growth factor receptor signaling pathway. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Biomarker of colon adenocarcinoma. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ceramide signaling pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: flt4 ligand; flt4-L; vascular endothelial growth factor-related protein; VEGF-C; VRP
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81644,445,293 - 44,560,887 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1644,445,293 - 44,560,887 (-)EnsemblGRCr8
mRatBN7.21637,712,251 - 37,827,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1643,068,855 - 43,184,449 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01646,429,675 - 46,545,267 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01641,783,170 - 41,898,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01640,440,371 - 40,555,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)Ensemblrn6Rnor6.0
Rnor_5.01640,216,307 - 40,331,753 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41640,624,435 - 40,739,692 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1635,834,400 - 35,949,683 (-)NCBICelera
RGSC_v3.11640,624,509 - 40,739,767 (-)NCBI
Cytogenetic Map16p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
AM-251  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
Azoxymethane  (EXP,ISO)
baicalin  (EXP)
bendroflumethiazide  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BQ 123  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorpyrifos  (ISO)
chlorthalidone  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
crocidolite asbestos  (ISO)
cypermethrin  (EXP)
cytarabine  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
dieldrin  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
etoposide  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furosemide  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hexaconazole  (ISO)
hexane  (EXP)
hydrogen chloride  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
losartan  (ISO)
LY294002  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
minocycline  (ISO)
mithramycin SK  (ISO)
naringin  (EXP)
nickel dichloride  (EXP,ISO)
nimesulide  (ISO)
NS-398  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
PD 0325901  (ISO)
PhIP  (EXP)
prostaglandin E2  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
succimer  (ISO)
sulprostone  (ISO)
sunitinib  (ISO)
tebuconazole  (ISO)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
theophylline  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
undecane  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,IMP)
animal organ morphogenesis  (ISO)
cell differentiation  (IEA)
cellular response to leukemia inhibitory factor  (ISO)
induction of positive chemotaxis  (IBA,IEA,ISO)
morphogenesis of embryonic epithelium  (ISO)
negative regulation of blood pressure  (IMP)
negative regulation of cell population proliferation  (ISO)
negative regulation of osteoblast differentiation  (IEA,ISO)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IMP)
positive regulation of cell division  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IDA,IEA,ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of lymphangiogenesis  (ISO)
positive regulation of mast cell chemotaxis  (IBA,IEA,ISO)
positive regulation of mesenchymal stem cell proliferation  (IEA,ISO)
positive regulation of neuroblast proliferation  (IDA)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein autophosphorylation  (IMP)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein secretion  (IMP)
regulation of angiogenesis  (IEA,TAS)
regulation of vascular endothelial growth factor receptor signaling pathway  (IMP)
response to hypoxia  (IBA)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
sprouting angiogenesis  (IBA)
vascular endothelial growth factor receptor signaling pathway  (IBA,IEA,ISO,ISS)
vascular endothelial growth factor signaling pathway  (IBA,IEA,ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Differential vascular endothelial growth factor A protein expression between small hepatocellular carcinoma and cirrhosis correlates with serum vascular endothelial growth factor A and alpha-fetoprotein. Corradini SG, etal., Liver Int. 2009 Jan;29(1):103-12. doi: 10.1111/j.1478-3231.2008.01781.x. Epub 2008 Jun 9.
2. Cyclooxygenase-2 expression is associated with vascular endothelial growth factor-C and lymph node metastases in human prostate cancer. Di JM, etal., Arch Med Res. 2009 May;40(4):268-75. Epub 2009 Jun 4.
3. Altered gene expression in rat colonic adenocarcinomas induced in an azoxymethane plus 2-amino-1-methyl-6-phenylimidazo[4,5-b]- pyridine initiation-promotion model. Doi K, etal., Oncology. 2007;73(3-4):252-60. Epub 2008 Apr 17.
4. [Correlation analysis of vascular endothelial growth factor-C expression and clinicopathology in breast cancer.] Fu JM, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov;29(11):2266-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gaudio E, etal., Gastroenterology. 2006 Apr;130(4):1270-82.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma. Guo B, etal., Anat Rec (Hoboken). 2009 May;292(5):633-9.
9. The expression and clinical significance of pSTAT3, VEGF and VEGF-C in pancreatic adenocarcinoma. Huang C, etal., Neoplasma. 2012;59(1):52-61. doi: 10.4149/neo_2012_007.
10. Interpretation of Pin-1 and VEGF-C expression in breast infiltrating duct carcinoma. Kim BC, etal., Oncol Rep. 2009 Dec;22(6):1381-90.
11. Characterization of indolinones which preferentially inhibit VEGF-C- and VEGF-D-induced activation of VEGFR-3 rather than VEGFR-2. Kirkin V, etal., Eur J Biochem 2001 Nov;268(21):5530-40.
12. VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain. Le Bras B, etal., Nat Neurosci. 2006 Mar;9(3):340-8. Epub 2006 Feb 5.
13. Increasing lymphatic microvessel density in primary pterygia. Ling S, etal., Arch Ophthalmol. 2012 Jun;130(6):735-42. doi: 10.1001/archophthalmol.2012.293.
14. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Machnik A, etal., Nat Med. 2009 May;15(5):545-52. Epub 2009 May 3.
15. Molecular regulation of the VEGF family -- inducers of angiogenesis and lymphangiogenesis. McColl BK, etal., APMIS 2004 Jul-Aug;112(7-8):463-80.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Evaluation of the vascular endothelial growth factor (VEGF)-C role in urothelial carcinomas of the bladder. Mylona E, etal., Anticancer Res. 2006 Sep-Oct;26(5A):3567-71.
18. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. The significance of VEGF-C/VEGFR-2 interaction in the neovascularization and prognosis of nephroblastoma (Wilms' tumour). Nowicki M, etal., Histopathology. 2007 Feb;50(3):358-64.
20. VEGF receptor signalling - in control of vascular function. Olsson AK, etal., Nat Rev Mol Cell Biol. 2006 May;7(5):359-71.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia. Shin YJ, etal., Acta Neuropathol. 2008 Nov;116(5):517-27. Epub 2008 Aug 15.
27. Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue. Sinn BV, etal., Virchows Arch. 2009 Nov 13.
28. Expression of vascular endothelial growth factor family messenger RNA in diseased thyroid tissues. Tanaka K, etal., Surg Today. 2002;32(9):761-8.
29. The expression of vascular endothelial growth factor-A and -C, and receptors 1 and 3: correlation with lymph node metastasis and prognosis in tongue squamous cell carcinoma. Tanigaki Y, etal., Int J Mol Med. 2004 Sep;14(3):389-95.
30. Vascular endothelial growth factor (VEGF) receptor-2 signaling mediates VEGF-C(deltaNdeltaC)- and VEGF-A-induced angiogenesis in vitro. Tille JC, etal., Exp Cell Res. 2003 May 1;285(2):286-98.
31. Effect of pentoxifylline on vascular endothelial growth factor C and flk-1 expression on endometrial implants in the rat endometriosis model. Vlahos NF, etal., Fertil Steril. 2009 Jan 13.
32. The lymphatic system and its specific growth factor vascular endothelial growth factor C in kidney tissue and in renal cell carcinoma. Voss M, etal., BJU Int. 2009 Jul;104(1):94-9. Epub 2008 Dec 19.
33. Distinct characteristics of circulating vascular endothelial growth factor-a and C levels in human subjects. Wada H, etal., PLoS One. 2011;6(12):e29351. doi: 10.1371/journal.pone.0029351. Epub 2011 Dec 20.
34. The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma. Yu H, etal., J Exp Clin Cancer Res. 2009 Jul 9;28:98.
35. Expression of vascular endothelial growth factors-C and -D correlate with evidence of lymphangiogenesis and angiogenesis in pancreatic adenocarcinoma. Zhang B, etal., Cancer Detect Prev. 2007;31(6):436-42. doi: 10.1016/j.cdp.2007.10.016.
36. Vascular endothelial growth factor-C expression in bladder transitional cell cancer and its relationship to lymph node metastasis. Zu X, etal., BJU Int. 2006 Nov;98(5):1090-3.
Additional References at PubMed
PMID:9012504   PMID:9247316   PMID:10878616   PMID:14634646   PMID:17400713   PMID:18571474   PMID:19275959   PMID:20133819   PMID:20142563   PMID:20415667   PMID:20439489   PMID:22258325  
PMID:22818386   PMID:22959907   PMID:23565129   PMID:23878260   PMID:23990681   PMID:24006456   PMID:24379135   PMID:24464750   PMID:24552833   PMID:24559584   PMID:24654984   PMID:25124602  
PMID:25943477   PMID:26934950   PMID:30771456   PMID:31211440   PMID:31757960   PMID:32170506   PMID:34291766   PMID:35259773   PMID:35817403   PMID:38728943  


Genomics

Comparative Map Data
Vegfc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81644,445,293 - 44,560,887 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1644,445,293 - 44,560,887 (-)EnsemblGRCr8
mRatBN7.21637,712,251 - 37,827,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1643,068,855 - 43,184,449 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01646,429,675 - 46,545,267 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01641,783,170 - 41,898,773 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01640,440,371 - 40,555,178 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)Ensemblrn6Rnor6.0
Rnor_5.01640,216,307 - 40,331,753 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41640,624,435 - 40,739,692 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1635,834,400 - 35,949,683 (-)NCBICelera
RGSC_v3.11640,624,509 - 40,739,767 (-)NCBI
Cytogenetic Map16p11NCBI
VEGFC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384176,683,538 - 176,792,922 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4176,683,538 - 176,792,922 (-)Ensemblhg38GRCh38
GRCh374177,604,689 - 177,714,076 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364177,841,685 - 177,950,889 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344177,979,839 - 178,089,044NCBI
Celera4174,932,577 - 175,041,751 (-)NCBICelera
Cytogenetic Map4q34.3NCBI
HuRef4173,355,495 - 173,464,332 (-)NCBIHuRef
CHM1_14177,581,139 - 177,690,417 (-)NCBICHM1_1
T2T-CHM13v2.04180,022,579 - 180,131,932 (-)NCBIT2T-CHM13v2.0
Vegfc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39854,530,567 - 54,639,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl854,530,641 - 54,640,131 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38854,077,532 - 54,186,454 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl854,077,606 - 54,187,096 (+)Ensemblmm10GRCm38
MGSCv37855,162,886 - 55,271,808 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36855,576,324 - 55,685,149 (+)NCBIMGSCv36mm8
Celera856,790,779 - 56,893,425 (+)NCBICelera
Cytogenetic Map8B1.3NCBI
cM Map829.2NCBI
Vegfc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540331,016,423 - 31,130,892 (+)NCBIChiLan1.0ChiLan1.0
VEGFC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23174,404,689 - 174,551,470 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14174,784,868 - 174,914,832 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04168,870,941 - 168,999,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14181,104,737 - 181,236,024 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4181,104,737 - 181,236,030 (-)EnsemblpanPan2panpan1.1
VEGFC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11652,883,242 - 52,987,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1652,883,139 - 52,987,563 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1648,384,891 - 48,489,160 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01655,195,930 - 55,300,949 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1655,195,409 - 55,300,821 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11653,090,819 - 53,195,148 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01653,687,065 - 53,791,871 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01653,925,224 - 54,029,839 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vegfc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494326,803,257 - 26,918,269 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365167,217,543 - 7,332,559 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365167,217,543 - 7,332,531 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VEGFC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1539,039,311 - 39,132,936 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11539,037,764 - 39,136,234 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21544,742,834 - 44,773,339 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VEGFC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17122,772,539 - 122,893,486 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7122,772,182 - 122,893,512 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037102,869,061 - 102,989,877 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vegfc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247697,689,407 - 7,817,450 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247697,689,812 - 7,817,366 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vegfc
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12123,762,728 - 123,877,484 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vegfc
491 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:142
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000015529
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)163692878281928782Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)164199206486992064Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162846870173468701Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)163236104377361043Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)163188527176885271Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164445512389455123Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164445512389455123Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)163105803976058039Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)163439829479398294Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
D16Rat118  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81644,498,650 - 44,498,873 (+)Marker Load Pipeline
mRatBN7.21637,765,608 - 37,765,831 (+)MAPPERmRatBN7.2
Rnor_6.01640,492,300 - 40,492,522NCBIRnor6.0
Rnor_5.01640,268,236 - 40,268,458UniSTSRnor5.0
RGSC_v3.41640,677,636 - 40,677,858UniSTSRGSC3.4
RGSC_v3.41640,677,635 - 40,677,858RGDRGSC3.4
Celera1635,887,600 - 35,887,830UniSTS
RGSC_v3.11640,677,710 - 40,677,933RGD
SHRSP x BN Map1612.43RGD
SHRSP x BN Map1612.43UniSTS
Cytogenetic Map16p11UniSTS
AW228853  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21637,712,422 - 37,712,518 (+)MAPPERmRatBN7.2
Rnor_6.01640,440,386 - 40,440,481NCBIRnor6.0
Rnor_5.01640,216,322 - 40,216,417UniSTSRnor5.0
RGSC_v3.41640,624,450 - 40,624,545UniSTSRGSC3.4
Celera1635,834,415 - 35,834,510UniSTS
Cytogenetic Map16p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 158 91 90 59 82 59 6 346 182 11 133 81 92 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000015529   ⟹   ENSRNOP00000015529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1644,445,293 - 44,560,887 (-)Ensembl
mRatBN7.2 Ensembl1637,712,262 - 37,827,848 (-)Ensembl
Rnor_6.0 Ensembl1640,440,207 - 40,555,576 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119624   ⟹   ENSRNOP00000091258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1644,453,090 - 44,560,887 (-)Ensembl
mRatBN7.2 Ensembl1637,720,140 - 37,827,848 (-)Ensembl
RefSeq Acc Id: NM_053653   ⟹   NP_446105
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81644,445,293 - 44,560,887 (-)NCBI
mRatBN7.21637,712,251 - 37,827,845 (-)NCBI
Rnor_6.01640,440,371 - 40,555,178 (-)NCBI
Rnor_5.01640,216,307 - 40,331,753 (-)NCBI
RGSC_v3.41640,624,435 - 40,739,692 (-)RGD
Celera1635,834,400 - 35,949,683 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_446105 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB63248 (Get FASTA)   NCBI Sequence Viewer  
  AAK96009 (Get FASTA)   NCBI Sequence Viewer  
  EDL78943 (Get FASTA)   NCBI Sequence Viewer  
  EDL78944 (Get FASTA)   NCBI Sequence Viewer  
  EDL78945 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015529
  ENSRNOP00000015529.2
GenBank Protein O35757 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446105   ⟸   NM_053653
- Peptide Label: precursor
- UniProtKB: Q91ZE3 (UniProtKB/Swiss-Prot),   O35757 (UniProtKB/Swiss-Prot),   A6JPH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015529   ⟸   ENSRNOT00000015529
Ensembl Acc Id: ENSRNOP00000091258   ⟸   ENSRNOT00000119624
Protein Domains
Platelet-derived growth factor (PDGF) family

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35757-F1-model_v2 AlphaFold O35757 1-415 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619800 AgrOrtholog
BioCyc Gene G2FUF-11465 BioCyc
Ensembl Genes ENSRNOG00000011416 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015529 ENTREZGENE
  ENSRNOT00000015529.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro CXCXC_repeat UniProtKB/Swiss-Prot
  Cystine-knot_cytokine UniProtKB/Swiss-Prot
  PD_growth_factor_CS UniProtKB/Swiss-Prot
  PDGF/VEGF_dom UniProtKB/Swiss-Prot
  PDGF/VEGF_growth_factor UniProtKB/Swiss-Prot
KEGG Report rno:114111 UniProtKB/Swiss-Prot
NCBI Gene 114111 ENTREZGENE
PANTHER VASCULAR ENDOTHELIAL GROWTH FACTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR C UniProtKB/Swiss-Prot
Pfam CXCXC UniProtKB/Swiss-Prot
  PDGF UniProtKB/Swiss-Prot
PhenoGen Vegfc PhenoGen
PROSITE PDGF_1 UniProtKB/Swiss-Prot
  PDGF_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011416 RatGTEx
SMART PDGF UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniProt A0A8I6AEW4_RAT UniProtKB/TrEMBL
  A6JPH7_RAT UniProtKB/TrEMBL
  A6JPH8 ENTREZGENE, UniProtKB/TrEMBL
  A6JPH9_RAT UniProtKB/TrEMBL
  O35757 ENTREZGENE
  Q91ZE3 ENTREZGENE
  VEGFC_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q91ZE3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Vegfc  vascular endothelial growth factor C      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Vegfc  vascular endothelial growth factor C      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction can bind and activate VEGFR-3 receptors 727326
gene_product member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family 727326