Cdh23 (cadherin-related 23) - Rat Genome Database

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Pathways
Gene: Cdh23 (cadherin-related 23) Rattus norvegicus
Analyze
Symbol: Cdh23
Name: cadherin-related 23
RGD ID: 619760
Description: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including equilibrioception; photoreceptor cell maintenance; and regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within several processes, including inner ear development; righting reflex; and sensory perception of sound. Located in apical part of cell. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; autosomal recessive nonsyndromic deafness; autosomal recessive nonsyndromic deafness 12; and pituitary adenoma 5. Orthologous to human CDH23 (cadherin related 23); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cadherin 23 (otocadherin); cadherin related 23; cadherin-23; cadherin-23-like; LOC103694885; otocadherin; W; Waltzing
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,783,124 - 29,165,624 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2028,783,564 - 29,165,332 (-)EnsemblGRCr8
mRatBN7.22028,240,643 - 28,622,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,240,645 - 28,622,419 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2029,255,533 - 29,637,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,641,839 - 29,024,097 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,384,303 - 29,766,584 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,857,018 - 30,263,758 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,857,637 - 29,990,111 (-)Ensemblrn6Rnor6.0
Rnor_5.02031,668,747 - 32,073,985 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42027,622,049 - 28,016,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2029,678,961 - 30,059,893 (-)NCBICelera
RGSC_v3.12027,635,850 - 28,029,945 (-)NCBI
Cytogenetic Map20q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Di Palma F, etal., Nat Genet. 2001 Jan;27(1):103-7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mechanotransduction by hair cells: models, molecules, and mechanisms. Gillespie PG and Muller U, Cell. 2009 Oct 2;139(1):33-44. doi: 10.1016/j.cell.2009.09.010.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Association of cadherin23 single nucleotide polymorphism with age-related hearing impairment in Han Chinese. Hwang JH, etal., Otolaryngol Head Neck Surg. 2012 Sep;147(3):531-4. doi: 10.1177/0194599812446904. Epub 2012 May 11.
6. Sensing sound: molecules that orchestrate mechanotransduction by hair cells. Kazmierczak P and Muller U, Trends Neurosci. 2012 Apr;35(4):220-9. doi: 10.1016/j.tins.2011.10.007. Epub 2011 Dec 15.
7. Cdh23 mutations in the mouse are associated with retinal dysfunction but not retinal degeneration. Libby RT, etal., Exp Eye Res. 2003 Dec;77(6):731-9.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Cadherin 23 is a component of the transient lateral links in the developing hair bundles of cochlear sensory cells. Michel V, etal., Dev Biol 2005 Apr 15;280(2):281-94.
10. Mouse Genome Database (MGD) Mouse Genome Database (MGD)
11. Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs. Nakajima D, etal., Brain Res Mol Brain Res 2001 Oct 19;94(1-2):85-95.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Noben-Trauth K, etal., Nat Genet 2003 Sep;35(1):21-3. Epub 2003 Aug 10.
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Comprehensive gene review and curation RGD comprehensive gene curation
19. Cyclic nucleotide-gated channel alpha-3 (CNGA3) interacts with stereocilia tip-link cadherin 23 + exon 68 or alternatively with myosin VIIa, two proteins required for hair cell mechanotransduction. Selvakumar D, etal., J Biol Chem. 2013 Mar 8;288(10):7215-29. doi: 10.1074/jbc.M112.443226. Epub 2013 Jan 17.
20. Distribution and frequencies of CDH23 mutations in Japanese patients with non-syndromic hearing loss. Wagatsuma M, etal., Clin Genet. 2007 Oct;72(4):339-44.
21. Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait. Wright AF, etal., Nat Rev Genet. 2010 Apr;11(4):273-84. doi: 10.1038/nrg2717.
22. [Association of cadherin CDH23 gene polymorphisms with noise induced hearing loss in Chinese workers]. Yang M, etal., Wei Sheng Yan Jiu. 2006 Jan;35(1):19-22.
Additional References at PubMed
PMID:7610888   PMID:8790740   PMID:9039475   PMID:9325047   PMID:9447922   PMID:10452381   PMID:11322776   PMID:11386759   PMID:12121736   PMID:12485990   PMID:13336002   PMID:14578428  
PMID:14759567   PMID:15537665   PMID:15820310   PMID:15882574   PMID:15925194   PMID:16481439   PMID:16679490   PMID:16962269   PMID:17050716   PMID:17234811   PMID:17329413   PMID:18339676  
PMID:19756182   PMID:23217710   PMID:24920589  


Genomics

Comparative Map Data
Cdh23
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82028,783,124 - 29,165,624 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2028,783,564 - 29,165,332 (-)EnsemblGRCr8
mRatBN7.22028,240,643 - 28,622,490 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,240,645 - 28,622,419 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2029,255,533 - 29,637,791 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02028,641,839 - 29,024,097 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,384,303 - 29,766,584 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02029,857,018 - 30,263,758 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2029,857,637 - 29,990,111 (-)Ensemblrn6Rnor6.0
Rnor_5.02031,668,747 - 32,073,985 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42027,622,049 - 28,016,145 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2029,678,961 - 30,059,893 (-)NCBICelera
RGSC_v3.12027,635,850 - 28,029,945 (-)NCBI
Cytogenetic Map20q11NCBI
CDH23
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,396,920 - 71,815,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1071,396,920 - 71,815,947 (+)Ensemblhg38GRCh38
GRCh371073,156,677 - 73,575,704 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,826,697 - 73,245,710 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341072,826,696 - 73,076,543NCBI
Celera1066,439,492 - 66,858,274 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1067,150,783 - 67,156,961 (+)NCBIHuRef
CHM1_11073,439,263 - 73,857,682 (+)NCBICHM1_1
T2T-CHM13v2.01072,266,464 - 72,686,680 (+)NCBIT2T-CHM13v2.0
Cdh23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,138,527 - 60,532,291 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,138,527 - 60,532,269 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381060,302,748 - 60,696,513 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,302,748 - 60,696,490 (-)Ensemblmm10GRCm38
MGSCv371059,766,022 - 60,159,238 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361059,698,731 - 60,052,690 (-)NCBIMGSCv36mm8
Celera1061,400,142 - 61,796,629 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1030.11NCBI
Cdh23
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543719,684,473 - 20,003,819 (-)Ensembl
ChiLan1.0NW_00495543719,683,792 - 20,044,718 (-)NCBIChiLan1.0ChiLan1.0
LOC100983880
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,888,821 - 83,966,281 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,894,144 - 83,971,602 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,866,979 - 68,286,008 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,391,661 - 70,810,240 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,434,801 - 70,810,240 (+)EnsemblpanPan2panpan1.1
CDH23
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,206,972 - 22,570,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,207,001 - 22,571,131 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha422,343,327 - 22,708,459 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0422,485,192 - 22,847,328 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,438,303 - 22,847,265 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,382,421 - 22,753,409 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,588,293 - 22,952,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,941,027 - 23,306,533 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC101969963
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,586,064 - 58,899,858 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,010,360 - 7,340,842 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,078,874 - 7,285,361 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDH23
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,223,089 - 74,733,834 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11474,267,547 - 74,734,623 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,226,063 - 80,626,249 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDH23
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,475,126 - 59,893,824 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604820,118,874 - 20,208,512 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdh23
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,393,733 - 5,724,876 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247545,356,006 - 5,725,774 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Cdh23
2259 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:116
Interacting mature miRNAs:123
Transcripts:ENSRNOT00000048029
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202668936256021148Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)202074558556021148Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202668936256021148Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202679235356021148Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)201224324249189476Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202668936256021148Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202668936256021148Rat

Markers in Region
D20Got108  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22028,540,995 - 28,541,219 (+)MAPPERmRatBN7.2
Rnor_6.02030,181,841 - 30,182,064NCBIRnor6.0
Rnor_5.02031,992,210 - 31,992,433UniSTSRnor5.0
RGSC_v3.42027,934,411 - 27,934,634UniSTSRGSC3.4
Celera2029,978,381 - 29,978,604UniSTS
Cytogenetic Map20q11UniSTS
RH128021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22028,240,158 - 28,240,358 (+)MAPPERmRatBN7.2
Rnor_6.02029,856,534 - 29,856,733NCBIRnor6.0
Rnor_5.02031,668,263 - 31,668,462UniSTSRnor5.0
RGSC_v3.42027,621,565 - 27,621,764UniSTSRGSC3.4
Celera2029,678,477 - 29,678,676UniSTS
RH 3.4 Map21521.6UniSTS
Cytogenetic Map20q11UniSTS
RH131718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22028,303,636 - 28,303,837 (+)MAPPERmRatBN7.2
Rnor_6.02029,919,756 - 29,919,956NCBIRnor6.0
Rnor_5.02031,731,221 - 31,731,421UniSTSRnor5.0
RGSC_v3.42027,684,647 - 27,684,847UniSTSRGSC3.4
Celera2029,741,790 - 29,741,990UniSTS
Cytogenetic Map20q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 66 163 79 78 47 92 47 6 342 191 11 142 80 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB053447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000048029   ⟹   ENSRNOP00000048338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,784,183 - 29,165,332 (-)Ensembl
mRatBN7.2 Ensembl2028,241,262 - 28,622,419 (-)Ensembl
Rnor_6.0 Ensembl2029,857,637 - 29,990,111 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100038   ⟹   ENSRNOP00000086738
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,783,564 - 29,165,332 (-)Ensembl
mRatBN7.2 Ensembl2028,240,645 - 28,622,419 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118579   ⟹   ENSRNOP00000096099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2028,783,564 - 29,165,332 (-)Ensembl
mRatBN7.2 Ensembl2028,240,645 - 28,622,419 (-)Ensembl
RefSeq Acc Id: NM_053644   ⟹   NP_446096
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,564 - 29,165,332 (-)NCBI
mRatBN7.22028,240,643 - 28,622,419 (-)NCBI
Rnor_6.02029,857,018 - 30,263,758 (-)NCBI
Rnor_5.02031,668,747 - 32,073,985 (-)NCBI
RGSC_v3.42027,622,049 - 28,016,145 (-)RGD
Celera2029,678,961 - 30,059,893 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098377   ⟹   XP_038954305
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,874,489 - 29,165,624 (-)NCBI
mRatBN7.22028,335,235 - 28,622,488 (-)NCBI
RefSeq Acc Id: XM_063278914   ⟹   XP_063134984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,124 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278915   ⟹   XP_063134985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,124 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278916   ⟹   XP_063134986
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,124 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278917   ⟹   XP_063134987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,124 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278918   ⟹   XP_063134988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,124 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278919   ⟹   XP_063134989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,783,124 - 28,990,841 (-)NCBI
RefSeq Acc Id: XM_063278920   ⟹   XP_063134990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,788,252 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278921   ⟹   XP_063134991
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,790,978 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278922   ⟹   XP_063134992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,805,506 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278923   ⟹   XP_063134993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,805,506 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278925   ⟹   XP_063134995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,850,461 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278926   ⟹   XP_063134996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,849,271 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278927   ⟹   XP_063134997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,850,461 - 29,165,624 (-)NCBI
RefSeq Acc Id: XM_063278928   ⟹   XP_063134998
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82028,856,231 - 29,165,624 (-)NCBI
RefSeq Acc Id: NP_446096   ⟸   NM_053644
- Peptide Label: precursor
- UniProtKB: P58365 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000048338   ⟸   ENSRNOT00000048029
RefSeq Acc Id: XP_038954305   ⟸   XM_039098377
- Peptide Label: isoform X14
Ensembl Acc Id: ENSRNOP00000096099   ⟸   ENSRNOT00000118579
Ensembl Acc Id: ENSRNOP00000086738   ⟸   ENSRNOT00000100038
RefSeq Acc Id: XP_063134987   ⟸   XM_063278917
- Peptide Label: isoform X3
- UniProtKB: F1LPE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134986   ⟸   XM_063278916
- Peptide Label: isoform X2
- UniProtKB: P58365 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063134984   ⟸   XM_063278914
- Peptide Label: isoform X1
- UniProtKB: F1LPE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134988   ⟸   XM_063278918
- Peptide Label: isoform X4
- UniProtKB: F1LPE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134985   ⟸   XM_063278915
- Peptide Label: isoform X1
- UniProtKB: F1LPE5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134989   ⟸   XM_063278919
- Peptide Label: isoform X5
- UniProtKB: A6K3X5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134990   ⟸   XM_063278920
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A2T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134991   ⟸   XM_063278921
- Peptide Label: isoform X7
- UniProtKB: A0A8I6A2T2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063134993   ⟸   XM_063278923
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063134992   ⟸   XM_063278922
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063134996   ⟸   XM_063278926
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063134995   ⟸   XM_063278925
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063134997   ⟸   XM_063278927
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063134998   ⟸   XM_063278928
- Peptide Label: isoform X13
Protein Domains
Cadherin

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619760 AgrOrtholog
BioCyc Gene G2FUF-3742 BioCyc
Ensembl Genes ENSRNOG00000033087 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000118579 ENTREZGENE
Gene3D-CATH Cadherins UniProtKB/Swiss-Prot
InterPro Cadherin-like_dom UniProtKB/Swiss-Prot
  Cadherin-like_sf UniProtKB/Swiss-Prot
  Cadherin_CS UniProtKB/Swiss-Prot
KEGG Report rno:114102 UniProtKB/Swiss-Prot
NCBI Gene 114102 ENTREZGENE
PANTHER CADHERIN RELATED 23 UniProtKB/Swiss-Prot
  FAT ATYPICAL CADHERIN-RELATED UniProtKB/Swiss-Prot
Pfam Cadherin UniProtKB/Swiss-Prot
PhenoGen Cdh23 PhenoGen
PRINTS CADHERIN UniProtKB/Swiss-Prot
PROSITE CADHERIN_1 UniProtKB/Swiss-Prot
  CADHERIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033087 RatGTEx
SMART SM00112 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49313 UniProtKB/Swiss-Prot
UniProt A0A8I6A2T2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AP55_RAT UniProtKB/TrEMBL
  A6K3X5 ENTREZGENE, UniProtKB/TrEMBL
  CAD23_RAT UniProtKB/Swiss-Prot
  F1LPE5 ENTREZGENE, UniProtKB/TrEMBL
  P58365 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Cdh23  cadherin-related 23  LOC103694885  cadherin-23-like  Data merged from RGD:9245380 737654 PROVISIONAL
2014-08-25 LOC103694885  cadherin-23-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-01-06 Cdh23  cadherin-related 23  Cdh23  cadherin 23 (otocadherin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Cdh23  cadherin 23 (otocadherin)    cadherin related 23  Name updated 1299863 APPROVED
2002-08-07 Cdh23  cadherin related 23      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression enriched in testis 633048