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Gene: Sv2a (synaptic vesicle glycoprotein 2a) Rattus norvegicus

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Symbol:

Sv2a

Name:

synaptic vesicle glycoprotein 2a

RGD ID:

619715

Description:

Predicted to enable protein kinase binding activity. Involved in protein localization to synapse; regulation of gamma-aminobutyric acid secretion; and regulation of nervous system process. Located in dendrite; neuronal cell body; and presynaptic active zone. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A); PARTICIPATES IN cell-extracellular matrix signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; alpha-Zearalanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

MGC105346; Sv2; synaptic vesicle glycoprotein 2 a; synaptic vesicle protein 2; synaptic vesicle protein 2A; synaptic vesicle transmembrane transporter (SV2) RNA

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SV2A (synaptic vesicle glycoprotein 2A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Sv2a (synaptic vesicle glycoprotein 2a)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sv2a (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SV2A (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SV2A (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sv2a (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SV2A (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SV2A (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sv2a (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Sv2a (synaptic vesicle glycoprotein 2A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ATP7B (ATPase copper transporting beta)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Sv2a (synaptic vesicle glycoprotein 2a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SV2A (synaptic vesicle glycoprotein 2A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sv2a (synaptic vesicle glycoprotein 2A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG3168	Alliance	DIOPT (InParanoid\|OMA\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sv2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Sv2a^m1Kyo

Genetic Models:

F344-Sv2a^m1Kyo

Is Marker For:

Strains: F344-Sv2a^m1Kyo

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	186,430,363 - 186,446,161 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	186,430,345 - 186,448,065 (+)	Ensembl				GRCr8
mRatBN7.2	2	183,741,489 - 183,757,290 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	183,741,547 - 183,756,927 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	191,405,136 - 191,420,924 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	189,209,456 - 189,225,293 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	184,037,670 - 184,053,458 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	198,321,100 - 198,336,889 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	198,321,142 - 198,336,913 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	217,808,165 - 217,823,872 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	190,989,187 - 191,000,859 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	176,272,713 - 176,284,621 (+)	NCBI		Celera
RGSC_v3.1	2	190,948,188 - 190,963,566 (+)	NCBI
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Developmental and Epileptic Encephalopathy 113 (ISO)

Experimental Seizures (IMP)

genetic disease (ISO)

spinal muscular atrophy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

amitrole (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

bisphenol F (ISO)

Botulinum toxin type A (ISO)

Butylbenzyl phthalate (ISO)

cadmium dichloride (EXP)

carbamazepine (ISO)

cholesterol (ISO)

clarithromycin (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

flavonoids (EXP)

fonofos (ISO)

gamma-tocopherol (ISO)

glyphosate (EXP)

heroin (ISO)

hydrogen sulfide (ISO)

ivermectin (ISO)

Licochalcone B (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methyl beta-cyclodextrin (ISO)

oxaliplatin (EXP)

paracetamol (EXP)

parathion (ISO)

PCB138 (EXP)

perfluorooctanoic acid (EXP)

potassium chromate (ISO)

Ptaquiloside (ISO)

pyrogallol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

terbufos (ISO)

thapsigargin (EXP)

tocopherol (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chemical synaptic transmission (IEA)

intracellular calcium ion homeostasis (ISO)

modulation of inhibitory postsynaptic potential (IDA)

negative regulation of excitatory postsynaptic potential (IMP)

neurotransmitter transport (IEA,TAS)

protein localization to synapse (IMP)

regulation of gamma-aminobutyric acid secretion (IMP)

synaptic vesicle priming (IBA,ISO)

transmembrane transport (IEA)

Cellular Component

cell-cell junction (ISO)

cytoplasmic vesicle (IEA)

dendrite (IDA)

endoplasmic reticulum (ISO)

GABA-ergic synapse (ISO)

glutamatergic synapse (ISO)

membrane (IEA)

neuromuscular junction (ISO)

neuron projection (IBA,ISO)

neuronal cell body (IDA)

presynapse (IEA)

presynaptic active zone (IDA,ISO)

synapse (IDA)

synaptic vesicle (IEA,ISO)

synaptic vesicle membrane (EXP,IBA,IDA,IEA)

terminal bouton (HDA)

Molecular Function

protein binding (IPI)

protein kinase binding (ISO)

transmembrane transporter activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell-extracellular matrix signaling pathway (IEA)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

increased kindling response (IMP)

increased susceptibility to pharmacologically induced seizures (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	SV2, a brain synaptic vesicle protein homologous to bacterial transporters.	Bajjalieh SM, etal., Science 1992 Aug 28;257(5074):1271-3.
2.	Molecular profiling of synaptic vesicle docking sites reveals novel proteins but few differences between glutamatergic and GABAergic synapses.	Boyken J, etal., Neuron. 2013 Apr 24;78(2):285-97. doi: 10.1016/j.neuron.2013.02.027.
3.	SV2 renders primed synaptic vesicles competent for Ca2+ -induced exocytosis.	Chang WP and Südhof TC, J Neurosci. 2009 Jan 28;29(4):883-97. doi: 10.1523/JNEUROSCI.4521-08.2009.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Formation of Golgi-derived active zone precursor vesicles.	Maas C, etal., J Neurosci. 2012 Aug 8;32(32):11095-108. doi: 10.1523/JNEUROSCI.0195-12.2012.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Amyloid beta a4 precursor protein-binding family B member 1 (FE65) interactomics revealed synaptic vesicle glycoprotein 2A (SV2A) and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) as new binding proteins in the human brain.	Nensa FM, etal., Mol Cell Proteomics. 2014 Feb;13(2):475-88. doi: 10.1074/mcp.M113.029280. Epub 2013 Nov 27.
9.	Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain.	Pellet JB, etal., Eur J Neurosci. 2000 Feb;12(2):621-32.
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Isoform-specific, calcium-regulated interaction of the synaptic vesicle proteins SV2 and synaptotagmin.	Schivell AE, etal., J Biol Chem. 1996 Nov 1;271(44):27770-5.
15.	SV2A and SV2C contain a unique synaptotagmin-binding site.	Schivell AE, etal., Mol Cell Neurosci. 2005 May;29(1):56-64. doi: 10.1016/j.mcn.2004.12.011.
16.	Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.	Strotmeier J, etal., FEBS Lett. 2014 Apr 2;588(7):1087-93. doi: 10.1016/j.febslet.2014.02.034. Epub 2014 Feb 25.
17.	Molecular anatomy of a trafficking organelle.	Takamori S, etal., Cell. 2006 Nov 17;127(4):831-46.
18.	Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy.	Tejero R, etal., Hum Mol Genet. 2016 Aug 29. pii: ddw297.
19.	Synaptic vesicle glycoprotein 2A (SV2A) regulates kindling epileptogenesis via GABAergic neurotransmission.	Tokudome K, etal., Sci Rep. 2016 Jun 6;6:27420. doi: 10.1038/srep27420.
20.	Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins.	Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.

Additional References at PubMed

PMID:1355409	PMID:1426240	PMID:10455054	PMID:10624962	PMID:10625067	PMID:10747945	PMID:12074840	PMID:12477932	PMID:12687700	PMID:15210974	PMID:15489334	PMID:15713258
PMID:16306227	PMID:16543415	PMID:18524768	PMID:20410110	PMID:21307259	PMID:21664258	PMID:22871113	PMID:23530581	PMID:24035762	PMID:25205164	PMID:26489628	PMID:29476059
PMID:30336420	PMID:30905653	PMID:32407277	PMID:32538280	PMID:34435329	PMID:38801174

Genomics

Comparative Map Data

Sv2a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	186,430,363 - 186,446,161 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	2	186,430,345 - 186,448,065 (+)	Ensembl				GRCr8
mRatBN7.2	2	183,741,489 - 183,757,290 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	183,741,547 - 183,756,927 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	2	191,405,136 - 191,420,924 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	189,209,456 - 189,225,293 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	184,037,670 - 184,053,458 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	198,321,100 - 198,336,889 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	198,321,142 - 198,336,913 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	2	217,808,165 - 217,823,872 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	2	190,989,187 - 191,000,859 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	2	176,272,713 - 176,284,621 (+)	NCBI		Celera
RGSC_v3.1	2	190,948,188 - 190,963,566 (+)	NCBI
Cytogenetic Map	2	q34	NCBI

SV2A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	149,903,318 - 149,917,844 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	149,903,318 - 149,918,572 (-)	Ensembl			hg38	GRCh38
GRCh37	1	149,874,870 - 149,889,396 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	148,141,859 - 148,156,054 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	1	122,990,840 - 123,005,404 (-)	NCBI		Celera
Cytogenetic Map	1	q21.2	NCBI
HuRef	1	121,255,354 - 121,269,918 (-)	NCBI		HuRef
CHM1_1	1	151,271,444 - 151,286,008 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	149,027,459 - 149,041,985 (-)	NCBI		T2T-CHM13v2.0

Sv2a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	96,088,543 - 96,102,499 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	96,088,467 - 96,102,837 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	3	96,181,227 - 96,195,183 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	96,181,151 - 96,195,521 (+)	Ensembl			mm10	GRCm38
MGSCv37	3	95,985,150 - 95,999,106 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	3	96,266,632 - 96,280,588 (+)	NCBI		MGSCv36	mm8
Celera	3	97,620,657 - 97,631,186 (+)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	41.65	NCBI

Sv2a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	834,743 - 851,023 (+)	Ensembl
ChiLan1.0	NW_004955413	834,743 - 849,176 (+)	NCBI	ChiLan1.0	ChiLan1.0

SV2A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	99,921,893 - 99,936,495 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	99,676,850 - 99,691,458 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	125,247,429 - 125,262,041 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	128,904,140 - 128,918,829 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	128,904,151 - 128,918,829 (-)	Ensembl			panPan2	panpan1.1

SV2A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	59,185,715 - 59,195,888 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	59,187,244 - 59,195,888 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	58,633,794 - 58,647,878 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	60,182,727 - 60,196,808 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	60,182,738 - 60,196,859 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	59,032,197 - 59,046,284 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	59,115,941 - 59,130,018 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	59,843,004 - 59,857,105 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Sv2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	21,213,447 - 21,227,353 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936580	243,792 - 257,760 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936580	243,829 - 257,708 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SV2A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	99,138,342 - 99,153,149 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	4	99,138,319 - 99,153,153 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	108,567,034 - 108,581,274 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SV2A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666038	13,389,665 - 13,404,056 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sv2a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	17,681,299 - 17,696,884 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624772	17,684,061 - 17,698,728 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Sv2a
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	3	61,087,275 - 61,101,798 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Sv2a
40 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	330
Count of miRNA genes:	214
Interacting mature miRNAs:	257
Transcripts:	ENSRNOT00000028760
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	163997722	225110681	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	169358774	214358774	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170656145	239614549	Rat
631566	Bp90	Blood pressure QTL 90		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	149957381	221199885	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845370	229470703	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83465462	229820014	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	20695736	231474293	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	138595962	205135428	Rat
1581576	Pur7	Proteinuria QTL 7		0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	80396178	220931218	Rat
152025245	Scl81	Serum cholesterol level QTL 81	3.49		blood cholesterol amount (VT:0000180)		2	124537199	209621565	Rat
1581578	Cm49	Cardiac mass QTL 49	4.9	0.01	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	145807215	220931416	Rat
631198	Cm22	Cardiac mass QTL 22	4.3	0.0008	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	78269809	208420281	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	122597372	215234002	Rat
12879836	Kidm61	Kidney mass QTL 61		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	154723085	199723085	Rat
1581569	Uae32	Urinary albumin excretion QTL 32		0.0001	urine protein amount (VT:0005160)	urine albumin excretion rate (CMO:0000757)	2	80396178	220931218	Rat
10043136	Iddm54	Insulin dependent diabetes mellitus QTL 54	3.4	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	145807215	190807215	Rat
12879837	Am2	Aortic mass QTL 2		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	2	154723085	199723085	Rat
10043139	Iddm55	Insulin dependent diabetes mellitus QTL 55	3.1	0.0001	blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	150313808	195313808	Rat
12879838	Cm86	Cardiac mass QTL 86		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	2	154723085	199723085	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	205135267	Rat
12879839	Cm85	Cardiac mass QTL 85		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	2	154723085	199723085	Rat
1549833	Bp257	Blood pressure QTL 257		0.003	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	170652929	215652929	Rat
1358900	Bw48	Body weight QTL 48	4.88		body mass (VT:0001259)	body weight (CMO:0000012)	2	159440891	220931218	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	171994826	205135428	Rat
1359030	Bp277	Blood pressure QTL 277			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	143565208	188565208	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	4265106	205135428	Rat
12879840	Bw179	Body weight QTL 179		0.005	body mass (VT:0001259)	body weight (CMO:0000012)	2	154723085	199723085	Rat
1581502	Esta3	Estrogen-induced thymic atrophy QTL 3			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	139067258	192287892	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	184856304	229856304	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	184856304	229856304	Rat
1359032	Hrtrt18	Heart rate QTL 18			heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	159440760	195313808	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	144882354	205135428	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	67845182	205135428	Rat
1357991	Ael2	Aortic elastin QTL 2	4.2	0.000071	aorta elastin amount (VT:0003905)	aortic elastin	2	169227906	214227906	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83400752	223709938	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	44537979	205135428	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	184856304	229856304	Rat
1578671	Bmd10	Bone mineral density QTL 10	5.4		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	2	175931416	220931416	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	251712708	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	80396034	220931416	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78269809	205135428	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	182024327	227024327	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	159440760	228950743	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	184482291	229482291	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	143344967	251712708	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	143746578	205135428	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	143344967	251712708	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	114384617	215381366	Rat
1598805	Memor8	Memory QTL 8	3		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	150096616	195096616	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	145306936	212705578	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	27148328	206613235	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	113746222	205135428	Rat
61401	Niddm2	Non-insulin dependent diabetes mellitus QTL 2	4.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	147287892	192287892	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	114384617	215381366	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	151869660	223841096	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	117415288	205135428	Rat
1598833	Bp295	Blood pressure QTL 295	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	150096616	195096616	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	182635347	227635347	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83465462	225110681	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	47856345	205135428	Rat
631522	Bp74	Blood pressure QTL 74		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	175008837	220008837	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	184856304	229856304	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	165453811	210453811	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	163253030	208253030	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	166372086	229820014	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	76328396	209350714	Rat

Markers in Region

D2Got117

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	186,432,161 - 186,432,342 (+)	Marker Load Pipeline
mRatBN7.2	2	183,743,287 - 183,743,468 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	198,322,923 - 198,323,103	NCBI	Rnor6.0
Rnor_5.0	2	217,809,906 - 217,810,086	UniSTS	Rnor5.0
RGSC_v3.4	2	190,987,176 - 190,987,356	UniSTS	RGSC3.4
RGSC_v3.4	2	190,987,175 - 190,987,356	RGD	RGSC3.4
Celera	2	176,270,702 - 176,270,882	UniSTS
RGSC_v3.1	2	190,949,930 - 190,950,110	RGD
RH 3.4 Map	2	1221.5	RGD
RH 3.4 Map	2	1221.5	UniSTS
RH 2.0 Map	2	901.2	RGD
Cytogenetic Map	2	q34	UniSTS

D2Wox49

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	183,756,199 - 183,756,468 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	198,335,799 - 198,336,067	NCBI	Rnor6.0
Rnor_5.0	2	217,822,782 - 217,823,050	UniSTS	Rnor5.0
RGSC_v3.4	2	191,000,085 - 191,000,353	UniSTS	RGSC3.4
Celera	2	176,283,847 - 176,284,115	UniSTS
Cytogenetic Map	2	q34	UniSTS

AI746429

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	2	186,445,594 - 186,445,702 (+)	Marker Load Pipeline
mRatBN7.2	2	183,756,723 - 183,756,829 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	198,336,323 - 198,336,428	NCBI	Rnor6.0
Rnor_5.0	2	217,823,306 - 217,823,411	UniSTS	Rnor5.0
RGSC_v3.4	2	191,000,609 - 191,000,714	UniSTS	RGSC3.4
Celera	2	176,284,371 - 176,284,476	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH129295

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	183,757,052 - 183,757,232 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	198,336,652 - 198,336,831	NCBI	Rnor6.0
Rnor_5.0	2	217,823,635 - 217,823,814	UniSTS	Rnor5.0
RGSC_v3.4	2	191,000,938 - 191,001,117	UniSTS	RGSC3.4
Celera	2	176,284,700 - 176,284,879	UniSTS
RH 3.4 Map	2	1221.6	UniSTS
Cytogenetic Map	2	q34	UniSTS

RH143796

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	183,754,422 - 183,754,565 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	198,334,022 - 198,334,164	NCBI	Rnor6.0
Rnor_5.0	2	217,821,005 - 217,821,147	UniSTS	Rnor5.0
RGSC_v3.4	2	190,998,308 - 190,998,450	UniSTS	RGSC3.4
Celera	2	176,282,070 - 176,282,212	UniSTS
RH 3.4 Map	2	1221.4	UniSTS
Cytogenetic Map	2	q34	UniSTS

BE119349

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	183,740,816 - 183,740,982 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	198,320,452 - 198,320,617	NCBI	Rnor6.0
Rnor_5.0	2	217,807,435 - 217,807,600	UniSTS	Rnor5.0
RGSC_v3.4	2	190,984,705 - 190,984,870	UniSTS	RGSC3.4
Celera	2	176,268,103 - 176,268,268	UniSTS
RH 3.4 Map	2	1221.5	UniSTS
Cytogenetic Map	2	q34	UniSTS

Related Rat Strains

The following Strains have been annotated to Sv2a

F344-Sv2a^m1Kyo

Genetic Models

This gene Sv2a is modified in the following models/strains:

F344-Sv2a^m1Kyo

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_057210	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039101598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC092132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CQ819363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L01788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	L05435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000028760 ⟹ ENSRNOP00000028760

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	186,430,363 - 186,446,161 (+)	Ensembl
mRatBN7.2 Ensembl	2	183,741,547 - 183,756,927 (+)	Ensembl
Rnor_6.0 Ensembl	2	198,321,142 - 198,336,913 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000145133 ⟹ ENSRNOP00000104731

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	2	186,430,345 - 186,448,065 (+)	Ensembl

RefSeq Acc Id:

NM_057210 ⟹ NP_476558

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	186,430,363 - 186,446,161 (+)	NCBI
mRatBN7.2	2	183,741,489 - 183,757,290 (+)	NCBI
Rnor_6.0	2	198,324,934 - 198,336,573 (+)	NCBI
Rnor_5.0	2	217,808,165 - 217,823,872 (+)	NCBI
RGSC_v3.4	2	190,989,187 - 191,000,859 (+)	RGD
Celera	2	176,272,713 - 176,284,621 (+)	RGD

Sequence:

show sequence

GAAAAAGAAGCAGAGAGTAAGGTAGAGCCAGTGACTCGCCCCCAAGCCCCATCATGGAAGAAGG
CTTTCGAGACCGAGCAGCGTTCATCCGTGGGGCCAAAGACATTGCCAAGGAAGTTAAGAAGCAC
GCGGCCAAGAAGGTGGTGAAGGGTCTCGACAGAGTCCAGGATGAATATTCCCGAAGGTCCTACT
CCCGCTTTGAGGAGGAGGAGGATGATGATGACTTCCCTGCCCCTGCTGACGGCTATTACCGCGG
AGAAGGGGCCCAGGATGAGGAGGAAGGTGGCGCTTCCAGTGATGCCACTGAGGGCCACGATGAG
GATGATGAGATCTACGAGGGAGAATATCAGGGCATCCCCCGGGCAGAGTCTGGGGGCAAAGGCG
AACGGATGGCAGATGGGGCACCCCTGGCTGGAGTGAGAGGGGGCTTAAGTGATGGGGAGGGTCC
CCCTGGGGGTCGCGGGGAGGCGCAGCGGCGTAAAGATCGGGAAGAATTGGCTCAGCAGTATGAG
ACCATCCTCCGGGAGTGCGGCCATGGTCGCTTCCAGTGGACACTCTACTTCGTGCTGGGTCTGG
CGCTGATGGCCGATGGTGTAGAGGTCTTTGTGGTGGGCTTTGTGCTGCCCAGTGCTGAGAAAGA
TATGTGCCTGTCGGACTCCAACAAAGGCATGCTAGGCCTCATTGTGTACCTGGGCATGATGGTG
GGGGCCTTCCTCTGGGGAGGCCTGGCTGATCGGCTGGGTCGGAGACAGTGTCTGCTCATCTCGC
TCTCAGTCAACAGCGTCTTCGCTTTCTTCTCATCCTTCGTCCAGGGTTATGGCACCTTCCTTTT
CTGCCGCCTCCTTTCTGGGGTTGGGATTGGTGGTTCCATCCCCATTGTCTTCTCCTATTTTTCG
GAGTTTCTGGCCCAGGAGAAACGTGGGGAGCATTTGAGCTGGCTCTGTATGTTCTGGATGATTG
GTGGCGTGTATGCAGCTGCAATGGCCTGGGCCATCATCCCCCACTATGGGTGGAGTTTCCAGAT
GGGCTCTGCTTACCAGTTCCACAGCTGGAGGGTCTTTGTCCTCGTCTGTGCCTTTCCCTCTGTG
TTTGCCATCGGGGCTCTGACTACGCAGCCGGAGAGTCCCCGCTTCTTCTTAGAGAATGGGAAGC
ACGATGAGGCCTGGATGGTGCTGAAGCAGGTTCATGACACCAACATGCGAGCCAAGGGCCATCC
TGAGCGAGTCTTCTCAGTAACCCACATTAAAACGATTCATCAGGAGGATGAATTGATTGAGATC
CAGTCAGACACAGGAACCTGGTACCAGCGCTGGGGAGTGCGGGCTTTGAGCCTGGGGGGTCAGG
TTTGGGGGAACTTCCTCTCCTGCTTCAGTCCAGAGTACCGGCGCATCACTCTGATGATGATGGG
GGTATGGTTCACCATGTCCTTCAGCTACTACGGTTTGACTGTCTGGTTTCCCGACATGATCCGC
CATCTCCAGGCTGTGGACTATGCAGCCCGAACCAAAGTGTTCCCAGGGGAGCGCGTGGAGCACG
TGACATTTAACTTCACACTGGAGAATCAGATCCACCGAGGGGGACAGTACTTCAATGACAAGTT
CATCGGGCTGCGTCTGAAGTCAGTGTCCTTTGAGGATTCCCTGTTTGAGGAATGTTACTTTGAA
GATGTCACATCCAGCAACACATTCTTCCGCAACTGCACATTCATCAACACCGTGTTCTACAACA
CGGACCTGTTTGAGTACAAGTTCGTGAACAGCCGCCTGGTGAACAGCACATTCCTGCACAATAA
GGAAGGTTGCCCACTAGATGTGACAGGGACGGGCGAAGGTGCCTACATGGTGTACTTTGTCAGC
TTCTTGGGGACACTGGCTGTGCTCCCTGGAAATATTGTGTCTGCTCTGCTCATGGACAAGATTG
GCAGGCTCAGAATGCTTGCTGGTTCCAGTGTGTTGTCCTGTGTTTCCTGCTTCTTCCTGTCTTT
TGGGAACAGTGAGTCAGCCATGATCGCTCTGCTCTGCCTTTTTGGGGGAGTCAGTATTGCATCC
TGGAACGCGCTGGACGTGCTGACTGTTGAACTCTACCCTTCCGACAAGAGGACGACGGCCTTCG
GCTTCCTGAATGCCCTGTGTAAGCTGGCAGCTGTACTGGGCATCAGCATCTTCACGTCCTTTGT
GGGAATCACCAAGGCCGCTCCCATCCTCTTCGCCTCAGCTGCGCTTGCCCTTGGTAGCTCTCTG
GCTCTGAAGCTGCCTGAGACCCGGGGACAGGTGCTGCAGTGAGGGATGGGGGAGTGTCTCAGGG
GCTTTAGGGATGGCAGGCACACTGTGACCAATAATTTCTTTTATCCCTACCCTGCCCTGCTGTC
CTGGTCCTACTCCGTGTTTGGTGTCTTAGCTGTGTGCCTGTGTGCATGTGTGTGACCCTGACGG
GCAGGGGCTACGGGGAGGGTCCCTTTGTCCCATGTTTGGGAGGAGGGACTCCCCACCTGCTGCC
ACCCTCAACTTTGCACAAGGAGAAGGCTGAGCTGCATCCTTCTCTCCCTCAGTGTTAGCAGGGG
TGGGGACGACTGTTTCTCTGCTCCAGGTGTTCCAGAATTTCTGCCTTTCCCATCATTCCCTCCG
CCTAGGCCCTGGTGAACCACAGGTATGGAGTTATAGTGGGGGCTGAGGCTTGGACCAAAAGAAC
TTCTTGAGTGGGAGCCTCCCAAGGATGCTGGGGAGTAGCAATAAACCTTAGCCTCCGTTTTCAC
CTCAATTCAGGCTACAAGTGTGAAGCCTGGATTTTATGGAATTAGTTTTCTGATTCTTATTTAT
ATGTAAGTTCTGAGGCAGCTTAGCTGGACTGTGTGTGGATGTATACATACACTCATATGTGTGT
GTGTGTGCGCGCGTGCGTGTGCGTGTGTGTATGTGTGCCATGGGGTAGGGGTACCACTATACTG
TTCAATTATAAGCCAAGAGTAGTAGTTTCAGTGAGCACACACACAACACTGTTTTTCTATCGTA
ACTCCCAGAATCTTGTACCTGTGTTGGGGCTGCAGGCAGAAGTCCTTGGTCAGGCTGGGGTGAG
CCCTGCAATCTTGGGGGACCTGAGGGCACCTGACAAGGACTTTCTCCTTCCTCTAGAGAGGTTC
TACCCACTAGCCACAGCCCTCCCATCTGACCTGTCCACACAGGCAGTGTATCAGAGGAAAGAAA
GGGAAAATAACCAGGCACACATGGTCAAACCAGCAGGTCTGAAAGCACAAGAAGCTGGGGCAGG
GGCAGGAAGCAGGGGTCCATCCCCTAACCCTTCTCAAAAAGGCTGGGTCGTGAGGGACCCCTAA
TGCAGGGACCTGAAGCCTCAGTTTCCCCATCTTGCCCTTCCACAGAACAGCCTCTGTAGGTAGA
GCTGCCCCCCGTCCTACCCTACTCTTGTGGCTGCTTTCTTTGGTACTCTTCCCACTCCCACCGT
AGCTGTGACGTGTTGTAGTTTTTAGCTGTTTGTAAAATGTTAAAAAAAAAAAAAAGTTAAAAGG
AAGTTAAACTAAAAAAAAAAAAAAAAAAGAAAAA

hide sequence

RefSeq Acc Id:

XM_039101598 ⟹ XP_038957526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	186,436,362 - 186,446,161 (+)	NCBI
mRatBN7.2	2	183,747,488 - 183,757,290 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_476558	(Get FASTA)	NCBI Sequence Viewer
	XP_038957526	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA42188	(Get FASTA)	NCBI Sequence Viewer
	AAH92132	(Get FASTA)	NCBI Sequence Viewer
	CAG34349	(Get FASTA)	NCBI Sequence Viewer
	EDL85646	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000028760
	ENSRNOP00000028760.2
GenBank Protein	Q02563	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_476558 ⟸ NM_057210

- UniProtKB:

Q58DZ8 (UniProtKB/Swiss-Prot), Q02563 (UniProtKB/Swiss-Prot), A6K354 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEEDDDDFPAPADG
YYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSD
GEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPS
AEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYG
TFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGW
SFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRA
KGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITL
MMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYF
NDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTF
LHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCF
FLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIF
TSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ

hide sequence

Ensembl Acc Id:

ENSRNOP00000028760 ⟸ ENSRNOT00000028760

RefSeq Acc Id:	XP_038957526 ⟸ XM_039101598
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000104731 ⟸ ENSRNOT00000145133

Protein Domains

Major facilitator superfamily (MFS) profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q02563-F1-model_v2	AlphaFold	Q02563	1-742	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691569

Promoter ID:

EPDNEW_R2093

Type:

initiation region

Name:

Sv2a_1

Description:

synaptic vesicle glycoprotein 2a

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	198,321,138 - 198,321,198	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:619715	AgrOrtholog
BioCyc Gene	G2FUF-52050	BioCyc
Ensembl Genes	ENSRNOG00000021182	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000028760	ENTREZGENE
	ENSRNOT00000028760.5	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot
	E3 ubiquitin-protein ligase SopA	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7314271	IMAGE-MGC_LOAD
InterPro	LD_SV2	UniProtKB/Swiss-Prot
	MFS	UniProtKB/Swiss-Prot
	MFS_dom	UniProtKB/Swiss-Prot
	MFS_sugar_transport-like	UniProtKB/Swiss-Prot
	MFS_trans_sf	UniProtKB/Swiss-Prot
	Sugar_transporter_CS	UniProtKB/Swiss-Prot
	SV2	UniProtKB/Swiss-Prot
KEGG Report	rno:117559	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105346	IMAGE-MGC_LOAD
NCBI Gene	117559	ENTREZGENE
PANTHER	SYNAPTIC VESICLE GLYCOPROTEIN 2	UniProtKB/Swiss-Prot
	SYNAPTIC VESICLE GLYCOPROTEIN 2A	UniProtKB/Swiss-Prot
Pfam	LD_SV2	UniProtKB/Swiss-Prot
	MFS_1	UniProtKB/Swiss-Prot
	Sugar_tr	UniProtKB/Swiss-Prot
PhenoGen	Sv2a	PhenoGen
PROSITE	MFS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000021182	RatGTEx
Superfamily-SCOP	Pentapeptide repeat-like	UniProtKB/Swiss-Prot
	SSF103473	UniProtKB/Swiss-Prot
UniProt	A0ABK0LGK8_RAT	UniProtKB/TrEMBL
	A6K354	ENTREZGENE, UniProtKB/TrEMBL
	Q02563	ENTREZGENE
	Q58DZ8	ENTREZGENE
	SV2A_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q58DZ8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-12-14	Sv2a	synaptic vesicle glycoprotein 2a		synaptic vesicle glycoprotein 2 a	Name updated	1299863	APPROVED
2002-08-07	Sv2a	synaptic vesicle glycoprotein 2 a			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	has 12 transmembrane domains	634182
gene_expression	expressed in the endocrine cells and in the secretory vesicles in neurons	634182

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

Mammalian Phenotype