Kcnab1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1) - Rat Genome Database

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Gene: Kcnab1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1) Rattus norvegicus
Analyze
Symbol: Kcnab1
Name: potassium voltage-gated channel subfamily A regulatory beta subunit 1
RGD ID: 61827
Description: Enables aldo-keto reductase (NADPH) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Involved in several processes, including myoblast differentiation; negative regulation of delayed rectifier potassium channel activity; and skeletal muscle organ development. Located in dendrite; juxtaparanode region of axon; and perikaryon. Part of voltage-gated potassium channel complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in temporal lobe epilepsy. Orthologous to human KCNAB1 (potassium voltage-gated channel subfamily A regulatory beta subunit 1); INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: K(+) channel subunit beta-1; kv-beta-1; Kvbeta1.1; Kvbeta1.2; Kvbeta1.3; KvBeta3; MGC105463; potassium channel, voltage gated subfamily A regulatory beta subunit 1; potassium channel, voltage-gated shaker related subfamily A regulatory beta subunit 1; potassium voltage gated channel shaker related subfamily beta member 1; potassium voltage gated channel, shaker related subfamily, beta member 1; potassium voltage-gated channel subfamily A member regulatory beta subunit 1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel beta subunit; voltage-gated potassium channel subunit beta-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnab1Tn(sb-T2/Bart3)2.300Mcwi  
Genetic Models: F344-Kcnab1Tn(sb-T2/Bart3)2.300Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82151,446,975 - 151,913,636 (+)NCBIGRCr8
mRatBN7.22149,137,025 - 149,603,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2149,137,041 - 149,603,534 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2156,426,340 - 156,713,448 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02154,475,802 - 154,764,811 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02149,108,477 - 149,397,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02155,555,798 - 156,011,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2155,718,359 - 156,009,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02174,966,379 - 175,400,010 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42154,837,841 - 155,145,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12154,787,803 - 155,095,845 (+)NCBI
Celera2143,747,424 - 144,023,440 (+)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
haloperidol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (ISO)
methylseleninic acid  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
olanzapine  (ISO)
oxaliplatin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
testosterone  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Generation and characterization of subtype-specific monoclonal antibodies to K+ channel alpha- and beta-subunit polypeptides. Bekele-Arcuri Z, etal., Neuropharmacology. 1996;35(7):851-65.
2. Association of intronic variants of the KCNAB1 gene with lateral temporal epilepsy. Busolin G, etal., Epilepsy Res. 2011 Mar;94(1-2):110-6. doi: 10.1016/j.eplepsyres.2011.01.010. Epub 2011 Feb 18.
3. Differential expression of voltage-gated K(+) channel genes in arteries from spontaneously hypertensive and Wistar-Kyoto rats. Cox RH, etal., Hypertension. 2001 May;37(5):1315-22.
4. Comparative gene expression profile of mouse carotid body and adrenal medulla under physiological hypoxia. Ganfornina MD, etal., J Physiol. 2005 Jul 15;566(Pt 2):491-503. Epub 2005 May 12.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Voltage-dependent K+ channel beta subunits in muscle: differential regulation during postnatal development and myogenesis. Grande M, etal., J Cell Physiol. 2003 May;195(2):187-93.
7. Functional characterization of Kv channel beta-subunits from rat brain. Heinemann SH, etal., J Physiol. 1996 Jun 15;493 ( Pt 3):625-33.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Functional coupling between the Kv1.1 channel and aldoketoreductase Kvbeta1. Pan Y, etal., J Biol Chem. 2008 Mar 28;283(13):8634-42. doi: 10.1074/jbc.M709304200. Epub 2008 Jan 25.
11. Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit. Rettig J, etal., Nature 1994 May 26;369(6478):289-94.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Voltage-gated K+ channel beta subunits: expression and distribution of Kv beta 1 and Kv beta 2 in adult rat brain. Rhodes KJ, etal., J Neurosci. 1996 Aug 15;16(16):4846-60.
16. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
17. The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1. Schulte U, etal., Neuron. 2006 Mar 2;49(5):697-706.
18. Primary structure of a beta subunit of alpha-dendrotoxin-sensitive K+ channels from bovine brain. Scott VE, etal., Proc Natl Acad Sci U S A 1994 Mar 1;91(5):1637-41.
19. NMR structure and functional characteristics of the hydrophilic N terminus of the potassium channel beta-subunit Kvbeta1.1. Wissmann R, etal., J Biol Chem. 1999 Dec 10;274(50):35521-5. doi: 10.1074/jbc.274.50.35521.
Additional References at PubMed
PMID:7890032   PMID:7890764   PMID:10477520   PMID:11401852   PMID:12130714   PMID:12477932   PMID:14511342   PMID:15662035   PMID:17540341   PMID:18650555   PMID:18806782   PMID:19780818  
PMID:33168717  


Genomics

Comparative Map Data
Kcnab1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82151,446,975 - 151,913,636 (+)NCBIGRCr8
mRatBN7.22149,137,025 - 149,603,540 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2149,137,041 - 149,603,534 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2156,426,340 - 156,713,448 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02154,475,802 - 154,764,811 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02149,108,477 - 149,397,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02155,555,798 - 156,011,438 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2155,718,359 - 156,009,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02174,966,379 - 175,400,010 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42154,837,841 - 155,145,882 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12154,787,803 - 155,095,845 (+)NCBI
Celera2143,747,424 - 144,023,440 (+)NCBICelera
Cytogenetic Map2q31NCBI
KCNAB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383156,118,211 - 156,539,138 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3156,037,701 - 156,538,756 (+)EnsemblGRCh38hg38GRCh38
GRCh373155,838,337 - 156,256,927 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363157,321,031 - 157,739,621 (+)NCBINCBI36Build 36hg18NCBI36
Celera3154,260,612 - 154,680,263 (+)NCBICelera
Cytogenetic Map3q25.31NCBI
HuRef3153,234,046 - 153,652,872 (+)NCBIHuRef
CHM1_13155,801,446 - 156,218,577 (+)NCBICHM1_1
T2T-CHM13v2.03158,892,837 - 159,313,792 (+)NCBIT2T-CHM13v2.0
Kcnab1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39364,856,636 - 65,285,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl364,856,617 - 65,285,644 (+)EnsemblGRCm39 Ensembl
GRCm38364,949,212 - 65,378,225 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl364,949,196 - 65,378,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv37364,913,565 - 65,182,141 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36365,197,313 - 65,466,148 (+)NCBIMGSCv36mm8
Celera365,250,341 - 65,520,213 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.15NCBI
Kcnab1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554487,309,717 - 7,551,432 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554487,145,471 - 7,553,090 (+)NCBIChiLan1.0ChiLan1.0
KCNAB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22154,037,335 - 154,456,298 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13154,042,066 - 154,461,029 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03153,175,465 - 153,594,375 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13161,251,899 - 161,652,520 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3161,402,134 - 161,651,524 (+)Ensemblpanpan1.1panPan2
KCNAB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12349,775,790 - 50,135,372 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2349,776,089 - 50,133,707 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2349,650,372 - 50,009,284 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02350,409,624 - 50,768,980 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2350,409,741 - 50,767,309 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12349,994,486 - 50,352,950 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02350,044,700 - 50,403,869 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02350,331,182 - 50,690,531 (+)NCBIUU_Cfam_GSD_1.0
Kcnab1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560286,180,048 - 86,493,647 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365193,354,987 - 3,553,181 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365193,354,001 - 3,553,904 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNAB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1395,959,378 - 96,375,856 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11395,981,820 - 96,375,089 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213104,321,510 - 104,480,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNAB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11534,223,250 - 34,467,924 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1534,221,890 - 34,468,001 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660416,840,145 - 7,225,966 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnab1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473033,876,381 - 34,139,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473033,701,386 - 34,141,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kcnab1
2594 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:128
Interacting mature miRNAs:142
Transcripts:ENSRNOT00000049376
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
8662836Vetf8Vascular elastic tissue fragility QTL 80.66thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2104559726149559726Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
5135226Leukc2Leukocyte quantity QTL 2eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)2118111229149559726Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
D2Rat38  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,559,561 - 149,559,726 (+)MAPPERmRatBN7.2
Rnor_6.02155,965,557 - 155,965,721NCBIRnor6.0
Rnor_5.02175,354,307 - 175,354,471UniSTSRnor5.0
RGSC_v3.42155,102,058 - 155,102,222UniSTSRGSC3.4
RGSC_v3.42155,101,972 - 155,102,371RGDRGSC3.4
RGSC_v3.12155,052,021 - 155,052,185RGD
Celera2143,979,588 - 143,979,752UniSTS
RH 3.4 Map2972.8RGD
RH 3.4 Map2972.8UniSTS
RH 2.0 Map2698.5RGD
SHRSP x BN Map260.5198RGD
FHH x ACI Map267.7299RGD
Cytogenetic Map2q31UniSTS
D2Rat374  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,406,644 - 149,406,843 (+)MAPPERmRatBN7.2
Rnor_6.02155,820,112 - 155,820,310NCBIRnor6.0
Rnor_5.02175,203,295 - 175,203,493UniSTSRnor5.0
RGSC_v3.42154,940,356 - 154,940,555RGDRGSC3.4
RGSC_v3.42154,940,357 - 154,940,555UniSTSRGSC3.4
RGSC_v3.12154,890,319 - 154,890,518RGD
Celera2143,848,691 - 143,848,889UniSTS
FHH x ACI Map267.7299RGD
FHH x ACI Map267.7299UniSTS
Cytogenetic Map2q31UniSTS
D2Got107  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,380,288 - 149,380,565 (+)MAPPERmRatBN7.2
Rnor_6.02155,793,342 - 155,793,618NCBIRnor6.0
Rnor_5.02175,177,635 - 175,177,911UniSTSRnor5.0
RGSC_v3.42154,914,184 - 154,914,461RGDRGSC3.4
RGSC_v3.42154,914,185 - 154,914,461UniSTSRGSC3.4
RGSC_v3.12154,864,148 - 154,864,424RGD
Celera2143,822,989 - 143,823,273UniSTS
RH 3.4 Map2934.7UniSTS
RH 3.4 Map2934.7RGD
RH 2.0 Map2711.2RGD
Cytogenetic Map2q31UniSTS
BE097574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,603,367 - 149,603,537 (+)MAPPERmRatBN7.2
Rnor_6.02156,009,360 - 156,009,529NCBIRnor6.0
Rnor_5.02175,398,131 - 175,398,300UniSTSRnor5.0
RGSC_v3.42155,145,713 - 155,145,882UniSTSRGSC3.4
Celera2144,023,271 - 144,023,440UniSTS
RH 3.4 Map2790.6UniSTS
Cytogenetic Map2q31UniSTS
AU047443  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,502,816 - 149,503,031 (+)MAPPERmRatBN7.2
Rnor_6.02155,908,876 - 155,909,090NCBIRnor6.0
Rnor_5.02175,298,327 - 175,298,541UniSTSRnor5.0
RGSC_v3.42155,045,269 - 155,045,483UniSTSRGSC3.4
Celera2143,929,468 - 143,929,682UniSTS
Cytogenetic Map2q31UniSTS
BE119701  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,575,300 - 149,575,451 (+)MAPPERmRatBN7.2
Rnor_6.02155,981,296 - 155,981,446NCBIRnor6.0
Rnor_5.02175,370,070 - 175,370,220UniSTSRnor5.0
RGSC_v3.42155,117,797 - 155,117,947UniSTSRGSC3.4
Celera2143,995,325 - 143,995,475UniSTS
RH 3.4 Map2972.7UniSTS
Cytogenetic Map2q31UniSTS
BE119763  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,568,558 - 149,568,736 (+)MAPPERmRatBN7.2
Rnor_6.02155,974,554 - 155,974,731NCBIRnor6.0
Rnor_5.02175,363,304 - 175,363,481UniSTSRnor5.0
RGSC_v3.42155,111,055 - 155,111,232UniSTSRGSC3.4
Celera2143,988,584 - 143,988,761UniSTS
RH 3.4 Map2946.2UniSTS
Cytogenetic Map2q31UniSTS
AU049268  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22149,356,488 - 149,356,720 (+)MAPPERmRatBN7.2
Rnor_6.02155,770,405 - 155,770,636NCBIRnor6.0
Rnor_5.02175,154,698 - 175,154,929UniSTSRnor5.0
RGSC_v3.42154,889,885 - 154,890,116UniSTSRGSC3.4
Celera2143,799,163 - 143,799,394UniSTS
Cytogenetic Map2q31UniSTS


Genetic Models
This gene Kcnab1 is modified in the following models/strains:
F344-Kcnab1Tn(sb-T2/Bart3)2.300Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 89 88 57 25 57 6 216 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000077973   ⟹   ENSRNOP00000072289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2149,304,445 - 149,603,534 (+)Ensembl
Rnor_6.0 Ensembl2155,718,359 - 156,009,526 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097545   ⟹   ENSRNOP00000078062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2149,164,133 - 149,603,534 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000120207   ⟹   ENSRNOP00000095564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2149,137,041 - 149,603,534 (+)Ensembl
RefSeq Acc Id: NM_017303   ⟹   NP_058999
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82151,614,551 - 151,913,636 (+)NCBI
mRatBN7.22149,304,445 - 149,603,540 (+)NCBI
Rnor_6.02155,718,359 - 156,009,529 (+)NCBI
Rnor_5.02174,966,379 - 175,400,010 (+)NCBI
RGSC_v3.42154,837,841 - 155,145,882 (+)RGD
Celera2143,747,424 - 144,023,440 (+)RGD
Sequence:
RefSeq Acc Id: XM_017590798   ⟹   XP_017446287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82151,446,975 - 151,913,631 (+)NCBI
mRatBN7.22149,137,025 - 149,603,540 (+)NCBI
Rnor_6.02155,555,798 - 156,011,438 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102125   ⟹   XP_038958053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82151,474,245 - 151,913,631 (+)NCBI
mRatBN7.22149,164,187 - 149,603,540 (+)NCBI
RefSeq Acc Id: XM_063281680   ⟹   XP_063137750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82151,447,065 - 151,893,921 (+)NCBI
RefSeq Acc Id: NP_058999   ⟸   NM_017303
- UniProtKB: Q5FWS9 (UniProtKB/Swiss-Prot),   P63144 (UniProtKB/Swiss-Prot),   A6J5J1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446287   ⟸   XM_017590798
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AJY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072289   ⟸   ENSRNOT00000077973
RefSeq Acc Id: XP_038958053   ⟸   XM_039102125
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y1W3 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000078062   ⟸   ENSRNOT00000097545
Ensembl Acc Id: ENSRNOP00000095564   ⟸   ENSRNOT00000120207
RefSeq Acc Id: XP_063137750   ⟸   XM_063281680
- Peptide Label: isoform X3
Protein Domains
NADP-dependent oxidoreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63144-F1-model_v2 AlphaFold P63144 1-401 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61827 AgrOrtholog
BioCyc Gene G2FUF-52903 BioCyc
Ensembl Genes ENSRNOG00000056697 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055004540 UniProtKB/Swiss-Prot
  ENSRNOG00060001239 UniProtKB/Swiss-Prot
  ENSRNOG00065027103 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000077973.2 UniProtKB/Swiss-Prot
  ENSRNOT00000097545.1 UniProtKB/TrEMBL
  ENSRNOT00000120207.1 UniProtKB/TrEMBL
  ENSRNOT00055007187 UniProtKB/Swiss-Prot
  ENSRNOT00060001769 UniProtKB/Swiss-Prot
  ENSRNOT00065046799 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7320941 IMAGE-MGC_LOAD
InterPro K_chnl_volt-dep_bsu_KCNAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNAB-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  K_chnl_volt-dep_bsu_KCNAB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29737 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105463 IMAGE-MGC_LOAD
NCBI Gene 29737 ENTREZGENE
PANTHER PTHR43150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT BETA-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Aldo_ket_red UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnab1 PhenoGen
PRINTS KCNAB1CHANEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  KCNABCHANNEL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056697 RatGTEx
  ENSRNOG00055004540 RatGTEx
  ENSRNOG00060001239 RatGTEx
  ENSRNOG00065027103 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y1W3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJY2 ENTREZGENE, UniProtKB/TrEMBL
  A6J5J1 ENTREZGENE, UniProtKB/TrEMBL
  A6J5J3_RAT UniProtKB/TrEMBL
  KCAB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5FWS9 ENTREZGENE
UniProt Secondary P97380 UniProtKB/Swiss-Prot
  Q5FWS9 UniProtKB/Swiss-Prot
  Q61763 UniProtKB/Swiss-Prot
  Q63277 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Kcnab1  potassium voltage-gated channel, shaker-related subfamily, beta member 1    potassium voltage gated channel, shaker related subfamily, beta member 1  Name updated 1299863 APPROVED
2002-06-10 Kcnab1  potassium voltage gated channel, shaker related subfamily, beta member 1      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction interacts with Kv alpha subunits 61642