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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61827
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnab1
Name: potassium voltage-gated channel subfamily A regulatory beta subunit 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnab1affects expressionISOKCNAB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the expression of KCNAB1 mRNAPMID:22316170
Kcnab1affects methylationISOKCNAB1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of KCNAB1 exon; Benzo(a)pyrene affects the methylation of KCNAB1 intronPMID:27901495 PMID:30157460
Kcnab1decreases methylationISOKcnab1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of KCNAB1 intronPMID:27901495
Kcnab1increases expressionISOKcnab1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of KCNAB1 mRNAPMID:22228805
Kcnab1increases methylationISOKCNAB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of KCNAB1 promoterPMID:27901495
Kcnab1increases mutagenesisISOKCNAB1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased mutagenesis of KCNAB1 genePMID:25435355
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