Slc34a1 (solute carrier family 34 member 1) - Rat Genome Database

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Gene: Slc34a1 (solute carrier family 34 member 1) Rattus norvegicus
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Symbol: Slc34a1
Name: solute carrier family 34 member 1
RGD ID: 3708
Description: Enables PDZ domain binding activity; identical protein binding activity; and sodium:phosphate symporter activity. Involved in several processes, including arsenate ion transmembrane transport; phosphate ion transport; and regulation of phosphate transport. Located in several cellular components, including brush border membrane; cell surface; and perinuclear region of cytoplasm. Biomarker of autosomal dominant polycystic kidney disease; chronic kidney disease (multiple); hyperthyroidism; hypophosphatemia; and hypothyroidism. Human ortholog(s) of this gene implicated in several diseases, including Fanconi syndrome (multiple); chronic kidney disease; hereditary hypophosphatemic rickets with hypercalciuria; hypophosphatemic nephrolithiasis/osteoporosis 1; and nephrolithiasis. Orthologous to human SLC34A1 (solute carrier family 34 member 1); PARTICIPATES IN phosphate transport pathway; INTERACTS WITH ammonium chloride; bisphenol A; buspirone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: na(+)-dependent phosphate cotransporter 2A; na(+)/Pi cotransporter 2A; NaPi-2; naPi-2a; NAPI2A; Npt2; Slc17a2; sodium-dependent phosphate transport protein 2A; sodium-phosphate co-transporter type II; sodium-phosphate transport protein 2A; sodium/phosphate cotransporter 2A; solute carrier family 17 (sodium/hydrogen exchanger) member 2; solute carrier family 34 (sodium phosphate) member 1; Solute carrier family 34 (sodium phosphate), member 1; solute carrier family 34 (type II sodium/phosphate cotransporter), member 1; solute carrier family 34, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Slc34a1em1Mcwi
Genetic Models: SS-Slc34a1em1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,224,010 - 9,238,983 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,224,010 - 9,238,983 (-)EnsemblGRCr8
mRatBN7.2179,218,876 - 9,233,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,218,876 - 9,233,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,234,994 - 9,250,089 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,765,022 - 10,780,032 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,231,384 - 9,246,479 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,747,766 - 9,762,739 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,747,752 - 9,762,813 (-)Ensemblrn6Rnor6.0
Rnor_5.01711,856,946 - 11,872,100 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,262,929 - 15,277,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,297,383 - 9,312,355 (-)NCBICelera
RGSC_v3.11715,262,928 - 15,277,902 (-)NCBI
RH 3.4 Map1781.4RGD
Cytogenetic Map17p14NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arsenate ion transmembrane transport  (IDA)
bone remodeling  (ISO)
calcium ion homeostasis  (ISO)
cellular response to metal ion  (IEP)
cellular response to parathyroid hormone stimulus  (IEP)
cellular response to phosphate starvation  (IDA)
cellular response to staurosporine  (IEP)
dentinogenesis  (IEP)
gene expression  (ISO)
inorganic anion transport  (IEA)
inorganic diphosphate transport  (ISO)
intracellular phosphate ion homeostasis  (IBA)
kidney development  (IEP)
monoatomic ion transport  (IEA)
ossification  (IEP)
phosphate ion homeostasis  (IEA,ISO)
phosphate ion transmembrane transport  (IMP)
phosphate ion transport  (IEA,ISO)
positive regulation of membrane potential  (IDA,IMP)
positive regulation of phosphate transmembrane transport  (IDA)
positive regulation of sodium-dependent phosphate transport  (IDA,IEP,IMP)
response to cadmium ion  (IEA,ISO)
response to estradiol  (IEP)
response to growth hormone  (IEP)
response to lead ion  (IEA,ISO)
response to magnesium ion  (IEP)
response to mercury ion  (IEA,ISO)
response to nutrient  (IEP)
response to parathyroid hormone  (IEP)
response to peptide  (IEP)
response to peptide hormone  (IEP)
response to potassium ion  (IEP)
response to sodium phosphate  (ISO)
response to thyroid hormone  (IEP)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEP)
sodium ion import across plasma membrane  (IDA)
sodium ion transport  (IEA)
sodium-dependent phosphate transport  (IBA,IEA,IEP)
tricarboxylic acid metabolic process  (IEP)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of thyroid hormone in regulation of renal phosphate transport in young and aged rats. Alcalde AI, etal., Endocrinology. 1999 Apr;140(4):1544-51.
2. The renal Na+/phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone. Bacic D, etal., Kidney Int. 2006 Feb;69(3):495-503.
3. Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities. Beck L, etal., Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5372-7.
4. Differential Regulation of the Renal Sodium/Phosphate Co-Transporters NaPi-IIa, NaPi-IIc and PiT-2 in Dietary Potassium Deficiency. Breusegem SY, etal., Am J Physiol Renal Physiol. 2009 Jun 3.
5. Renal calcification in mice homozygous for the disrupted type IIa Na/Pi cotransporter gene Npt2. Chau H, etal., J Bone Miner Res. 2003 Apr;18(4):644-57.
6. Downregulation of NaPi-IIa and NaPi-IIb Na-coupled phosphate transporters by coexpression of Klotho. Dermaku-Sopjani M, etal., Cell Physiol Biochem. 2011;28(2):251-8. doi: 10.1159/000331737. Epub 2011 Aug 16.
7. Regulation of NaPi-IIa mRNA and transporter protein in chronic renal failure: role of parathyroid hormone (PTH) and dietary phosphate (Pi). Elhalel MD, etal., Pflugers Arch. 2004 Dec;449(3):265-70.
8. Estrogen downregulates the proximal tubule type IIa sodium phosphate cotransporter causing phosphate wasting and hypophosphatemia. Faroqui S, etal., Kidney Int. 2008 May;73(10):1141-50. doi: 10.1038/ki.2008.33. Epub 2008 Feb 27.
9. Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters. Forster IC, etal., Am J Physiol. 1999 Apr;276(4):F644-9. doi: 10.1152/ajprenal.1999.276.4.F644.
10. Protein kinase C activators induce membrane retrieval of type II Na+-phosphate cotransporters expressed in Xenopus oocytes. Forster IC, etal., J Physiol. 1999 Jun 1;517 ( Pt 2):327-40.
11. FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Gattineni J, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F282-91. doi: 10.1152/ajprenal.90742.2008. Epub 2009 Jun 10.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex. Hioki H, etal., Neuroscience 2003;117(1):1-6.
15. Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule. Hu MC, etal., FASEB J. 2010 Sep;24(9):3438-50. doi: 10.1096/fj.10-154765. Epub 2010 May 13.
16. Partitioning of NaPi cotransporter in cholesterol-, sphingomyelin-, and glycosphingolipid-enriched membrane domains modulates NaPi protein diffusion, clustering, and activity. Inoue M, etal., J Biol Chem. 2004 Nov 19;279(47):49160-71. Epub 2004 Sep 7.
17. A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. Iwaki T, etal., J Am Soc Nephrol. 2008 Sep;19(9):1753-62. doi: 10.1681/ASN.2007121360. Epub 2008 Jun 11.
18. Type 2a sodium-phosphate co-transporter serves as a histological predictor of renal dysfunction and tubular apical damage in the kidneys of septic mice. Kamimoto M, etal., Biomed Res. 2009 Aug;30(4):251-8.
19. Effects of receptor-mediated endocytosis and tubular protein composition on volume retention in experimental glomerulonephritis. Kastner C, etal., Am J Physiol Renal Physiol. 2009 Apr;296(4):F902-11. doi: 10.1152/ajprenal.90451.2008. Epub 2009 Feb 4.
20. Acute regulation by dietary phosphate of the sodium-dependent phosphate transporter (NaP(i)-2) in rat kidney. Katai K, etal., J Biochem. 1997 Jan;121(1):50-5. doi: 10.1093/oxfordjournals.jbchem.a021569.
21. Akt2/PKBbeta-sensitive regulation of renal phosphate transport. Kempe DS, etal., Acta Physiol (Oxf). 2010 Sep;200(1):75-85. doi: 10.1111/j.1748-1716.2010.02109.x. Epub 2010 Mar 17.
22. Ultrastructural investigation of crystal deposits in Npt2a knockout mice: are they similar to human Randall's plaques? Khan SR and Canales BK, J Urol. 2011 Sep;186(3):1107-13. doi: 10.1016/j.juro.2011.04.109. Epub 2011 Jul 23.
23. Calcium oxalate crystal deposition in kidneys of hypercalciuric mice with disrupted type IIa sodium-phosphate cotransporter. Khan SR and Glenton PA, Am J Physiol Renal Physiol. 2008 May;294(5):F1109-15. doi: 10.1152/ajprenal.00620.2007. Epub 2008 Mar 12.
24. Identification of functionally important sites in the first intracellular loop of the NaPi-IIa cotransporter. Kohler K, etal., Am J Physiol Renal Physiol. 2002 Apr;282(4):F687-96.
25. Essential cysteine residues of the type IIa Na+/Pi cotransporter. Kohler K, etal., Pflugers Arch. 2003 May;446(2):203-10. Epub 2003 Mar 26.
26. New loci associated with kidney function and chronic kidney disease. Kottgen A, etal., Nat Genet. 2010 May;42(5):376-84. doi: 10.1038/ng.568. Epub 2010 Apr 11.
27. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
28. Cysteine residues and the structure of the rat renal proximal tubular type II sodium phosphate cotransporter (rat NaPi IIa). Lambert G, etal., J Membr Biol. 2000 Jul 15;176(2):133-41.
29. Cleavage of disulfide bonds leads to inactivation and degradation of the type IIa, but not type IIb sodium phosphate cotransporter expressed in Xenopus laevis oocytes. Lambert G, etal., J Membr Biol. 2000 Jul 15;176(2):143-9.
30. Studies on the topology of the renal type II NaPi-cotransporter. Lambert G, etal., Pflugers Arch. 1999 May;437(6):972-8.
31. Hereditary hypophosphatemic rickets with hypercalciuria is caused by mutations in the sodium-phosphate cotransporter gene SLC34A3. Lorenz-Depiereux B, etal., Am J Hum Genet. 2006 Feb;78(2):193-201. Epub 2005 Dec 9.
32. Rapid downregulation of rat renal Na/P(i) cotransporter in response to parathyroid hormone involves microtubule rearrangement. Lotscher M, etal., J Clin Invest. 1999 Aug;104(4):483-94.
33. Type II Na+-Pi cotransporters in osteoblast mineral formation: regulation by inorganic phosphate. Lundquist P, etal., Cell Physiol Biochem. 2007;19(1-4):43-56.
34. Phosphate and calcium uptake by rat odontoblast-like MRPC-1 cells concomitant with mineralization. Lundquist P, etal., J Bone Miner Res. 2002 Oct;17(10):1801-13.
35. Regulation of rat renal Na/Pi-cotransporter by parathyroid hormone: immunohistochemistry. Lötscher M, etal., Kidney Int. 1996 Apr;49(4):1010-1. doi: 10.1038/ki.1996.145.
36. Expression cloning of human and rat renal cortex Na/Pi cotransport. Magagnin S, etal., Proc Natl Acad Sci U S A 1993 Jul 1;90(13):5979-83.
37. A loss-of-function mutation in NaPi-IIa and renal Fanconi's syndrome. Magen D, etal., N Engl J Med. 2010 Mar 25;362(12):1102-9. doi: 10.1056/NEJMoa0905647.
38. Matrix extracellular phosphoglycoprotein inhibits phosphate transport. Marks J, etal., J Am Soc Nephrol. 2008 Dec;19(12):2313-20. doi: 10.1681/ASN.2008030315. Epub 2008 Nov 12.
39. Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors. Masuda M, etal., Biochem J. 2010 Aug 1;429(3):583-92. doi: 10.1042/BJ20100484.
40. Shank2E binds NaP(i) cotransporter at the apical membrane of proximal tubule cells. McWilliams RR, etal., Am J Physiol Cell Physiol. 2005 Oct;289(4):C1042-51. Epub 2005 May 25.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. The pathophysiology of early-stage chronic kidney disease-mineral bone disorder (CKD-MBD) and response to phosphate binders in the rat. Moe SM, etal., J Bone Miner Res. 2011 Nov;26(11):2672-81. doi: 10.1002/jbmr.485.
43. Thyroid hormone deficiency alters expression of acid-base transporters in rat kidney. Mohebbi N, etal., Am J Physiol Renal Physiol. 2007 Jul;293(1):F416-27. Epub 2007 Apr 4.
44. The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. Mohebbi N, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
45. Role of the sodium-dependent phosphate co-transporters and of the phosphate complexes of uranyl in the cytotoxicity of uranium in LLC-PK1 cells. Muller D, etal., Toxicol Appl Pharmacol. 2006 Jul 15;214(2):166-77. Epub 2006 Feb 14.
46. Overexpression of regucalcin enhances its nuclear localization and suppresses L-type Ca2+ channel and calcium-sensing receptor mRNA expressions in cloned normal rat kidney proximal tubular epithelial NRK52E cells. Nakagawa T and Yamaguchi M, J Cell Biochem. 2006 Nov 1;99(4):1064-77.
47. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. Nakatani T, etal., FASEB J. 2009 Feb;23(2):433-41. doi: 10.1096/fj.08-114397. Epub 2008 Oct 3.
48. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
49. Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption. Nowik M, etal., Pflugers Arch. 2008 Nov;457(2):539-49. doi: 10.1007/s00424-008-0530-5. Epub 2008 Jun 6.
50. Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging. Ohnishi M and Razzaque MS, FASEB J. 2010 Sep;24(9):3562-71. doi: 10.1096/fj.09-152488. Epub 2010 Apr 23.
51. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
52. Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters. Picard N, etal., Pflugers Arch. 2010 Aug;460(3):677-87. doi: 10.1007/s00424-010-0841-1. Epub 2010 Jun 5.
53. Phosphate handling: new genes, new molecules. Prie D, etal., Horm Res Paediatr. 2011;76 Suppl 1:71-5. doi: 10.1159/000329175. Epub 2011 Jul 21.
54. P-glycoprotein inhibitors stimulate renal phosphate reabsorption in rats. Prie D, etal., Kidney Int. 2001 Sep;60(3):1069-76.
55. GOA pipeline RGD automated data pipeline
56. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
57. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
58. Effects of phosphate intake on distribution of type II Na/Pi cotransporter mRNA in rat kidney. Ritthaler T, etal., Kidney Int. 1999 Mar;55(3):976-83.
59. Regulation of the renal sodium-dependent phosphate cotransporter NaPi2 (Npt2) in acute renal failure due to ischemia and reperfusion. Rubinger D, etal., Nephron Physiol. 2005;100(1):p1-12. Epub 2005 Mar 17.
60. Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter. Segawa H, etal., Am J Physiol Renal Physiol. 2007 Jan;292(1):F395-403. Epub 2006 Sep 19.
61. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Segawa H, etal., Am J Physiol Renal Physiol. 2009 Sep;297(3):F671-8. doi: 10.1152/ajprenal.00156.2009. Epub 2009 Jul 1.
62. Growth-related renal type II Na/Pi cotransporter. Segawa H, etal., J Biol Chem 2002 May 31;277(22):19665-72. Epub 2002 Mar 5.
63. Gentamicin causes endocytosis of Na/Pi cotransporter protein (NaPi-2). Sorribas V, etal., Kidney Int. 2001 Mar;59(3):1024-36.
64. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
65. Effects of dietary Pi on the renal Na+-dependent Pi transporter NaPi-2 in thyroparathyroidectomized rats. Takahashi F, etal., Biochem J. 1998 Jul 1;333 ( Pt 1):175-81.
66. Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. Tanimura A, etal., J Med Invest. 2011 Feb;58(1-2):140-7.
67. Identification of three isoforms for the Na+-dependent phosphate cotransporter (NaPi-2) in rat kidney. Tatsumi S, etal., J Biol Chem 1998 Oct 30;273(44):28568-75.
68. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
69. Magnesium stimulates renal phosphate reabsorption. Thumfart J, etal., Am J Physiol Renal Physiol. 2008 Oct;295(4):F1126-33. Epub 2008 Aug 13.
70. Distribution of the sodium/phosphate transporter during postnatal ontogeny of the rat kidney. Traebert M, etal., J Am Soc Nephrol. 1999 Jul;10(7):1407-15.
71. A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1. Urabe Y, etal., PLoS Genet. 2012;8(3):e1002541. doi: 10.1371/journal.pgen.1002541. Epub 2012 Mar 1.
72. Arsenate transport by sodium/phosphate cotransporter type IIb. Villa-Bellosta R and Sorribas V, Toxicol Appl Pharmacol. 2010 Aug 15;247(1):36-40. doi: 10.1016/j.taap.2010.05.012. Epub 2010 May 25.
73. Altered expression of type II sodium/phosphate cotransporter in polycystic kidney disease. Vogel M, etal., J Am Soc Nephrol. 2000 Oct;11(10):1926-32.
74. Regulation of renal NaPi-2 expression and tubular phosphate reabsorption by growth hormone in the juvenile rat. Woda CB, etal., Am J Physiol Renal Physiol. 2004 Jul;287(1):F117-23. Epub 2004 Mar 2.
75. Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO. Xiao L, etal., J Biol Chem. 2010 Jan 22;285(4):2834-46. doi: 10.1074/jbc.M109.030577. Epub 2009 Nov 20.
76. Involvement of disulphide bonds in the renal sodium/phosphate co-transporter NaPi-2. Xiao Y, etal., Biochem J. 1997 Apr 15;323 ( Pt 2):401-8.
77. Effects of angiotensin II on NaPi-IIa co-transporter expression and activity in rat renal cortex. Xu L, etal., Biochim Biophys Acta. 2004 Dec 15;1667(2):114-21.
78. Effects of phosphonoformic acid and renagel on renal type IIa sodium-dependent phosphate cotransporter mRNA expression in hyperphosphatemia rats. Zeng M, etal., Ren Fail. 2012;34(3):358-63. doi: 10.3109/0886022X.2011.647341. Epub 2012 Jan 20.
Additional References at PubMed
PMID:8898024   PMID:9465116   PMID:9530108   PMID:12606316   PMID:12851820   PMID:15489334   PMID:15618618   PMID:16710700   PMID:17206517   PMID:17574207   PMID:20119884   PMID:20810910  
PMID:23344572   PMID:23509734   PMID:23816829   PMID:23863468   PMID:24500689   PMID:25608964   PMID:26047794   PMID:26460967   PMID:26782594   PMID:30696771   PMID:32853180  


Genomics

Comparative Map Data
Slc34a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,224,010 - 9,238,983 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl179,224,010 - 9,238,983 (-)EnsemblGRCr8
mRatBN7.2179,218,876 - 9,233,852 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,218,876 - 9,233,852 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx179,234,994 - 9,250,089 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,765,022 - 10,780,032 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,231,384 - 9,246,479 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,747,766 - 9,762,739 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,747,752 - 9,762,813 (-)Ensemblrn6Rnor6.0
Rnor_5.01711,856,946 - 11,872,100 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41715,262,929 - 15,277,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera179,297,383 - 9,312,355 (-)NCBICelera
RGSC_v3.11715,262,928 - 15,277,902 (-)NCBI
RH 3.4 Map1781.4RGD
Cytogenetic Map17p14NCBI
SLC34A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,384,434 - 177,398,848 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,379,235 - 177,398,848 (+)Ensemblhg38GRCh38
GRCh375176,811,435 - 176,825,849 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,744,041 - 176,758,455 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345176,744,060 - 176,758,454NCBI
Celera5171,675,605 - 171,689,835 (-)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,732,061 - 171,746,276 (+)NCBIHuRef
CHM1_15176,244,481 - 176,258,897 (+)NCBICHM1_1
T2T-CHM13v2.05177,927,652 - 177,942,066 (+)NCBIT2T-CHM13v2.0
Slc34a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,547,435 - 55,562,508 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,546,000 - 55,563,405 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381355,399,622 - 55,414,695 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,398,187 - 55,415,592 (+)Ensemblmm10GRCm38
MGSCv371355,501,009 - 55,516,056 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361355,409,326 - 55,423,713 (+)NCBIMGSCv36mm8
Celera1356,453,307 - 56,468,818 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1329.81NCBI
Slc34a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,626,775 - 29,640,875 (+)Ensembl
ChiLan1.0NW_00495540829,626,775 - 29,640,811 (+)NCBIChiLan1.0ChiLan1.0
SLC34A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,468,456 - 172,483,032 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,607,995 - 170,622,571 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,685,862 - 172,700,440 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,748,492 - 179,762,804 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,748,492 - 179,762,975 (+)EnsemblpanPan2panpan1.1
SLC34A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,961,394 - 35,973,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,961,958 - 35,973,657 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha435,928,819 - 35,941,165 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0436,327,621 - 36,339,965 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,328,185 - 36,339,882 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,152,845 - 36,165,191 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,339,065 - 36,351,380 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,848,297 - 36,860,641 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc34a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,642,609 - 122,659,626 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365971,667,569 - 1,684,539 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365971,667,700 - 1,684,533 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC34A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,548,232 - 80,563,321 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1280,548,208 - 80,563,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SLC34A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,395,923 - 79,410,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,396,250 - 79,411,695 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607510,585,375 - 10,600,418 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc34a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,685,546 - 12,699,901 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473312,685,544 - 12,699,908 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc34a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11473,720,109 - 73,735,143 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc34a1
62 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:43
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000033749
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
Slc34a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2179,218,991 - 9,219,155 (+)MAPPERmRatBN7.2
Rnor_6.0179,747,882 - 9,748,045NCBIRnor6.0
Rnor_5.01711,857,062 - 11,857,225UniSTSRnor5.0
RGSC_v3.41715,263,045 - 15,263,208UniSTSRGSC3.4
Celera179,297,499 - 9,297,662UniSTS
RH 3.4 Map1781.4UniSTS
Cytogenetic Map17p14UniSTS


Genetic Models
This gene Slc34a1 is modified in the following models/strains:
SS-Slc34a1em1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
5 8 18 95 46 46 24 52 24 2 198 80 1 83 81 57 22 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000033749   ⟹   ENSRNOP00000031764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl179,224,010 - 9,238,983 (-)Ensembl
mRatBN7.2 Ensembl179,218,876 - 9,233,852 (-)Ensembl
Rnor_6.0 Ensembl179,747,752 - 9,762,813 (-)Ensembl
RefSeq Acc Id: NM_013030   ⟹   NP_037162
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8179,224,010 - 9,238,983 (-)NCBI
mRatBN7.2179,218,876 - 9,233,852 (-)NCBI
Rnor_6.0179,747,766 - 9,762,739 (-)NCBI
Rnor_5.01711,856,946 - 11,872,100 (-)NCBI
RGSC_v3.41715,262,929 - 15,277,902 (-)RGD
Celera179,297,383 - 9,312,355 (-)RGD
Sequence:
RefSeq Acc Id: NP_037162   ⟸   NM_013030
- UniProtKB: Q06496 (UniProtKB/Swiss-Prot),   A6KAT2 (UniProtKB/TrEMBL),   A6KAT1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031764   ⟸   ENSRNOT00000033749

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06496-F1-model_v2 AlphaFold Q06496 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700308
Promoter ID:EPDNEW_R10831
Type:single initiation site
Name:Slc34a1_1
Description:solute carrier family 34 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0179,762,750 - 9,762,810EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3708 AgrOrtholog
BioCyc Gene G2FUF-10202 BioCyc
Ensembl Genes ENSRNOG00000015262 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033749 ENTREZGENE
  ENSRNOT00000033749.6 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109613 IMAGE-MGC_LOAD
InterPro Na/Pi_transpt UniProtKB/Swiss-Prot
KEGG Report rno:25548 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93556 IMAGE-MGC_LOAD
NCBI Gene 25548 ENTREZGENE
PANTHER PTHR10010 UniProtKB/Swiss-Prot
  PTHR10010:SF21 UniProtKB/Swiss-Prot
Pfam Na_Pi_cotrans UniProtKB/Swiss-Prot
PhenoGen Slc34a1 PhenoGen
RatGTEx ENSRNOG00000015262 RatGTEx
TIGR TC204997
UniProt A6KAT1 ENTREZGENE, UniProtKB/TrEMBL
  A6KAT2 ENTREZGENE, UniProtKB/TrEMBL
  A6KAT3_RAT UniProtKB/TrEMBL
  A6KAT4_RAT UniProtKB/TrEMBL
  NPT2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-11-26 Slc34a1  solute carrier family 34 (type II sodium/phosphate cotransporter), member 1  Slc34a1  solute carrier family 34 (type II sodium/phosphate contransporter), member 1  Name changed 629549 APPROVED
2004-09-10 Slc34a1  solute carrier family 34 (sodium phosphate), member 1    solute carrier family 34, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc34a1  solute carrier family 34, member 1    Solute carrier family 34 (sodium phosphate), member 1  Name updated 629478 APPROVED
2001-06-22 Slc34a1  Solute carrier family 34 (sodium phosphate), member 1      Name updated 67952 APPROVED
2001-06-22 Slc17a2  Solute carrier family 17 (sodium/hydrogen exchanger), member 2      Symbol withdrawn, duplicate of Slc34a1 (RGD:3708) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_domains protein contains 3 putative transmembrane domains 730045
gene_expression mRNA expressed in kidney 730120
gene_process may be involved with sodium/phosphate cotransport in the renal brush border 730120
gene_protein predicted protein contains 337 aa residues and masses 36 kDa 730045