Slc1a1 (solute carrier family 1 member 1) - Rat Genome Database

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Gene: Slc1a1 (solute carrier family 1 member 1) Rattus norvegicus
Analyze
Symbol: Slc1a1
Name: solute carrier family 1 member 1
RGD ID: 3696
Description: Enables amino acid transmembrane transporter activity; glutamate binding activity; and identical protein binding activity. Involved in L-glutamate transmembrane transport. Acts upstream of or within cellular response to hypoxia. Located in several cellular components, including dendrite; perikaryon; and perisynaptic space. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Eaac1; Eaat3; excitatory amino acid carrier 1; excitatory amino acid transporter 3; excitatory amino acid transporter-3; excitatory amino-acid carrier 1; REAAC1; sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1; Solute carrier family 1 A1 (brain glutamate transporter); solute carrier family 1, member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81235,963,455 - 236,043,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1235,963,437 - 236,045,469 (+)EnsemblGRCr8
mRatBN7.21226,549,932 - 226,631,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,549,842 - 226,630,402 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1234,954,243 - 235,033,486 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,883,904 - 241,963,149 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,707,753 - 234,788,324 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,955,017 - 247,035,159 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,954,980 - 247,037,056 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,195,480 - 254,274,919 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,469,746 - 232,549,584 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,704,163 - 223,782,895 (+)NCBICelera
RGSC_v3.11232,633,737 - 232,715,504 (+)NCBI
Cytogenetic Map1q52NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3alpha-hydroxy-5beta-pregnan-20-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonia  (EXP)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (EXP)
arsenite(3-)  (ISO)
astemizole  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP)
caffeine  (EXP)
calcitriol  (ISO)
Calphostin C  (EXP)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
chelerythrine  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clozapine  (EXP)
cobalt dichloride  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diallyl disulfide  (ISO)
Diallyl sulfide  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
diphenyl diselenide  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fonofos  (ISO)
fulvestrant  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP)
Ibotenic acid  (EXP)
ivermectin  (ISO)
kainic acid  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP)
lipoic acid  (EXP)
LY294002  (EXP)
menadione  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (EXP,ISO)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nicotine  (EXP)
okadaic acid  (ISO)
paclitaxel  (EXP)
panobinostat  (ISO)
paracetamol  (EXP)
paraoxon  (EXP)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
pregabalin  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
profenofos  (EXP)
progesterone  (EXP,ISO)
propofol  (EXP)
resveratrol  (EXP)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
staurosporine  (EXP)
sunitinib  (ISO)
tamibarotene  (EXP)
terbufos  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
thallium atom  (EXP)
thimerosal  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
WIN 55212-2  (EXP)
wortmannin  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zonisamide  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase B activity  (ISO)
adult behavior  (IEA,ISO)
amino acid transport  (IEA)
behavioral fear response  (ISO)
blood vessel morphogenesis  (ISO)
brain development  (IEA,ISO)
cellular response to ammonium ion  (ISO)
cellular response to bisphenol A  (ISO)
cellular response to cocaine  (IEA,ISO)
cellular response to hypoxia  (IDA)
cellular response to mercury ion  (ISO)
cellular response to oxidative stress  (ISO)
chloride transmembrane transport  (IEA,ISO,ISS)
conditioned place preference  (IEA,ISO)
cysteine transmembrane transport  (IEA,ISO)
cysteine transport  (IEA,ISO,ISS)
cytokine-mediated signaling pathway  (IEA,ISO)
D-aspartate import across plasma membrane  (IEA,ISO)
D-aspartate transmembrane transport  (IEA,ISO)
dopamine metabolic process  (IEA,ISO)
establishment of protein localization  (ISO)
G protein-coupled dopamine receptor signaling pathway  (IEA,ISO)
gene expression  (IEA,ISO)
glutamate receptor signaling pathway  (IEA,ISO)
glutathione biosynthetic process  (IEA,ISO)
glutathione metabolic process  (ISO)
grooming behavior  (IEA,ISO)
heart contraction  (ISO)
intracellular glutamate homeostasis  (ISO)
intracellular zinc ion homeostasis  (IEA,ISO)
L-aspartate import across plasma membrane  (IEA,ISO,ISS)
L-aspartate transmembrane transport  (IEA,ISO)
L-glutamate import  (IEA,ISO)
L-glutamate import across plasma membrane  (IEA,ISO,ISS)
L-glutamate transmembrane transport  (IBA,IDA,IEA,ISO)
learning or memory  (ISO)
locomotory behavior  (IEA,ISO)
long-term synaptic potentiation  (ISO)
maintenance of blood-brain barrier  (ISO)
memory  (IEA,ISO)
motor behavior  (IEA,ISO)
motor neuron apoptotic process  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
neurogenesis  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neurotransmitter receptor transport to plasma membrane  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of heart rate  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of protein phosphorylation  (ISO)
regulation of protein targeting to membrane  (ISO)
response to amphetamine  (IEA,ISO)
response to anesthetic  (ISO)
response to axon injury  (ISO)
response to decreased oxygen levels  (ISO)
response to morphine  (IEA,ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (IEA,ISO)
retina layer formation  (ISO)
righting reflex  (ISO)
superoxide metabolic process  (IEA,ISO)
synapse organization  (IEA,ISO)
zinc ion transmembrane transport  (IEA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and expression of a neuronal rat brain glutamate transporter. Bjoras M, etal., Brain Res Mol Brain Res 1996 Feb;36(1):163-8.
2. Association of excitatory amino acid transporters, especially EAAT2, with cholesterol-rich lipid raft microdomains: importance for excitatory amino acid transporter localization and function. Butchbach ME, etal., J Biol Chem. 2004 Aug 13;279(33):34388-96. doi: 10.1074/jbc.M403938200. Epub 2004 Jun 8.
3. EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex. Conti F, etal., Cereb Cortex. 1998 Mar;8(2):108-16. doi: 10.1093/cercor/8.2.108.
4. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. Furuta A, etal., J Neurosci. 1997 Nov 1;17(21):8363-75.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1. Gonzalez MI, etal., J Neurochem. 2005 Sep;94(5):1180-8. Epub 2005 Jul 25.
8. Constitutive endocytosis and recycling of the neuronal glutamate transporter, excitatory amino acid carrier 1. González MI, etal., J Neurochem. 2007 Dec;103(5):1917-31. doi: 10.1111/j.1471-4159.2007.04881.x. Epub 2007 Sep 14.
9. Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other. Grewer C, etal., Biochemistry. 2005 Sep 6;44(35):11913-23.
10. Is the glutamate residue Glu-373 the proton acceptor of the excitatory amino acid carrier 1? Grewer C, etal., J Biol Chem 2003 Jan 24;278(4):2585-92.
11. Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus. He Y, etal., J Comp Neurol. 2000 Mar 13;418(3):255-69.
12. Altered expression of glutamate transporters under hypoxic conditions in vitro. Hsu L, etal., J Neurosci Res. 2001 Apr 15;64(2):193-202. doi: 10.1002/jnr.1065.
13. Neuronal high-affinity glutamate transport in the rat central nervous system. Kanai Y, etal., Neuroreport 1995 Nov 27;6(17):2357-62.
14. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. Liu Y, etal., J Biol Chem. 2008 Mar 7;283(10):6561-71. doi: 10.1074/jbc.M708096200. Epub 2007 Dec 20.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Excitatory Amino Acid Transporter 1-Mediated L-Glutamate Transport at the Inner Blood-Retinal Barrier: Possible Role in L-Glutamate Elimination from the Retina. Sakurai T, etal., Biol Pharm Bull. 2015;38(7):1087-91. doi: 10.1248/bpb.b15-00226.
24. Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Sari Y, etal., Neuroscience. 2016 Jun 21;326:117-125. doi: 10.1016/j.neuroscience.2016.04.004. Epub 2016 Apr 7.
25. Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody. Shashidharan P, etal., Brain Res. 1997 Oct 31;773(1-2):139-48. doi: 10.1016/s0006-8993(97)00921-9.
26. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
27. Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Ubhi K, etal., Eur J Neurosci. 2014 Mar;39(6):1026-41. doi: 10.1111/ejn.12444. Epub 2013 Dec 5.
28. Localization and possible function of the glutamate transporter, EAAC1, in the rat retina. Wiessner M, etal., Cell Tissue Res 2002 Oct;310(1):31-40.
29. Neuregulin 1 Controls Glutamate Uptake by Up-regulating Excitatory Amino Acid Carrier 1 (EAAC1). Yu HN, etal., J Biol Chem. 2015 Aug 14;290(33):20233-44. doi: 10.1074/jbc.M114.591867. Epub 2015 Jun 19.
Additional References at PubMed
PMID:7521911   PMID:7914198   PMID:8613726   PMID:8738164   PMID:8772431   PMID:8857541   PMID:11242046   PMID:12119102   PMID:12123836   PMID:12151387   PMID:12237337   PMID:12620282  
PMID:12843260   PMID:12875997   PMID:12923633   PMID:15009636   PMID:15197183   PMID:15489334   PMID:15736956   PMID:15737330   PMID:15914650   PMID:16368696   PMID:16417946   PMID:16442237  
PMID:16478724   PMID:16516346   PMID:16538232   PMID:16566829   PMID:16723357   PMID:16858406   PMID:16959903   PMID:17389249   PMID:17459877   PMID:17715130   PMID:17854777   PMID:18056970  
PMID:18079058   PMID:18400334   PMID:18671901   PMID:19056867   PMID:19804828   PMID:19843789   PMID:19922365   PMID:20378543   PMID:20493242   PMID:20521381   PMID:21123949   PMID:21127051  
PMID:21185901   PMID:21233495   PMID:22479505   PMID:22540959   PMID:22578356   PMID:23356950   PMID:23361868   PMID:23694703   PMID:24355585   PMID:25350110   PMID:25839761   PMID:26037264  
PMID:26599339   PMID:26690923   PMID:26790351   PMID:27358480   PMID:27507301   PMID:29350434   PMID:30840898   PMID:32827867   PMID:33550531  


Genomics

Comparative Map Data
Slc1a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81235,963,455 - 236,043,572 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1235,963,437 - 236,045,469 (+)EnsemblGRCr8
mRatBN7.21226,549,932 - 226,631,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1226,549,842 - 226,630,402 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1234,954,243 - 235,033,486 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01241,883,904 - 241,963,149 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,707,753 - 234,788,324 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01246,955,017 - 247,035,159 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1246,954,980 - 247,037,056 (+)Ensemblrn6Rnor6.0
Rnor_5.01254,195,480 - 254,274,919 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41232,469,746 - 232,549,584 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1223,704,163 - 223,782,895 (+)NCBICelera
RGSC_v3.11232,633,737 - 232,715,504 (+)NCBI
Cytogenetic Map1q52NCBI
SLC1A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3894,490,468 - 4,587,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl94,490,225 - 4,587,469 (+)Ensemblhg38GRCh38
GRCh3794,490,468 - 4,587,469 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3694,480,444 - 4,577,469 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3494,480,439 - 4,577,258NCBI
Celera94,412,118 - 4,509,171 (+)NCBICelera
Cytogenetic Map9p24.2NCBI
HuRef94,445,524 - 4,542,606 (+)NCBIHuRef
CHM1_194,490,396 - 4,587,442 (+)NCBICHM1_1
T2T-CHM13v2.094,494,107 - 4,591,140 (+)NCBIT2T-CHM13v2.0
Slc1a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391928,812,535 - 28,891,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1928,812,449 - 28,891,360 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381928,835,135 - 28,913,960 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1928,835,049 - 28,913,960 (+)Ensemblmm10GRCm38
MGSCv371928,909,656 - 28,988,450 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361928,901,163 - 28,979,957 (+)NCBIMGSCv36mm8
Celera1929,610,074 - 29,689,176 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.5NCBI
Slc1a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554348,790,685 - 8,879,757 (+)Ensembl
ChiLan1.0NW_0049554348,790,685 - 8,879,757 (+)NCBIChiLan1.0ChiLan1.0
SLC1A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211119,970,573 - 120,068,724 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,977,375 - 120,074,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v094,323,124 - 4,420,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.194,511,491 - 4,608,337 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl94,511,491 - 4,608,337 (+)EnsemblpanPan2panpan1.1
SLC1A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1192,898,274 - 92,978,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl192,898,274 - 92,978,260 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha193,370,688 - 93,450,612 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0193,451,994 - 93,532,207 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl193,451,891 - 93,532,204 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,083,822 - 93,163,810 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0192,807,174 - 92,887,351 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0193,572,134 - 93,652,376 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947140,482,449 - 140,559,751 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936503613,223 - 690,721 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936503613,250 - 690,555 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC1A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1217,366,499 - 217,441,674 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11217,366,493 - 217,441,643 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21243,230,452 - 243,270,312 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC1A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11274,949,560 - 75,041,455 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,949,028 - 75,041,369 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603863,278,537 - 63,371,858 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc1a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247369,246,262 - 9,325,485 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247369,246,348 - 9,325,671 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc1a1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1228,896,050 - 28,976,447 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc1a1
495 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:200
Count of miRNA genes:146
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000020272
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6480786Bw97Body weight QTL 975.03body mass (VT:0001259)body weight (CMO:0000012)1234540191237018045Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH130525  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,631,740 - 226,631,924 (+)MAPPERmRatBN7.2
Rnor_6.01247,036,873 - 247,037,056NCBIRnor6.0
Rnor_5.01254,276,633 - 254,276,816UniSTSRnor5.0
RGSC_v3.41232,551,298 - 232,551,481UniSTSRGSC3.4
Celera1223,784,609 - 223,784,792UniSTS
RH 3.4 Map11614.8UniSTS
Cytogenetic Map1q52UniSTS
BE120573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,629,825 - 226,629,978 (+)MAPPERmRatBN7.2
Rnor_6.01247,034,958 - 247,035,110NCBIRnor6.0
Rnor_5.01254,274,718 - 254,274,870UniSTSRnor5.0
RGSC_v3.41232,549,383 - 232,549,535UniSTSRGSC3.4
Celera1223,782,694 - 223,782,846UniSTS
RH 3.4 Map11651.4UniSTS
Cytogenetic Map1q52UniSTS
BF399845  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,551,852 - 226,552,026 (+)MAPPERmRatBN7.2
Rnor_6.01246,956,938 - 246,957,111NCBIRnor6.0
Rnor_5.01254,197,401 - 254,197,574UniSTSRnor5.0
RGSC_v3.41232,471,667 - 232,471,840UniSTSRGSC3.4
Celera1223,706,084 - 223,706,257UniSTS
RH 3.4 Map11612.4UniSTS
Cytogenetic Map1q52UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 67 66 35 79 35 6 331 179 11 145 93 98 31 18 18

Sequence


Ensembl Acc Id: ENSRNOT00000020272   ⟹   ENSRNOP00000020272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1235,963,437 - 236,043,946 (+)Ensembl
mRatBN7.2 Ensembl1226,549,842 - 226,630,401 (+)Ensembl
Rnor_6.0 Ensembl1246,954,980 - 247,037,056 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099702   ⟹   ENSRNOP00000096736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1235,963,437 - 236,045,469 (+)Ensembl
mRatBN7.2 Ensembl1226,550,021 - 226,630,402 (+)Ensembl
RefSeq Acc Id: NM_013032   ⟹   NP_037164
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81235,963,455 - 236,043,572 (+)NCBI
mRatBN7.21226,549,932 - 226,630,027 (+)NCBI
Rnor_6.01246,955,017 - 247,035,159 (+)NCBI
Rnor_5.01254,195,480 - 254,274,919 (+)NCBI
RGSC_v3.41232,469,746 - 232,549,584 (+)RGD
Celera1223,704,163 - 223,782,895 (+)RGD
Sequence:
RefSeq Acc Id: NP_037164   ⟸   NM_013032
- UniProtKB: Q63727 (UniProtKB/Swiss-Prot),   O88389 (UniProtKB/Swiss-Prot),   Q9JJP8 (UniProtKB/Swiss-Prot),   P51907 (UniProtKB/Swiss-Prot),   A6I0U4 (UniProtKB/TrEMBL),   A0A8I6AVI3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020272   ⟸   ENSRNOT00000020272
Ensembl Acc Id: ENSRNOP00000096736   ⟸   ENSRNOT00000099702

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51907-F1-model_v2 AlphaFold P51907 1-523 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690839
Promoter ID:EPDNEW_R1363
Type:single initiation site
Name:Slc1a1_1
Description:solute carrier family 1 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01246,954,999 - 246,955,059EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3696 AgrOrtholog
BioCyc Gene G2FUF-55991 BioCyc
Ensembl Genes ENSRNOG00000014816 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020272.8 UniProtKB/Swiss-Prot
  ENSRNOT00000099702 ENTREZGENE
Gene3D-CATH 1.10.3860.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599027 IMAGE-MGC_LOAD
InterPro DAACS UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter UniProtKB/Swiss-Prot
  Na-dicarboxylate_symporter_CS UniProtKB/Swiss-Prot
  Na:dicarbo_symporter_sf UniProtKB/Swiss-Prot
KEGG Report rno:25550 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72260 IMAGE-MGC_LOAD
NCBI Gene 25550 ENTREZGENE
PANTHER EXCITATORY AMINO ACID TRANSPORTER 3 UniProtKB/Swiss-Prot
  SODIUM/DICARBOXYLATE SYMPORTER-RELATED UniProtKB/Swiss-Prot
Pfam SDF UniProtKB/Swiss-Prot
PhenoGen Slc1a1 PhenoGen
PRINTS EDTRNSPORT UniProtKB/Swiss-Prot
PROSITE NA_DICARBOXYL_SYMP_1 UniProtKB/Swiss-Prot
  NA_DICARBOXYL_SYMP_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014816 RatGTEx
Superfamily-SCOP SSF118215 UniProtKB/Swiss-Prot
UniProt A0A8I6AVI3 ENTREZGENE, UniProtKB/TrEMBL
  A6I0U4 ENTREZGENE, UniProtKB/TrEMBL
  A6I0U5_RAT UniProtKB/TrEMBL
  EAA3_RAT UniProtKB/Swiss-Prot
  O88389 ENTREZGENE
  P51907 ENTREZGENE
  Q63727 ENTREZGENE
  Q9JJP8 ENTREZGENE
UniProt Secondary O88389 UniProtKB/Swiss-Prot
  Q63727 UniProtKB/Swiss-Prot
  Q9JJP8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-25 Slc1a1  solute carrier family 1 member 1  Slc1a1  solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc1a1  solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1    solute carrier family 1, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc1a1  solute carrier family 1, member 1    Solute carrier family 1 A1 (brain glutamate transporter)  Name updated 629478 APPROVED
2002-06-10 Slc1a1  Solute carrier family 1 A1 (brain glutamate transporter)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process Glu-373 mediates proton binding and transmembrane proton transport 729828