Sgk1 (serum/glucocorticoid regulated kinase 1) - Rat Genome Database

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Gene: Sgk1 (serum/glucocorticoid regulated kinase 1) Rattus norvegicus
Analyze
Symbol: Sgk1
Name: serum/glucocorticoid regulated kinase 1
RGD ID: 3668
Description: Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and tau protein binding activity. Involved in several processes, including learning or memory; negative regulation of microtubule polymerization; and positive regulation of dendrite morphogenesis. Acts upstream of or within cellular response to insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1); PARTICIPATES IN glucocorticoid signaling pathway; insulin signaling pathway; mTOR signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 11-dehydrocorticosterone; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: serine/threonine protein kinase SGK; serine/threonine-protein kinase Sgk1; serum/glucocorticoid regulated kinase; serum/glucocorticoid-regulated kinase 1; Sgk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,799,391 - 24,916,886 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl124,799,396 - 24,807,231 (-)EnsemblGRCr8
mRatBN7.2122,980,257 - 23,098,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,980,261 - 23,098,283 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx122,760,448 - 22,768,284 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,465,432 - 1,473,268 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,957,500 - 22,965,337 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,185,451 - 24,302,309 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)Ensemblrn6Rnor6.0
Rnor_5.0125,652,750 - 25,769,448 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4123,501,257 - 23,506,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,704,048 - 21,711,886 (-)NCBICelera
RGSC_v3.1123,504,206 - 23,509,647 (-)NCBI
Cytogenetic Map1p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-colchicine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
11-dehydrocorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
actinomycin D  (ISO)
adenine  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amosite asbestos  (ISO)
amphetamine  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
barium(0)  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
bleomycin A5  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysin  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
clomiphene  (ISO)
clotrimazole  (EXP)
clozapine  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP,ISO)
cortisone  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cyproterone  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
dexamethasone  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dichromium trioxide  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
estrone  (ISO)
ethanol  (ISO)
ethisterone  (ISO)
ethyl methanesulfonate  (ISO)
farglitazar  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP)
fluvastatin  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
haloperidol  (EXP)
hexestrol  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxyurea  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
melphalan  (ISO)
mercury dibromide  (ISO)
mestranol  (ISO)
metformin  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl carbamate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
metyrapone  (EXP)
mifepristone  (EXP,ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-methylformamide  (ISO)
naphthalene  (ISO)
nefazodone  (EXP)
nevirapine  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
norethisterone  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
organoselenium compound  (ISO)
orphenadrine  (EXP)
ouabain  (ISO)
oxybenzone  (ISO)
ozone  (EXP)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phencyclidine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
pregnenolone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
Primycin  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dichromate  (EXP)
spironolactone  (EXP,ISO)
starch  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Serum and glucocorticoid-responsive kinase-1 regulates cardiomyocyte survival and hypertrophic response. Aoyama T, etal., Circulation. 2005 Apr 5;111(13):1652-9. Epub 2005 Mar 28.
2. The serum- and glucocorticoid-induced kinase is a physiological mediator of aldosterone action. Bhargava A, etal., Endocrinology 2001 Apr;142(4):1587-94.
3. Cell cycle and hormonal control of nuclear-cytoplasmic localization of the serum- and glucocorticoid-inducible protein kinase, Sgk, in mammary tumor cells. A novel convergence point of anti-proliferative and proliferative cell signaling pathways. Buse P, etal., J Biol Chem. 1999 Mar 12;274(11):7253-63.
4. Serum- and glucocorticoid-regulated kinase (SGK1) gene and blood pressure. Busjahn A, etal., Hypertension. 2002 Sep;40(3):256-60.
5. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
6. Expression of serum- and glucocorticoid-inducible kinase is regulated in an experience-dependent manner and can cause dendrite growth. David S, etal., J Neurosci. 2005 Jul 27;25(30):7048-53.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Enrichment enhances the expression of sgk, a glucocorticoid-induced gene, and facilitates spatial learning through glutamate AMPA receptor mediation. Lee EH, etal., Eur J Neurosci. 2003 Nov;18(10):2842-52.
10. Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2. Lee IH, etal., J Biol Chem. 2007 Oct 12;282(41):29866-73. Epub 2007 Aug 22.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Mineralocorticoid effects in the kidney: correlation between alphaENaC, GILZ, and Sgk-1 mRNA expression and urinary excretion of Na+ and K+. Muller OG, etal., J Am Soc Nephrol 2003 May;14(5):1107-15.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Alteration of serum/glucocorticoid regulated kinase-1 (sgk-1) gene expression in rat hippocampus after transient global ischemia. Nishida Y, etal., Brain Res Mol Brain Res. 2004 Apr 7;123(1-2):121-5.
15. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway. Park J, etal., EMBO J. 1999 Jun 1;18(11):3024-33.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. 11Beta-hydroxysteroid dehydrogenase 1 transforms 11-dehydrocorticosterone into transcriptionally active glucocorticoid in neonatal rat heart. Sheppard KE and Autelitano DJ, Endocrinology 2002 Jan;143(1):198-204.
22. SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression. Tai DJ, etal., J Biol Chem. 2009 Feb 13;284(7):4073-89. Epub 2008 Dec 16.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients. Trochen N, etal., Nephrol Dial Transplant. 2004 Oct;19(10):2499-504. Epub 2004 Aug 10.
25. sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. Tsai KJ, etal., Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3990-5.
26. Genetic variance of SGK-1 is associated with blood pressure, blood pressure change over time and strength of the insulin-diastolic blood pressure relationship. von Wowern F, etal., Kidney Int. 2005 Nov;68(5):2164-72.
27. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Webster MK, etal., Mol Cell Biol 1993 Apr;13(4):2031-40.
28. Serum- and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Yang YC, etal., Mol Cell Biol. 2006 Nov;26(22):8357-70. Epub 2006 Sep 18.
Additional References at PubMed
PMID:7740159   PMID:7854047   PMID:8647846   PMID:9058378   PMID:12477932   PMID:12631736   PMID:12642512   PMID:12734207   PMID:15007040   PMID:15234985   PMID:15383658   PMID:15838307  
PMID:15958725   PMID:16426574   PMID:16495212   PMID:16553792   PMID:16756948   PMID:17157265   PMID:17568772   PMID:17692313   PMID:18088355   PMID:18184857   PMID:18586672   PMID:18615584  
PMID:19051070   PMID:19468237   PMID:19521108   PMID:19609277   PMID:19910698   PMID:20051515   PMID:20664544   PMID:20738430   PMID:20933037   PMID:21224398   PMID:21849984   PMID:22327331  
PMID:22797923   PMID:22980744   PMID:23516288   PMID:23589291   PMID:23650397   PMID:23826409   PMID:24429675   PMID:24825325   PMID:25515054   PMID:26506154   PMID:27592201   PMID:27655894  
PMID:28376115   PMID:28980287   PMID:29497029   PMID:32139897   PMID:32645929   PMID:32946263   PMID:33063281   PMID:34898378   PMID:36781297   PMID:37371111  


Genomics

Comparative Map Data
Sgk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8124,799,391 - 24,916,886 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl124,799,396 - 24,807,231 (-)EnsemblGRCr8
mRatBN7.2122,980,257 - 23,098,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,980,261 - 23,098,283 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx122,760,448 - 22,768,284 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.011,465,432 - 1,473,268 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,957,500 - 22,965,337 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0124,185,451 - 24,302,309 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)Ensemblrn6Rnor6.0
Rnor_5.0125,652,750 - 25,769,448 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4123,501,257 - 23,506,651 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera121,704,048 - 21,711,886 (-)NCBICelera
RGSC_v3.1123,504,206 - 23,509,647 (-)NCBI
Cytogenetic Map1p12NCBI
SGK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386134,169,256 - 134,318,112 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6134,169,248 - 134,318,112 (-)Ensemblhg38GRCh38
GRCh376134,490,394 - 134,639,250 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366134,532,081 - 134,537,695 (-)NCBIBuild 36Build 36hg18NCBI36
Build 346134,532,081 - 134,537,695NCBI
Celera6135,231,367 - 135,380,168 (-)NCBICelera
Cytogenetic Map6q23.2NCBI
HuRef6132,059,144 - 132,203,585 (-)NCBIHuRef
CHM1_16134,752,625 - 134,901,421 (-)NCBICHM1_1
T2T-CHM13v2.06135,357,191 - 135,506,235 (-)NCBIT2T-CHM13v2.0
Sgk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391021,758,083 - 21,875,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1021,758,083 - 21,875,802 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381021,882,184 - 21,999,903 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1021,882,184 - 21,999,903 (+)Ensemblmm10GRCm38
MGSCv371021,601,990 - 21,719,709 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361021,684,112 - 21,689,308 (+)NCBIMGSCv36mm8
Celera1021,774,459 - 21,893,673 (+)NCBICelera
Cytogenetic Map10A3NCBI
cM Map109.83NCBI
Sgk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554392,290,035 - 2,406,587 (+)Ensembl
ChiLan1.0NW_0049554392,399,992 - 2,406,587 (+)NCBIChiLan1.0ChiLan1.0
SGK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25154,142,635 - 154,288,380 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16152,048,314 - 152,194,060 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06131,936,397 - 132,082,670 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16136,033,851 - 136,180,121 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6136,033,851 - 136,180,121 (-)EnsemblpanPan2panpan1.1
SGK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1127,086,431 - 27,196,601 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl127,087,361 - 27,196,521 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha127,967,769 - 28,077,630 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0127,245,018 - 27,354,617 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl127,245,018 - 27,354,852 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1127,128,500 - 27,238,272 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0127,008,812 - 27,118,227 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0127,318,579 - 27,428,323 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Sgk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946122,200,588 - 122,229,971 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365601,979,808 - 2,088,329 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365601,979,804 - 2,009,167 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl129,745,114 - 29,753,602 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1129,625,786 - 29,753,619 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2133,226,672 - 33,256,205 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103240340
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11339,152,289 - 39,306,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1339,300,567 - 39,306,183 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604011,341,622 - 11,492,670 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624942507,605 - 641,585 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624942508,035 - 641,349 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Sgk1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12208,448,634 - 208,572,960 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Sgk1
929 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:336
Count of miRNA genes:93
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000016121, ENSRNOT00000040736, ENSRNOT00000061157
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
D1Got27  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8124,801,574 - 24,801,720 (+)Marker Load Pipeline
mRatBN7.2122,982,440 - 22,982,586 (+)MAPPERmRatBN7.2
Rnor_6.0124,187,635 - 24,187,780NCBIRnor6.0
Rnor_5.0125,654,934 - 25,655,079UniSTSRnor5.0
RGSC_v3.4123,503,441 - 23,503,586UniSTSRGSC3.4
RGSC_v3.4123,503,440 - 23,503,586RGDRGSC3.4
Celera121,706,232 - 21,706,377UniSTS
RGSC_v3.1123,506,386 - 23,506,531RGD
RH 3.4 Map1229.3RGD
RH 3.4 Map1229.3UniSTS
RH 2.0 Map1156.8RGD
Cytogenetic Map1p12UniSTS
RH129312  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,980,317 - 22,980,472 (+)MAPPERmRatBN7.2
Rnor_6.0124,185,512 - 24,185,666NCBIRnor6.0
Rnor_5.0125,652,811 - 25,652,965UniSTSRnor5.0
RGSC_v3.4123,501,318 - 23,501,472UniSTSRGSC3.4
Celera121,704,109 - 21,704,263UniSTS
RH 3.4 Map1232.5UniSTS
Cytogenetic Map1p12UniSTS
AU048783  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2122,982,308 - 22,982,576 (+)MAPPERmRatBN7.2
Rnor_6.0124,187,503 - 24,187,770NCBIRnor6.0
Rnor_5.0125,654,802 - 25,655,069UniSTSRnor5.0
RGSC_v3.4123,503,309 - 23,503,576UniSTSRGSC3.4
Celera121,706,100 - 21,706,367UniSTS
Cytogenetic Map1p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000016121   ⟹   ENSRNOP00000016121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,980,261 - 22,985,702 (-)Ensembl
Rnor_6.0 Ensembl124,185,456 - 24,190,896 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000040736   ⟹   ENSRNOP00000046277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,799,396 - 24,807,231 (-)Ensembl
mRatBN7.2 Ensembl122,980,262 - 22,988,097 (-)Ensembl
Rnor_6.0 Ensembl124,185,456 - 24,193,567 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000061157   ⟹   ENSRNOP00000057871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl124,799,396 - 24,805,663 (-)Ensembl
mRatBN7.2 Ensembl122,980,262 - 22,986,436 (-)Ensembl
Rnor_6.0 Ensembl124,185,456 - 24,191,908 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083452   ⟹   ENSRNOP00000069545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,980,262 - 23,098,283 (-)Ensembl
Rnor_6.0 Ensembl124,185,435 - 24,302,298 (-)Ensembl
RefSeq Acc Id: NM_001193568   ⟹   NP_001180497
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,805,570 (-)NCBI
mRatBN7.2122,980,257 - 22,986,436 (-)NCBI
Rnor_6.0124,185,451 - 24,191,630 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
Celera121,704,048 - 21,710,227 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001193569   ⟹   NP_001180498
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,807,231 (-)NCBI
mRatBN7.2122,980,257 - 22,988,097 (-)NCBI
Rnor_6.0124,185,451 - 24,193,567 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
Celera121,704,048 - 21,711,886 (-)NCBI
Sequence:
RefSeq Acc Id: NM_019232   ⟹   NP_062105
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,804,831 (-)NCBI
mRatBN7.2122,980,257 - 22,985,697 (-)NCBI
Rnor_6.0124,185,451 - 24,190,891 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
RGSC_v3.4123,501,257 - 23,506,651 (-)RGD
Celera121,704,048 - 21,709,488 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227723   ⟹   XP_006227785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,916,886 (-)NCBI
mRatBN7.2122,980,257 - 23,098,122 (-)NCBI
Rnor_6.0124,185,451 - 24,302,309 (-)NCBI
Rnor_5.0125,652,750 - 25,769,448 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109489   ⟹   XP_038965417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8124,799,391 - 24,869,119 (-)NCBI
mRatBN7.2122,980,257 - 23,050,000 (-)NCBI
RefSeq Acc Id: NP_062105   ⟸   NM_019232
- Peptide Label: isoform 3
- UniProtKB: Q06226 (UniProtKB/Swiss-Prot),   Q68G05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001180498   ⟸   NM_001193569
- Peptide Label: isoform 2
- UniProtKB: Q06226 (UniProtKB/Swiss-Prot),   F1LXA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001180497   ⟸   NM_001193568
- Peptide Label: isoform 1
- UniProtKB: Q06226 (UniProtKB/Swiss-Prot),   D4A128 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227785   ⟸   XM_006227723
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JVM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016121   ⟸   ENSRNOT00000016121
Ensembl Acc Id: ENSRNOP00000057871   ⟸   ENSRNOT00000061157
Ensembl Acc Id: ENSRNOP00000069545   ⟸   ENSRNOT00000083452
Ensembl Acc Id: ENSRNOP00000046277   ⟸   ENSRNOT00000040736
RefSeq Acc Id: XP_038965417   ⟸   XM_039109489
- Peptide Label: isoform X2
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q06226-F1-model_v2 AlphaFold Q06226 1-430 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689538
Promoter ID:EPDNEW_R62
Type:single initiation site
Name:Sgk1_1
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R63  EPDNEW_R64  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,190,896 - 24,190,956EPDNEW
RGD ID:13689539
Promoter ID:EPDNEW_R63
Type:multiple initiation site
Name:Sgk1_2
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R62  EPDNEW_R64  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,191,852 - 24,191,912EPDNEW
RGD ID:13689540
Promoter ID:EPDNEW_R64
Type:single initiation site
Name:Sgk1_3
Description:serum/glucocorticoid regulated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R62  EPDNEW_R63  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0124,193,594 - 24,193,654EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3668 AgrOrtholog
BioCyc Gene G2FUF-62032 BioCyc
Ensembl Genes ENSRNOG00000011815 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000040736 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7130800 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
MGC_CLONE MGC:93480 IMAGE-MGC_LOAD
NCBI Gene 29517 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Sgk1 PhenoGen
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011815 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC217781
UniProt A0A0G2JVM7 ENTREZGENE
  D4A128 ENTREZGENE, UniProtKB/TrEMBL
  F1LXA3 ENTREZGENE, UniProtKB/TrEMBL
  Q06226 ENTREZGENE
  Q68G05 ENTREZGENE, UniProtKB/TrEMBL
  SGK1_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-02 Sgk1  serum/glucocorticoid regulated kinase 1  Sgk  serum/glucocorticoid regulated kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Sgk  serum/glucocorticoid regulated kinase      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a GRE in the promoter region 69995
gene_process in the heart acts as a converging point between steroid signalling and other ligands that activate phosphoinositide 3-kinase 69995
gene_process in the heart acts as a converging point between steroid signalling and other ligands that activate phosphoinositide 3-kinase 70436
gene_process may mediate early aldosterone effects by stimulating epitherlial sodium channel (ENaC)-mediated sodium transport in kidneys 628514
gene_process may mediate effects of aldosterone on Na homeostasis 628514
gene_regulation aldosterone induces expression in kidney collecting duct and distal colon 628514