RGD Reference Report - sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats. - Rat Genome Database

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sgk, a primary glucocorticoid-induced gene, facilitates memory consolidation of spatial learning in rats.

Authors: Tsai, KJ  Chen, SK  Ma, YL  Hsu, WL  Lee, EH 
Citation: Tsai KJ, etal., Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3990-5.
RGD ID: 729761
Pubmed: PMID:11891330   (View Abstract at PubMed)
PMCID: PMC122636   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.062405399   (Journal Full-text)

By using differential display PCR, we have identified 98 cDNA fragments from the rat dorsal hippocampus that are expressed differentially between the fast learners and slow learners in the water maze learning task. One of these cDNA fragments encodes the rat serum- and glucocorticoid-inducible kinase (sgk) gene. Northern blot analysis revealed that the sgk mRNA level was approximately 4-fold higher in the hippocampus of fast learners than slow learners. In situ hybridization results indicated that sgk mRNA level was increased markedly in CA1, CA3, and dentate gyrus of hippocampus in fast learners. Transient transfection of the sgk mutant DNA to the CA1 area impaired, whereas transfection of the sgk wild-type DNA facilitated water maze performance in rats. These results provide direct evidence that enhanced sgk expression facilitates memory consolidation of spatial learning in rats. These results also elucidate the molecular mechanism of glucocorticoid-induced memory facilitation in mammals.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
long-term memory  IMP 729761 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sgk1  (serum/glucocorticoid regulated kinase 1)


Additional Information