Pomc (proopiomelanocortin) - Rat Genome Database

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Gene: Pomc (proopiomelanocortin) Rattus norvegicus
Analyze
Symbol: Pomc
Name: proopiomelanocortin
RGD ID: 3366
Description: Predicted to enable hormone activity and melanocortin receptor binding activity. Involved in several processes, including motor behavior; negative regulation of inflammatory response to antigenic stimulus; and response to lipopolysaccharide. Located in extracellular region and neuronal cell body. Used to study alcohol dependence; heroin dependence; and obesity. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; obesity; opiate dependence (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; familial Mediterranean fever; nicotine dependence; obesity; and osteoarthritis. Orthologous to human POMC (proopiomelanocortin); PARTICIPATES IN alfentanil pharmacodynamics pathway; altered energy homeostasis pathway; altered melanocortin system pathway; INTERACTS WITH (S)-colchicine; (S)-nicotine; (Z)-hex-3-en-1-ol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ACTH; adrenocorticotropic hormone; adrenocorticotropin; alpha-melanocyte-stimulating hormone; alphaMSH; corticotropin-lipotropin; Pomc1; Pomc2; pro-opiomelanocortin; pro-opiomelanocortin-alpha; proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin); proopiomelanocortin, beta (endorphin, beta); proopoimelanocortin, beta (endorphin, beta)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,659,137 - 32,665,175 (+)NCBIGRCr8
mRatBN7.2626,939,844 - 26,945,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,232,130 - 27,237,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,548,037 - 27,553,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,026,040 - 27,031,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,382,937 - 28,388,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,191,989 - 38,197,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,931,969 - 26,937,789 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,934,921 - 26,940,742 (+)NCBI
Celera626,415,706 - 26,421,526 (+)NCBICelera
RH 3.4 Map6117.99RGD
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
PomcRatAdrenal Insufficiency  ISOPOMC (Homo sapiens)1357926 RGD 
PomcRatalcohol dependence  ISOPOMC (Homo sapiens)405878074mRNA:increased expression:blood and lymphocytesRGD 
PomcRatalcohol dependence no_associationISOPOMC (Homo sapiens)401850579DNA:SNP: :rs934778 (human)RGD 
PomcRatalcohol dependence  ISOPOMC (Homo sapiens)407431644DNA:hypermethylation:promoter:bloodRGD 
PomcRatalcohol dependence  IDA 407572518 RGD 
PomcRatalcohol dependence  IEP 407424597mRNA:decreased expression:hypothalamusRGD 
PomcRatalcohol dependence  IEP 406179436mRNA:increased expression:pituitary glandRGD 
PomcRatalcohol dependence  ISOPOMC (Homo sapiens)405878079mRNA:increased expression:blood and lymphocyteRGD 
PomcRatalcohol dependence  ISOPOMC (Homo sapiens)405878078DNA:hypermethylation:blood and promoterRGD 
PomcRatalcohol dependence  ISOPOMC (Homo sapiens)405878075DNA more ...RGD 
PomcRatalcohol use disorder  ISOPomc (Mus musculus)407571692mRNA more ...RGD 
PomcRatalcohol use disorder  IEP 401976284protein:decreased expression:brain (rat)RGD 
PomcRatalcohol use disorder  ISOPomc (Mus musculus)407550221DNA more ...RGD 
PomcRatalcohol use disorder  IEP 407572515mRNA:altered expression: arcuate nucleus of hypothalamusRGD 
PomcRatalcohol use disorder  IEP 407572513protein:increased expression:plasmaRGD 
PomcRatalcohol use disorder sexual_dimorphismIEP 407572513associated with Prenatal Exposure Delayed Effects and mRNA:altered expression:adenohypophysisRGD 
PomcRatalcohol use disorder  IEP 405878072mRNA:increased expression: hypothalamus more ...RGD 
PomcRatalcohol withdrawal syndrome  IEP 407424597mRNA:increased expression:hypothalamusRGD 
PomcRatalcohol withdrawal syndrome  ISOPOMC (Homo sapiens)407550224protein:decreased expression:plasmaRGD 
PomcRatalcohol withdrawal syndrome  ISOPOMC (Homo sapiens)407550223protein:decreased expression:plasmaRGD 
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Original Reference(s)
PomcRatgenetic disease  ISOPOMC (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25356970 more ...
PomcRatobesity  ISOPOMC (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10193875 more ...
PomcRatobesity  ISOPOMC (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10193875 more ...
PomcRatProopiomelanocortin Deficiency  ISOPOMC (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10193875 more ...
PomcRatTatton-Brown-Rahman syndrome  ISOPOMC (Homo sapiens)8554872ClinVar Annotator: match by term: Tatton-Brown-Rahman overgrowth syndromeClinVarPMID:24614070 more ...
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PomcRatACTH Syndrome, Ectopic  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1459535 more ...
PomcRatacute kidney failure  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17216604
PomcRatacute kidney tubular necrosis  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:4358912 and PMID:6254450
PomcRatAcute Liver Failure  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15313186
PomcRatadrenal cortex disease  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:11370731
PomcRatamnestic disorder  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2841920
PomcRatautistic disorder  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8570775
PomcRatbipolar disorder  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2843795 and PMID:9664777
PomcRatBody Weight  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1316127
PomcRatBradycardia  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1676337 more ...
PomcRatBurns  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2968671
PomcRatcalcinosis  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6143199
PomcRatCardiomegaly  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1965992 more ...
PomcRatcardiomyopathy  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6143199
PomcRatCatalepsy  ISOPOMC (Homo sapiens)11554173CTD more ...CTDPMID:2999739 and PMID:6329457
PomcRatCerebral Hemorrhage  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6254450
PomcRatcerebral palsy  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8980841
PomcRatcholestasis  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:3421781
PomcRatchondrocalcinosis  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:8035395
PomcRatCocaine-Related Disorders  ISOPOMC (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11750770 more ...
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PomcRatobesity  ISSPomc (Mus musculus)13592920OMIM:601665MouseDO 
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PomcRatobesity susceptibilityISOPOMC (Homo sapiens)7240710 OMIM 
PomcRatProopiomelanocortin Deficiency susceptibilityISOPOMC (Homo sapiens)7240710 OMIM 

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Original Reference(s)
PomcRat(-)-epigallocatechin 3-gallate decreases expressionISOPOMC (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of POMC mRNACTDPMID:20706672
PomcRat(20S)-20-hydroxypregn-4-en-3-one multiple interactionsISOPomc (Mus musculus)6480464Cadmium Chloride inhibits the reaction [POMC protein results in increased secretion of 20-alpha-Dihydroprogesterone]CTDPMID:8299002
PomcRat(20S)-20-hydroxypregn-4-en-3-one increases secretionISOPomc (Mus musculus)6480464POMC protein results in increased secretion of 20-alpha-DihydroprogesteroneCTDPMID:8299002
PomcRat(S)-colchicine increases secretionEXP 6480464Colchicine results in increased secretion of POMC proteinCTDPMID:2453250
PomcRat(S)-nicotine affects response to substanceISOPomc (Mus musculus)6480464POMC protein affects the susceptibility to NicotineCTDPMID:19376143
PomcRat(S)-nicotine decreases expressionEXP 6480464Nicotine results in decreased expression of POMC proteinCTDPMID:28555334
PomcRat(S)-nicotine affects expressionEXP 6480464Nicotine affects the expression of POMC proteinCTDPMID:22975262
PomcRat(S)-nicotine multiple interactionsISOPomc (Mus musculus)6480464POMC protein affects the reaction [Nicotine results in increased abundance of Dopamine]CTDPMID:15689546
PomcRat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of POMC protein alternative formCTDPMID:23623838
PomcRat(Z)-hex-3-en-1-ol multiple interactionsEXP 6480464[2 more ...CTDPMID:19103229 and PMID:21515296
PomcRat1,2-dimethylhydrazine increases expressionISOPomc (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of POMC mRNACTDPMID:22206623
PomcRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionISOPOMC (Homo sapiens)6480464Citalopram results in increased expression of POMC proteinCTDPMID:20414043
PomcRat11-deoxycorticosterone increases abundanceISOPOMC (Homo sapiens)6480464POMC protein results in increased abundance of DesoxycorticosteroneCTDPMID:3015796
PomcRat17alpha-ethynylestradiol increases expressionISOPomc (Mus musculus)6480464Ethinyl Estradiol results in increased expression of POMC mRNACTDPMID:17942748
PomcRat17alpha-ethynylestradiol multiple interactionsISOPomc (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of POMC mRNACTDPMID:17942748
PomcRat17beta-estradiol multiple interactionsEXP 6480464Estradiol affects the reaction [Dronabinol results in increased expression of POMC mRNA] and Estradiol inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in decreased activity of HTR1A protein] which results in increased expression of POMC protein modified form]CTDPMID:11528220 and PMID:22265196
PomcRat17beta-estradiol decreases expressionISOPomc (Mus musculus)6480464Estradiol results in decreased expression of POMC mRNACTDPMID:29092056
PomcRat18-hydroxycortisol increases abundanceISOPOMC (Homo sapiens)6480464POMC protein results in increased abundance of 18-hydroxycortisolCTDPMID:3015796
PomcRat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:27291303
PomcRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:21394737

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Biological Process
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Original Reference(s)
PomcRatcalcium-mediated signaling acts_upstream_of_or_withinISOPomc (Mus musculus)1624291 PMID:25096581RGDPMID:25096581
PomcRatcalcium-mediated signaling acts_upstream_of_or_withinIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatcell-cell signaling involved_inIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatcell-cell signaling involved_inISOPOMC (Homo sapiens)1624291 PMID:9620771RGDPMID:9620771
PomcRatcellular pigmentation involved_inIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatcellular pigmentation involved_inISOPOMC (Homo sapiens)1624291 PMID:9620771RGDPMID:9620771
PomcRatcortisol secretion involved_inISOPOMC (Sus scrofa) and UniProtKB:P01192-PRO_00000250181624291 PMID:15201064RGDPMID:15201064
PomcRatgeneration of precursor metabolites and energy involved_inISOPOMC (Homo sapiens)1624291 PMID:9620771RGDPMID:9620771
PomcRatgeneration of precursor metabolites and energy involved_inIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatglucose homeostasis acts_upstream_of_or_withinIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatglucose homeostasis acts_upstream_of_or_withinISOPomc (Mus musculus)1624291MGI:2687084 PMID:21184805RGDPMID:21184805
PomcRatmotor behavior  IDA 407580529 RGD 
PomcRatnegative regulation of apoptotic process  IDA 407580527 RGD 
PomcRatnegative regulation of inflammatory response to antigenic stimulus  IMP 407574731 RGD 
PomcRatnegative regulation of tumor necrosis factor production involved_inIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatnegative regulation of tumor necrosis factor production involved_inISOPOMC (Homo sapiens)1624291 PMID:10233018RGDPMID:10233018
PomcRatneuropeptide signaling pathway involved_inIEAUniProtKB-KW:KW-02571600115GO_REF:0000043UniProtGO_REF:0000043
PomcRatpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inISOPomc (Mus musculus)1624291 PMID:25096581RGDPMID:25096581
PomcRatpositive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway involved_inIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatpositive regulation of cell population proliferation  IDA 407580526 RGD 
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Cellular Component
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PomcRatcytoplasm located_inISOPomc (Mus musculus)1624291 PMID:18388149RGDPMID:18388149
PomcRatcytoplasm located_inIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatextracellular region  IDA 1601431 RGD 
PomcRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
PomcRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
PomcRatextracellular region located_inIEAInterPro:IPR0019411600115GO_REF:0000002InterProGO_REF:0000002
PomcRatextracellular space located_inIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatextracellular space located_inISOPomc (Mus musculus)1624291 PMID:16219686RGDPMID:16219686
PomcRatextracellular space is_active_inIBAMGI:97742 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PomcRatextracellular space located_inIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatextracellular space located_inISOPOMC (Homo sapiens)1624291 PMID:9620771RGDPMID:9620771
PomcRatneuronal cell body  IDA 407984716 RGD 
PomcRatperoxisomal matrix located_inISOPOMC (Homo sapiens) more ...1624291 PMID:20810565RGDPMID:20810565
PomcRatperoxisome NOT|located_inISOPOMC (Homo sapiens) more ...1624291 PMID:20810565RGDPMID:20810565
PomcRatsecretory granule located_inIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatsecretory granule is_active_inIBAMGI:97742 and PANTHER:PTN0085176301600115GO_REF:0000033GO_CentralGO_REF:0000033
PomcRatsecretory granule located_inISOPomc (Mus musculus)1624291 PMID:1329576 and PMID:16219686RGDPMID:1329576 and PMID:16219686
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Molecular Function
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PomcRatG protein-coupled receptor binding enablesISOPOMC (Homo sapiens)1624291 PMID:19452503RGDPMID:19452503
PomcRatG protein-coupled receptor binding enablesIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatG protein-coupled receptor binding enablesIBAPANTHER:PTN008517630 and UniProtKB:P011891600115GO_REF:0000033GO_CentralGO_REF:0000033
PomcRathormone activity enablesIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRathormone activity enablesIEAInterPro:IPR0019411600115GO_REF:0000002InterProGO_REF:0000002
PomcRathormone activity enablesIEAUniProtKB-KW:KW-03721600115GO_REF:0000043UniProtGO_REF:0000043
PomcRathormone activity enablesISOPomc (Mus musculus)1624291 PMID:15467755RGDPMID:15467755
PomcRathormone activity enablesISOPOMC (Sus scrofa) and UniProtKB:P01192-PRO_00000250181624291 PMID:15201064RGDPMID:15201064
PomcRathormone activity enablesISOPOMC (Homo sapiens)1624291 PMID:9620771RGDPMID:9620771
PomcRathormone activity enablesIEAUniProtKB:P01193 and ensembl:ENSMUSP000001515041600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRatmolecular_function  ND 159840710/2024: no relevant rat dataRGD 
PomcRatprotein binding enablesISOPOMC (Homo sapiens)1624291UniProtKB:O75031 more ...RGDPMID:32296183
PomcRatprotein binding enablesISOPomc (Mus musculus)1624291PR:P26339 more ...RGDPMID:16219686
PomcRatsignaling receptor binding enablesISOPOMC (Homo sapiens)1624291 PMID:9620771RGDPMID:9620771
PomcRatsignaling receptor binding enablesIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRattype 1 melanocortin receptor binding enablesIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRattype 1 melanocortin receptor binding enablesISOPOMC (Homo sapiens)1624291UniProtKB:Q01726 more ...RGDPMID:18292087 and PMID:19743876
PomcRattype 3 melanocortin receptor binding enablesISOPOMC (Homo sapiens)1624291UniProtKB:P41968 and PMID:19743876RGDPMID:19743876
PomcRattype 3 melanocortin receptor binding enablesIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
PomcRattype 4 melanocortin receptor binding enablesIEAUniProtKB:P01189 and ensembl:ENSP000003791701600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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PomcRatalfentanil pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00413
PomcRatbupivacaine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00393
PomcRatbuprenorphine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00684
PomcRatchloroprocaine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00394
PomcRatcitalopram pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00424
PomcRatcocaine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00395
PomcRatcodeine and morphine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00405
PomcRatcodeine and morphine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00406
PomcRatdesipramine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00423
PomcRatdiphenoxylate pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00675
PomcRatescitalopram pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00425
PomcRatethylmorphine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00681
PomcRatfentanyl pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00415
PomcRatfluoxetine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00426
PomcRatheroin pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00407
PomcRathydrocodone pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00411
PomcRathydromorphone pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00410
PomcRatimipramine pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00422
PomcRatlevacetylmethadol pharmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00677
PomcRatlevobupivacaine phgarmacodynamics pathway  ISOPOMC (Homo sapiens)10402751 SMPDBSMP:00397
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Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PomcRatsyndecan signaling pathway  ISOPOMC (Homo sapiens)6484113 PIDPID:200198

1 to 20 of 81 rows
#
Reference Title
Reference Citation
1. Preconception Alcohol Exposure Increases the Susceptibility to Diabetes in the Offspring. Al-Yasari A, etal., Endocrinology. 2021 Jan 1;162(1):bqaa188. doi: 10.1210/endocr/bqaa188.
2. The tripeptide KdPT protects from intestinal inflammation and maintains intestinal barrier function. Bettenworth D, etal., Am J Pathol. 2011 Sep;179(3):1230-42. Epub 2011 Jul 8.
3. Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing. Cakir I, etal., J Biol Chem. 2013 Jun 14;288(24):17675-88. doi: 10.1074/jbc.M113.475343. Epub 2013 May 2.
4. Hypothyroidism Induces Hypophagia Associated with Alterations in Protein Expression of Neuropeptide Y and Proopiomelanocortin in the Arcuate Nucleus, Independently of Hypothalamic Nuclei-Specific Changes in Leptin Signaling. Calvino C, etal., Thyroid. 2016 Jan;26(1):134-43. doi: 10.1089/thy.2015.0384. Epub 2015 Dec 1.
5. Chronic ethanol consumption impairs the circadian rhythm of pro-opiomelanocortin and period genes mRNA expression in the hypothalamus of the male rat. Chen CP, etal., J Neurochem. 2004 Mar;88(6):1547-54. doi: 10.1046/j.1471-4159.2003.02300.x.
6. Prenatal ethanol exposure alters the expression of period genes governing the circadian function of beta-endorphin neurons in the hypothalamus. Chen CP, etal., J Neurochem. 2006 May;97(4):1026-33. doi: 10.1111/j.1471-4159.2006.03839.x.
7. Opioid system genes in alcoholism: a case-control study in Croatian population. Cupic B, etal., Neuropeptides. 2013 Oct;47(5):315-9. doi: 10.1016/j.npep.2013.08.002. Epub 2013 Aug 28.
8. Enhanced activity of the brain beta-endorphin system by free-choice ethanol drinking in C57BL/6 but not DBA/2 mice. De Waele JP and Gianoulakis C, Eur J Pharmacol. 1994 Jun 2;258(1-2):119-29. doi: 10.1016/0014-2999(94)90064-7.
9. Congenital vasopressin deficiency and acute and chronic opiate effects on hypothalamo-pituitary-adrenal axis activity in Brattleboro rats. Domokos A, etal., J Endocrinol. 2008 Jan;196(1):113-21. doi: 10.1677/JOE-07-0356.
10. Plasma levels of beta-endorphin, adrenocorticotropic hormone and cortisol during early and late alcohol withdrawal. Esel E, etal., Alcohol Alcohol. 2001 Nov-Dec;36(6):572-6. doi: 10.1093/alcalc/36.6.572.
11. ACTH promotes chondrogenic nodule formation and induces transient elevations in intracellular calcium in rat bone marrow cell cultures via MC2-R signaling. Evans JF, etal., Cell Tissue Res. 2013 May;352(2):413-25. doi: 10.1007/s00441-013-1561-6. Epub 2013 Jan 29.
12. Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons. Fitting S, etal., Am J Pathol. 2010 Sep;177(3):1397-410. doi: 10.2353/ajpath.2010.090945. Epub 2010 Jul 22.
13. Hypermethylation of Proopiomelanocortin and Period 2 Genes in Blood Are Associated with Greater Subjective and Behavioral Motivation for Alcohol in Humans. Gangisetty O, etal., Alcohol Clin Exp Res. 2019 Feb;43(2):212-220. doi: 10.1111/acer.13932. Epub 2018 Dec 31.
14. Transgenerational inheritance of fetal alcohol effects on proopiomelanocortin gene expression and methylation, cortisol response to stress, and anxiety-like behaviors in offspring for three generations in rats: Evidence for male germline transmission. Gangisetty O, etal., PLoS One. 2022 Feb 10;17(2):e0263340. doi: 10.1371/journal.pone.0263340. eCollection 2022.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Effect of chronic morphine treatment on beta-endorphin biosynthesis by the rat neurointermediate lobe. Gianoulakis C, etal., Eur J Pharmacol. 1981 Jul 10;72(4):313-21. doi: 10.1016/0014-2999(81)90569-0.
17. Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. Govorko D, etal., Biol Psychiatry. 2012 Sep 1;72(5):378-88. doi: 10.1016/j.biopsych.2012.04.006. Epub 2012 May 22.
18. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
19. Trauma Severity in Early Childhood Correlates with Stress and Satiety Hormone Levels in a Pilot Cohort Receiving Diamorphine Maintenance Treatment. Groh A, etal., Eur Addict Res. 2020;26(2):103-108. doi: 10.1159/000505293. Epub 2020 Jan 15.
20. Hemorrhage activates proopiomelanocortin neurons in the rat hypothalamus. Göktalay G, etal., Brain Res. 2006 Jan 27;1070(1):45-55. doi: 10.1016/j.brainres.2005.11.076. Epub 2006 Jan 5.
1 to 20 of 81 rows
1 to 10 of 11 rows
PMID:1329576   PMID:2998878   PMID:6255341   PMID:9620771   PMID:10233018   PMID:10670585   PMID:11814629   PMID:12142539   PMID:12372001   PMID:12372003   PMID:12438160   PMID:12477932  
PMID:12586751   PMID:12697721   PMID:12736179   PMID:14561641   PMID:14568996   PMID:14576191   PMID:14630714   PMID:14660008   PMID:15019806   PMID:15201064   PMID:15226502   PMID:15280541  
PMID:15283974   PMID:15386812   PMID:15467755   PMID:15472174   PMID:15489638   PMID:15572204   PMID:15585943   PMID:15666806   PMID:16165252   PMID:16219686   PMID:16243970   PMID:16325304  
PMID:16584812   PMID:16921546   PMID:17038560   PMID:17068131   PMID:17085933   PMID:17304115   PMID:17341551   PMID:17347308   PMID:17388940   PMID:17505816   PMID:17531155   PMID:17551755  
PMID:17636405   PMID:17936371   PMID:17980426   PMID:18006626   PMID:18292087   PMID:18363807   PMID:18384674   PMID:18388149   PMID:18562281   PMID:18588949   PMID:18712053   PMID:18937973  
PMID:18948970   PMID:19017729   PMID:19074588   PMID:19082512   PMID:19088253   PMID:19297540   PMID:19333140   PMID:19452503   PMID:19476550   PMID:19743876   PMID:19952342   PMID:19968967  
PMID:20071607   PMID:20080115   PMID:20471454   PMID:20619468   PMID:20810565   PMID:21179736   PMID:21184805   PMID:21191001   PMID:21193556   PMID:21291921   PMID:21366729   PMID:21565854  
PMID:21589937   PMID:21605503   PMID:21821286   PMID:21855588   PMID:22064014   PMID:22146310   PMID:22177137   PMID:22403619   PMID:22432124   PMID:22432126   PMID:22450045   PMID:22902858  
PMID:23050949   PMID:23069669   PMID:23321476   PMID:23413810   PMID:23468969   PMID:23640796   PMID:23735696   PMID:24094067   PMID:24262750   PMID:25409090   PMID:25446223   PMID:25595971  
PMID:25624461   PMID:26702900   PMID:27503597   PMID:28429261   PMID:29777232   PMID:29943847   PMID:30528733   PMID:31394504   PMID:31691569   PMID:32446530   PMID:32980456   PMID:33338550  
1 to 10 of 11 rows



Pomc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8632,659,137 - 32,665,175 (+)NCBIGRCr8
mRatBN7.2626,939,844 - 26,945,666 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx627,232,130 - 27,237,950 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0627,548,037 - 27,553,857 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0627,026,040 - 27,031,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0628,382,937 - 28,388,771 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0638,191,989 - 38,197,809 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4626,931,969 - 26,937,789 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1626,934,921 - 26,940,742 (+)NCBI
Celera626,415,706 - 26,421,526 (+)NCBICelera
RH 3.4 Map6117.99RGD
Cytogenetic Map6q14NCBI
POMC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38225,160,860 - 25,168,580 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl225,160,853 - 25,168,903 (-)EnsemblGRCh38hg38GRCh38
GRCh37225,383,729 - 25,391,449 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36225,237,226 - 25,245,063 (-)NCBINCBI36Build 36hg18NCBI36
Build 34225,295,438 - 25,303,103NCBI
Celera225,224,014 - 25,231,854 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,121,466 - 25,129,306 (-)NCBIHuRef
CHM1_1225,313,607 - 25,321,447 (-)NCBICHM1_1
T2T-CHM13v2.0225,195,313 - 25,203,034 (-)NCBIT2T-CHM13v2.0
Pomc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39124,004,945 - 4,010,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl124,004,951 - 4,010,642 (+)EnsemblGRCm39 Ensembl
GRCm38123,954,945 - 3,960,643 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,954,951 - 3,960,642 (+)EnsemblGRCm38mm10GRCm38
MGSCv37123,954,951 - 3,960,618 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,954,967 - 3,960,634 (+)NCBIMGSCv36mm8
Celera123,882,694 - 3,888,357 (+)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.99NCBI
Pomc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554697,217,363 - 7,220,386 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554697,217,233 - 7,220,401 (-)NCBIChiLan1.0ChiLan1.0
POMC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212101,353,171 - 101,357,103 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A101,357,136 - 101,361,068 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A25,161,668 - 25,165,600 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A25,258,768 - 25,266,806 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A25,258,768 - 25,262,706 (-)Ensemblpanpan1.1panPan2
POMC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11719,431,396 - 19,438,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1719,431,585 - 19,434,440 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1719,328,041 - 19,334,822 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01719,706,608 - 19,713,398 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1719,706,796 - 19,714,128 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11719,440,669 - 19,447,445 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01719,450,362 - 19,457,130 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01719,496,844 - 19,503,629 (-)NCBIUU_Cfam_GSD_1.0
Pomc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629263,774,289 - 63,781,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364937,061,587 - 7,065,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364937,060,747 - 7,065,276 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POMC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3113,661,004 - 113,670,418 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13113,661,712 - 113,668,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23120,766,352 - 120,772,976 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POMC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11482,491,296 - 82,499,289 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1482,494,323 - 82,499,447 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604529,662,185 - 29,670,382 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pomc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247387,442,292 - 7,445,020 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247387,442,223 - 7,448,513 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Pomc
14 total Variants

Predicted Target Of
Summary Value
Count of predictions:97
Count of miRNA genes:82
Interacting mature miRNAs:88
Transcripts:ENSRNOT00000016976
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat

1 to 10 of 33 rows
RH130758  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,945,327 - 26,945,534 (+)MAPPERmRatBN7.2
Rnor_6.0628,388,433 - 28,388,639NCBIRnor6.0
Rnor_5.0638,197,473 - 38,197,679UniSTSRnor5.0
RGSC_v3.4626,937,453 - 26,937,659UniSTSRGSC3.4
Celera626,421,190 - 26,421,396UniSTS
RH 3.4 Map6118.6UniSTS
Cytogenetic Map6q14UniSTS
RH94496  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,939,389 - 26,939,551 (+)MAPPERmRatBN7.2
Rnor_6.0628,382,495 - 28,382,656NCBIRnor6.0
Rnor_5.0638,191,535 - 38,191,696UniSTSRnor5.0
RGSC_v3.4626,931,515 - 26,931,676UniSTSRGSC3.4
Celera626,415,252 - 26,415,413UniSTS
RH 3.4 Map6117.99UniSTS
Cytogenetic Map6q14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016976   ⟹   ENSRNOP00000016976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl626,939,837 - 26,945,664 (+)Ensembl
Rnor_6.0 Ensembl628,382,962 - 28,388,967 (+)Ensembl
RefSeq Acc Id: NM_139326   ⟹   NP_647542
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,659,353 - 32,665,173 (+)NCBI
mRatBN7.2626,939,844 - 26,945,664 (+)NCBI
Rnor_6.0628,382,949 - 28,388,769 (+)NCBI
Rnor_5.0638,191,989 - 38,197,809 (+)NCBI
RGSC_v3.4626,931,969 - 26,937,789 (+)RGD
Celera626,415,706 - 26,421,526 (+)RGD
Sequence:
RefSeq Acc Id: XM_017594033   ⟹   XP_017449522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,659,137 - 32,665,175 (+)NCBI
mRatBN7.2626,939,860 - 26,945,666 (+)NCBI
Rnor_6.0628,382,937 - 28,388,771 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063261551   ⟹   XP_063117621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8632,659,266 - 32,665,175 (+)NCBI
RefSeq Acc Id: NP_647542   ⟸   NM_139326
- Peptide Label: precursor
- UniProtKB: P01194 (UniProtKB/Swiss-Prot),   Q8K422 (UniProtKB/TrEMBL),   A6HAG6 (UniProtKB/TrEMBL),   F6PTD9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449522   ⟸   XM_017594033
- Peptide Label: isoform X1
- UniProtKB: P01194 (UniProtKB/Swiss-Prot),   Q8K422 (UniProtKB/TrEMBL),   A6HAG6 (UniProtKB/TrEMBL),   F6PTD9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016976   ⟸   ENSRNOT00000016976
RefSeq Acc Id: XP_063117621   ⟸   XM_063261551
- Peptide Label: isoform X1
- UniProtKB: P01194 (UniProtKB/Swiss-Prot),   A6HAG6 (UniProtKB/TrEMBL),   F6PTD9 (UniProtKB/TrEMBL),   Q8K422 (UniProtKB/TrEMBL)
Opiodes neuropeptide   Pro-opiomelanocortin N-terminal   Pro-opiomelanocortin/corticotropin ACTH central

Name Modeler Protein Id AA Range Protein Structure
AF-P01194-F1-model_v2 AlphaFold P01194 1-235 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38285 BioCyc
Ensembl Genes ENSRNOG00000012686 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000016976 ENTREZGENE
IMAGE_CLONE IMAGE:6919050 IMAGE-MGC_LOAD
InterPro Mcrtin_ACTH_cent UniProtKB/Swiss-Prot
  Melanocortin_N UniProtKB/Swiss-Prot
  Opioid_neuropept UniProtKB/Swiss-Prot
  PMOC UniProtKB/Swiss-Prot
  POMC-derived_peptides UniProtKB/Swiss-Prot
MGC_CLONE MGC:72676 IMAGE-MGC_LOAD
NCBI Gene 24664 ENTREZGENE
PANTHER PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
  PRO-OPIOMELANOCORTIN UniProtKB/Swiss-Prot
Pfam ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot
  Op_neuropeptide UniProtKB/Swiss-Prot
PharmGKB POMC RGD
PhenoGen Pomc PhenoGen
PRINTS MELANOCORTIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012686 RatGTEx
SMART ACTH_domain UniProtKB/Swiss-Prot
  NPP UniProtKB/Swiss-Prot
  Op_neuropeptide UniProtKB/Swiss-Prot
UniProt A6HAG4_RAT UniProtKB/TrEMBL
  A6HAG6 ENTREZGENE
  COLI_RAT UniProtKB/Swiss-Prot
  F6PTD9 ENTREZGENE, UniProtKB/TrEMBL
  P01194 ENTREZGENE
  Q8K422 ENTREZGENE, UniProtKB/TrEMBL
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-03 Pomc  proopiomelanocortin  Pomc  proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Pomc  proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)  Pomc  pro-opiomelanocortin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-01 Pomc  pro-opiomelanocortin  Pomc2  proopiomelanocortin, beta (endorphin, beta)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 Pomc2  Proopoimelanocortin, beta (endorphin, beta)      Symbol and Name status set to approved 70586 APPROVED