Ldlr (low density lipoprotein receptor) - Rat Genome Database

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Gene: Ldlr (low density lipoprotein receptor) Rattus norvegicus
Analyze
Symbol: Ldlr
Name: low density lipoprotein receptor
RGD ID: 2998
Description: Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study aortic atherosclerosis; atherosclerosis; familial hyperlipidemia; steatotic liver disease; and xanthomatosis. Biomarker of metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor); PARTICIPATES IN atherosclerosis pathway; bile acid transport pathway; endocytosis pathway; INTERACTS WITH (25R)-cholest-5-ene-3beta,26-diol; 1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LDL receptor; LDLRA; low-density lipoprotein receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ldlrem4Mcwi ; Ldlrem3Mcwi ; Ldlrem1Mcwi ; Ldlrem2Mcwi ; Ldlrem1Sage ; Ldlrem1 ; Ldlrem1Dlli
Genetic Models: SD-Ldlrem1 ; SD-Ldlrem1Dlli ; SS-Ldlrem3Mcwi ; SS-Ldlrem4Mcwi ; SS-Ldlrem1Mcwi ; SS-Ldlrem2Mcwi ; SD-Ldlrem1Sage
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,546,191 - 28,569,075 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,546,146 - 28,570,675 (+)EnsemblGRCr8
mRatBN7.2820,270,020 - 20,292,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,270,041 - 20,294,580 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,305,445 - 24,328,327 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,600,993 - 22,623,875 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,499,706 - 20,522,587 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,750,425 - 22,773,305 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,750,336 - 22,774,903 (+)Ensemblrn6Rnor6.0
Rnor_5.0822,804,325 - 22,827,199 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,824,040 - 20,846,920 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,660,761 - 21,683,616 (+)NCBICelera
RGSC_v3.1820,824,039 - 20,846,920 (+)NCBI
RH 3.4 Map8178.16RGD
RH 3.4 Map8178.16RGD
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-isolariciresinol  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-trans-epsilon-viniferin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (EXP,ISO)
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid  (ISO)
(S)-nicotine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
11-dehydro-thromboxane B2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
ampicillin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arachidonic acid  (ISO)
Archazolid B  (ISO)
argatroban  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
atrazine  (ISO)
aucubin  (ISO)
avobenzone  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
bathocuproine disulfonic acid  (ISO)
benzalkonium chloride  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (EXP,ISO)
beta-naphthoflavone  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bromobenzene  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (EXP)
caffeine  (EXP,ISO)
calciol  (EXP)
calcitriol  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
celastrol  (ISO)
cetylpyridinium  (ISO)
chenodeoxycholic acid  (ISO)
chlordecone  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
cholesterol  (EXP,ISO)
cholic acid  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
colesevelam hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corosolic acid  (ISO)
cortisol  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
curcumin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyproconazole  (ISO)
D-glucose  (ISO)
DDE  (EXP)
deoxycholic acid  (ISO)
desmosterol  (ISO)
desogestrel  (ISO)
dexamethasone  (EXP,ISO)
Di-n-hexyl phthalate  (EXP)
Di-n-octyl phthalate  (ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
Dicyclohexyl phthalate  (EXP)
Didecyldimethylammonium  (ISO)
dieldrin  (ISO)
diethyl maleate  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dimethylarsinic acid  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
dipentyl phthalate  (EXP)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (EXP,ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ezetimibe  (ISO)
Febrifugine  (ISO)
fenthion  (ISO)
flufenamic acid  (ISO)
fluoranthene  (ISO)
flusilazole  (ISO)
flutamide  (EXP)
fluvastatin  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
gallic acid  (ISO)
Ganoderic acid A  (ISO)
gedunin  (ISO)
genistein  (ISO)
geraniol  (ISO)
Ginsenoside Rh4  (ISO)
glucose  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
graphene oxide  (ISO)
GSK-J4  (ISO)
GW 3965  (ISO)
haloperidol  (ISO)
hexaconazole  (ISO)
hexadecanoic acid  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
ibuprofen  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
isoflavones  (ISO)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
leflunomide  (ISO)
levonorgestrel  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
lovastatin  (EXP,ISO)
lycopene  (ISO)
Maduramicin  (EXP)
menadione  (ISO)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
metronidazole  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitogen  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (EXP)
monosodium L-glutamate  (ISO)
N-desethylamiodarone  (ISO)
naled  (ISO)
nefazodone  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nicotine  (ISO)
obeticholic acid  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleic acid  (ISO)
ozone  (EXP,ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phenylpropanolamine  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (ISO)
proanthocyanidin  (EXP)
progesterone  (EXP,ISO)
propamocarb  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
puromycin  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
risperidone  (ISO)
rotenone  (EXP)
rottlerin  (EXP)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Sodium oleate  (ISO)
sotorasib  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
sucrose  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (EXP,ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
Yessotoxin  (ISO)
zearalenone  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IEA,ISO)
amyloid-beta clearance by cellular catabolic process  (IEA,ISO)
artery development  (ISO)
artery morphogenesis  (IEA,ISO)
cellular response to fatty acid  (IEA,ISO)
cellular response to low-density lipoprotein particle stimulus  (IEA,ISO)
cholesterol homeostasis  (IBA,IEA,IEP,ISO)
cholesterol import  (IEA,ISO)
cholesterol metabolic process  (IEA,ISO)
cholesterol transport  (IEA,ISO)
endocytosis  (IEA,IMP)
high-density lipoprotein particle clearance  (IEA,ISO)
intestinal cholesterol absorption  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
lipid transport  (IEA)
lipoprotein catabolic process  (ISO)
lipoprotein metabolic process  (ISO)
long-term memory  (IEA,ISO)
low-density lipoprotein particle clearance  (IEA,ISO)
negative regulation of amyloid fibril formation  (IEA,ISO)
negative regulation of astrocyte activation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of low-density lipoprotein particle clearance  (IEA,ISO)
negative regulation of microglial cell activation  (IEA,ISO)
negative regulation of protein metabolic process  (IEA,ISO)
negative regulation of receptor recycling  (IEA,ISO)
phagocytosis  (IEA,ISO)
phospholipid transport  (IEA,ISO)
plasma lipoprotein particle clearance  (IEA,ISO)
positive regulation of catabolic process  (IEA)
positive regulation of gene expression  (IEA,ISO)
positive regulation of inflammatory response  (IEA,ISO)
positive regulation of lysosomal protein catabolic process  (IEA,ISO)
positive regulation of triglyceride biosynthetic process  (IEA,ISO)
positive regulation of triglyceride catabolic process  (IMP)
positive regulation of triglyceride metabolic process  (IEA)
receptor-mediated endocytosis  (IEA,ISO)
receptor-mediated endocytosis involved in cholesterol transport  (IBA,IEA,ISO)
regulation of cholesterol metabolic process  (IEA,ISO)
regulation of lipid catabolic process  (IEA)
regulation of phosphatidylcholine catabolic process  (IEA,ISO)
regulation of protein metabolic process  (IEA,ISO)
response to caloric restriction  (IEA,ISO)
response to estradiol  (IEP)
response to estrogen  (IEP)
response to ethanol  (IEP)
response to glucagon  (IEP)
response to hormone  (IEP)
response to hypoxia  (IEP)
retinoid metabolic process  (IEA,ISO)
steroid metabolic process  (IEA)
transcytosis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Abifadel M, etal., Nat Genet. 2003 Jun;34(2):154-6.
2. Hypercholesterolemia and atherosclerosis in low density lipoprotein receptor mutant rats. Asahina M, etal., Biochem Biophys Res Commun. 2012 Feb 17;418(3):553-8. doi: 10.1016/j.bbrc.2012.01.067. Epub 2012 Jan 24.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. The LDLR locus in Alzheimer's disease: a family-based study and meta-analysis of case-control data. Bertram L, etal., Neurobiol Aging. 2007 Jan;28(1):18.e1-4. Epub 2005 Dec 27.
5. Structure of the hamster low density lipoprotein receptor gene. Bishop RW J Lipid Res 1992 Apr;33(4):549-57.
6. Development of the ACTH and corticosterone response to acute hypoxia in the neonatal rat. Bruder ED, etal., Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1195-203. Epub 2008 Aug 13.
7. Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease. Cheng D, etal., J Med Genet. 2005 Feb;42(2):129-31.
8. Characterization of the estrogen-induced lipoprotein receptor of rat liver. Cooper AD, etal., J Lipid Res. 1987 Jan;28(1):59-68.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Low-density lipoprotein receptor structure and folding. Gent J and Braakman I, Cell Mol Life Sci. 2004 Oct;61(19-20):2461-70.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Genetic association of low density lipoprotein receptor and Alzheimer's disease. Gopalraj RK, etal., Neurobiol Aging. 2005 Jan;26(1):1-7.
13. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
14. Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia. Hayashi T, etal., Neurol Res. 2006 Dec;28(8):822-5.
15. Association of low-density lipoprotein receptor polymorphisms and outcome of hepatitis C infection. Hennig BJ, etal., Genes Immun. 2002 Sep;3(6):359-67.
16. Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. Katsouri L and Georgopoulos S, PLoS One. 2011;6(7):e21880. Epub 2011 Jul 6.
17. Low-density lipoprotein receptor-mediated endocytosis of PEGylated nanoparticles in rat brain endothelial cells. Kim HR, etal., Cell Mol Life Sci. 2007 Feb;64(3):356-64.
18. Dietary isoflavones reduce plasma cholesterol and atherosclerosis in C57BL/6 mice but not LDL receptor-deficient mice. Kirk EA, etal., J Nutr. 1998 Jun;128(6):954-9.
19. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
20. Genetic study evaluating LDLR polymorphisms and Alzheimer's disease. Lamsa R, etal., Neurobiol Aging. 2008 Jun;29(6):848-55. Epub 2007 Jan 18.
21. Genetic polymorphisms of low density lipoprotein receptor can modify stroke presentation. Lee JD, etal., Neurol Res. 2010 Jun;32(5):535-40. Epub 2009 Jul 8.
22. Nucleotide sequence of the rat low density lipoprotein receptor cDNA. Lee LY, etal., Nucleic Acids Res 1989 Feb 11;17(3):1259-60.
23. Activation of the hepatic LDL receptor promoter by thyroid hormone. Lopez D, etal., Biochim Biophys Acta. 2007 Sep;1771(9):1216-25. Epub 2007 May 21.
24. The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s). Lucarelli M, etal., FEBS Lett 2002 Jul 3;522(1-3):19-23.
25. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Malloy SI, etal., Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):91-7. Epub 2003 Sep 11.
26. A common Lithuanian mutation causing familial hypercholesterolemia in Ashkenazi Jews. Meiner V, etal., Am J Hum Genet. 1991 Aug;49(2):443-9.
27. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
28. Investigation of an LDLR gene polymorphism (19p13.2) in susceptibility to migraine without aura. Mochi M, etal., J Neurol Sci. 2003 Sep 15;213(1-2):7-10.
29. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Association of the low-density lipoprotein receptor with caveolae in hamster and rat liver. Ness GC, etal., Biochem Biophys Res Commun 2003 Mar 28;303(1):177-81.
31. Diabetes alters LDL receptor and PCSK9 expression in rat liver. Niesen M, etal., Arch Biochem Biophys. 2008 Feb 15;470(2):111-5. Epub 2007 Nov 22.
32. Genomic characterization of five deletions in the LDL receptor gene in Danish Familial Hypercholesterolemic subjects. Nissen PH, etal., BMC Med Genet. 2006 Jun 26;7:55.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. Modified HMG-CoA reductase and LDLr regulation is deeply involved in age-related hypercholesterolemia. Pallottini V, etal., J Cell Biochem. 2006 Aug 1;98(5):1044-53.
35. Importance of proprotein convertase subtilisin/kexin type 9 in the hormonal and dietary regulation of rat liver low-density lipoprotein receptors. Persson L, etal., Endocrinology. 2009 Mar;150(3):1140-6. Epub 2008 Nov 13.
36. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
37. Influence of low-density lipoprotein (LDL) receptor on lipid composition, inflammation and parasitism during Toxoplasma gondii infection. Portugal LR, etal., Microbes Infect. 2008 Mar;10(3):276-84. Epub 2007 Dec 8.
38. GOA pipeline RGD automated data pipeline
39. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus. Rivas L, etal., Autoimmunity. 2009 May;42(4):266-8.
42. No association between low density lipoprotein receptor genetic variants and Alzheimer's disease risk. Rodriguez E, etal., Am J Med Genet B Neuropsychiatr Genet. 2006 Jul 5;141B(5):541-3.
43. Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats. Sithu SD, etal., JCI Insight. 2017 May 4;2(9). pii: 86442. doi: 10.1172/jci.insight.86442.
44. The low-density lipoprotein receptor is regulated by estrogen and forms a functional complex with the estrogen-regulated protein ezrin in pituitary GH3 somatolactotropes. Smith PM, etal., Endocrinology. 2004 Jul;145(7):3075-83. Epub 2004 Mar 24.
45. Mechanisms of disease: genetic causes of familial hypercholesterolemia. Soutar AK and Naoumova RP, Nat Clin Pract Cardiovasc Med. 2007 Apr;4(4):214-25.
46. A tubular endosomal fraction from rat liver: biochemical evidence of receptor sorting by default. Verges M, etal., Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10146-51.
47. Combined effects of apoE-CI-CII cluster and LDL-R gene polymorphisms on chromosome 19 and coronary artery disease risk. Wang C, etal., Int J Hyg Environ Health. 2006 May;209(3):265-73. Epub 2006 Feb 3.
48. A lipidomics study reveals hepatic lipid signatures associating with deficiency of the LDL receptor in a rat model. Wang HY, etal., Biol Open. 2016 Jul 15;5(7):979-86. doi: 10.1242/bio.019802.
49. Chronic alcohol consumption disrupted cholesterol homeostasis in rats: down-regulation of low-density lipoprotein receptor and enhancement of cholesterol biosynthesis pathway in the liver. Wang Z, etal., Alcohol Clin Exp Res. 2010 Mar 1;34(3):471-8. doi: 10.1111/j.1530-0277.2009.01111.x. Epub 2009 Dec 18.
50. Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. Xu ZE, etal., Am J Physiol Renal Physiol. 2011 Oct;301(4):F713-22. doi: 10.1152/ajprenal.00341.2010. Epub 2011 Jul 27.
51. Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats. Zhao Y, etal., Atherosclerosis. 2018 Apr;271:26-35. doi: 10.1016/j.atherosclerosis.2018.02.015. Epub 2018 Feb 12.
Additional References at PubMed
PMID:6091915   PMID:6299582   PMID:7848292   PMID:8626535   PMID:9788969   PMID:11092755   PMID:11120757   PMID:12072432   PMID:12746448   PMID:13130124   PMID:15140193   PMID:15166224  
PMID:15741654   PMID:15805190   PMID:16166565   PMID:16647292   PMID:17071966   PMID:17110914   PMID:17142622   PMID:17148552   PMID:17203467   PMID:17461796   PMID:17674160   PMID:17905649  
PMID:18175806   PMID:18341993   PMID:19946888   PMID:20005821   PMID:20458492   PMID:21763412   PMID:21792919   PMID:22081141   PMID:22383525   PMID:22848640   PMID:22927332   PMID:23280554  
PMID:23382219   PMID:23580231   PMID:24006456   PMID:24255059   PMID:24412220   PMID:24530906   PMID:24619822   PMID:25524771   PMID:26246324   PMID:26526611   PMID:26965651   PMID:27401460  
PMID:28108572   PMID:29938676   PMID:30483910  


Genomics

Comparative Map Data
Ldlr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,546,191 - 28,569,075 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl828,546,146 - 28,570,675 (+)EnsemblGRCr8
mRatBN7.2820,270,020 - 20,292,981 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl820,270,041 - 20,294,580 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx824,305,445 - 24,328,327 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,600,993 - 22,623,875 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0820,499,706 - 20,522,587 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,750,425 - 22,773,305 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,750,336 - 22,774,903 (+)Ensemblrn6Rnor6.0
Rnor_5.0822,804,325 - 22,827,199 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4820,824,040 - 20,846,920 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera821,660,761 - 21,683,616 (+)NCBICelera
RGSC_v3.1820,824,039 - 20,846,920 (+)NCBI
RH 3.4 Map8178.16RGD
RH 3.4 Map8178.16RGD
Cytogenetic Map8q13NCBI
LDLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381911,089,463 - 11,133,820 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1911,089,418 - 11,133,830 (+)Ensemblhg38GRCh38
GRCh371911,200,139 - 11,244,496 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361911,061,132 - 11,105,490 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341911,061,131 - 11,105,490NCBI
Celera1911,094,887 - 11,139,322 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,777,128 - 10,820,847 (+)NCBIHuRef
CHM1_11911,201,264 - 11,245,760 (+)NCBICHM1_1
T2T-CHM13v2.01911,216,460 - 11,260,830 (+)NCBIT2T-CHM13v2.0
Ldlr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,634,872 - 21,661,215 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,634,779 - 21,661,215 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38921,723,576 - 21,749,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,723,483 - 21,749,919 (+)Ensemblmm10GRCm38
MGSCv37921,528,038 - 21,554,363 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36921,474,180 - 21,498,819 (+)NCBIMGSCv36mm8
Celera918,993,187 - 19,019,513 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.87NCBI
Ldlr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554952,114,434 - 2,138,056 (+)Ensembl
ChiLan1.0NW_0049554952,114,702 - 2,135,584 (+)NCBIChiLan1.0ChiLan1.0
LDLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22016,006,932 - 16,050,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11915,005,600 - 15,049,123 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,640,225 - 10,683,728 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11911,357,311 - 11,402,736 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1911,357,311 - 11,396,791 (+)EnsemblpanPan2panpan1.1
LDLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,115,175 - 50,152,443 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,048,736 - 50,152,355 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2049,988,705 - 50,026,032 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02050,636,154 - 50,673,474 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2050,636,157 - 50,673,423 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,846,492 - 49,883,796 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,273,144 - 50,310,479 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02050,515,859 - 50,553,174 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ldlr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,054,161 - 209,095,215 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,259,369 - 1,302,294 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,259,405 - 1,300,545 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LDLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,828,332 - 69,864,827 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1269,828,348 - 69,864,823 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2270,193,426 - 70,206,818 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LDLR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1610,062,204 - 10,091,780 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl610,062,790 - 10,091,377 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660749,815,946 - 9,867,321 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ldlr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,999,169 - 3,021,987 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248282,999,122 - 3,021,893 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ldlr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1817,993,107 - 18,017,686 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ldlr
108 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:154
Interacting mature miRNAs:170
Transcripts:ENSRNOT00000013496
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8132882639Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
RH94592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,292,786 - 20,292,978 (+)MAPPERmRatBN7.2
Rnor_6.0822,773,111 - 22,773,302NCBIRnor6.0
Rnor_5.0822,827,005 - 22,827,196UniSTSRnor5.0
RGSC_v3.4820,846,726 - 20,846,917UniSTSRGSC3.4
Celera821,683,422 - 21,683,613UniSTS
Cytogenetic Map8q13UniSTS
RH94809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2820,269,978 - 20,270,230 (+)MAPPERmRatBN7.2
Rnor_6.0822,750,308 - 22,750,559NCBIRnor6.0
Rnor_5.0822,804,208 - 22,804,459UniSTSRnor5.0
RGSC_v3.4820,823,923 - 20,824,174UniSTSRGSC3.4
Celera821,660,644 - 21,660,895UniSTS
RH 3.4 Map8178.16UniSTS
Cytogenetic Map8q13UniSTS


Genetic Models
This gene Ldlr is modified in the following models/strains:
SD-Ldlrem1     SD-Ldlrem1Dlli     SS-Ldlrem3Mcwi     SS-Ldlrem4Mcwi     SS-Ldlrem1Mcwi     SS-Ldlrem2Mcwi     SD-Ldlrem1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000013496   ⟹   ENSRNOP00000013496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,546,146 - 28,570,675 (+)Ensembl
mRatBN7.2 Ensembl820,270,041 - 20,294,580 (+)Ensembl
Rnor_6.0 Ensembl822,750,336 - 22,774,903 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108195   ⟹   ENSRNOP00000080955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,553,311 - 28,570,675 (+)Ensembl
mRatBN7.2 Ensembl820,277,217 - 20,294,580 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000162425   ⟹   ENSRNOP00000102223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl828,546,158 - 28,570,675 (+)Ensembl
RefSeq Acc Id: NM_175762   ⟹   NP_786938
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,546,191 - 28,569,075 (+)NCBI
mRatBN7.2820,270,096 - 20,292,981 (+)NCBI
Rnor_6.0822,750,425 - 22,773,305 (+)NCBI
Rnor_5.0822,804,325 - 22,827,199 (+)NCBI
RGSC_v3.4820,824,040 - 20,846,920 (+)RGD
Celera821,660,761 - 21,683,616 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_786938 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA32001 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000013496
GenBank Protein P35952 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_786938   ⟸   NM_175762
- Peptide Label: precursor
- UniProtKB: A6JNU1 (UniProtKB/TrEMBL),   G3V7A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013496   ⟸   ENSRNOT00000013496
Ensembl Acc Id: ENSRNOP00000080955   ⟸   ENSRNOT00000108195
Ensembl Acc Id: ENSRNOP00000102223   ⟸   ENSRNOT00000162425
Protein Domains
EGF-like   LDL-receptor class A

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35952-F1-model_v2 AlphaFold P35952 1-879 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695786
Promoter ID:EPDNEW_R6311
Type:initiation region
Name:Ldlr_1
Description:low density lipoprotein receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0822,750,416 - 22,750,476EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2998 AgrOrtholog
BioCyc Gene G2FUF-31411 BioCyc
Ensembl Genes ENSRNOG00000009946 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013496 ENTREZGENE
Gene3D-CATH 2.120.10.30 UniProtKB/Swiss-Prot
  4.10.400.10 UniProtKB/Swiss-Prot
  EGF-type module UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot
  EGF-like_Ca-bd_dom UniProtKB/Swiss-Prot
  EGF-like_dom UniProtKB/Swiss-Prot
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot
  EGF_Ca-bd_CS UniProtKB/Swiss-Prot
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot
  LDL_receptor-like_sf UniProtKB/Swiss-Prot
  LDLR-related UniProtKB/Swiss-Prot
  LDLR_class-A_CS UniProtKB/Swiss-Prot
  LDLR_classB_rpt UniProtKB/Swiss-Prot
  LDrepeatLR_classA_rpt UniProtKB/Swiss-Prot
  NOTCH1_EGF-like UniProtKB/Swiss-Prot
KEGG Report rno:300438 UniProtKB/Swiss-Prot
NCBI Gene Ldlr ENTREZGENE
PANTHER LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED UniProtKB/Swiss-Prot
  LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED UniProtKB/Swiss-Prot
Pfam EGF_CA UniProtKB/Swiss-Prot
  FXa_inhibition UniProtKB/Swiss-Prot
  Ldl_recept_a UniProtKB/Swiss-Prot
  Ldl_recept_b UniProtKB/Swiss-Prot
PharmGKB LDLR RGD
PhenoGen Ldlr PhenoGen
PRINTS LDLRECEPTOR UniProtKB/Swiss-Prot
PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLRA_1 UniProtKB/Swiss-Prot
  LDLRA_2 UniProtKB/Swiss-Prot
  LDLRB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009946 RatGTEx
SMART EGF UniProtKB/Swiss-Prot
  EGF_CA UniProtKB/Swiss-Prot
  LDLa UniProtKB/Swiss-Prot
  SM00135 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57184 UniProtKB/Swiss-Prot
  SSF57424 UniProtKB/Swiss-Prot
  YWTD domain UniProtKB/Swiss-Prot
UniProt A0A8I5ZRX1_RAT UniProtKB/TrEMBL
  A0ABK0LA27_RAT UniProtKB/TrEMBL
  A6JNU1 ENTREZGENE, UniProtKB/TrEMBL
  A6JNU2_RAT UniProtKB/TrEMBL
  G3V7A5 ENTREZGENE, UniProtKB/TrEMBL
  LDLR_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ldlr  Low density lipoprotein receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization mainly located in caveolae in liver 1298981
gene_expression expressed in both brain microvessel endothelial cells and in astrocytes 633388
gene_regulation expression is upregulated in brain microvessel endothelial cells by co-cultivation with astrocytes 633388