RGD Reference Report - Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus. - Rat Genome Database

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Decreased transcription, expression and function of low-density lipoprotein receptor in leukocytes from patients with systemic lupus erythematosus.

Authors: Rivas, L  Zabaleta, M  Toro, F  Bianco, NE  De Sanctis, JB 
Citation: Rivas L, etal., Autoimmunity. 2009 May;42(4):266-8.
RGD ID: 5490253
Pubmed: PMID:19811272   (View Abstract at PubMed)

The low-density lipoprotein receptor (LDLR) is directly involved in the metabolism of low-density lipoprotein (LDL) and its impairment causes accumulation of plasmatic LDL leading to atherosclerosis, a prevalent disease in patients with systemic lupus erythematosus (SLE). We studied LDLR transcription, expression and function in leukocytes patients with SLE and normal healthy donors (NHD). The ratio LDLR/glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNAs the expression of LDLR and the uptake of LDL-DiI were significantly lower (p < 0.001) in the patients with SLE. On the contrary, patients with SLE had significantly higher (p < 0.0001) levels of total cholesterol, LDL cholesterol and anti-oxLDL autoantibodies (AAb) as compared to NHD. No correlation between LDLR transcription, expression and function with the SLE disease activity index or with treatment was found. The decreased function of LDLR was independent of treatment. It seems dependent on the sterol regulatory binding protein and may be responsible for the increase of plasma LDL cholesterol and oxLDL AAb further increasing the risk of vascular diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systemic lupus erythematosus  IEP 5490253mRNA:decreased expression:leukocyteRGD 
systemic lupus erythematosus  ISOLDLR (Homo sapiens)5490253; 5490253mRNA:decreased expression:leukocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ldlr  (low density lipoprotein receptor)

Genes (Mus musculus)
Ldlr  (low density lipoprotein receptor)

Genes (Homo sapiens)
LDLR  (low density lipoprotein receptor)


Additional Information