RGD Reference Report - Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia. - Rat Genome Database

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Different expression of low density lipoprotein receptor and ApoE between young adult and old rat brains after ischemia.

Authors: Hayashi, T  Kamada, H  Jin, G  Deguchi, K  Nagotani, S  Sehara, Y  Zhang, H  Nagano, I  Shoji, M  Abe, K 
Citation: Hayashi T, etal., Neurol Res. 2006 Dec;28(8):822-5.
RGD ID: 2324630
Pubmed: PMID:17288738   (View Abstract at PubMed)
DOI: DOI:10.1179/016164105X40002   (Journal Full-text)

OBJECTIVES: Reduction of brain plasticity underlies the poor outcome of aged stroke patients. The molecular mechanism of plasticity reduction by aging is uncertain, but disturbed lipid metabolism may be implicated. METHODS: We investigated the expression of low density lipoprotein receptors (LDL-R) and apolipoprotein E (ApoE), both of which play active roles in lipid metabolism in young adult and old rat brains after ischemia. RESULTS: LDL-R, trivially expressed in the sham-operated brain neurons, was increased from day 1 and became prominent at days 7 and 21 at the peri-ischemic cortex. The magnitude was smaller in the old than in the young adult rats. ApoE was increased in the astrocytes and neurons of the peri-ischemic cortex at day 1, which became further pronounced in the neurons but not in the astrocytes at days 7 and 21. ApoE expression was again less prominent in the old animals at days 7 and 21. DISCUSSION: As ApoE-containing lipoprotein is recruited via LDL-R, the present results suggest that old brains had less capability to induce LDL-R, which resulted in impaired recruitment of lipoprotein after the ischemic injury. Impaired lipid recruitment causes disturbance of synaptogenesis and thus brain plasticity reduction. This molecular mechanism may result in poor functional recovery of aged stroke patients.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Reperfusion Injury  ISOLdlr (Rattus norvegicus)2324630; 2324630 RGD 
Reperfusion Injury  IEP 2324630 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ldlr  (low density lipoprotein receptor)

Genes (Mus musculus)
Ldlr  (low density lipoprotein receptor)

Genes (Homo sapiens)
LDLR  (low density lipoprotein receptor)


Additional Information