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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2998 Species: Rattus norvegicus RGD Object: Gene Symbol: Ldlr Name: low density lipoprotein receptor

Acc ID: CHEBI:46195 Term: paracetamol Definition: A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group. CasRN: 103-90-2 Chemical ID: MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:735594	6480464	CTD	Acetaminophen promotes the reaction [Cholesterol, LDL binds to LDLR protein] Acetaminophen promotes the reaction [[Cholesterol, LDL binds to LDLR protein] which results in increased degradation of Cholesterol, LDL]	PMID:10395027
increases expression	ISO	RGD:735594	6480464	CTD	Acetaminophen results in increased expression of LDLR mRNA	PMID:21420995