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Gene: Kcna4 (potassium voltage-gated channel subfamily A member 4) Rattus norvegicus

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Symbol:

Kcna4

Name:

potassium voltage-gated channel subfamily A member 4

RGD ID:

2952

Description:

Enables voltage-gated potassium channel activity. Involved in potassium ion transmembrane transport. Located in several cellular components, including asymmetric synapse; cell surface; and dendrite. Part of voltage-gated potassium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Orthologous to human KCNA4 (potassium voltage-gated channel subfamily A member 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; amitriptyline.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

KCHAN; Kv1.4; Kv4; potassium channel, voltage gated shaker related subfamily A, member 4; Potassium voltage gated channel, shaker related subfamily, member 4; potassium voltage-gated channel, shaker-related subfamily, member 4; RCK4; RHK1; RK3; voltage-gated potassium channel subunit Kv1.4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	114,211,091 - 114,218,545 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	114,210,998 - 114,344,932 (+)	Ensembl				GRCr8
mRatBN7.2	3	93,756,399 - 93,778,004 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	93,756,446 - 93,769,162 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	97,313,368 - 97,316,494 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	105,912,302 - 105,915,428 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	103,683,372 - 103,686,498 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	98,293,295 - 98,300,763 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	98,297,554 - 98,300,680 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	104,897,715 - 104,905,175 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	92,781,795 - 92,784,921 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	92,807,179 - 92,810,305 (+)	NCBI		Celera
RGSC_v3.1	3	92,678,222 - 92,681,349 (+)	NCBI
Cytogenetic Map	3	q33	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Microcephaly, Cataracts, Impaired Intellectual Development, and Dystonia with Abnormal Striatum (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-palmitoylglycerol (ISO)

3,3',5-triiodo-L-thyronine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

amitriptyline (EXP)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

Butylbenzyl phthalate (ISO)

carmustine (EXP)

CGP 52608 (ISO)

clofibrate (ISO)

Cuprizon (EXP)

dichlorine (EXP)

doxorubicin (ISO)

fulvestrant (ISO)

genistein (EXP)

gentamycin (EXP)

hydrogen chloride (EXP)

levetiracetam (EXP)

methoxychlor (EXP)

ozone (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

potassium chloride (EXP)

S-butyl-DL-homocysteine (S,R)-sulfoximine (EXP)

scopolamine (EXP)

serpentine asbestos (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

action potential (IBA)

monoatomic ion transmembrane transport (IEA)

monoatomic ion transport (IEA)

potassium ion transmembrane transport (IBA,IEA,IMP,ISO)

potassium ion transport (IEA,TAS)

protein homooligomerization (IEA)

regulation of presynaptic membrane potential (IEA)

transmembrane transport (IEA)

Cellular Component

asymmetric synapse (IDA)

axon (IBA,IDA,IEA)

axon initial segment (ISO)

cell surface (IDA)

dendritic shaft (IDA)

dendritic spine (IBA,IDA)

glutamatergic synapse (IDA)

membrane (IBA,IDA,IEA,ISO)

monoatomic ion channel complex (IEA)

plasma membrane (IEA,IMP,ISO)

postsynaptic membrane (IDA)

presynaptic membrane (IDA)

voltage-gated potassium channel complex (IBA,IDA,IEA,ISO)

Molecular Function

delayed rectifier potassium channel activity (IBA)

monoatomic ion channel activity (IDA,IEA)

potassium channel activity (IDA,IEA)

potassium ion binding (IEA)

protein binding (IPI,ISO)

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (ISO)

voltage-gated potassium channel activity (IDA,IEA,IMP,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	KCNE1 and KCNE2 inhibit forward trafficking of homomeric N-type voltage-gated potassium channels.	Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1354-63. doi: 10.1016/j.bpj.2011.08.015. Epub 2011 Sep 20.
4.	KCNE1 and KCNE2 provide a checkpoint governing voltage-gated potassium channel a-subunit composition.	Kanda VA, etal., Biophys J. 2011 Sep 21;101(6):1364-75. doi: 10.1016/j.bpj.2011.08.014. Epub 2011 Sep 20.
5.	Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.	Kim E, etal., Nature. 1995 Nov 2;378(6552):85-8.
6.	Immunohistochemical localization of the voltage-gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat.	Luján R, etal., J Chem Neuroanat. 2003 Nov;26(3):209-24.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin.	Naisbitt S, etal., Neuron 1999 Jul;23(3):569-82.
9.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.	Altered K(+) channel gene expression in diabetic rat ventricle: isoform switching between Kv4.2 and Kv1.4.	Nishiyama A, etal., Am J Physiol Heart Circ Physiol 2001 Oct;281(4):H1800-7.
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes.	Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
14.	The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.	Schulte U, etal., Neuron. 2006 Mar 2;49(5):697-706.
15.	Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.	Sheng M, etal., Nature. 1993 Sep 2;365(6441):72-5.
16.	Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.	Stuhmer W, etal., EMBO J 1989 Nov;8(11):3235-44.
17.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18.	Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library.	Tseng-Crank JC, etal., FEBS Lett 1990 Jul 30;268(1):63-8.
19.	Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle.	Wickenden AD, etal., Am J Physiol 1999 May;276(5 Pt 2):H1599-607.

Additional References at PubMed

PMID:8495559	PMID:8601796	PMID:9000078	PMID:9581762	PMID:11988171	PMID:12590144	PMID:14688283	PMID:15207333	PMID:15454398	PMID:15885224	PMID:16000151	PMID:16207878
PMID:17359997	PMID:17584507	PMID:18603586	PMID:19029372	PMID:19279288	PMID:19453640	PMID:19888682	PMID:19912772	PMID:21352098	PMID:21451062	PMID:22871113	PMID:23413915
PMID:24082096	PMID:24423395	PMID:28054303	PMID:31487241

Genomics

Comparative Map Data

Kcna4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	114,211,091 - 114,218,545 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	114,210,998 - 114,344,932 (+)	Ensembl				GRCr8
mRatBN7.2	3	93,756,399 - 93,778,004 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	93,756,446 - 93,769,162 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	97,313,368 - 97,316,494 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	105,912,302 - 105,915,428 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	103,683,372 - 103,686,498 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	98,293,295 - 98,300,763 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	98,297,554 - 98,300,680 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	104,897,715 - 104,905,175 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	92,781,795 - 92,784,921 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	92,807,179 - 92,810,305 (+)	NCBI		Celera
RGSC_v3.1	3	92,678,222 - 92,681,349 (+)	NCBI
Cytogenetic Map	3	q33	NCBI

KCNA4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	30,009,730 - 30,017,030 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	30,009,552 - 30,017,030 (-)	Ensembl			hg38	GRCh38
GRCh37	11	30,031,277 - 30,038,577 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	29,988,341 - 29,995,064 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	29,988,340 - 29,995,064	NCBI
Celera	11	30,177,828 - 30,184,551 (-)	NCBI		Celera
Cytogenetic Map	11	p14.1	NCBI
HuRef	11	29,723,661 - 29,730,948 (-)	NCBI		HuRef
CHM1_1	11	30,030,186 - 30,037,475 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	30,143,826 - 30,151,124 (-)	NCBI		T2T-CHM13v2.0

Kcna4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	107,120,934 - 107,157,149 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	107,120,984 - 107,128,847 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	107,290,589 - 107,326,804 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	107,290,639 - 107,298,502 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	107,130,746 - 107,138,661 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	107,091,493 - 107,099,343 (+)	NCBI		MGSCv36	mm8
Celera	2	108,498,776 - 108,506,689 (+)	NCBI		Celera
Cytogenetic Map	2	E3	NCBI
cM Map	2	56.12	NCBI

Kcna4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	8,622,019 - 8,623,980 (-)	Ensembl
ChiLan1.0	NW_004955476	8,621,019 - 8,624,764 (-)	NCBI	ChiLan1.0	ChiLan1.0

KCNA4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	32,230,491 - 32,237,640 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	32,206,256 - 32,242,513 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	29,975,072 - 29,991,716 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	29,876,486 - 29,882,630 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

KCNA4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	21	50,114,251 - 50,120,070 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	21	50,115,506 - 50,117,506 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	21	49,557,789 - 49,560,814 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	21	51,289,806 - 51,292,829 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	21	51,289,841 - 51,291,841 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	21	50,305,592 - 50,307,634 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	21	50,435,227 - 50,437,266 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	21	51,057,264 - 51,060,288 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Kcna4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	34,464,135 - 34,471,672 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936533	7,588,950 - 7,596,696 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936533	7,588,965 - 7,596,467 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KCNA4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	30,605,564 - 30,613,452 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	30,605,503 - 30,615,997 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	33,068,113 - 33,074,583 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KCNA4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	35,155,318 - 35,162,813 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	35,159,671 - 35,161,632 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	132,340,152 - 132,349,028 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kcna4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	19,155,792 - 19,161,647 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624766	19,154,841 - 19,161,810 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Kcna4
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	85,182,045 - 85,189,482 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Kcna4
86 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	252
Count of miRNA genes:	157
Interacting mature miRNAs:	191
Transcripts:	ENSRNOT00000006524
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	74364268	119364268	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	101255536	134750886	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	70311536	115311536	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	81541464	126563126	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat

Markers in Region

PMC24571P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	93,760,512 - 93,760,922 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	98,297,423 - 98,297,832	NCBI	Rnor6.0
Rnor_5.0	3	104,901,835 - 104,902,244	UniSTS	Rnor5.0
RGSC_v3.4	3	92,781,664 - 92,782,073	UniSTS	RGSC3.4
Celera	3	92,807,048 - 92,807,457	UniSTS
Cytogenetic Map	3	q33	UniSTS

PMC20269P1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	93,760,720 - 93,761,240 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	98,297,631 - 98,298,150	NCBI	Rnor6.0
Rnor_5.0	3	104,902,043 - 104,902,562	UniSTS	Rnor5.0
RGSC_v3.4	3	92,781,872 - 92,782,391	UniSTS	RGSC3.4
Celera	3	92,807,256 - 92,807,775	UniSTS
Cytogenetic Map	3	q33	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
7	6	63	140	51	47	22	15	22	6	197	95	2	126	67	78	25	15	15

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_012971	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234673	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M32867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006524 ⟹ ENSRNOP00000006524

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	114,210,998 - 114,344,932 (+)	Ensembl
mRatBN7.2 Ensembl	3	93,756,446 - 93,769,162 (+)	Ensembl
Rnor_6.0 Ensembl	3	98,297,554 - 98,300,680 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000132453 ⟹ ENSRNOP00000110060

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	114,211,112 - 114,219,934 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000147371 ⟹ ENSRNOP00000112159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	114,211,000 - 114,247,780 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000153929 ⟹ ENSRNOP00000112783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	114,213,638 - 114,219,934 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000167706 ⟹ ENSRNOP00000107472

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	114,211,700 - 114,247,780 (+)	Ensembl

RefSeq Acc Id:

NM_012971 ⟹ NP_037103

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	114,215,336 - 114,218,462 (+)	NCBI
mRatBN7.2	3	93,760,644 - 93,763,770 (+)	NCBI
Rnor_6.0	3	98,297,554 - 98,300,680 (+)	NCBI
Rnor_5.0	3	104,897,715 - 104,905,175 (+)	NCBI
RGSC_v3.4	3	92,781,795 - 92,784,921 (+)	RGD
Celera	3	92,807,179 - 92,810,305 (+)	RGD

Sequence:

show sequence

CCGGGTAAGAAAATAAGCTGCCCTATTTTTCTTTCTTCTTCTCTTACAACTGGAACCAGCCATT
TCCCCAAACTACCACCATGGAGGTGGCAATGGTGAGTGCCGAGAGCTCAGGGTGCAACAGCCAC
ATGCCTTATGGTTATGCTGCCCAGGCCAGGGCTCGAGAGAGGGAGAGACTTGCTCACTCCAGGG
CAGCTGCAGCTCTGGCTGTTGCAGCTGCCACGGCTGCGGTGGAAGGCACTGGAGGTTCTGGTGG
AGGCCCCCACCATCATCATCAGACACGTGGGGCCTACTCCTCCCATGATCCTCAAGGAAGCCGA
GGTAGTCGGAGGAGGAGGCGACAGCGAACTGAGAAGAAGAAACTCCACCACAGGCAGAGCAGTT
TTCCTCATTGCTCAGACCTGATGCCCAGTGGCTCTGAAGAGAAGATCCTTAGGGAGCTGAGCGA
GGAGGAGGAAGACGAGGAGGAGGAAGAGGAGGAGGAAGAGGAGGGAAGGTTTTACTATAGTGAA
GAGGACCATGGGGATGGGTGTTCCTACACTGACCTACTGCCACAGGATGATGGGGGTGGCGGCG
GCTACAGTTCAGTCCGCTACAGTGACTGTTGTGAACGCGTGGTAATAAATGTGTCTGGTCTACG
CTTCGAAACCCAAATGAAAACTTTGGCTCAGTTTCCAGAAACTCTGTTGGGAGACCCTGAGAAG
AGGACTCAGTACTTCGACCCTTTGCGCAATGAGTATTTTTTTGATAGGAACCGTCCCAGCTTTG
ATGCCATTTTGTATTATTACCAGTCAGGAGGCCGCCTGAAGAGGCCAGTCAATGTCCCCTTTGA
TATCTTCACTGAGGAGGTGAAGTTCTATCAGTTGGGAGAGGAAGCCCTGCTCAAGTTCCGTGAG
GATGAGGGCTTTGTGAGAGAAGAGGAGGACAGGGCTCTGCCAGAAAATGAATTTAAAAAACAGA
TTTGGCTTCTCTTTGAATATCCCGAGAGTTCCAGCCCTGCCAGGGCGATAGCCATCGTATCTGT
CCTGGTCATCTTAATCTCTATTGTCATATTTTGCCTGGAAACCTTGCCTGAGTTCAGGGATGAT
AGGGACCTCATCATGGCCCTCAGCGCAGGTGGACACAGCAGATTATTGAATGACACCTCGGCAC
CCCACCTGGAGAACTCAGGGCACACAATATTCAATGACCCTTTCTTCATTGTGGAGACAGTATG
TATCGTGTGGTTTTCCTTTGAGTTTGTGGTTCGATGCTTTGCTTGTCCCAGTCAAGCACTCTTC
TTCAAAAACATCATGAACATCATTGATATCGTCTCCATTTTGCCTTACTTCATCACTCTGGGCA
CCGATCTGGCCCAGCAGCAGGGGGGTGGCAACGGCCAGCAGCAGCAGGCTATGTCCTTTGCCAT
CCTCAGGATCATCCGTCTGGTCCGAGTGTTCCGGATCTTCAAGCTCTCCAGACACTCCAAGGGC
CTGCAGATCCTGGGCCACACCCTAAGAGCCAGCATGCGTGAACTGGGCCTTCTTATCTTTTTCC
TCTTCATCGGGGTCATCCTCTTTTCCAGCGCTGTGTATTTTGCAGAGGCAGATGAACCTACCAC
CCATTTCCAAAGCATTCCAGATGCGTTTTGGTGGGCTGTGGTAACCATGACAACTGTGGGCTAC
GGGGACATGAAGCCCATCACAGTGGGAGGAAAGATTGTGGGGTCCCTGTGTGCCATTGCGGGTG
TCTTAACCATTGCTTTGCCCGTGCCGGTGATTGTGTCTAACTTTAACTATTTCTACCACAGAGA
GACTGAAAACGAAGAACAGACCCAGCTGACCCAAAACGCAGTCAGTTGCCCATACCTACCTTCT
AATTTGCTCAAGAAATTTCGGAGCTCTACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAG
AGATGGAAGAAGGGGTCAAGGAGTCTTTATGTGGAAAGGAAGAGAAGTGTCAGGGAAAGGGGGA
TGACAGCGAGACAGATAAAAACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGAATC
TCTTTCCCCACCTGCCGTGCCGCCGCCCAGCTCCGAATATATTCATACATAAAGAATGCAGTTA
TGAAAATGAGATATGCACTGCATACAGTAATACACTGCTTAATGGCGATACATGGCATAATTGT
GGCGAAACGTGTATTGCATATCAAATAAGTGATGCATCTTGGAGAAGAGGGAGGCATTAAAAAC
AGCAGATCTATCTTTATATTTTTTAATAGAATGCAAGAATTTTGCACATAATGGGAAAATGTTA
ATAGTAAAGGTGGTCCCGAGGAGAGTGAGTGTGTGTGAGAGAGTGAGAGAGTGTGTGGCCATGG
GAGTGTAAGTAAATTGTCAACATTGTTGGGAATTGTGCCGTGATGGGAAAAGTTGGCATTCTGA
AGTATTTACTATGTAAGAACTAATGAACTTGAGCAGTCTTTTACCAGTGTTTTAATAACATCTC
CTATGTCTTTGGATTCTGTAGTTGTTTTCTAGAAATTGTAAGAATTACTGTGTAGAAAAAAGAG
AAAGTAAATTATTTAATAGTATATAGGTCACAATTTAATCTTGGATTTAATTAAAGTTTATTTT
TAACTGGAAATTAACTTTTGAAAAGGCTGCAGGGCCTTAGAAATTGATTATATTTTGTTATTAA
TTTTGGGAGATATACTAGCAAATGCCTAATGTTCTGGAGGAAATGTAACAAGTTTTGTTCACAG
GTCTTAAGACTGGAATTTTTTTTTCTTTTGCACTACTTTCTATGCTGAAGCCCGAGAGAGACTT
CATACTGTGAATGTTTACTAACGCACCAATCAGTTCAATGACAATCATTGGAAGAATGGTTTCT
TCGTCTCATTTATTGTTCTTTTCATTTTGTGAGACTAATGAGCACACAGATAACAGCACACGAT
TCCTGCTTTAAAATCTGAACAACCGATCTACAAAGGGACTACGAAGTAACGTTCAGCAGCCGAA
TCTTTCAAAATTGGTTTGTTACAATGATGCTTCAGAAACCATACTATTTTCAATACTCTTCTGC
CTTTTAAGTCCAGAATAATTTAACCAAAGTTATTGCATGCACAGAAAGAATTC

hide sequence

RefSeq Acc Id:

XM_006234673 ⟹ XP_006234735

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	114,211,091 - 114,218,545 (+)	NCBI
mRatBN7.2	3	93,756,399 - 93,778,004 (+)	NCBI
Rnor_6.0	3	98,293,295 - 98,300,763 (+)	NCBI
Rnor_5.0	3	104,897,715 - 104,905,175 (+)	NCBI

Sequence:

show sequence

CCACACCCTCTGCCCGGCCATGCCCCGCCCCCGCCCGTGCGCGCTGGCAGCCTGGGGAGGTGTG
TGCTGCTCCTGCAGCCAGCTAGAGAGCAAGACTGGGATGGATACTGGAGAAGGAGTGCAGGCTT
AACAAGTGATCGCTGCTGTCTAGGATTTTGAGTCTTTTTCGGGGAACCTTGACTTCCGTTCCCA
GCCCAGGTCTGCTGTGCCGAACTCCAGAGGAACCAGAAATCTCCGGGGTCTATCTTGGGGCGTC
CCCAATCTCCACCTCTGGGCTCCCGTAAAGAGGACTCTGTGACACCCCGTAGCCCCCGGCCAAG
GCGACAGAACTTGTTCCGTGGATATTTGGGATCTTTCACCTGCCAAATCCGAGTGATTTTTTTT
GTACTGCGCCCCCACCCCCAATGATTCTGCCCCTCCTCCAGCTGTTGCAGCTTGAAAGGGGGAA
ACAAATCACCGGGGGGATTTTTTTTTCTATTTTTATTTTTCGCACTTGCTGGGAATGGTGAAGT
GCTCCTTCTGAATGATTCTAGCCAAAGGAGGCTCTTCACTTCCTGCTTTCTATGGATACCTCAG
TGTTGAGTTTGCCCCTGCTGGAACCCCATCTACCACCTTCTCTACCTTTCAAGGTCTTTATCTA
CAACCTGCCATTGTCTGTGGTTCCGTGAAGGCTTTGATGACCTTAGAGGGAAGGTCTGGGAGAC
CATCCTCATAGACTGAGCAGCAATGGCTGGGCATATTTTAAGCCACATTTTAACATGGGTCAAG
CTATCACTAGAAGGCAAGTGCTAAGACTAAAGACTTATTTGCATTTTATTTAAATTAGATGGAC
TTGGCTTTGGACAATTTCCATACAAGAAAAAAAAATATTTCATTTTCTAGGCACAACTTCTGAC
TGTCAGATTCTTGCTGCCTTTGAGTCTTGTAGCGTCATCATCAGACCGCATCCCAGACAGACTT
CCAGATTTGAACACCTACCCCCCAAAACGTAGGTGTTTGGGAGACCACATCACTTCATGACTTA
TGTTTGAGGAGCACTAGGCTGTTGTCTAGACTAAGCAAGCTCTGGAAAGCAATGCTGAGTCTCT
GAGAAGAGGGAGCATGGGGTGTGCTGATTTAAAAACAGAAAATGCAAAGTTGGACTGAAAATAT
CCCAAGTCTTCTAAGCAATCTGCTTAAGGCTTCCAAACTTACCTTAATTTGGTAAGAAAATAAG
CTGCCCTATTTTTCTTTCTTCTTCTCTTACAACTGGAACCAGCCATTTCCCCAAACTACCACCA
TGGAGGTGGCAATGGTGAGTGCCGAGAGCTCAGGGTGCAACAGCCACATGCCTTATGGTTATGC
TGCCCAGGCCAGGGCTCGAGAGAGGGAGAGACTTGCTCACTCCAGGGCAGCTGCAGCTGCTGCT
GTTGCAGCTGCCACGGCTGCGGTGGAAGGCACTGGAGGTTCTGGTGGAGGCCCCCACCATCATC
ATCAGACACGTGGGGCCTACTCCTCCCATGATCCTCAAGGAAGCCGAGGTAGTCGGAGGAGGAG
GCGACAGCGAACTGAGAAGAAGAAACTCCACCACAGGCAGAGCAGTTTTCCTCATTGCTCAGAC
CTGATGCCCAGTGGCTCTGAAGAGAAGATCCTTAGGGAGCTGAGCGAGGAGGAGGAAGACGAGG
AGGAGGAAGAGGAGGAGGAAGAGGAGGGAAGGTTTTACTATAGTGAAGAGGACCATGGGGATGG
GTGTTCCTACACTGACCTACTGCCACAGGATGATGGGGGTGGCGGCGGCTACAGTTCAGTCCGC
TACAGTGACTGTTGTGAACGCGTGGTAATAAATGTGTCTGGTCTACGCTTCGAAACCCAAATGA
AAACTTTGGCTCAGTTTCCAGAAACTCTGTTGGGAGACCCTGAGAAGAGGACTCAGTACTTCGA
CCCTTTGCGCAATGAGTATTTTTTTGATAGGAACCGTCCCAGCTTTGATGCCATTTTGTATTAT
TACCAGTCAGGAGGCCGCCTGAAGAGGCCAGTCAATGTCCCCTTTGATATCTTCACTGAGGAGG
TGAAGTTCTATCAGTTGGGAGAGGAAGCCCTGCTCAAGTTCCGTGAGGATGAGGGCTTTGTGAG
AGAAGAGGAGGACAGGGCTCTGCCAGAAAATGAATTTAAAAAACAGATTTGGCTTCTCTTTGAA
TATCCCGAGAGTTCCAGCCCTGCCAGGGGCATAGCCATCGTATCTGTCCTGGTCATCTTAATCT
CTATTGTCATATTTTGCCTGGAAACCTTGCCTGAGTTCAGGGATGATAGGGACCTCATCATGGC
CCTCAGCGCAGGTGGACACAGCAGATTATTGAATGACACCTCGGCACCCCACCTGGAGAACTCA
GGGCACACAATATTCAATGACCCTTTCTTCATTGTGGAGACAGTATGTATCGTGTGGTTTTCCT
TTGAGTTTGTGGTTCGATGCTTTGCTTGTCCCAGTCAAGCACTCTTCTTCAAAAACATCATGAA
CATCATTGATATCGTCTCCATTTTGCCTTACTTCATCACTCTGGGCACCGATCTGGCCCAGCAG
CAGGGGGGTGGCAACGGCCAGCAGCAGCAGGCTATGTCCTTTGCCATCCTCAGGATCATCCGTC
TGGTCCGAGTGTTCCGGATCTTCAAGCTCTCCAGACACTCCAAGGGCCTGCAGATCCTGGGCCA
CACCCTAAGAGCCAGCATGCGTGAACTGGGCCTTCTTATCTTTTTCCTCTTCATCGGGGTCATC
CTCTTTTCCAGCGCTGTGTATTTTGCAGAGGCAGATGAACCTACCACCCATTTCCAAAGCATTC
CAGATGCGTTTTGGTGGGCTGTGGTAACCATGACAACTGTGGGCTACGGGGACATGAAGCCCAT
CACAGTGGGAGGAAAGATTGTGGGGTCCCTGTGTGCCATTGCGGGTGTCTTAACCATTGCTTTG
CCCGTGCCGGTGATTGTGTCTAACTTTAACTATTTCTACCACAGAGAGACTGAAAACGAAGAAC
AGACCCAGCTGACCCAAAACGCAGTCAGTTGCCCATACCTACCTTCTAATTTGCTCAAGAAATT
TCGGAGCTCTACTTCTTCTTCCCTGGGGGACAAGTCAGAGTATCTAGAGATGGAAGAAGGGGTC
AAGGAGTCTTTATGTGGAAAGGAAGAGAAGTGTCAGGGAAAGGGGGATGACAGCGAGACAGATA
AAAACAACTGTTCTAATGCAAAGGCTGTGGAGACTGATGTGTGAATCTCTTTCCCCACCTGCCG
CTGCCGCCCGCCCAGCTCCGAATATATTCATACATAAAGAATGCAGTTATGAAAATGAGATATG
CACTGCATACAGTAATACACTGCTTAATGGCGATACATGGCATAATTGTGGCGAAACGTGTATT
GCATATCAAATAAGTGATGCATCTTGGAGAAGAGGGAGGCATTAAAAACAGCAGATCTATCTTT
ATATTTTTTAATAGAATGCAAGAATTTTGCACATAATGGGAAAATGTTAATAGTAAAGGTGGTC
CCGAGGAGAGTGAGTGTGTGTGAGAGAGTGAGAGAGTGTGTGGCCATGGGAGTGTAAGTAAATT
GTCAACATTGTTGGGAATTGTGCCGTGATGGGAAAAGTTGGCATTCTGAAGTATTTACTATGTA
AGAACTAATGAACTTGAGCAGTCTTTTACCAGTGTTTTAATAACATCTCCTATGTCTTTGGATT
CTGTAGTTGTTTTCTAGAAATTGTAAGAATTACTGTGTAGAAAAAAGAGAAAGTAAATTATTTA
ATAGAATATAGGTCACAATTTAATCTTGGATTTAATTAAAGTTTATTTTTAACTGGAAATTAAC
TTTTGAAAAGGCTGCAGGGGCCTTTAGAAATTGATTATATTTTGTTATTAATTTTGGGGAGATA
TACTAGCAAATGCCTAATGTTCTGGAGGAAATGTAACAAGTTTTGTTCACAGGTCTTAAGACTG
GAATTTTTTTTTCTTTTGCACTACTTTCTATGCTGAAGCCCGAGAGAGACTTCATACTGTGAAT
GTTTACTAACGCACCAATCAGTTCAATGACAATCATTGGAAGAATGGTTTCTTCGTCTCATTTA
TTGTTCTTTTCATTTTGTGAGACTAATGAGCACACAGATAACAGCACACGATTCCTGCTTTAAA
ATCTGAACAACCGATCTACAAAGGGACTACGAAGTAACGTTCAGCAGCCGAATCTTTCAAAATT
GGTTTGTTACAATGATGCTTCAGAAACCATACTATTTTCAATACTCTTCTGCCTTTTAAGTCCA
GAATAATTTAACCAAAGTTATTGCATGCACAGAAAGAATTCTTGGAGAAATAAGGCGCCCAGCA
GCTACAGCAATTATGGCTTAAGATCTTTTTATTAAATATGCAACAAAATGCTAGAATTCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_037103	(Get FASTA)	NCBI Sequence Viewer
	XP_006234735	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41469	(Get FASTA)	NCBI Sequence Viewer
	EDL79747	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000110060
GenBank Protein	P15385	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_037103 ⟸ NM_012971

- UniProtKB:

P15385 (UniProtKB/Swiss-Prot), G3V6L7 (UniProtKB/TrEMBL), A6HNZ6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAALAVAAATAAVEGTGGSGGGPHHH
HQTRGAYSSHDPQGSRGSRRRRRQRTEKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDE
EEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQM
KTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEE
VKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARAIAIVSVLVILI
SIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFS
FEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIR
LVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSI
PDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE
QTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETD
KNNCSNAKAVETDV

hide sequence

RefSeq Acc Id:

XP_006234735 ⟸ XM_006234673

- Peptide Label:

isoform X1

- Sequence:

show sequence

MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGTGGSGGGPHHH
HQTRGAYSSHDPQGSRGSRRRRRQRTEKKKLHHRQSSFPHCSDLMPSGSEEKILRELSEEEEDE
EEEEEEEEEGRFYYSEEDHGDGCSYTDLLPQDDGGGGGYSSVRYSDCCERVVINVSGLRFETQM
KTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEE
VKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILI
SIVIFCLETLPEFRDDRDLIMALSAGGHSRLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFS
FEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIR
LVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSI
PDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEE
QTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCGKEEKCQGKGDDSETD
KNNCSNAKAVETDV

hide sequence

Ensembl Acc Id:

ENSRNOP00000006524 ⟸ ENSRNOT00000006524

Ensembl Acc Id:

ENSRNOP00000112783 ⟸ ENSRNOT00000153929

Ensembl Acc Id:

ENSRNOP00000110060 ⟸ ENSRNOT00000132453

Ensembl Acc Id:

ENSRNOP00000107472 ⟸ ENSRNOT00000167706

Ensembl Acc Id:

ENSRNOP00000112159 ⟸ ENSRNOT00000147371

Protein Domains

BTB

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P15385-F1-model_v2	AlphaFold	P15385	1-655	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2952	AgrOrtholog
BioCyc Gene	G2FUF-48501	BioCyc
Ensembl Genes	ENSRNOG00000004918	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000132453	ENTREZGENE
Gene3D-CATH	1.10.287.70	UniProtKB/Swiss-Prot
	1.20.120.350	UniProtKB/Swiss-Prot
	1.20.5.600	UniProtKB/Swiss-Prot
	Potassium Channel Kv1.1, Chain A	UniProtKB/Swiss-Prot
InterPro	BTB/POZ_dom	UniProtKB/Swiss-Prot
	Ion_trans_dom	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv1	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv1.4	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv1.4_TID	UniProtKB/Swiss-Prot
	K_chnl_volt-dep_Kv1.4_TID_sf	UniProtKB/Swiss-Prot
	SKP1/BTB/POZ_sf	UniProtKB/Swiss-Prot
	T1-type_BTB	UniProtKB/Swiss-Prot
	VG_K_chnl	UniProtKB/Swiss-Prot
	Volt_channel_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:25469	UniProtKB/Swiss-Prot
NCBI Gene	25469	ENTREZGENE
PANTHER	POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY A MEMBER 4	UniProtKB/Swiss-Prot
	PTHR11537	UniProtKB/Swiss-Prot
Pfam	BTB_2	UniProtKB/Swiss-Prot
	Ion_trans	UniProtKB/Swiss-Prot
	K_channel_TID	UniProtKB/Swiss-Prot
PhenoGen	Kcna4	PhenoGen
PRINTS	KCHANNEL	UniProtKB/Swiss-Prot
	KV14CHANNEL	UniProtKB/Swiss-Prot
	KVCHANNEL	UniProtKB/Swiss-Prot
	SHAKERCHANEL	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000004918	RatGTEx
SMART	BTB	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF54695	UniProtKB/Swiss-Prot
	Voltage-gated potassium channels	UniProtKB/Swiss-Prot
TIGR	TC209532
UniProt	A6HNZ6	ENTREZGENE, UniProtKB/TrEMBL
	G3V6L7	ENTREZGENE, UniProtKB/TrEMBL
	KCNA4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Kcna4	potassium voltage-gated channel subfamily A member 4	Kcna4	potassium channel, voltage gated shaker related subfamily A, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2015-01-26	Kcna4	potassium channel, voltage gated shaker related subfamily A, member 4	Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4		potassium voltage gated channel, shaker related subfamily, member 4	Name updated	1299863	APPROVED
2002-06-10	Kcna4	potassium voltage gated channel, shaker related subfamily, member 4			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	increased expression observed in diabetes mellitus	69869
gene_disease	increased expression observed in diabetes mellitus	628458
gene_disease	increased expression observed in diabetes mellitus	628470
gene_domains	has a segment which maybe involved in voltage sensing and another one involved in gating, has an unusual amino terminus about 140 residues longer than other members of the family	69869
gene_domains	has a segment which maybe involved in voltage sensing and another one involved in gating, has an unusual amino terminus about 140 residues longer than other members of the family	628458
gene_domains	has a segment which maybe involved in voltage sensing and another one involved in gating, has an unusual amino terminus about 140 residues longer than other members of the family	628470
gene_expression	mRNA expressed in the adult rat ventricle and also in the brain	69869
gene_expression	mRNA expressed in the adult rat ventricle and also in the brain	628458
gene_expression	mRNA expressed in the adult rat ventricle and also in the brain	628470
gene_function	forms voltage-gated outward current during repolarization in cardiac myocytes	69869
gene_other	channel formed creates a 4-aminopyridine (4-AP)-sensitive transient outward current	69869
gene_process	in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction	69869
gene_process	in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction	628458
gene_process	in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction	628470
gene_process	contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle	69869
gene_process	contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle	628458
gene_process	contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle	628470
gene_protein	654 amino acid in size	69869
gene_protein	654 amino acid in size	628458
gene_protein	654 amino acid in size	628470
gene_regulation	increased expression level observed in hypertensive rats whereas the level of Kcnd2 and Kcnd3 was decreased	69869
gene_regulation	increased expression level observed in hypertensive rats whereas the level of Kcnd2 and Kcnd3 was decreased	628458
gene_regulation	increased expression level observed in hypertensive rats whereas the level of Kcnd2 and Kcnd3 was decreased	628470

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM