Gene: KCNA4 (potassium voltage-gated channel subfamily A member 4) Homo sapiens
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Symbol: KCNA4
Name: potassium voltage-gated channel subfamily A member 4
Description: Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cardiac potassium channel; fetal skeletal muscle potassium channel; HBK4; HK1; HPCN2; HUKII; KCNA4L; KCNA8; KV1.4; OTTHUMP00000231998; PCN2; potassium channel 2; potassium channel, voltage gated shaker related subfamily A, member 4; potassium voltage-gated channel, shaker-related subfamily, member 4; potassium voltage-gated channel, shaker-related subfamily, member 4-like; rapidly inactivating potassium channel; shaker-related potassium channel Kv1.4; type A potassium channel; voltage-gated K(+) channel HuKII; voltage-gated potassium channel HBK4; voltage-gated potassium channel HK1; voltage-gated potassium channel subunit Kv1.4
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381130,009,741 - 30,017,030 (-)NCBIGRCh38hg38GRCh38
GRCh371130,031,288 - 30,038,577 (-)NCBIGRCh37hg19GRCh37
Build 361129,988,341 - 29,995,064 (-)NCBINCBI36hg18NCBI36
Build 341129,988,340 - 29,995,064NCBI
Celera1130,177,828 - 30,184,551 (-)NCBI
Cytogenetic Map11p14.1NCBImapview
HuRef1129,723,661 - 29,730,948 (-)NCBI
CHM1_11130,030,186 - 30,037,475 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

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Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on KCNA4
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RGD Object Information
RGD ID: 731771
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2017-06-13
Status: ACTIVE