RGD Reference Report - Presynaptic A-current based on heteromultimeric K+ channels detected in vivo. - Rat Genome Database

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Presynaptic A-current based on heteromultimeric K+ channels detected in vivo.

Authors: Sheng, M  Liao, YJ  Jan, YN  Jan, LY 
Citation: Sheng M, etal., Nature. 1993 Sep 2;365(6441):72-5.
RGD ID: 10047358
Pubmed: PMID:8361540   (View Abstract at PubMed)
DOI: DOI:10.1038/365072a0   (Journal Full-text)

A wide variety of voltage-gated K+ channels are involved in the regulation of neuronal excitability and synaptic transmission. Their heterogeneity arises in part from the large number of genes encoding different K+ channel subunits (reviewed in ref. 1). In addition, heterologous expression studies indicate that assembly of distinct subunits into heteromultimeric channels may contribute further to K+ channel diversity. A question has been whether heteromeric K+ channels actually form in vivo, and if so, whether specific combinations of subunits could account for major K+ currents identified in neurons. We present here biochemical evidence that Kv1.4 and Kv1.2, two K+ channel subunits of the Shaker subfamily, co-assemble in rat brain. The Kv1.4/Kv1.2 heteromultimer combines features of both parent subunits, resulting in an A-type K+ channel. Immunocytochemical evidence suggests that the heteromultimers are localized in axons and nerve terminals. We propose that Kv1.4/Kv1.2 heteromultimers may form the molecular basis of a presynaptic A-type K+ channel involved in the regulation of neurotransmitter release.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon located_inIDA 10047358PMID:8361540UniProt 
membrane located_inIDA 10047358PMID:8361540UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Kcna4  (potassium voltage-gated channel subfamily A member 4)


Additional Information