Kcna2 (potassium voltage-gated channel subfamily A member 2) - Rat Genome Database

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Gene: Kcna2 (potassium voltage-gated channel subfamily A member 2) Rattus norvegicus
Analyze
Symbol: Kcna2
Name: potassium voltage-gated channel subfamily A member 2
RGD ID: 2950
Description: Enables kinesin binding activity and voltage-gated monoatomic ion channel activity. Involved in several processes, including nervous system development; neuronal action potential; and potassium ion export across plasma membrane. Located in juxtaparanode region of axon; lamellipodium; and plasma membrane. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 32. Orthologous to human KCNA2 (potassium voltage-gated channel subfamily A member 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BK2; NGK1; Potassium (K+) channel protein alpha 2 voltage dependent; Potassium (K+) channel protein alpha 2, voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 2; Potassium voltage gated channel shaker related subfamily member 2; Potassium voltage gated channel, shaker related subfamily, member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RAK; RBK2; RCK5; voltage-gated potassium channel subunit Kv1.2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,392,746 - 197,406,606 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2197,392,698 - 197,407,519 (+)EnsemblGRCr8
mRatBN7.22194,704,555 - 194,718,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2202,344,285 - 202,348,438 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,231,405 - 200,235,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,048,348 - 195,052,508 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,838,607 - 209,852,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,838,869 - 209,852,471 (+)Ensemblrn6Rnor6.0
Rnor_5.02229,303,490 - 229,316,755 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42202,560,152 - 202,564,305 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2187,366,228 - 187,370,362 (+)NCBICelera
RGSC_v3.12202,522,944 - 202,527,059 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Banerjee A, etal., Elife. 2013 May 21;2:e00594. doi: 10.7554/eLife.00594.
2. The small GTP-binding protein RhoA regulates a delayed rectifier potassium channel. Cachero TG, etal., Cell. 1998 Jun 12;93(6):1077-85. doi: 10.1016/s0092-8674(00)81212-x.
3. Molecular basis of dysfunctional Kv channels in small coronary artery smooth muscle cells of streptozotocin-induced diabetic rats. Chai Q, etal., Chin J Physiol. 2007 Aug 31;50(4):171-7.
4. Two heteromeric Kv1 potassium channels differentially regulate action potential firing. Dodson PD, etal., J Neurosci. 2002 Aug 15;22(16):6953-61.
5. Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion. Dodson PD, etal., J Physiol. 2003 Jul 1;550(Pt 1):27-33. doi: 10.1113/jphysiol.2003.046250. Epub 2003 May 30.
6. Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons. Fan L, etal., Mol Pain. 2014 Jan 29;10:8. doi: 10.1186/1744-8069-10-8.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. Hattan D, etal., J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.
10. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain. Huang CY, etal., J Comp Neurol. 2012 Nov 1;520(16):3650-72. doi: 10.1002/cne.23119.
11. Distinct roles of Kv1 and Kv3 potassium channels at the calyx of Held presynaptic terminal. Ishikawa T, etal., J Neurosci. 2003 Nov 12;23(32):10445-53.
12. Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. Kim E, etal., Nature. 1995 Nov 2;378(6552):85-8.
13. Contributions of Kv1.2, Kv1.5 and Kv2.1 subunits to the native delayed rectifier K(+) current in rat mesenteric artery smooth muscle cells. Lu Y, etal., Life Sci. 2002 Aug 9;71(12):1465-73.
14. Isolation of a cDNA clone coding for a putative second potassium channel indicates the existence of a gene family. McKinnon D J Biol Chem 1989 May 15;264(14):8230-6.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. Ogawa Y, etal., J Neurosci. 2010 Jan 20;30(3):1038-48. doi: 10.1523/JNEUROSCI.4661-09.2010.
18. Cloning and expression of a rat cardiac delayed rectifier potassium channel. Paulmichl M, etal., Proc Natl Acad Sci U S A 1991 Sep 1;88(17):7892-5.
19. The molecular basis for the actions of KVbeta1.2 on the opening and closing of the KV1.2 delayed rectifier channel. Peters CJ, etal., Channels (Austin). 2009 Sep-Oct;3(5):314-22. Epub 2009 Sep 16.
20. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. Poliak S, etal., Neuron. 1999 Dec;24(4):1037-47.
21. GOA pipeline RGD automated data pipeline
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Association and colocalization of the Kvbeta1 and Kvbeta2 beta-subunits with Kv1 alpha-subunits in mammalian brain K+ channel complexes. Rhodes KJ, etal., J Neurosci. 1997 Nov 1;17(21):8246-58.
24. The role of Kif5B in axonal localization of Kv1 K(+) channels. Rivera J, etal., Eur J Neurosci. 2007 Jan;25(1):136-46.
25. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain. Stuhmer W, etal., EMBO J 1989 Nov;8(11):3235-44.
Additional References at PubMed
PMID:8046438   PMID:8608002   PMID:11007484   PMID:11086297   PMID:11401852   PMID:12963709   PMID:12975355   PMID:15102918   PMID:16002581   PMID:16122713   PMID:16306173   PMID:16525039  
PMID:16770729   PMID:17675568   PMID:17922012   PMID:17925011   PMID:18056633   PMID:18174882   PMID:18504314   PMID:18627436   PMID:18638484   PMID:18760366   PMID:19247844   PMID:19912772  
PMID:19947938   PMID:20231479   PMID:20534430   PMID:20694152   PMID:20805574   PMID:21233214   PMID:21602278   PMID:22764231   PMID:22871113   PMID:23725331   PMID:23792947   PMID:25378149  
PMID:25588216   PMID:25661478   PMID:26047212   PMID:26835990   PMID:26950215   PMID:29056068   PMID:29263036   PMID:31140423   PMID:32315300   PMID:32621322   PMID:34632937  


Genomics

Comparative Map Data
Kcna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,392,746 - 197,406,606 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2197,392,698 - 197,407,519 (+)EnsemblGRCr8
mRatBN7.22194,704,555 - 194,718,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2202,344,285 - 202,348,438 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,231,405 - 200,235,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,048,348 - 195,052,508 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,838,607 - 209,852,471 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,838,869 - 209,852,471 (+)Ensemblrn6Rnor6.0
Rnor_5.02229,303,490 - 229,316,755 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42202,560,152 - 202,564,305 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2187,366,228 - 187,370,362 (+)NCBICelera
RGSC_v3.12202,522,944 - 202,527,059 (+)NCBI
Cytogenetic Map2q34NCBI
KCNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,593,580 - 110,631,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,519,837 - 110,631,474 (-)Ensemblhg38GRCh38
GRCh371111,136,202 - 111,174,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,947,299 - 110,949,868 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341110,857,818 - 110,860,387NCBI
Celera1109,392,891 - 109,395,460 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1109,007,594 - 109,045,483 (-)NCBIHuRef
CHM1_11111,251,494 - 111,289,381 (-)NCBICHM1_1
T2T-CHM13v2.01110,608,515 - 110,647,421 (-)NCBIT2T-CHM13v2.0
Kcna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,998,203 - 107,022,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,008,462 - 107,022,321 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383107,090,883 - 107,115,005 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,101,146 - 107,115,005 (+)Ensemblmm10GRCm38
MGSCv373106,904,485 - 106,909,797 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363107,229,623 - 107,234,935 (+)NCBIMGSCv36mm8
Celera3109,430,684 - 109,436,074 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.61NCBI
Kcna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,074,346 - 14,078,806 (-)Ensembl
ChiLan1.0NW_00495543514,074,346 - 14,080,026 (-)NCBIChiLan1.0ChiLan1.0
KCNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,433,108 - 116,484,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,580,649 - 115,631,586 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,187,158 - 113,256,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,087,801 - 127,118,724 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,090,829 - 127,092,328 (+)EnsemblpanPan2panpan1.1
KCNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,405,453 - 41,415,727 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,407,070 - 41,408,823 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha644,184,430 - 44,186,175 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0641,736,857 - 41,747,996 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,736,845 - 41,741,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,459,141 - 41,460,886 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,429,846 - 41,431,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,865,201 - 41,866,946 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,094,671 - 18,109,123 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,007,577 - 2,017,764 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,007,577 - 2,019,520 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,557,973 - 109,560,998 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14109,534,923 - 109,570,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,933,524 - 22,942,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,940,154 - 22,941,650 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603835,517,971 - 35,523,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,305,550 - 6,309,906 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247726,298,113 - 6,311,614 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcna2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1351,149,324 - 51,156,034 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcna2
89 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:29
Count of miRNA genes:26
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000050149
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
KCNA2_869  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22194,708,480 - 194,709,316 (+)MAPPERmRatBN7.2
Rnor_6.02209,842,565 - 209,843,400NCBIRnor6.0
Rnor_5.02229,307,375 - 229,308,210UniSTSRnor5.0
RGSC_v3.42202,563,322 - 202,564,157UniSTSRGSC3.4
Celera2187,369,379 - 187,370,214UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 10 57 165 83 82 51 64 51 6 285 152 11 144 65 91 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006233135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008761371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000050149   ⟹   ENSRNOP00000042653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2209,840,404 - 209,843,649 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086836   ⟹   ENSRNOP00000074851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2209,849,848 - 209,850,102 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092365   ⟹   ENSRNOP00000075841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2209,838,869 - 209,843,588 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092450   ⟹   ENSRNOP00000075852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2194,705,199 - 194,718,400 (+)Ensembl
Rnor_6.0 Ensembl2209,839,299 - 209,852,471 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100022   ⟹   ENSRNOP00000089201
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2197,392,698 - 197,407,519 (+)Ensembl
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108979   ⟹   ENSRNOP00000079590
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2197,392,987 - 197,406,898 (+)Ensembl
mRatBN7.2 Ensembl2194,704,888 - 194,718,400 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116262   ⟹   ENSRNOP00000090952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2197,393,420 - 197,407,519 (+)Ensembl
mRatBN7.2 Ensembl2194,705,683 - 194,718,400 (+)Ensembl
RefSeq Acc Id: NM_012970   ⟹   NP_037102
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,530 - 197,397,683 (+)NCBI
mRatBN7.22194,705,311 - 194,709,464 (+)NCBI
Rnor_6.02209,839,395 - 209,843,548 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
RGSC_v3.42202,560,152 - 202,564,305 (+)RGD
Celera2187,366,228 - 187,370,362 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233132   ⟹   XP_006233194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,950 - 197,406,606 (+)NCBI
mRatBN7.22194,705,727 - 194,718,387 (+)NCBI
Rnor_6.02209,839,810 - 209,852,471 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233133   ⟹   XP_006233195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,392,746 - 197,406,606 (+)NCBI
mRatBN7.22194,704,555 - 194,718,387 (+)NCBI
Rnor_6.02209,838,607 - 209,852,471 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233134   ⟹   XP_006233196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,392,973 - 197,406,606 (+)NCBI
mRatBN7.22194,704,879 - 194,718,387 (+)NCBI
Rnor_6.02209,838,891 - 209,852,471 (+)NCBI
Rnor_5.02229,303,490 - 229,316,755 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008761371   ⟹   XP_008759593
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,711 - 197,406,606 (+)NCBI
mRatBN7.22194,705,493 - 194,718,387 (+)NCBI
Rnor_6.02209,839,520 - 209,852,471 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101795   ⟹   XP_038957723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,950 - 197,406,606 (+)NCBI
mRatBN7.22194,705,727 - 194,718,387 (+)NCBI
RefSeq Acc Id: XM_039101797   ⟹   XP_038957725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,950 - 197,406,606 (+)NCBI
mRatBN7.22194,705,727 - 194,718,387 (+)NCBI
RefSeq Acc Id: XM_063281362   ⟹   XP_063137432
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,353 - 197,406,606 (+)NCBI
RefSeq Acc Id: XM_063281363   ⟹   XP_063137433
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,392,776 - 197,406,606 (+)NCBI
RefSeq Acc Id: XM_063281364   ⟹   XP_063137434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82197,393,711 - 197,406,606 (+)NCBI
RefSeq Acc Id: NP_037102   ⟸   NM_012970
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233195   ⟸   XM_006233133
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233196   ⟸   XM_006233134
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233194   ⟸   XM_006233132
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008759593   ⟸   XM_008761371
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075841   ⟸   ENSRNOT00000092365
Ensembl Acc Id: ENSRNOP00000075852   ⟸   ENSRNOT00000092450
Ensembl Acc Id: ENSRNOP00000074851   ⟸   ENSRNOT00000086836
Ensembl Acc Id: ENSRNOP00000042653   ⟸   ENSRNOT00000050149
RefSeq Acc Id: XP_038957725   ⟸   XM_039101797
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957723   ⟸   XM_039101795
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079590   ⟸   ENSRNOT00000108979
Ensembl Acc Id: ENSRNOP00000089201   ⟸   ENSRNOT00000100022
Ensembl Acc Id: ENSRNOP00000090952   ⟸   ENSRNOT00000116262
RefSeq Acc Id: XP_063137433   ⟸   XM_063281363
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137432   ⟸   XM_063281362
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063137434   ⟸   XM_063281364
- Peptide Label: isoform X1
- UniProtKB: P63142 (UniProtKB/Swiss-Prot),   A6HUS5 (UniProtKB/TrEMBL)
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63142-F1-model_v2 AlphaFold P63142 1-499 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2950 AgrOrtholog
BioCyc Gene G2FUF-51688 BioCyc
Ensembl Genes ENSRNOG00000018285 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000092450.2 UniProtKB/Swiss-Prot
  ENSRNOT00000100022 ENTREZGENE
  ENSRNOT00000100022.1 UniProtKB/Swiss-Prot
  ENSRNOT00000108979 ENTREZGENE
  ENSRNOT00000108979.1 UniProtKB/Swiss-Prot
  ENSRNOT00000116262 ENTREZGENE
  ENSRNOT00000116262.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv1 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv1.2 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  VG_K_chnl UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:25468 UniProtKB/Swiss-Prot
NCBI Gene 25468 ENTREZGENE
PANTHER PTHR11537 UniProtKB/Swiss-Prot
  PTHR11537:SF23 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
PhenoGen Kcna2 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV12CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHAKERCHANEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018285 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A6HUS4_RAT UniProtKB/TrEMBL
  A6HUS5 ENTREZGENE, UniProtKB/TrEMBL
  KCNA2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P15386 UniProtKB/Swiss-Prot
  Q02010 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcna2  potassium voltage-gated channel subfamily A member 2  Kcna2  potassium channel, voltage gated shaker related subfamily A, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcna2  potassium channel, voltage gated shaker related subfamily A, member 2  Kcna2  potassium voltage-gated channel, shaker-related subfamily, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Kcna2  potassium voltage-gated channel, shaker-related subfamily, member 2    potassium voltage gated channel, shaker related subfamily, member 2   Symbol and Name updated 625702 APPROVED
2002-06-10 Kcna2  potassium voltage gated channel, shaker related subfamily, member 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference