KCNA2 (potassium voltage-gated channel subfamily A member 2) - Rat Genome Database

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Gene: KCNA2 (potassium voltage-gated channel subfamily A member 2) Chlorocebus sabaeus
Analyze
Symbol: KCNA2
Name: potassium voltage-gated channel subfamily A member 2
RGD ID: 18426534
Description: ENCODES a protein that exhibits kinesin binding (ortholog); outward rectifier potassium channel activity (ortholog); voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (ortholog); INVOLVED IN cerebral cortex development (ortholog); corpus callosum development (ortholog); neuronal action potential (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); developmental and epileptic encephalopathy 1 (ortholog); FOUND IN axon initial segment (ortholog); calyx of Held (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,933,524 - 22,942,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,940,154 - 22,941,650 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,517,971 - 35,523,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,933,524 - 22,942,074 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,940,154 - 22,941,650 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603835,517,971 - 35,523,444 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
KCNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381110,593,580 - 110,631,440 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1110,519,837 - 110,631,474 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,136,202 - 111,174,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,947,299 - 110,949,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 341110,857,818 - 110,860,387NCBI
Celera1109,392,891 - 109,395,460 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1109,007,594 - 109,045,483 (-)NCBIHuRef
CHM1_11111,251,494 - 111,289,381 (-)NCBICHM1_1
T2T-CHM13v2.01110,608,515 - 110,647,421 (-)NCBIT2T-CHM13v2.0
Kcna2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393106,998,203 - 107,022,321 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,008,462 - 107,022,321 (+)EnsemblGRCm39 Ensembl
GRCm383107,090,883 - 107,115,005 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,101,146 - 107,115,005 (+)EnsemblGRCm38mm10GRCm38
MGSCv373106,904,485 - 106,909,797 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363107,229,623 - 107,234,935 (+)NCBIMGSCv36mm8
Celera3109,430,684 - 109,436,074 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.61NCBI
Kcna2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82197,392,746 - 197,406,606 (+)NCBIGRCr8
mRatBN7.22194,704,555 - 194,718,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2194,704,639 - 194,718,400 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2202,344,285 - 202,348,438 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02200,231,405 - 200,235,565 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,048,348 - 195,052,508 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02209,838,607 - 209,852,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2209,838,869 - 209,852,471 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02229,303,490 - 229,316,755 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42202,560,152 - 202,564,305 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12202,522,944 - 202,527,059 (+)NCBI
Celera2187,366,228 - 187,370,362 (+)NCBICelera
Cytogenetic Map2q34NCBI
Kcna2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,074,346 - 14,078,806 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,074,346 - 14,080,026 (-)NCBIChiLan1.0ChiLan1.0
KCNA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21116,433,108 - 116,484,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11115,580,649 - 115,631,586 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01113,187,158 - 113,256,260 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,087,801 - 127,118,724 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,090,829 - 127,092,328 (+)Ensemblpanpan1.1panPan2
KCNA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1641,405,453 - 41,415,727 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl641,407,070 - 41,408,823 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,184,430 - 44,186,175 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0641,736,857 - 41,747,996 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl641,736,845 - 41,741,870 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1641,459,141 - 41,460,886 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0641,429,846 - 41,431,591 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0641,865,201 - 41,866,946 (+)NCBIUU_Cfam_GSD_1.0
Kcna2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,094,671 - 18,109,123 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367042,007,577 - 2,017,764 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367042,007,577 - 2,019,520 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4109,557,973 - 109,560,998 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14109,534,923 - 109,570,172 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Kcna2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247726,305,550 - 6,309,906 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247726,298,113 - 6,311,614 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 5 41
Low 30 16 19
Below cutoff 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000018367   ⟹   ENSCSAP00000017824
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl2022,940,154 - 22,941,650 (+)Ensembl
RefSeq Acc Id: XM_007977620   ⟹   XP_007975811
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12022,937,870 - 22,942,074 (+)NCBI
Vero_WHO_p1.0NW_02366603835,517,971 - 35,522,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007977621   ⟹   XP_007975812
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12022,937,390 - 22,942,074 (+)NCBI
Vero_WHO_p1.0NW_02366603835,517,971 - 35,522,908 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007977622   ⟹   XP_007975813
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.12022,937,063 - 22,942,074 (+)NCBI
Vero_WHO_p1.0NW_02366603835,517,971 - 35,523,444 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007975811 (Get FASTA)   NCBI Sequence Viewer  
  XP_007975812 (Get FASTA)   NCBI Sequence Viewer  
  XP_007975813 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000017824.1
Reference Protein Sequences
RefSeq Acc Id: XP_007975813   ⟸   XM_007977622
- UniProtKB: A0A0D9SAD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007975812   ⟸   XM_007977621
- UniProtKB: A0A0D9SAD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007975811   ⟸   XM_007977620
- UniProtKB: A0A0D9SAD5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000017824   ⟸   ENSCSAT00000018367


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000000168 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000018367.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv1.2 UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report csab:103224240 UniProtKB/TrEMBL
NCBI Gene KCNA2 ENTREZGENE
PANTHER PTHR11537 UniProtKB/TrEMBL
  PTHR11537:SF23 UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KV12CHANNEL UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/TrEMBL
  SHAKERCHANEL UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0D9SAD5 ENTREZGENE, UniProtKB/TrEMBL