Grm2 (glutamate metabotropic receptor 2) - Rat Genome Database

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Gene: Grm2 (glutamate metabotropic receptor 2) Rattus norvegicus
Analyze
Symbol: Grm2
Name: glutamate metabotropic receptor 2
RGD ID: 2743
Description: Enables group II metabotropic glutamate receptor activity and scaffold protein binding activity. Involved in several processes, including behavioral response to nicotine; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and regulation of amine transport. Located in astrocyte projection and axon. Is active in presynaptic membrane. Used to study heroin dependence. Biomarker of schizophrenia. Orthologous to human GRM2 (glutamate metabotropic receptor 2); PARTICIPATES IN glutamate signaling pathway; INTERACTS WITH (+)-pilocarpine; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutamate receptor, metabotropic 2; metabotropic glutamate receptor 2; mGlu2; mGluR2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Grm2em1
Genetic Models: WI-Grm2em1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,158,810 - 116,171,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8116,158,810 - 116,171,857 (-)EnsemblGRCr8
mRatBN7.28107,280,099 - 107,293,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,280,099 - 107,293,146 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,903,031 - 112,916,129 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,102,213 - 111,115,309 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,944,991 - 108,958,085 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,344,999 - 115,358,628 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,344,999 - 115,358,046 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,705,123 - 114,718,193 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48111,837,086 - 111,850,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8106,592,051 - 106,605,096 (-)NCBICelera
RGSC_v3.18111,857,819 - 111,869,581 (-)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
astrocyte projection  (IDA,IEA)
axon  (IDA)
dendrite  (IEA)
glutamatergic synapse  (IEA,ISO)
membrane  (IEA)
neuron projection  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,TAS)
postsynaptic membrane  (IEA,ISO)
presynaptic membrane  (IDA,IMP)
synapse  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Subsynaptic mobility of presynaptic mGluR types is differentially regulated by intra- and extracellular interactions. Bodzęta A, etal., Mol Biol Cell. 2022 Jul 1;33(8):ar66. doi: 10.1091/mbc.E21-10-0484. Epub 2022 May 5.
2. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. Dev KK, etal., J Neurosci. 2000 Oct 1;20(19):7252-7.
3. Differences in 5-HT2A and mGlu2 Receptor Expression Levels and Repressive Epigenetic Modifications at the 5-HT2A Promoter Region in the Roman Low- (RLA-I) and High- (RHA-I) Avoidance Rat Strains. Fomsgaard L, etal., Mol Neurobiol. 2018 Mar;55(3):1998-2012. doi: 10.1007/s12035-017-0457-y. Epub 2017 Mar 6.
4. Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats. Gao JT, etal., Neuropsychopharmacology. 2018 Dec;43(13):2615-2626. doi: 10.1038/s41386-018-0231-5. Epub 2018 Oct 3.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. Luján R, etal., J Chem Neuroanat. 1997 Oct;13(4):219-41.
8. Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex. Maeda J, etal., Neurosci Lett 2003 Jan 23;336(3):171-4.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus. Poisik O, etal., Neuropharmacology. 2005;49 Suppl 1:57-69.
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Ritter-Makinson SL, etal., Neuroscience. 2017 Jun 14;353:58-75. doi: 10.1016/j.neuroscience.2017.03.060. Epub 2017 Apr 7.
17. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. Rives ML, etal., EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.
18. Enhancement of low-voltage-activated calcium currents by group II metabotropic glutamate receptors in rat retinal ganglion cells. Robbins J, etal., Mol Cell Neurosci 2003 Jul;23(3):341-50.
19. Ethanol concentration-dependent alterations in gene expression during acute binge drinking in the HIV-1 transgenic rat. Sarkar S and Chang SL, Alcohol Clin Exp Res. 2013 Jul;37(7):1082-90. doi: 10.1111/acer.12077. Epub 2013 Feb 15.
20. RanBPM is expressed in synaptic layers of the mammalian retina and binds to metabotropic glutamate receptors. Seebahn A, etal., FEBS Lett. 2008 Jul 9;582(16):2453-7. doi: 10.1016/j.febslet.2008.06.010. Epub 2008 Jun 13.
21. A family of metabotropic glutamate receptors. Tanabe Y, etal., Neuron 1992 Jan;8(1):169-79.
22. Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. Yang HJ, etal., Cell Rep. 2017 Jul 11;20(2):319-332. doi: 10.1016/j.celrep.2017.06.046.
Additional References at PubMed
PMID:1298933   PMID:7965099   PMID:8662555   PMID:11584003   PMID:11850456   PMID:12074840   PMID:12746871   PMID:14645456   PMID:15208212   PMID:15494036   PMID:15861463   PMID:15862522  
PMID:16000629   PMID:16408587   PMID:16760343   PMID:16793029   PMID:17005860   PMID:17030435   PMID:17216195   PMID:17401670   PMID:17948876   PMID:18804094   PMID:19026992   PMID:19429193  
PMID:19776267   PMID:20826132   PMID:20923868   PMID:21198990   PMID:21470207   PMID:21677028   PMID:21681341   PMID:21896740   PMID:22479593   PMID:22531751   PMID:22653971   PMID:22914798  
PMID:22973014   PMID:22984605   PMID:23382250   PMID:23407939   PMID:23455609   PMID:24067361   PMID:24082084   PMID:24486391   PMID:24495291   PMID:26051401   PMID:26071959   PMID:26134564  
PMID:26987983   PMID:27385724   PMID:27565411   PMID:28661401   PMID:28821279   PMID:28829739   PMID:29024663   PMID:30005976   PMID:31050077   PMID:32534177   PMID:32640261   PMID:33201416  
PMID:37917117  


Genomics

Comparative Map Data
Grm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,158,810 - 116,171,857 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8116,158,810 - 116,171,857 (-)EnsemblGRCr8
mRatBN7.28107,280,099 - 107,293,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,280,099 - 107,293,146 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8112,903,031 - 112,916,129 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,102,213 - 111,115,309 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,944,991 - 108,958,085 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,344,999 - 115,358,628 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,344,999 - 115,358,046 (-)Ensemblrn6Rnor6.0
Rnor_5.08114,705,123 - 114,718,193 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48111,837,086 - 111,850,133 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8106,592,051 - 106,605,096 (-)NCBICelera
RGSC_v3.18111,857,819 - 111,869,581 (-)NCBI
Cytogenetic Map8q32NCBI
GRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38351,707,068 - 51,718,613 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl351,707,061 - 51,718,616 (+)Ensemblhg38GRCh38
GRCh37351,741,084 - 51,752,629 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,718,004 - 51,727,669 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34351,718,037 - 51,727,168NCBI
Celera351,718,848 - 51,731,506 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef351,802,839 - 51,816,142 (+)NCBIHuRef
CHM1_1351,693,893 - 51,705,447 (+)NCBICHM1_1
T2T-CHM13v2.0351,738,578 - 51,751,605 (+)NCBIT2T-CHM13v2.0
Grm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,521,733 - 106,533,308 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,520,294 - 106,533,281 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm389106,644,534 - 106,656,109 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,643,095 - 106,656,082 (-)Ensemblmm10GRCm38
MGSCv379106,546,865 - 106,558,440 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369106,546,755 - 106,558,434 (-)NCBIMGSCv36mm8
Celera9106,265,562 - 106,277,130 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.98NCBI
Grm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555323,309,028 - 3,320,966 (+)Ensembl
ChiLan1.0NW_0049555323,309,034 - 3,320,954 (+)NCBIChiLan1.0ChiLan1.0
GRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2251,694,559 - 51,707,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1351,699,333 - 51,712,208 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0351,639,792 - 51,652,779 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1352,873,144 - 52,884,401 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl352,873,144 - 52,884,395 (+)EnsemblpanPan2panpan1.1
GRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,915,178 - 37,926,276 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,915,665 - 37,924,296 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2037,895,193 - 37,906,256 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02038,264,331 - 38,275,394 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2038,264,304 - 38,275,372 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,627,888 - 37,638,953 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,036,604 - 38,047,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,321,755 - 38,332,818 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,281,725 - 66,293,182 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365293,042,248 - 3,053,673 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365293,042,220 - 3,053,670 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,926,804 - 33,938,269 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11333,924,303 - 33,938,279 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,130,553 - 37,141,351 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,044,974 - 13,056,469 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,046,641 - 13,056,453 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666041153,898,374 - 153,910,372 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247305,419,896 - 5,431,361 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247305,419,892 - 5,431,268 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Grm2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1897,938,585 - 97,950,517 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grm2
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:437
Count of miRNA genes:228
Interacting mature miRNAs:281
Transcripts:ENSRNOT00000017607
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)882352698127352698Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)861019838121662124Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)849849908118871671Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)880768445125768445Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)880768445125768445Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)870041301121080908Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)868690349119799881Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
8693654Alc32Alcohol consumption QTL 3220.755drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)897492344116428905Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)855428333127966348Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8111249511117802327Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)898145073122898010Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)880768445125768445Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)880768445125768445Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat


Genetic Models
This gene Grm2 is modified in the following models/strains:
WI-Grm2em1    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 10 28 131 62 61 30 35 30 6 156 83 115 25 59 31 15 15

Sequence


Ensembl Acc Id: ENSRNOT00000017607   ⟹   ENSRNOP00000017607
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8116,158,810 - 116,171,857 (-)Ensembl
mRatBN7.2 Ensembl8107,280,099 - 107,293,146 (-)Ensembl
Rnor_6.0 Ensembl8115,344,999 - 115,358,046 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098540   ⟹   ENSRNOP00000091771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8116,160,735 - 116,171,857 (-)Ensembl
mRatBN7.2 Ensembl8107,282,024 - 107,293,146 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101861   ⟹   ENSRNOP00000081739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8116,158,810 - 116,171,857 (-)Ensembl
mRatBN7.2 Ensembl8107,280,099 - 107,293,146 (-)Ensembl
RefSeq Acc Id: NM_001105711   ⟹   NP_001099181
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,158,810 - 116,171,857 (-)NCBI
mRatBN7.28107,280,099 - 107,293,146 (-)NCBI
Rnor_6.08115,344,999 - 115,358,046 (-)NCBI
Rnor_5.08114,705,123 - 114,718,193 (-)NCBI
RGSC_v3.48111,837,086 - 111,850,133 (-)RGD
Celera8106,592,051 - 106,605,096 (-)RGD
Sequence:
RefSeq Acc Id: XM_063264894   ⟹   XP_063120964
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,160,086 - 116,171,844 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001099181 (Get FASTA)   NCBI Sequence Viewer  
  XP_063120964 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77281 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017607
  ENSRNOP00000017607.2
  ENSRNOP00000091771
GenBank Protein P31421 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099181   ⟸   NM_001105711
- Peptide Label: precursor
- UniProtKB: P31421 (UniProtKB/Swiss-Prot),   A6I2U6 (UniProtKB/TrEMBL),   A0A8I6AGD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017607   ⟸   ENSRNOT00000017607
Ensembl Acc Id: ENSRNOP00000081739   ⟸   ENSRNOT00000101861
Ensembl Acc Id: ENSRNOP00000091771   ⟸   ENSRNOT00000098540
RefSeq Acc Id: XP_063120964   ⟸   XM_063264894
- Peptide Label: isoform X1
- UniProtKB: P31421 (UniProtKB/Swiss-Prot),   A0A8I6AGD5 (UniProtKB/TrEMBL),   A6I2U6 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 3 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31421-F1-model_v2 AlphaFold P31421 1-872 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2743 AgrOrtholog
BIND 144397
BioCyc Gene G2FUF-29226 BioCyc
Ensembl Genes ENSRNOG00000013171 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000017607 ENTREZGENE
  ENSRNOT00000017607.4 UniProtKB/Swiss-Prot
  ENSRNOT00000098540 ENTREZGENE
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  GPCR_3 UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot
  GPCR_3_C UniProtKB/Swiss-Prot
  GPCR_3_CS UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt_2 UniProtKB/Swiss-Prot
  mGluR UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24415 UniProtKB/Swiss-Prot
NCBI Gene 24415 ENTREZGENE
PANTHER METABOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_3 UniProtKB/Swiss-Prot
  ANF_receptor UniProtKB/Swiss-Prot
  NCD3G UniProtKB/Swiss-Prot
PhenoGen Grm2 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot
  MTABOTROPC2R UniProtKB/Swiss-Prot
  MTABOTROPICR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013171 RatGTEx
Superfamily-SCOP SSF53822 UniProtKB/Swiss-Prot
UniProt A0A8I5ZT60_RAT UniProtKB/TrEMBL
  A0A8I6AGD5 ENTREZGENE, UniProtKB/TrEMBL
  A6I2U6 ENTREZGENE, UniProtKB/TrEMBL
  GRM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Grm2  glutamate metabotropic receptor 2  Grm2  glutamate receptor, metabotropic 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Grm2  glutamate receptor, metabotropic 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Grm2  glutamate receptor, metabotropic 2    Glutamate receptor, metabotropic 2  Name updated 625702 APPROVED
2002-06-10 Grm2  Glutamate receptor, metabotropic 2      Symbol and Name status set to approved 70586 APPROVED