Grm1 (glutamate metabotropic receptor 1) - Rat Genome Database

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Gene: Grm1 (glutamate metabotropic receptor 1) Rattus norvegicus
Analyze
Symbol: Grm1
Name: glutamate metabotropic receptor 1
RGD ID: 2742
Description: Enables nuclear estrogen receptor binding activity. Involved in calcium-mediated signaling; chemical synaptic transmission; and regulation of glutamatergic synaptic transmission. Located in several cellular components, including dendritic spine; neuronal cell body; and presynaptic membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 13 and spinocerebellar ataxia 44. Orthologous to human GRM1 (glutamate metabotropic receptor 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; glutamate signaling pathway; Huntington's disease pathway; INTERACTS WITH (+)-pilocarpine; (S)-3,5-dihydroxyphenylglycine; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: G protein coupled receptor family C group 1 member A; G protein coupled receptor, family C, group 1, member A; glutamate receptor, metabotropic 1; Gprc1a; metabotropic glutamate receptor 1; mGluR1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr816,878,542 - 7,273,447 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl16,878,545 - 7,273,443 (-)EnsemblGRCr8
mRatBN7.215,058,285 - 5,453,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15,058,292 - 5,453,170 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14,753,399 - 5,148,239 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0110,753,754 - 11,148,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015,035,595 - 5,430,440 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014,753,141 - 5,165,859 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)Ensemblrn6Rnor6.0
Rnor_5.016,815,959 - 6,818,380 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.016,413,420 - 6,685,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415,318,617 - 5,744,593 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera13,589,875 - 3,976,624 (-)NCBICelera
RGSC_v3.115,318,616 - 5,744,590 (-)NCBI
SHRSP x BN Map15.6799RGD
Cytogenetic Map1p13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-3,5-dihydroxyphenylglycine  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (EXP)
1,2-dichloroethane  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-aminoethoxydiphenylborane  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
allethrin  (EXP)
ammonia  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
Ampullosporin  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
caffeine  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
CGP 52608  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyanuric acid  (EXP)
cyhalothrin  (EXP)
cypermethrin  (EXP)
DDT  (EXP)
decabromodiphenyl ether  (EXP)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
doxorubicin  (ISO)
enalaprilat dihydrate  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
fentanyl  (EXP)
fenvalerate  (EXP)
flufenamic acid  (EXP)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
haloperidol  (EXP)
hexachlorophene  (ISO)
isocyanuric acid  (EXP)
ketamine  (EXP)
lead diacetate  (EXP,ISO)
lipopolysaccharide  (ISO)
lithium chloride  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
morphine  (EXP)
nicotine  (EXP)
Nonylphenol  (EXP)
oxidopamine  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium atom  (EXP)
pyrethrins  (EXP)
quinine  (EXP)
quinoline  (ISO)
ruthenium red  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SKF-96365 hydrochloride  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
Soman  (EXP)
theophylline  (EXP)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
trichloroethene  (EXP)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala. Agassandian K and Cassell MD, Brain Res. 2008 Aug 21;1226:39-55. Epub 2008 Jun 11.
2. The metabotropic glutamate receptor (mGluR1 alpha) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction. Baude A, etal., Neuron. 1993 Oct;11(4):771-87.
3. Homer: a protein that selectively binds metabotropic glutamate receptors. Brakeman PR, etal., Nature 1997 Mar 20;386(6622):284-8.
4. Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences. Croci C, etal., J Biol Chem. 2003 Dec 12;278(50):50682-90. Epub 2003 Sep 30.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Group I metabotropic glutamate receptors activate a calcium-sensitive transient receptor potential-like conductance in rat hippocampus. Gee CE, etal., J Physiol 2003 Feb 1;546(Pt 3):655-64.
7. Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus. Gillard SE, etal., J Comp Neurol 2003 Jun 30;461(3):317-32.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1. Kim SJ, etal., Nature 2003 Nov 20;426(6964):285-91. Epub 2003 Nov 12.
10. Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. Kitano J, etal., J Neurosci 2002 Feb 15;22(4):1280-9.
11. Pretreatment with group I metabotropic glutamate receptors antagonists attenuates lethality induced by acute cocaine overdose and expression of sensitization to hyperlocomotor effect of cocaine in mice. Kotlinska J and Bochenski M, Neurotox Res. 2011 Jan;19(1):23-30. doi: 10.1007/s12640-009-9136-8. Epub 2009 Nov 21.
12. Membrane estrogen receptor-alpha interacts with metabotropic glutamate receptor type 1a to mobilize intracellular calcium in hypothalamic astrocytes. Kuo J, etal., Endocrinology. 2009 Mar;150(3):1369-76. Epub 2008 Oct 23.
13. Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse. Kushmerick C, etal., J Neurosci 2004 Jun 30;24(26):5955-65.
14. Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. Luján R, etal., J Chem Neuroanat. 1997 Oct;13(4):219-41.
15. Different roles of group I and group II metabotropic glutamate receptors on phencyclidine-induced dopamine release in the rat prefrontal cortex. Maeda J, etal., Neurosci Lett 2003 Jan 23;336(3):171-4.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Comparative analysis of the subcellular and subsynaptic localization of mGluR1a and mGluR5 metabotropic glutamate receptors in the shell and core of the nucleus accumbens in rat and monkey. Mitrano DA and Smith Y, J Comp Neurol. 2007 Feb 1;500(4):788-806. doi: 10.1002/cne.21214.
18. Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens. Mitrano DA, etal., J Comp Neurol. 2010 Apr 15;518(8):1315-29. doi: 10.1002/cne.22277.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. Neugebauer V, etal., J Neurosci 2003 Jan 1;23(1):52-63.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
23. The activation of metabotropic glutamate receptors differentially affects GABA and alpha-melanocyte stimulating hormone release from the hypothalamus and the posterior pituitary of male rats. Pampillo M, etal., Neurosci Lett 2002 Jul 19;327(2):95-8.
24. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
25. Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. Poisik OV, etal., J Neurosci 2003 Jan 1;23(1):122-30.
26. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
28. Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration. Rives ML, etal., EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.
29. Identification, cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR1 mRNA1. Soloviev MM, etal., Biochim Biophys Acta 1999 Jul 7;1446(1-2):161-6.
30. Metabotropic glutamate receptors and dopamine receptors cooperate to enhance extracellular signal-regulated kinase phosphorylation in striatal neurons. Voulalas PJ, etal., J Neurosci. 2005 Apr 13;25(15):3763-73. doi: 10.1523/JNEUROSCI.4574-04.2005.
31. Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata. Wittmann M, etal., Neuroscience. 2001;105(4):881-9.
32. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
33. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Xiao B, etal., Neuron 1998 Oct;21(4):707-16.
Additional References at PubMed
PMID:1309649   PMID:1438218   PMID:1656524   PMID:1847995   PMID:8312606   PMID:9647694   PMID:10469171   PMID:10846166   PMID:10945991   PMID:11356865   PMID:11487615   PMID:11562444  
PMID:11785964   PMID:11897107   PMID:12213280   PMID:12411524   PMID:12694926   PMID:12898387   PMID:14596868   PMID:15044519   PMID:15086529   PMID:15152047   PMID:15176087   PMID:15372499  
PMID:15579147   PMID:15738140   PMID:15862522   PMID:16051747   PMID:16393337   PMID:16394070   PMID:16410359   PMID:16421200   PMID:16497716   PMID:16719794   PMID:16763042   PMID:16885225  
PMID:16905160   PMID:16931548   PMID:16982110   PMID:17030435   PMID:17156362   PMID:17228082   PMID:17250682   PMID:17292864   PMID:17303286   PMID:17331504   PMID:17360426   PMID:17548216  
PMID:17640528   PMID:17672856   PMID:18003824   PMID:18022605   PMID:18056795   PMID:18174329   PMID:18479833   PMID:18510247   PMID:18554818   PMID:18602428   PMID:18691652   PMID:18716215  
PMID:19005059   PMID:19094988   PMID:19186170   PMID:19413649   PMID:19490024   PMID:19508696   PMID:19549872   PMID:19628026   PMID:19657020   PMID:19776280   PMID:19807846   PMID:19879871  
PMID:19894497   PMID:19961906   PMID:20043967   PMID:20180987   PMID:20193665   PMID:20519363   PMID:20603338   PMID:20826542   PMID:20848228   PMID:21052544   PMID:21162731   PMID:21185314  
PMID:21269340   PMID:21576272   PMID:21593322   PMID:21613584   PMID:21668889   PMID:21749491   PMID:21795692   PMID:21849555   PMID:21880942   PMID:21980366   PMID:21984253   PMID:22172929  
PMID:22311599   PMID:22362014   PMID:22442667   PMID:22486777   PMID:22973005   PMID:23426668   PMID:23978512   PMID:24495291   PMID:24603153   PMID:25113912   PMID:25149878   PMID:25158311  
PMID:25161282   PMID:25266126   PMID:25377770   PMID:25421413   PMID:25449406   PMID:25451626   PMID:25894678   PMID:25934040   PMID:26033576   PMID:26095359   PMID:26134564   PMID:26318863  
PMID:26389591   PMID:26758963   PMID:27041217   PMID:27306787   PMID:27542344   PMID:27618534   PMID:27721389   PMID:27796752   PMID:28009293   PMID:28088471   PMID:28886343   PMID:28948209  
PMID:29097780   PMID:29253887   PMID:30222904   PMID:30590038   PMID:30599269   PMID:30607810   PMID:31146278   PMID:31369778   PMID:31600563   PMID:31710636   PMID:31919348   PMID:31996247  
PMID:34197893   PMID:34327719   PMID:34981453   PMID:35046120   PMID:35798932   PMID:37622292   PMID:37714421   PMID:37909134  


Genomics

Comparative Map Data
Grm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr816,878,542 - 7,273,447 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl16,878,545 - 7,273,443 (-)EnsemblGRCr8
mRatBN7.215,058,285 - 5,453,170 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl15,058,292 - 5,453,170 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx14,753,399 - 5,148,239 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0110,753,754 - 11,148,593 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.015,035,595 - 5,430,440 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.014,753,141 - 5,165,859 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)Ensemblrn6Rnor6.0
Rnor_5.016,815,959 - 6,818,380 (-)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.016,413,420 - 6,685,561 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.415,318,617 - 5,744,593 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera13,589,875 - 3,976,624 (-)NCBICelera
RGSC_v3.115,318,616 - 5,744,590 (-)NCBI
SHRSP x BN Map15.6799RGD
Cytogenetic Map1p13NCBI
GRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386146,027,707 - 146,437,601 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6146,027,646 - 146,437,601 (+)Ensemblhg38GRCh38
GRCh376146,348,843 - 146,758,737 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366146,392,112 - 146,800,427 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346146,392,111 - 146,800,427NCBI
Celera6147,089,147 - 147,499,119 (+)NCBICelera
Cytogenetic Map6q24.3NCBI
HuRef6143,912,141 - 144,322,105 (+)NCBIHuRef
CHM1_16146,612,129 - 147,021,949 (+)NCBICHM1_1
T2T-CHM13v2.06147,215,189 - 147,630,683 (+)NCBIT2T-CHM13v2.0
Grm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391010,561,803 - 10,958,126 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1010,561,803 - 10,958,100 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381010,686,059 - 11,082,382 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1010,686,059 - 11,082,356 (-)Ensemblmm10GRCm38
MGSCv371010,408,551 - 10,802,129 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361010,378,943 - 10,772,546 (-)NCBIMGSCv36mm8
Celera1010,578,372 - 10,975,041 (-)NCBICelera
Cytogenetic Map10A1NCBI
cM Map103.44NCBI
Grm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543614,264,387 - 14,644,622 (-)Ensembl
ChiLan1.0NW_00495543614,264,470 - 14,377,581 (-)NCBIChiLan1.0ChiLan1.0
GRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25166,025,841 - 166,437,798 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16163,918,480 - 164,330,347 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06143,819,364 - 144,231,304 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16148,535,492 - 148,945,327 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6148,537,036 - 148,947,047 (+)EnsemblpanPan2panpan1.1
GRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1137,205,817 - 37,600,048 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl137,206,542 - 37,598,134 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha138,098,496 - 38,490,369 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0137,381,684 - 37,767,160 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl137,381,685 - 37,768,980 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1137,260,006 - 37,645,862 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0137,124,615 - 37,516,108 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0137,448,182 - 37,846,268 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946132,167,285 - 132,544,694 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493662590,299 - 466,395 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493662591,229 - 468,242 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl119,183,218 - 19,572,853 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1119,183,221 - 19,572,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2121,438,453 - 21,816,533 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11325,380,855 - 25,816,945 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666040201,340,468 - 201,782,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247537,994,321 - 8,436,120 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247537,994,419 - 8,498,243 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grm1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12226,130,164 - 226,499,428 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grm1
3168 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:856
Count of miRNA genes:328
Interacting mature miRNAs:443
Transcripts:ENSRNOT00000019319, ENSRNOT00000044325
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1126564886Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
2313090Bmd69Bone mineral density QTL 694.40.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)1529322934184556Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1354647Despr8Despair related QTL 80.0000341locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1126564886Rat
2317755Glom22Glomerulus QTL 223.8urine protein amount (VT:0005160)urine protein level (CMO:0000591)1134184556Rat
1300170Rf6Renal function QTL 63.14renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)1128483164Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
2313070Bss52Bone structure and strength QTL 524.40.0001body length (VT:0001256)body length (CMO:0000013)1529322934184556Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
2313053Bss51Bone structure and strength QTL 513.80.0001tibia length (VT:0004357)tibia length (CMO:0000450)1529322934184556Rat

Markers in Region
D1Got3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215,240,453 - 5,240,670 (+)MAPPERmRatBN7.2
Rnor_6.014,946,906 - 4,947,122NCBIRnor6.0
Rnor_5.016,604,430 - 6,604,646UniSTSRnor5.0
RGSC_v3.415,501,536 - 5,501,752UniSTSRGSC3.4
RGSC_v3.415,501,535 - 5,501,752RGDRGSC3.4
Celera13,771,599 - 3,771,815UniSTS
RGSC_v3.115,501,536 - 5,501,752RGD
RH 3.4 Map186.7UniSTS
RH 3.4 Map186.7RGD
RH 2.0 Map10.0RGD
Cytogenetic Map1p13UniSTS
D1Arb40  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr816,881,198 - 6,881,526 (+)Marker Load Pipeline
mRatBN7.215,060,945 - 5,061,273 (+)MAPPERmRatBN7.2
Rnor_6.014,755,798 - 4,756,125NCBIRnor6.0
Rnor_5.016,416,074 - 6,416,401UniSTSRnor5.0
RGSC_v3.415,321,271 - 5,321,598UniSTSRGSC3.4
Celera13,592,529 - 3,592,856UniSTS
RGSC_v3.115,321,270 - 5,321,598RGD
Cytogenetic Map1p13UniSTS
GRM1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr816,881,195 - 6,881,422 (+)Marker Load Pipeline
mRatBN7.215,060,942 - 5,061,169 (+)MAPPERmRatBN7.2
Rnor_6.014,755,795 - 4,756,021NCBIRnor6.0
Rnor_5.016,416,071 - 6,416,297UniSTSRnor5.0
RGSC_v3.415,321,268 - 5,321,494UniSTSRGSC3.4
Celera13,592,526 - 3,592,752UniSTS
Cytogenetic Map1p13UniSTS
GDB:4585461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.215,113,078 - 5,113,543 (+)MAPPERmRatBN7.2
mRatBN7.22204,488,197 - 204,489,350 (+)MAPPERmRatBN7.2
Rnor_6.014,808,164 - 4,808,630NCBIRnor6.0
Rnor_6.02219,570,237 - 219,571,389NCBIRnor6.0
Rnor_5.016,469,160 - 6,469,626UniSTSRnor5.0
RGSC_v3.415,373,322 - 5,373,788UniSTSRGSC3.4
RGSC_v3.42212,765,766 - 212,766,918UniSTSRGSC3.4
Celera2196,980,884 - 196,982,036UniSTS
Cytogenetic Map2q41UniSTS
Cytogenetic Map1p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 5 10 126 21 23 13 6 13 3 65 24 2 125 15 64 10 19 19

Sequence


Ensembl Acc Id: ENSRNOT00000019319   ⟹   ENSRNOP00000019319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl16,878,545 - 7,273,443 (-)Ensembl
mRatBN7.2 Ensembl15,058,292 - 5,453,170 (-)Ensembl
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000044325   ⟹   ENSRNOP00000047790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl16,878,545 - 7,273,443 (-)Ensembl
mRatBN7.2 Ensembl15,058,292 - 5,453,170 (-)Ensembl
Rnor_6.0 Ensembl14,753,144 - 5,165,859 (-)Ensembl
RefSeq Acc Id: NM_001114330   ⟹   NP_001107802
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr816,878,545 - 7,273,443 (-)NCBI
mRatBN7.215,058,292 - 5,453,170 (-)NCBI
Rnor_6.014,753,144 - 5,165,859 (-)NCBI
Rnor_5.016,413,420 - 6,685,561 (-)NCBI
Rnor_5.016,815,959 - 6,818,380 (-)NCBI
RGSC_v3.415,318,617 - 5,744,593 (-)RGD
Celera13,589,875 - 3,976,624 (-)RGD
Sequence:
RefSeq Acc Id: NM_017011   ⟹   NP_058707
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr816,878,545 - 7,273,443 (-)NCBI
mRatBN7.215,058,292 - 5,453,170 (-)NCBI
Rnor_6.014,753,144 - 5,165,859 (-)NCBI
Rnor_5.016,413,420 - 6,685,561 (-)NCBI
Rnor_5.016,815,959 - 6,818,380 (-)NCBI
RGSC_v3.415,318,617 - 5,744,593 (-)RGD
Celera13,589,875 - 3,976,624 (-)RGD
Sequence:
RefSeq Acc Id: XM_017588777   ⟹   XP_017444266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr816,878,542 - 7,273,447 (-)NCBI
mRatBN7.215,058,285 - 5,453,155 (-)NCBI
Rnor_6.014,753,141 - 5,165,809 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280712   ⟹   XP_063136782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr816,882,261 - 7,273,446 (-)NCBI
RefSeq Acc Id: NP_058707   ⟸   NM_017011
- Peptide Label: isoform alpha precursor
- UniProtKB: P23385 (UniProtKB/Swiss-Prot),   G3V7U1 (UniProtKB/TrEMBL),   A6JP39 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001107802   ⟸   NM_001114330
- Peptide Label: isoform beta precursor
- UniProtKB: P23385 (UniProtKB/Swiss-Prot),   Q9WTJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017444266   ⟸   XM_017588777
- Peptide Label: isoform X1
- UniProtKB: P23385 (UniProtKB/Swiss-Prot),   G3V7U1 (UniProtKB/TrEMBL),   A6JP39 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047790   ⟸   ENSRNOT00000044325
Ensembl Acc Id: ENSRNOP00000019319   ⟸   ENSRNOT00000019319
RefSeq Acc Id: XP_063136782   ⟸   XM_063280712
- Peptide Label: isoform X2
Protein Domains
G-protein coupled receptors family 3 profile   LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8R5M3-F1-model_v2 AlphaFold Q8R5M3 1-578 view protein structure
AF-P23385-F1-model_v2 AlphaFold P23385 1-1199 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2742 AgrOrtholog
BIND 144392
BioCyc Gene G2FUF-62408 BioCyc
Ensembl Genes ENSRNOG00000014290 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019319 ENTREZGENE
  ENSRNOT00000044325 ENTREZGENE
  ENSRNOT00000044325.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.50.30 UniProtKB/Swiss-Prot
  3.40.50.2300 UniProtKB/Swiss-Prot
  3.80.10.10 UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Cys-rich_flank_reg_C UniProtKB/Swiss-Prot
  GPCR_3 UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_dom UniProtKB/Swiss-Prot
  GPCR_3_9-Cys_sf UniProtKB/Swiss-Prot
  GPCR_3_C UniProtKB/Swiss-Prot
  GPCR_3_CS UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt UniProtKB/Swiss-Prot
  GPCR_3_mtglu_rcpt_1 UniProtKB/Swiss-Prot
  Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_4 UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot
  Metabotropic_Glu_rcpt_Homer-bd UniProtKB/Swiss-Prot
  mGluR UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24414 UniProtKB/Swiss-Prot
  rno:246296 UniProtKB/Swiss-Prot
NCBI Gene 24414 ENTREZGENE
PANTHER IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS UniProtKB/Swiss-Prot
  METABOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
  TIR DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
Pfam 7tm_3 UniProtKB/Swiss-Prot
  ANF_receptor UniProtKB/Swiss-Prot
  GluR_Homer-bdg UniProtKB/Swiss-Prot
  LRR_1 UniProtKB/Swiss-Prot
  LRR_4 UniProtKB/Swiss-Prot
  LRR_8 UniProtKB/Swiss-Prot
  NCD3G UniProtKB/Swiss-Prot
PhenoGen Grm1 PhenoGen
PRINTS GPCRMGR UniProtKB/Swiss-Prot
  MTABOTROPC1R UniProtKB/Swiss-Prot
  MTABOTROPICR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F3_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_3 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F3_4 UniProtKB/Swiss-Prot
  LRR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014290 RatGTEx
SMART GluR_Homer-bdg UniProtKB/Swiss-Prot
  LRR_SD22 UniProtKB/Swiss-Prot
  LRR_TYP UniProtKB/Swiss-Prot
  LRRCT UniProtKB/Swiss-Prot
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A6JP38_RAT UniProtKB/TrEMBL
  A6JP39 ENTREZGENE, UniProtKB/TrEMBL
  A6JRV2_RAT UniProtKB/TrEMBL
  G3V7U1 ENTREZGENE, UniProtKB/TrEMBL
  GRM1_RAT UniProtKB/Swiss-Prot
  LRC15_RAT UniProtKB/Swiss-Prot
  M0R476_RAT UniProtKB/TrEMBL
  P23385 ENTREZGENE
  Q9WTJ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Grm1  glutamate metabotropic receptor 1  Grm1  glutamate receptor, metabotropic 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Grm1  glutamate receptor, metabotropic 1      Symbol and Name updated 629477 APPROVED
2003-03-12 Grm1  glutamate receptor, metabotropic 1  Gprc1a  G protein coupled receptor, family C, group 1, member A  Data merged from RGD:70555 628472 PROVISIONAL
2002-11-06 Grm1  glutamate receptor, metabotropic 1    Glutamate receptor, metabotropic 1  Name updated 625702 APPROVED
2002-06-10 Gprc1a  G protein coupled receptor, family C, group 1, member A      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Grm1  Glutamate receptor, metabotropic 1      Symbol and Name status set to approved 70586 APPROVED