Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) - Rat Genome Database

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Gene: Grin2a (glutamate ionotropic receptor NMDA type subunit 2A) Rattus norvegicus
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Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
RGD ID: 2737
Description: Enables several functions, including enzyme binding activity; glutamate binding activity; and monoatomic ion channel activity. Contributes to extracellularly glutamate-gated ion channel activity and monoatomic cation channel activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Used to study hyperhomocysteinemia and transient cerebral ischemia. Biomarker of cognitive disorder; placental insufficiency; post-traumatic stress disorder; status epilepticus; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A); PARTICIPATES IN excitatory synaptic transmission pathway; long term depression; long term potentiation; INTERACTS WITH (+)-pilocarpine; (25R)-cholest-5-ene-3beta,26-diol; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GluN2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor ionotropic, NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; NMDAR2A; NR2A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Grin2aem1Sidb
Genetic Models: LE-Grin2aem1Sidb
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8106,136,458 - 6,560,003 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl106,138,037 - 6,551,378 (+)EnsemblGRCr8
mRatBN7.2105,629,683 - 6,053,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1010,321,074 - 10,740,259 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,846,997 - 10,269,259 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,478,407 - 5,901,217 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)Ensemblrn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera104,645,710 - 5,048,399 (+)NCBICelera
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Cytogenetic Map10q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
alcohol dependence  (ISO)
alcohol use disorder  (IEP)
Alzheimer's disease  (ISO)
autistic disorder  (ISO)
autosomal dominant intellectual developmental disorder 21  (ISO)
benign epilepsy with centrotemporal spikes  (ISO)
bipolar disorder  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Central Nervous System Viral Diseases  (IEP)
cognitive disorder  (IEP)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
developmental and epileptic encephalopathy 11  (ISO)
Developmental Disabilities  (ISO)
epilepsy  (ISO)
familial temporal lobe epilepsy 1  (ISO)
Fetal Growth Retardation  (IEP)
focal epilepsy  (ISO)
Focal Epilepsy with Speech Disorder and with or without Mental Retardation  (ISO)
generalized epilepsy  (ISO)
genetic disease  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IDA)
hyperhomocysteinemia  (IDA)
intellectual disability  (ISO)
Landau-Kleffner syndrome  (ISO)
Language Development Disorders  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
morphine dependence  (ISO)
nasopharynx carcinoma  (ISO)
neonatal abstinence syndrome  (ISO)
Neuralgia  (IEP)
NEURODEVELOPMENTAL DISORDER WITH MICROCEPHALY, ARTHROGRYPOSIS, AND STRUCTURAL BRAIN ANOMALIES  (ISO)
Neurodevelopmental Disorders  (ISO)
opioid abuse  (ISO)
placental insufficiency  (IEP)
post-traumatic stress disorder  (IEP)
pyridoxine-dependent epilepsy  (ISO)
Reperfusion Injury  (IEP)
schizophrenia  (ISO)
Sepsis  (IEP)
speech disorder  (ISO)
status epilepticus  (IEP)
Tinnitus  (IEP)
transient cerebral ischemia  (IDA,IMP,ISO)
vascular dementia  (ISO)
withdrawal disorder  (IEP,ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(R)-lipoic acid  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2-palmitoylglycerol  (ISO)
26-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
6-propyl-2-thiouracil  (EXP)
AB-Fubinaca  (ISO)
acetamide  (EXP)
acetamiprid  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
allopurinol  (EXP)
alpha-pinene  (EXP)
Amaranth  (EXP)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
astragaloside IV  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Brilliant Blue  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (EXP)
celecoxib  (ISO)
chaetocin  (EXP)
chlorpyrifos  (EXP,ISO)
choline  (EXP)
chromium(6+)  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyanuric acid  (EXP)
cypermethrin  (EXP,ISO)
D-aspartic acid  (EXP)
decabromodiphenyl ether  (EXP)
dextromethorphan  (EXP)
Diacetoxyscirpenol  (ISO)
diazepam  (ISO)
diazinon  (EXP)
dinitrogen oxide  (ISO)
diphenyl diselenide  (ISO)
dizocilpine maleate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
erythrosin B  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
ethylparaben  (ISO)
excitatory amino acid agonist  (ISO)
felbamate  (EXP)
fentanyl  (EXP)
Fluorocitric acid  (EXP)
fluoxetine  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
haloperidol  (EXP)
hydrogen peroxide  (ISO)
indigo carmine  (EXP)
isocyanuric acid  (EXP)
kainic acid  (ISO)
ketamine  (EXP,ISO)
L-ascorbic acid  (ISO)
lanthanum trichloride  (EXP)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
leflunomide  (ISO)
linoleic acid  (EXP)
lipoic acid  (EXP)
lipoteichoic acid  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
melatonin  (EXP)
memantine  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (EXP)
midazolam  (ISO)
minocycline  (EXP)
morphine  (ISO)
N-methyl-N-nitrosourea  (EXP)
nickel atom  (ISO)
nobiletin  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ochratoxin A  (EXP)
ouabain  (EXP)
oxybenzone  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
pentobarbital  (EXP,ISO)
phencyclidine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(cytidylic acid)  (EXP)
profenofos  (EXP)
propofol  (ISO)
prostaglandin E2  (ISO)
quercetin  (EXP)
rimonabant  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sterigmatocystin  (EXP)
sulfur dioxide  (EXP)
Sunset Yellow FCF  (EXP)
suvorexant  (ISO)
T-2 toxin  (ISO)
tadalafil  (ISO)
tannic acid  (EXP)
tartrazine  (EXP)
tetrodotoxin  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP,ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IMP)
associative learning  (IEA)
auditory behavior  (IEP)
calcium ion transmembrane import into cytosol  (IEA,ISO,ISS)
calcium ion transmembrane transport  (IEA,ISO)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to amino acid stimulus  (IMP)
cellular response to amyloid-beta  (ISO)
cellular response to dsRNA  (IEP)
cellular response to glycine  (IEP)
cellular response to growth factor stimulus  (IEP)
cellular response to lipid  (IEP)
cellular response to magnesium ion  (IEP)
cellular response to manganese ion  (IEP)
cellular response to zinc ion  (IMP)
cerebral cortex development  (IEP)
chemical synaptic transmission  (IMP,ISO)
conditioned place preference  (IEP)
dendritic spine organization  (IMP)
directional locomotion  (ISO)
dopamine metabolic process  (ISO)
excitatory postsynaptic potential  (IBA,IEA,IMP,ISO)
glutamate receptor signaling pathway  (IEA,ISO)
hippocampus development  (IEP)
ionotropic glutamate receptor signaling pathway  (IDA,IEA,ISS)
learning  (ISO)
learning or memory  (ISO)
locomotion  (ISO)
long-term synaptic potentiation  (IBA,IEA,IEP,ISO)
memory  (IDA,ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
modulation of excitatory postsynaptic potential  (IMP)
monoatomic cation transmembrane transport  (IDA,IEA,ISO,ISS)
monoatomic ion transmembrane transport  (IEA)
monoatomic ion transport  (IEA)
multicellular organismal response to stress  (IEP)
negative regulation of protein catabolic process  (ISO)
neurogenesis  (ISO)
neuron development  (IEP)
neurotransmitter receptor transport, plasma membrane to endosome  (IMP)
positive regulation of apoptotic process  (ISO)
positive regulation of excitatory postsynaptic potential  (IDA,IEA,IMP,ISS)
positive regulation of inhibitory postsynaptic potential  (IMP)
positive regulation of protein targeting to membrane  (IMP)
positive regulation of synaptic transmission, glutamatergic  (IDA,IEA,ISS)
protein localization to postsynaptic membrane  (ISO)
receptor recycling  (IMP)
regulation of ARF protein signal transduction  (IGI)
regulation of long-term neuronal synaptic plasticity  (IMP)
regulation of membrane potential  (IMP,ISO)
regulation of monoatomic cation transmembrane transport  (IDA,ISS)
regulation of neuronal synaptic plasticity  (NAS)
regulation of NMDA receptor activity  (IMP)
regulation of postsynaptic membrane potential  (ISO)
regulation of presynaptic membrane potential  (IEA)
regulation of response to alcohol  (IEP)
regulation of synaptic plasticity  (IEA,ISO,ISS)
response to amine  (IEA,IEP)
response to ammonium ion  (IEP)
response to amphetamine  (ISO)
response to calcium ion  (IEP)
response to carbohydrate  (IEP)
response to cocaine  (IEP)
response to environmental enrichment  (IEP)
response to ethanol  (IEA,IEP,IMP,ISO)
response to fungicide  (IEP)
response to glycoside  (IEP)
response to hydrogen sulfide  (IEP)
response to lead ion  (IEP)
response to light stimulus  (IEA,IEP)
response to lithium ion  (IDA)
response to manganese ion  (IEP)
response to methylmercury  (IEP)
response to nicotine  (IEP)
response to other organism  (IEP)
response to wounding  (ISO)
response to xenobiotic stimulus  (IEA,IEP,ISO)
rhythmic process  (IDA)
sensory perception of pain  (ISO)
serotonin metabolic process  (ISO)
sleep  (ISO)
sodium ion transmembrane transport  (IEA,ISO)
spinal cord development  (IEP)
startle response  (ISO)
synaptic transmission, glutamatergic  (IBA)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway   (ISO)
Alzheimer's disease pathway  (IEA)
amyotrophic lateral sclerosis pathway  (IEA)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway   (IEA)
calcium/calmodulin dependent kinase 2 signaling pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (IDA)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
glutamate signaling pathway  (IEA)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term depression  (IMP)
long term potentiation  (IEA,IMP)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
methadone pharmacokinetics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway   (ISO)
Reelin signaling pathway  (ISO,TAS)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
systemic lupus erythematosus pathway  (IEA)
tramadol pharmacodynamics pathway  (ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit. Abe M, etal., J Neurosci. 2004 Aug 18;24(33):7292-304. doi: 10.1523/JNEUROSCI.1261-04.2004.
2. Chronic fluoxetine treatment induces structural plasticity and selective changes in glutamate receptor subunits in the rat cerebral cortex. Ampuero E, etal., Neuroscience. 2010 Apr 22.
3. Potential involvement of GRIN2B encoding the NMDA receptor subunit NR2B in the spectrum of Alzheimer's disease. Andreoli V, etal., J Neural Transm (Vienna). 2014 May;121(5):533-42. doi: 10.1007/s00702-013-1125-7. Epub 2013 Dec 1.
4. Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. Anson LC, etal., J Neurosci. 1998 Jan 15;18(2):581-9.
5. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner. Arning L, etal., Hum Genet. 2007 Sep;122(2):175-82. Epub 2007 Jun 14.
6. NR2A and NR2B receptor gene variations modify age at onset in Huntington disease. Arning L, etal., Neurogenetics. 2005 Feb;6(1):25-8. Epub 2004 Nov 17.
7. Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors. Aroniadou-Anderjaska V, etal., Neuroscience. 2018 Mar 1;373:145-158. doi: 10.1016/j.neuroscience.2018.01.021. Epub 2018 Jan 13.
8. Subunit-specific NMDA receptor trafficking to synapses. Barria A and Malinow R, Neuron. 2002 Jul 18;35(2):345-53.
9. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus. Bartlett TE, etal., Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.
10. Differential interaction of the tSXV motifs of the NR1 and NR2A NMDA receptor subunits with PSD-95 and SAP97. Bassand P, etal., Eur J Neurosci. 1999 Jun;11(6):2031-43.
11. Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses. Berg LK, etal., Neuroscience. 2013 Jan 29;230:139-50. doi: 10.1016/j.neuroscience.2012.10.061. Epub 2012 Nov 14.
12. Intracerebroventricular administration of ouabain to rats changes the expression of NMDA receptor subunits in cerebral cortex and hippocampus. Bersier MG and Rodriguez de Lores Arnaiz G, Neurochem Res. 2009 Sep;34(9):1650-7. Epub 2009 Mar 26.
13. Presynaptic NR2A-containing NMDA receptors implement a high-pass filter synaptic plasticity rule. Bidoret C, etal., Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14126-31. Epub 2009 Aug 4.
14. Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Chapman DE, etal., J Neurophysiol 2003 Jan;89(1):69-80.
15. Association between NMDA receptor subunit 2b gene polymorphism and Alzheimer's disease in Chinese Han population in Shanghai. Chen C, etal., Neurosci Bull. 2010 Oct;26(5):395-400. doi: 10.1007/s12264-010-0729-2.
16. Tyrosine kinase and tyrosine phosphatase participate in regulation of interactions of NMDA receptor subunit 2A with Src and Fyn mediated by PSD-95 after transient brain ischemia. Chen M, etal., Neurosci Lett. 2003 Mar 13;339(1):29-32.
17. CaMKII regulation in information processing and storage. Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19.
18. Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95. Cousins SL and Stephenson FA, J Biol Chem. 2012 Apr 13;287(16):13465-76. doi: 10.1074/jbc.M111.292862. Epub 2012 Feb 28.
19. Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain. Cui Z, etal., Neuron. 2004 Mar 4;41(5):781-93. doi: 10.1016/s0896-6273(04)00072-8.
20. N-methyl-D-aspartate glutamate receptor blockade attenuates lung injury associated with experimental sepsis. da Cunha AA, etal., Chest. 2010 Feb;137(2):297-302. Epub 2009 Oct 16.
21. Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. Dalby NO and Mody I, J Neurophysiol 2003 Aug;90(2):786-97.
22. NMDA receptor subunits change in the prefrontal cortex of pure-opioid and multi-drug abusers: a post-mortem study. Daneshparvar H, etal., Eur Arch Psychiatry Clin Neurosci. 2019 Apr;269(3):309-315. doi: 10.1007/s00406-018-0900-8. Epub 2018 May 16.
23. EFFECT of nicotine on hippocampal nicotinic acetylcholine alpha7 receptor and NMDA receptor subunits 2A and 2B expression in young and old rats. Delibas N, etal., Int J Neurosci. 2005 Aug;115(8):1151-63. doi: 10.1080/00207450590914437.
24. Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism. Domart MC, etal., Addict Biol. 2012 Jul;17(4):783-5. doi: 10.1111/j.1369-1600.2011.00321.x. Epub 2011 Apr 20.
25. Early modifications in N-methyl-D-aspartate receptor subunit mRNA levels in an oxygen and glucose deprivation model using rat hippocampal brain slices. Dos-Anjos S, etal., Neuroscience. 2009 Dec 15;164(3):1119-26. Epub 2009 Sep 15.
26. Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation. Elagabani MN, etal., J Biol Chem. 2016 Apr 22;291(17):9105-18. doi: 10.1074/jbc.M115.691717. Epub 2016 Feb 16.
27. Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease. Fan MM, etal., J Neurosci. 2007 Apr 4;27(14):3768-79.
28. Distinct roles of NR2A and NR2B cytoplasmic tails in long-term potentiation. Foster KA, etal., J Neurosci. 2010 Feb 17;30(7):2676-85.
29. Functional excitatory synapses in HEK293 cells expressing neuroligin and glutamate receptors. Fu Z, etal., J Neurophysiol. 2003 Dec;90(6):3950-7. Epub 2003 Aug 20.
30. Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Fukumori R, etal., J Pharmacol Sci. 2010 Mar 19;112(3):273-81. Epub 2010 Feb 18.
31. Viral-like brain inflammation during development causes increased seizure susceptibility in adult rats. Galic MA, etal., Neurobiol Dis. 2009 Nov;36(2):343-51. Epub 2009 Aug 4.
32. CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. Gardoni F, etal., J Biol Chem 2003 Nov 7;278(45):44745-52. Epub 2003 Aug 21.
33. Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. Gardoni F, etal., J Biol Chem. 2001 Mar 9;276(10):7609-13. Epub 2000 Dec 4.
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50. Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. Ishii T, etal., J Biol Chem 1993 Feb 5;268(4):2836-43.
51. Genetic analysis of a functional GRIN2A promoter (GT)n repeat in bipolar disorder pedigrees in humans. Itokawa M, etal., Neurosci Lett 2003 Jul 10;345(1):53-6.
52. Structural insights into competitive antagonism in NMDA receptors. Jespersen A, etal., Neuron. 2014 Jan 22;81(2):366-78. doi: 10.1016/j.neuron.2013.11.033.
53. Sigma-1 receptor activation ameliorates anxiety-like behavior through NR2A-CREB-BDNF signaling pathway in a rat model submitted to single-prolonged stress. Ji LL, etal., Mol Med Rep. 2017 Oct;16(4):4987-4993. doi: 10.3892/mmr.2017.7185. Epub 2017 Aug 7.
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56. Immunoblot analyses on the differential distribution of NR2A and NR2B subunits in the adult rat brain. Jin DH, etal., Mol Cells. 1997 Dec 31;7(6):749-54.
57. Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors. Jindal A, etal., Neurobiol Dis. 2019 Jul;127:287-302. doi: 10.1016/j.nbd.2019.03.012. Epub 2019 Mar 15.
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59. NMDA receptor GluN2A subunit deletion protects against dependence-like ethanol drinking. Jury NJ, etal., Behav Brain Res. 2018 Nov 1;353:124-128. doi: 10.1016/j.bbr.2018.06.029. Epub 2018 Jun 25.
60. Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression. Kawashima H, etal., Neuroscience. 2010 Feb 17;165(4):1301-11. Epub 2009 Dec 1.
61. The N-methyl-D-aspartate receptor type 2A is frequently methylated in human colorectal carcinoma and suppresses cell growth. Kim MS, etal., Oncogene. 2008 Mar 27;27(14):2045-54. doi: 10.1038/sj.onc.1210842. Epub 2007 Oct 8.
62. Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Kornau HC, etal., Science. 1995 Sep 22;269(5231):1737-40.
63. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. Lau LF, etal., J Biol Chem. 1996 Aug 30;271(35):21622-8.
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78. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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91. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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94. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
95. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
96. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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101. GOA pipeline RGD automated data pipeline
102. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
103. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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117. The nonkinase phorbol ester receptor alpha 1-chimerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density. Van de Ven TJ, etal., J Neurosci. 2005 Oct 12;25(41):9488-96.
118. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Wang J, etal., Nat Neurosci 2003 Oct;6(10):1039-47. Epub 2003 Sep 21.
119. Transduced PDZ1 domain of PSD-95 decreases Src phosphorylation and increases nNOS (Ser847) phosphorylation contributing to neuroprotection after cerebral ischemia. Wang WW, etal., Brain Res. 2010 Apr 30;1328:162-70. Epub 2010 Mar 1.
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122. Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Woo TU, etal., Brain Res. 2008 Jul 7;1218:267-77. Epub 2008 Apr 16.
123. Manganese exposure alters the expression of N-methyl-D-aspartate receptor subunit mRNAs and proteins in rat striatum. Xu B, etal., J Biochem Mol Toxicol. 2010 Jan;24(1):1-9.
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125. Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats. Yang J, etal., J Neurosci. 2006 Jan 11;26(2):406-10.
126. Cdk5 inhibitor roscovitine alleviates neuropathic pain in the dorsal root ganglia by downregulating N-methyl-D-aspartate receptor subunit 2A. Yang L, etal., Neurol Sci. 2014 Sep;35(9):1365-71. doi: 10.1007/s10072-014-1713-9.
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131. The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. Yuan H, etal., J Biol Chem. 2009 May 8;284(19):12862-73. Epub 2009 Feb 24.
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135. Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina. Zhang J and Diamond JS, J Neurosci. 2009 Apr 1;29(13):4274-86.
136. Activity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memory. Zhang XM, etal., Cell Res. 2015 Jul;25(7):818-36. doi: 10.1038/cr.2015.75. Epub 2015 Jun 19.
137. Cysteine residues 87 and 320 in the amino terminal domain of NMDA receptor GluN2A govern its homodimerization but do not influence GluN2A/GluN1 heteromeric assembly. Zhang XM, etal., Neurosci Bull. 2013 Dec;29(6):671-84. doi: 10.1007/s12264-013-1335-x. Epub 2013 Apr 20.
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Genomics

Comparative Map Data
Grin2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8106,136,458 - 6,560,003 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl106,138,037 - 6,551,378 (+)EnsemblGRCr8
mRatBN7.2105,629,683 - 6,053,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1010,321,074 - 10,740,259 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,846,997 - 10,269,259 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0105,478,407 - 5,901,217 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,707,806 - 6,123,568 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)Ensemblrn6Rnor6.0
Rnor_5.0104,523,233 - 4,940,912 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4105,588,229 - 6,004,780 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera104,645,710 - 5,048,399 (+)NCBICelera
RGSC_v3.1105,588,940 - 6,006,076 (+)NCBI
Cytogenetic Map10q11NCBI
GRIN2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38169,753,404 - 10,182,908 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl169,753,404 - 10,183,337 (-)Ensemblhg38GRCh38
GRCh37169,847,261 - 10,276,765 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36169,762,923 - 10,184,112 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34169,762,922 - 10,184,112NCBI
Celera1610,014,039 - 10,444,548 (-)NCBICelera
Cytogenetic Map16p13.2NCBI
HuRef169,767,577 - 9,952,307 (-)NCBIHuRef
HuRef1610,193,124 - 10,195,907 (-)NCBIHuRef
CHM1_1169,847,229 - 10,277,115 (-)NCBICHM1_1
T2T-CHM13v2.0169,786,917 - 10,217,640 (-)NCBIT2T-CHM13v2.0
Grin2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39169,385,765 - 9,813,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl169,385,762 - 9,813,424 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38169,567,901 - 9,996,083 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl169,567,898 - 9,995,560 (-)Ensemblmm10GRCm38
MGSCv37169,577,803 - 9,992,626 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36169,491,265 - 9,906,111 (-)NCBIMGSCv36mm8
Celera1610,217,398 - 10,625,063 (-)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.28NCBI
Grin2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554428,174,232 - 8,562,059 (+)Ensembl
ChiLan1.0NW_0049554428,171,114 - 8,565,187 (+)NCBIChiLan1.0ChiLan1.0
GRIN2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21810,282,307 - 10,710,062 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11614,057,703 - 14,490,979 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0168,682,169 - 9,105,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1169,909,406 - 10,339,147 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl169,919,143 - 10,336,167 (-)EnsemblpanPan2panpan1.1
GRIN2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1632,132,070 - 32,678,319 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl632,303,121 - 32,668,960 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha633,514,238 - 34,067,205 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0632,315,346 - 32,865,008 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl632,484,833 - 32,856,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1632,128,354 - 32,680,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0632,000,797 - 32,549,532 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,426,676 - 32,972,580 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Grin2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344110,432,891 - 110,765,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365308,287,574 - 8,608,343 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365308,286,101 - 8,612,183 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRIN2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,750,700 - 33,143,499 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1332,749,329 - 33,149,350 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,810,701 - 33,913,481 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRIN2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.159,233,028 - 9,707,322 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl59,286,775 - 9,462,828 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606820,460,991 - 20,885,559 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grin2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248247,137,909 - 7,507,910 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248247,128,169 - 7,513,360 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Grin2a
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1912,309,204 - 12,719,272 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Grin2a
3340 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir132rno-miR-132-3pMirtarbaseexternal_infoWestern blotFunctional MTI19958814

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:24
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000044626
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10117749933Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat

Markers in Region
D10Got12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,801,990 - 5,802,227 (+)MAPPERmRatBN7.2
Rnor_6.0105,877,536 - 5,877,770NCBIRnor6.0
Rnor_5.0104,695,640 - 4,695,874UniSTSRnor5.0
RGSC_v3.4105,761,139 - 5,761,373UniSTSRGSC3.4
RGSC_v3.4105,761,138 - 5,761,372RGDRGSC3.4
Celera104,812,755 - 4,813,001UniSTS
RGSC_v3.1105,761,138 - 5,761,372RGD
RH 3.4 Map1060.5UniSTS
RH 3.4 Map1060.5RGD
RH 2.0 Map100.0RGD
Cytogenetic Map10q11UniSTS
D10Got164  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,933,009 - 5,933,133 (+)MAPPERmRatBN7.2
Rnor_6.0106,009,414 - 6,009,537NCBIRnor6.0
Rnor_5.0104,827,340 - 4,827,463UniSTSRnor5.0
RGSC_v3.4105,894,189 - 5,894,313RGDRGSC3.4
RGSC_v3.4105,894,190 - 5,894,313UniSTSRGSC3.4
Celera104,938,649 - 4,938,772UniSTS
RGSC_v3.1105,894,189 - 5,894,313RGD
RH 2.0 Map100.0RGD
Cytogenetic Map10q11UniSTS
D10Got9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,684,047 - 5,684,259 (+)MAPPERmRatBN7.2
Rnor_6.0105,760,565 - 5,760,774NCBIRnor6.0
Rnor_5.0104,578,252 - 4,578,461UniSTSRnor5.0
RGSC_v3.4105,641,332 - 5,641,541UniSTSRGSC3.4
RGSC_v3.4105,641,331 - 5,641,541RGDRGSC3.4
Celera104,696,381 - 4,696,598UniSTS
RGSC_v3.1105,641,332 - 5,641,541RGD
RH 3.4 Map1066.7UniSTS
RH 3.4 Map1066.7RGD
RH 2.0 Map100.0RGD
Cytogenetic Map10q11UniSTS
D10Ulb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2221,143,394 - 21,144,889 (+)MAPPERmRatBN7.2
mRatBN7.2105,796,328 - 5,796,484 (+)MAPPERmRatBN7.2
Rnor_6.0105,872,003 - 5,872,158NCBIRnor6.0
Rnor_6.0218,873,175 - 18,874,669NCBIRnor6.0
Rnor_5.0104,690,107 - 4,690,262UniSTSRnor5.0
Rnor_5.0218,748,955 - 18,750,449UniSTSRnor5.0
RGSC_v3.4220,104,168 - 20,105,662UniSTSRGSC3.4
RGSC_v3.4105,755,479 - 5,755,634UniSTSRGSC3.4
Celera104,807,109 - 4,807,263UniSTS
Celera217,271,726 - 17,273,220UniSTS
Cytogenetic Map2q12UniSTS
Cytogenetic Map10q11UniSTS
Grin2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2106,042,978 - 6,043,203 (+)MAPPERmRatBN7.2
Rnor_6.0106,119,535 - 6,119,759NCBIRnor6.0
Rnor_5.0104,936,511 - 4,936,735UniSTSRnor5.0
RGSC_v3.4106,004,418 - 6,004,642UniSTSRGSC3.4
Celera105,048,037 - 5,048,261UniSTS
Cytogenetic Map10q11UniSTS
BE120369  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,670,580 - 5,670,760 (+)MAPPERmRatBN7.2
Rnor_6.0105,747,098 - 5,747,277NCBIRnor6.0
Rnor_5.0104,564,785 - 4,564,964UniSTSRnor5.0
RGSC_v3.4105,627,865 - 5,628,044UniSTSRGSC3.4
Celera104,682,926 - 4,683,105UniSTS
RH 3.4 Map1085.81UniSTS
Cytogenetic Map10q11UniSTS
BF413021  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,629,039 - 5,629,155 (+)MAPPERmRatBN7.2
Rnor_6.0105,706,163 - 5,706,278NCBIRnor6.0
Rnor_5.0104,523,319 - 4,523,434UniSTSRnor5.0
RGSC_v3.4105,586,586 - 5,586,701UniSTSRGSC3.4
Celera104,644,067 - 4,644,182UniSTS
RH 3.4 Map1067.3UniSTS
Cytogenetic Map10q11UniSTS
ha2303  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2105,783,618 - 5,784,012 (+)MAPPERmRatBN7.2
Rnor_6.0105,859,293 - 5,859,686NCBIRnor6.0
Rnor_5.0104,677,397 - 4,677,790UniSTSRnor5.0
RGSC_v3.4105,742,769 - 5,743,162UniSTSRGSC3.4
Celera104,794,399 - 4,794,792UniSTS
Cytogenetic Map10q11UniSTS
Grin2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2106,041,709 - 6,042,108 (+)MAPPERmRatBN7.2
Rnor_6.0106,118,266 - 6,118,664NCBIRnor6.0
Rnor_5.0104,935,242 - 4,935,640UniSTSRnor5.0
Celera105,046,768 - 5,047,166UniSTS
Cytogenetic Map10q11UniSTS


Genetic Models
This gene Grin2a is modified in the following models/strains:
LE-Grin2aem1Sidb    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
8 7 37 140 58 60 37 20 37 6 162 80 9 120 30 88 23 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000044626   ⟹   ENSRNOP00000042235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl106,138,037 - 6,551,378 (+)Ensembl
mRatBN7.2 Ensembl105,631,369 - 6,044,637 (+)Ensembl
Rnor_6.0 Ensembl105,930,298 - 6,119,990 (+)Ensembl
RefSeq Acc Id: NM_012573   ⟹   NP_036705
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8106,136,458 - 6,560,003 (+)NCBI
mRatBN7.2105,629,683 - 6,053,262 (+)NCBI
Rnor_6.0105,707,806 - 6,119,897 (+)NCBI
Rnor_5.0104,523,233 - 4,940,912 (+)NCBI
RGSC_v3.4105,588,229 - 6,004,780 (+)RGD
Celera104,645,710 - 5,048,399 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036705 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC03565 (Get FASTA)   NCBI Sequence Viewer  
  AAN76450 (Get FASTA)   NCBI Sequence Viewer  
  BAA02498 (Get FASTA)   NCBI Sequence Viewer  
  CAB58540 (Get FASTA)   NCBI Sequence Viewer  
  CAC83648 (Get FASTA)   NCBI Sequence Viewer  
  EDL96236 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042235
GenBank Protein Q00959 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036705   ⟸   NM_012573
- Peptide Label: precursor
- UniProtKB: Q63728 (UniProtKB/Swiss-Prot),   O08948 (UniProtKB/Swiss-Prot),   Q00959 (UniProtKB/Swiss-Prot),   G3V9C5 (UniProtKB/TrEMBL),   A6K4L3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000042235   ⟸   ENSRNOT00000044626
Protein Domains
Ionotropic glutamate receptor C-terminal   Ionotropic glutamate receptor L-glutamate and

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q00959-F1-model_v2 AlphaFold Q00959 1-1464 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2737 AgrOrtholog
BioCyc Gene G2FUF-26122 BioCyc
Ensembl Genes ENSRNOG00000033942 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000044626 ENTREZGENE
Gene3D-CATH 3.40.50.2300 UniProtKB/Swiss-Prot
  Periplasmic binding protein-like II UniProtKB/Swiss-Prot
InterPro ANF_lig-bd_rcpt UniProtKB/Swiss-Prot
  Glu/Gly-bd UniProtKB/Swiss-Prot
  Iono_rcpt_met UniProtKB/Swiss-Prot
  Ionotropic_Glu_rcpt UniProtKB/Swiss-Prot
  Iontro_rcpt UniProtKB/Swiss-Prot
  NMDAR2_C UniProtKB/Swiss-Prot
  Peripla_BP_I UniProtKB/Swiss-Prot
KEGG Report rno:24409 UniProtKB/Swiss-Prot
NCBI Gene 24409 ENTREZGENE
PANTHER IONOTROPIC GLUTAMATE RECEPTOR UniProtKB/Swiss-Prot
Pfam ANF_receptor UniProtKB/Swiss-Prot
  Lig_chan UniProtKB/Swiss-Prot
  Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  NMDAR2_C UniProtKB/Swiss-Prot
PhenoGen Grin2a PhenoGen
PRINTS NMDARECEPTOR UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033942 RatGTEx
SMART Lig_chan-Glu_bd UniProtKB/Swiss-Prot
  PBPe UniProtKB/Swiss-Prot
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/Swiss-Prot
  SSF53822 UniProtKB/Swiss-Prot
UniProt A6K4L3 ENTREZGENE, UniProtKB/TrEMBL
  G3V9C5 ENTREZGENE, UniProtKB/TrEMBL
  NMDE1_RAT UniProtKB/Swiss-Prot
  O08948 ENTREZGENE
  Q00959 ENTREZGENE
  Q63728 ENTREZGENE
  Q8CGM3_RAT UniProtKB/TrEMBL
UniProt Secondary O08948 UniProtKB/Swiss-Prot
  Q63728 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Grin2a  glutamate ionotropic receptor NMDA type subunit 2A  Grin2a  glutamate receptor, ionotropic, N-methyl D-aspartate 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Grin2a  glutamate receptor, ionotropic, N-methyl D-aspartate 2A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression colocalized with cdk 5 in cerebral cortex, hipppocampus 69667
gene_expression expressed in majority of gonadotrophin releasing hormone (GnRH) neurons 625682
gene_expression expressed abundantly in hypothalamus in females of all ages 625682
gene_function N-methyl-D-aspartate (NMDA) class, glutamate receptor subunit 69667
gene_process modulates neuronal function of N-methyl-D-aspartate (NMDA) 69667
gene_process may play a role in synaptic transmission 69667
gene_process receptor for glutamate that influences reproductive physiology in females 625682
gene_regulation phosphorylated by various kinases such as PKC, cdk5 and Fyn (a tyrosine kinase) 69667