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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2737
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Grin2a
Name: glutamate ionotropic receptor NMDA type subunit 2A
Acc ID: CHEBI:27958
Term: cocaine
Definition: A tropane alkaloid obtained from leaves of the South American shrub Erythroxylon coca.
Chemical ID: MESH:D003042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Grin2aaffects expressionEXP 6480464CTDCocaine affects the expression of GRIN2A mRNA; Cocaine affects the expression of GRIN2A proteinPMID:19105975 PMID:20187946
Grin2aincreases expressionEXP 6480464CTDCocaine results in increased expression of GRIN2A mRNA; Cocaine results in increased expression of GRIN2A proteinPMID:17898221 PMID:19306440 PMID:19474322
Grin2amultiple interactionsEXP 6480464CTDifenprodil inhibits the reaction [Cocaine results in increased expression of GRIN2A protein]PMID:19474322
Grin2amultiple interactionsISOGrin2a (Mus musculus)6480464CTDHDAC5 affects the reaction [Cocaine affects the expression of GRIN2A mRNA]PMID:17988634
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