Got1 (glutamic-oxaloacetic transaminase 1) - Rat Genome Database

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Gene: Got1 (glutamic-oxaloacetic transaminase 1) Rattus norvegicus
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Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1
RGD ID: 2721
Description: Enables L-aspartate:2-oxoglutarate aminotransferase activity; L-cysteine transaminase activity; and carboxylic acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; dicarboxylic acid metabolic process; and negative regulation of collagen biosynthetic process. Located in axon terminus. Used to study transient cerebral ischemia. Biomarker of cardiomyopathy. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1); PARTICIPATES IN gluconeogenesis pathway; AGAT deficiency pathway; alkaptonuria pathway; INTERACTS WITH (+)-taxifolin; (2E,4E)-hexa-2,4-dienoic acid; (E)-thiamethoxam.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AAT1; ASAT; aspartate aminotransferase 1; aspartate aminotransferase, cytoplasmic; Aspat; cAspAT; cCAT; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; cytosolic aspartate aminotransferase; Gaspat; glutamate oxaloacetate transaminase 1; glutamate oxaloacetate transaminase 1, soluble; Glutamic-oxaloacetic transaminase 1 soluble (aspartate aminotransferase cytosolic) see also D1Mgh12; glutamic-oxaloacetic transaminase 1, soluble; glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12; transaminase A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Rf1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,306,541 - 252,337,622 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,284,434 - 252,329,871 (-)EnsemblGRCr8
mRatBN7.21242,357,293 - 242,381,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,357,306 - 242,380,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1250,507,277 - 250,530,462 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,204,438 - 257,227,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01249,857,429 - 249,880,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,246,248 - 263,269,762 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)Ensemblrn6Rnor6.0
Rnor_5.01270,691,424 - 270,714,958 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41247,324,285 - 247,347,553 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1238,178,819 - 238,202,121 (-)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q54NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-taxifolin  (EXP)
(1->4)-beta-D-glucan  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(2E,4E)-hexa-2,4-dienoic acid  (EXP)
(E)-thiamethoxam  (EXP)
(R,R)-tramadol  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2-(tert-butylimino)-5-phenyl-3-(propan-2-yl)-1,3,5-thiadiazinan-4-one  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-methylcholine  (ISO)
3,3'-diindolylmethane  (ISO)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
afzelechin  (EXP)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
Alisol B  (ISO)
allyl methyl disulfide  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apremilast  (EXP)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
aucubin  (ISO)
Augmentin  (EXP)
baicalin  (EXP,ISO)
barium chloride  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Bergenin  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP,ISO)
Bisphenol B  (ISO)
boric acid  (EXP)
Brodifacoum  (EXP)
bromobenzene  (EXP)
bromuconazole  (EXP)
buprofezin  (ISO)
butylated hydroxyanisole  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcium propionate  (EXP)
cantharidin  (EXP)
capecitabine  (EXP)
capsaicin  (EXP)
captopril  (EXP)
carbamazepine  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (EXP)
carvedilol  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chloroethene  (ISO)
chlorophyll  (EXP)
chlorpyrifos  (ISO)
choline  (EXP)
chromium trioxide  (ISO)
chrysin  (EXP)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofloxacin  (EXP)
cis-caffeic acid  (EXP)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
coenzyme Q10  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin B  (ISO)
curcumin  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (EXP,ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
desloratadine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP)
difenoconazole  (EXP)
digoxin  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP,ISO)
diuron  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzalutamide  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP,ISO)
eugenol  (EXP)
eumelanin  (ISO)
fenofibrate  (EXP)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
Fexaramine  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
furfural  (ISO)
gallic acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (EXP)
glucose  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
hexachlorobenzene  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
ibuprofen  (ISO)
icariside II  (ISO)
imetit  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
inulin  (ISO)
iodide salt  (EXP)
iron atom  (EXP)
iron dextran  (EXP)
iron trichloride  (ISO)
iron(0)  (EXP)
iron(3+) sulfate  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
itraconazole  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
lead diacetate  (ISO)
lead nitrate  (ISO)
levetiracetam  (EXP)
lipopolysaccharide  (EXP)
lithocholic acid  (ISO)
loperamide  (EXP)
magnesium atom  (EXP)
malaoxon  (ISO)
malathion  (EXP)
mancozeb  (EXP)
manganese(II) chloride  (ISO)
melatonin  (EXP,ISO)
mercury dichloride  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (EXP)
Microcystin la  (ISO)
MK 571  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monosodium L-glutamate  (ISO)
montelukast  (EXP)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naringin  (ISO)
nefazodone  (EXP)
nicotinic acid  (ISO)
nitrofen  (EXP)
oleanolic acid  (ISO)
oltipraz  (ISO)
oxaloacetic acid  (ISO)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
pioglitazone  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (EXP)
progesterone  (EXP,ISO)
propiconazole  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
ranitidine  (EXP)
resveratrol  (EXP)
rifampicin  (ISO)
risperidone  (EXP)
rotenone  (EXP)
S-allylcysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
silibinin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium benzoate  (EXP)
sodium chloride  (ISO)
sodium fluoride  (ISO)
sodium nitrate  (ISO)
sodium nitrite  (EXP)
sodium silicate  (EXP)
streptozocin  (EXP,ISO)
sucrose  (EXP)
sulfur dioxide  (EXP)
sunitinib  (ISO)
syringic acid  (EXP)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
tartrazine  (EXP)
taurodeoxycholic acid  (ISO)
telmisartan  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thiamethoxam  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP)
thymoquinone  (EXP)
titanium dioxide  (ISO)
toosendanin  (ISO)
Torularhodin  (ISO)
tramadol  (EXP)
trans-caffeic acid  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (EXP,ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tuberostemonine  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon terminus  (IDA)
cytoplasm  (IEA,ISO)
cytosol  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
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2. Purification and characterization of cysteine aminotransferase from rat liver cytosol. Akagi R Acta Med Okayama. 1982 Jun;36(3):187-97.
3. Immunolocalization of cytosolic aspartate aminotransferase (cAAT) in axon terminals that form synapses in the rat cerebellar cortex. A study at the electron microscopic level. Arenas Diaz G and Martinez-Rodriguez R, Brain Res. 1990 May 14;516(1):77-83.
4. Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver. Athmouni K, etal., Int J Biol Macromol. 2018 Mar;108:853-862. doi: 10.1016/j.ijbiomac.2017.10.175. Epub 2017 Oct 31.
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11. Peripheral and central effects of intracerebroventricular microinjection of Hottentotta gentili (Pallary, 1924) (Scorpiones, Buthidae) venom. El Hidan MA, etal., Toxicon. 2016 Mar 1;111:22-30. doi: 10.1016/j.toxicon.2015.12.010. Epub 2015 Dec 22.
12. Carcinogenic Activities and Sperm Abnormalities of Methicillin Resistance Staphylococcus aureus and Inhibition of Their Virulence Potentials by Ayamycin. El-Gendy MMAA, etal., Appl Biochem Biotechnol. 2017 Nov;183(3):833-852. doi: 10.1007/s12010-017-2467-7. Epub 2017 Apr 7.
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14. Anti-fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats. Fahmy SR, BMC Complement Altern Med. 2015 Feb 5;15:14. doi: 10.1186/s12906-015-0533-7.
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17. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
18. Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats. Han Y, etal., Neurosci Lett. 2014 Mar 20;563:149-54. doi: 10.1016/j.neulet.2013.12.042. Epub 2013 Dec 25.
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23. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Effect of 3-keto-1,5-bisphosphonates on obese-liver's rats. Lahbib K and Touil S, Biomed Pharmacother. 2016 Oct;83:186-193. doi: 10.1016/j.biopha.2016.06.022. Epub 2016 Jun 28.
26. Can TiC nanoparticles produce toxicity in oral administration to rats? Laloy J, etal., Toxicol Rep. 2014 May 12;1:172-187. doi: 10.1016/j.toxrep.2014.03.004. eCollection 2014.
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32. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
37. Human recombinant glutamate oxaloacetate transaminase 1 (GOT1) supplemented with oxaloacetate induces a protective effect after cerebral ischemia. Pérez-Mato M, etal., Cell Death Dis. 2014 Jan 9;5:e992. doi: 10.1038/cddis.2013.507.
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39. GOA pipeline RGD automated data pipeline
40. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
41. Oxygen-inducible glutamate oxaloacetate transaminase as protective switch transforming neurotoxic glutamate to metabolic fuel during acute ischemic stroke. Rink C, etal., Antioxid Redox Signal. 2011 May 15;14(10):1777-85. doi: 10.1089/ars.2011.3930. Epub 2011 Mar 28.
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43. Combined Treatment of an Amyotrophic Lateral Sclerosis Rat Model with Recombinant GOT1 and Oxaloacetic Acid: A Novel Neuroprotective Treatment. Ruban A, etal., Neurodegener Dis. 2015;15(4):233-42. doi: 10.1159/000382034. Epub 2015 Jun 23.
44. Therapeutic effect of apple pectin in obese rats. Samout N, etal., Biomed Pharmacother. 2016 Oct;83:1233-1238. doi: 10.1016/j.biopha.2016.08.038. Epub 2016 Aug 23.
45. Effect of pyridoxine-deficiency on degradation of cytosolic aspartate aminotransferase in rat liver lysosomes. Sato A, etal., J Nutr Sci Vitaminol (Tokyo). 1991 Aug;37(4):419-24.
46. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Son J, etal., Nature. 2013 Apr 4;496(7443):101-5. doi: 10.1038/nature12040. Epub 2013 Mar 27.
47. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
48. Effects of sulfur dioxide on hypoxic pulmonary vascular structural remodeling. Sun Y, etal., Lab Invest. 2010 Jan;90(1):68-82. Epub 2009 Oct 12.
49. Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione. Tordjman J, etal., J Biol Chem. 2007 Aug 10;282(32):23591-602. Epub 2007 Jun 1.
50. Pirimidine derivatives as hepatoprotective agents. Vyshtakalyuk AB, etal., Int J Risk Saf Med. 2015;27 Suppl 1:S78-9. doi: 10.3233/JRS-150698.
51. Cytosolic aspartate aminotransferase mediates the mitochondrial membrane potential and cell survival by maintaining the calcium homeostasis of BV2 microglia. Wang C, etal., Neuroreport. 2018 Jan 17;29(2):99-105. doi: 10.1097/WNR.0000000000000914.
52. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
53. Targeting glutamatergic and cellular prion protein mechanisms of amyloid ß-mediated persistent synaptic plasticity disruption: Longitudinal studies. Zhang D, etal., Neuropharmacology. 2017 Jul 15;121:231-246. doi: 10.1016/j.neuropharm.2017.03.036. Epub 2017 Apr 5.
54. Brain neuroprotection by scavenging blood glutamate. Zlotnik A, etal., Exp Neurol. 2007 Jan;203(1):213-20. doi: 10.1016/j.expneurol.2006.08.021. Epub 2006 Oct 2.
Additional References at PubMed
PMID:1914521   PMID:2182221   PMID:2241899   PMID:2307672   PMID:2731362   PMID:3242498   PMID:4193185   PMID:6391741   PMID:7060339   PMID:7444718   PMID:8396422   PMID:15489334  
PMID:19056867   PMID:19199708   PMID:20458337   PMID:21630459   PMID:22871113   PMID:23376485   PMID:23533145   PMID:24611772   PMID:25446530   PMID:35038133  


Genomics

Comparative Map Data
Got1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,306,541 - 252,337,622 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1252,284,434 - 252,329,871 (-)EnsemblGRCr8
mRatBN7.21242,357,293 - 242,381,535 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,357,306 - 242,380,633 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1250,507,277 - 250,530,462 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01257,204,438 - 257,227,634 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01249,857,429 - 249,880,622 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01263,246,248 - 263,269,762 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)Ensemblrn6Rnor6.0
Rnor_5.01270,691,424 - 270,714,958 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41247,324,285 - 247,347,553 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1238,178,819 - 238,202,121 (-)NCBICelera
RH 3.4 Map1 RGD
Cytogenetic Map1q54NCBI
GOT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381099,396,870 - 99,430,624 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1099,396,870 - 99,430,671 (-)Ensemblhg38GRCh38
GRCh3710101,156,627 - 101,190,381 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610101,146,618 - 101,180,336 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410101,146,617 - 101,180,336NCBI
Celera1094,893,454 - 94,927,360 (-)NCBICelera
Cytogenetic Map10q24.2NCBI
HuRef1094,783,264 - 94,817,025 (-)NCBIHuRef
CHM1_110101,438,925 - 101,472,830 (-)NCBICHM1_1
T2T-CHM13v2.010100,278,791 - 100,312,550 (-)NCBIT2T-CHM13v2.0
Got1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391943,488,191 - 43,514,743 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1943,488,191 - 43,513,044 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381943,499,752 - 43,524,605 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1943,499,752 - 43,524,605 (-)Ensemblmm10GRCm38
MGSCv371943,574,242 - 43,599,095 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361943,553,066 - 43,577,820 (-)NCBIMGSCv36mm8
Celera1944,291,421 - 44,309,811 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1936.67NCBI
Got1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555075,346,838 - 5,370,072 (-)Ensembl
ChiLan1.0NW_0049555075,346,937 - 5,370,072 (-)NCBIChiLan1.0ChiLan1.0
GOT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28111,304,324 - 111,338,214 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110111,309,640 - 111,343,509 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01096,012,345 - 96,046,266 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11099,506,205 - 99,540,178 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1099,506,205 - 99,540,178 (-)EnsemblpanPan2panpan1.1
GOT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12812,352,658 - 12,377,960 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2812,352,659 - 12,414,579 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2812,536,462 - 12,561,764 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02812,820,566 - 12,845,869 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2812,820,567 - 12,882,397 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12812,367,262 - 12,392,563 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02812,398,502 - 12,423,851 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02812,539,850 - 12,565,179 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Got1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721334,578,280 - 34,601,317 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936636617,356 - 640,932 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936636617,376 - 640,424 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GOT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14110,608,430 - 110,635,874 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114110,608,422 - 110,635,825 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214120,054,006 - 120,080,894 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GOT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1992,463,017 - 92,489,227 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl992,462,782 - 92,488,310 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604853,459,704 - 53,486,298 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Got1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473711,115,066 - 11,153,211 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473711,114,818 - 11,153,209 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Got1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1243,007,536 - 43,031,259 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Got1
225 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:370
Count of miRNA genes:214
Interacting mature miRNAs:244
Transcripts:ENSRNOT00000022309
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Mgh12  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01270,716,905 - 270,717,037NCBIRnor5.0
RGSC_v3.41247,322,146 - 247,322,277RGDRGSC3.4
Celera1238,204,080 - 238,204,181UniSTS
RGSC_v3.11247,436,621 - 247,436,752RGD
RH 3.4 Map11616.91UniSTS
RH 3.4 Map11616.91RGD
RH 2.0 Map11221.1RGD
SHRSP x BN Map1133.51RGD
Cytogenetic Map1q54UniSTS
GOT1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,361,857 - 242,362,003 (+)MAPPERmRatBN7.2
Rnor_6.01263,250,813 - 263,250,958NCBIRnor6.0
Rnor_5.01270,695,989 - 270,696,134UniSTSRnor5.0
RGSC_v3.41247,342,845 - 247,342,990UniSTSRGSC3.4
Celera1238,183,384 - 238,183,529UniSTS
Cytogenetic Map1q54UniSTS
RH128564  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,357,367 - 242,357,560 (+)MAPPERmRatBN7.2
Rnor_6.01263,246,323 - 263,246,515NCBIRnor6.0
Rnor_5.01270,691,499 - 270,691,691UniSTSRnor5.0
RGSC_v3.41247,347,288 - 247,347,480UniSTSRGSC3.4
Celera1238,178,894 - 238,179,086UniSTS
RH 3.4 Map11619.38UniSTS
Cytogenetic Map1q54UniSTS
RH132794  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,357,883 - 242,358,074 (+)MAPPERmRatBN7.2
Rnor_6.01263,246,839 - 263,247,029NCBIRnor6.0
Rnor_5.01270,692,015 - 270,692,205UniSTSRnor5.0
RGSC_v3.41247,346,774 - 247,346,964UniSTSRGSC3.4
Celera1238,179,410 - 238,179,600UniSTS
Cytogenetic Map1q54UniSTS
RH94745  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,357,493 - 242,357,651 (+)MAPPERmRatBN7.2
Rnor_6.01263,246,449 - 263,246,606NCBIRnor6.0
Rnor_5.01270,691,625 - 270,691,782UniSTSRnor5.0
RGSC_v3.41247,347,197 - 247,347,354UniSTSRGSC3.4
Celera1238,179,020 - 238,179,177UniSTS
RH 3.4 Map11619.22UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB578328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK600227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM055803 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN802619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB922163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB922489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC979572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC979898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000022309   ⟹   ENSRNOP00000022309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,284,434 - 252,329,871 (-)Ensembl
mRatBN7.2 Ensembl1242,359,355 - 242,380,633 (-)Ensembl
Rnor_6.0 Ensembl1263,246,248 - 263,269,762 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119131   ⟹   ENSRNOP00000080441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,306,541 - 252,329,871 (-)Ensembl
mRatBN7.2 Ensembl1242,357,306 - 242,379,572 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000156525   ⟹   ENSRNOP00000102125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,306,541 - 252,328,937 (-)Ensembl
RefSeq Acc Id: NM_012571   ⟹   NP_036703
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,306,541 - 252,329,871 (-)NCBI
mRatBN7.21242,357,293 - 242,380,623 (-)NCBI
Rnor_6.01263,246,248 - 263,269,762 (-)NCBI
Rnor_5.01270,691,424 - 270,714,958 (-)NCBI
RGSC_v3.41247,324,285 - 247,347,553 (+)RGD
Celera1238,178,819 - 238,202,121 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063280638   ⟹   XP_063136708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,310,933 - 252,337,622 (-)NCBI
RefSeq Acc Id: NP_036703   ⟸   NM_012571
- UniProtKB: Q64570 (UniProtKB/Swiss-Prot),   Q6P721 (UniProtKB/Swiss-Prot),   P13221 (UniProtKB/Swiss-Prot),   A6JHC9 (UniProtKB/TrEMBL),   A0A8I6G6L5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022309   ⟸   ENSRNOT00000022309
Ensembl Acc Id: ENSRNOP00000080441   ⟸   ENSRNOT00000119131
RefSeq Acc Id: XP_063136708   ⟸   XM_063280638
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000102125   ⟸   ENSRNOT00000156525
Protein Domains
Aminotransferase class I/classII large

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P13221-F1-model_v2 AlphaFold P13221 1-413 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690925
Promoter ID:EPDNEW_R1449
Type:initiation region
Name:Got1_1
Description:glutamic-oxaloacetic transaminase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01263,269,747 - 263,269,807EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2721 AgrOrtholog
BioCyc Gene G2FUF-55626 BioCyc
BioCyc Pathway ASPARAGINE-DEG1-PWY-1 [L-asparagine degradation III (mammalian)] BioCyc
  ASPARTATE-DEG1-PWY [L-aspartate degradation I] BioCyc
  ASPARTATESYN-PWY [L-aspartate biosynthesis] BioCyc
  MALATE-ASPARTATE-SHUTTLE-PWY [malate/L-aspartate shuttle pathway] BioCyc
  PWY-5886 [3-(4-hydroxyphenyl)pyruvate biosynthesis] BioCyc
  PWY-6318 [L-phenylalanine degradation IV (mammalian, via side chain)] BioCyc
  TYRFUMCAT-PWY [L-tyrosine degradation I] BioCyc
BioCyc Pathway Image ASPARAGINE-DEG1-PWY-1 BioCyc
  ASPARTATE-DEG1-PWY BioCyc
  ASPARTATESYN-PWY BioCyc
  MALATE-ASPARTATE-SHUTTLE-PWY BioCyc
  PWY-5886 BioCyc
  PWY-6318 BioCyc
  TYRFUMCAT-PWY BioCyc
Ensembl Genes ENSRNOG00000016356 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000119131 ENTREZGENE
Gene3D-CATH 3.40.640.10 UniProtKB/Swiss-Prot
  3.90.1150.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599273 IMAGE-MGC_LOAD
InterPro Aminotransferase_I/II UniProtKB/Swiss-Prot
  Asp_trans UniProtKB/Swiss-Prot
  NHTrfase_class1_PyrdxlP-BS UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_dom1 UniProtKB/Swiss-Prot
  PyrdxlP-dep_Trfase_major UniProtKB/Swiss-Prot
KEGG Report rno:24401 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72537 IMAGE-MGC_LOAD
NCBI Gene 24401 ENTREZGENE
PANTHER ASPARTATE AMINOTRANSFERASE, CYTOPLASMIC UniProtKB/Swiss-Prot
  PTHR11879 UniProtKB/Swiss-Prot
Pfam Aminotran_1_2 UniProtKB/Swiss-Prot
PhenoGen Got1 PhenoGen
PRINTS TRANSAMINASE UniProtKB/Swiss-Prot
PROSITE AA_TRANSFER_CLASS_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016356 RatGTEx
Superfamily-SCOP SSF53383 UniProtKB/Swiss-Prot
UniProt A0A8I6G6L5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UJT3_RAT UniProtKB/TrEMBL
  A0ABK0LKG7_RAT UniProtKB/TrEMBL
  A6JHC9 ENTREZGENE, UniProtKB/TrEMBL
  A6JHD0_RAT UniProtKB/TrEMBL
  AATC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64570 ENTREZGENE
  Q6P721 ENTREZGENE
UniProt Secondary Q64570 UniProtKB/Swiss-Prot
  Q6P721 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Got1  glutamic-oxaloacetic transaminase 1  Got1  glutamic-oxaloacetic transaminase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-06-05 Got1  glutamic-oxaloacetic transaminase 1, soluble  Got1  glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Got1  glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)  Got1  glutamate oxaloacetate transaminase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Got1  glutamate oxaloacetate transaminase 1, soluble  Got1  glutamate oxaloacetate transaminase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Got1  glutamate oxaloacetate transaminase 1    Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12  Name updated 625702 APPROVED
2002-06-10 Got1  Glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase, cytosolic) see also D1Mgh12      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation enzyme activity in liver and kidney increase in response to glucocorticoids 632937