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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2721
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Got1
Name: glutamic-oxaloacetic transaminase 1
Acc ID: CHEBI:27744
Term: glyphosate
Definition: A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).
Chemical ID: MESH:C010974
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Got1increases expressionISOGot1 (Mus musculus)6480464CTDGlyphosate results in increased expression of GOT1 proteinPMID:37208198
Got1multiple interactionsISOGOT1 (Homo sapiens)6480464CTD[Glyphosate results in increased abundance of aminomethylphosphonic acid (AMPA)] which results in increased activity of GOT1 proteinPMID:36856429
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