Cpt1b (carnitine palmitoyltransferase 1B) - Rat Genome Database

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Gene: Cpt1b (carnitine palmitoyltransferase 1B) Rattus norvegicus
Analyze
Symbol: Cpt1b
Name: carnitine palmitoyltransferase 1B
RGD ID: 2397
Description: Enables carnitine O-palmitoyltransferase activity. Involved in carnitine metabolic process; fatty acid metabolic process; and long-chain fatty acid transport. Located in mitochondrion. Orthologous to human CPT1B (carnitine palmitoyltransferase 1B); PARTICIPATES IN fatty acid beta degradation pathway; forkhead class A signaling pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: carnitine O-palmitoyltransferase 1, muscle isoform; carnitine O-palmitoyltransferase I, muscle isoform; Carnitine palmitoyltransferase 1 beta muscle isoform; Carnitine palmitoyltransferase 1 beta, muscle isoform; Carnitine palmitoyltransferase 1 muscle; Carnitine palmitoyltransferase 1, muscle; carnitine palmitoyltransferase 1b, muscle; carnitine palmitoyltransferase I-like protein; carnitine palmitoyltransferase Ibeta 1; carnitine palmitoyltransferase Ibeta 2; carnitine palmitoyltransferase Ibeta 3; CPT I; CPT-IB; CPT-Ibeta 1; CPT-Ibeta 3; CPT1-M; CPTI-M; M-CPTI; MGC93637
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Cpt1b_v1   Cpt1b_v2   Cpt1b_v3  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,370,974 - 122,380,473 (-)NCBIGRCr8
mRatBN7.27120,491,354 - 120,500,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,491,354 - 120,500,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,243,327 - 122,252,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,469,475 - 124,478,518 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,431,532 - 124,440,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,395,211 - 130,404,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,395,194 - 130,405,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,080,032 - 130,089,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,737,129 - 127,746,179 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,771,358 - 127,780,409NCBI
Celera7116,963,968 - 116,973,018 (-)NCBICelera
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
benzo[a]pyrene  (ISO)
beta-carotene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bezafibrate  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
choline  (ISO)
ciprofibrate  (EXP,ISO)
CL316243  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
dicyclanil  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
dipentyl phthalate  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenofibrate  (EXP)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gemfibrozil  (EXP)
gentamycin  (EXP)
graphite  (ISO)
GW 501516  (EXP)
GW 6471  (ISO)
GW 7647  (ISO)
hydroxytyrosol  (ISO)
indole-3-methanol  (EXP)
isoprenaline  (EXP)
ketoconazole  (EXP)
L-methionine  (ISO)
lenvatinib  (EXP,ISO)
lipopolysaccharide  (ISO)
meldonium  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
metoprolol  (EXP)
Monobutylphthalate  (ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (EXP)
nitrofen  (EXP)
orphenadrine  (EXP)
oxybenzone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
perflubutane  (ISO)
perfluorobutyric acid  (ISO)
perfluorodecanoic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
picrotoxin  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
pravastatin  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
pyrazinecarboxamide  (EXP)
quercetin  (ISO)
rotenone  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
tamoxifen  (EXP)
temozolomide  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (EXP,ISO)
zaragozic acid A  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. Campbell SE, etal., J Biol Chem. 2004 Aug 27;279(35):36235-41. Epub 2004 May 25.
2. Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipocytes. Esser V, etal., J Biol Chem. 1996 Mar 22;271(12):6972-7. doi: 10.1074/jbc.271.12.6972.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Comparison of the catalytic activities of three isozymes of carnitine palmitoyltransferase 1 expressed in COS7 cells. Hada T, etal., Appl Biochem Biotechnol. 2014 Feb;172(3):1486-96. doi: 10.1007/s12010-013-0619-y. Epub 2013 Nov 13.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Evidence of a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity in red skeletal muscle. Kim JY, etal., Am J Physiol Endocrinol Metab 2002 May;282(5):E1014-22.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. A single amino acid change (substitution of the conserved Glu-590 with alanine) in the C-terminal domain of rat liver carnitine palmitoyltransferase I increases its malonyl-CoA sensitivity close to that observed with the muscle isoform of the enzyme. Napal L, etal., J Biol Chem 2003 Sep 5;278(36):34084-9. Epub 2003 Jun 25.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Structural insight into function and regulation of carnitine palmitoyltransferase. Rufer AC, etal., Cell Mol Life Sci. 2009 Aug;66(15):2489-501. Epub 2009 May 9.
17. Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. Sebastian D, etal., J Lipid Res. 2009 May 9.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. Structural and functional genomics of the CPT1B gene for muscle-type carnitine palmitoyltransferase I in mammals. van der Leij FR, etal., J Biol Chem 2002 Jul 26;277(30):26994-7005. Epub 2002 May 15.
20. Genomic DNA sequence, promoter expression, and chromosomal mapping of rat muscle carnitine palmitoyltransferase I. Wang D, etal., Genomics 1998 Mar 15;48(3):314-23.
21. A region in the first exon/intron of rat carnitine palmitoyltransferase Ibeta is involved in enhancement of basal transcription. Wang GL, etal., Biochem J 2002 Mar 15;362(Pt 3):609-18.
Additional References at PubMed
PMID:7729550   PMID:9714790   PMID:12477932   PMID:14651853   PMID:15489334   PMID:18614015   PMID:19375767   PMID:20047222   PMID:20833797   PMID:21600121   PMID:22928974   PMID:25855307  
PMID:26080315   PMID:27558315  


Genomics

Comparative Map Data
Cpt1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87122,370,974 - 122,380,473 (-)NCBIGRCr8
mRatBN7.27120,491,354 - 120,500,833 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7120,491,354 - 120,500,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7122,243,327 - 122,252,370 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07124,469,475 - 124,478,518 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07124,431,532 - 124,440,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07130,395,211 - 130,404,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7130,395,194 - 130,405,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07130,080,032 - 130,089,314 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47127,737,129 - 127,746,179 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17127,771,358 - 127,780,409NCBI
Celera7116,963,968 - 116,973,018 (-)NCBICelera
Cytogenetic Map7q34NCBI
CPT1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382250,568,861 - 50,578,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2250,568,861 - 50,578,465 (-)EnsemblGRCh38hg38GRCh38
GRCh372251,007,290 - 51,017,041 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362249,354,156 - 49,363,862 (-)NCBINCBI36Build 36hg18NCBI36
Build 342249,297,433 - 49,311,538NCBI
Celera2234,883,323 - 34,893,129 (-)NCBICelera
Cytogenetic Map22q13.33NCBI
HuRef2233,898,289 - 33,908,095 (-)NCBIHuRef
CHM1_12250,966,023 - 50,975,829 (-)NCBICHM1_1
T2T-CHM13v2.02251,079,388 - 51,089,140 (-)NCBIT2T-CHM13v2.0
Cpt1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391589,300,608 - 89,310,065 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1589,300,608 - 89,310,066 (-)EnsemblGRCm39 Ensembl
GRCm381589,416,405 - 89,425,862 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1589,416,405 - 89,425,863 (-)EnsemblGRCm38mm10GRCm38
MGSCv371589,246,836 - 89,256,293 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361589,244,172 - 89,253,114 (-)NCBIMGSCv36mm8
Celera1591,545,496 - 91,554,925 (-)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1544.89NCBI
Cpt1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541333,578,355 - 33,588,674 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541333,578,734 - 33,588,055 (-)NCBIChiLan1.0ChiLan1.0
CPT1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22360,488,826 - 60,499,113 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12263,179,408 - 63,189,695 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02230,815,073 - 30,825,341 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12249,926,405 - 49,936,633 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2249,926,893 - 49,935,420 (-)Ensemblpanpan1.1panPan2
CPT1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11016,737,106 - 16,744,626 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1016,737,289 - 16,744,624 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1016,714,785 - 16,722,260 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01017,463,472 - 17,470,978 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1017,463,343 - 17,470,976 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11017,187,860 - 17,195,337 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01017,510,879 - 17,518,347 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01017,643,053 - 17,650,532 (+)NCBIUU_Cfam_GSD_1.0
Cpt1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945246,924 - 255,324 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936629247,005 - 255,537 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936629246,876 - 255,537 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CPT1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl5155,643 - 163,531 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.15155,552 - 163,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CPT1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11933,044,272 - 33,055,197 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1933,043,916 - 33,054,247 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604592,286,953 - 92,297,911 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cpt1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624752190,462 - 201,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624752191,539 - 200,483 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cpt1b
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:209
Count of miRNA genes:140
Interacting mature miRNAs:157
Transcripts:ENSRNOT00000013985
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)7116677189127103496Rat
1558655Swd4Spike wave discharge measurement QTL 43.680.0002brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge severity grade (CMO:0001988)786983365131983365Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
1582240Sffal1Serum free fatty acids level QTL 13.40.0021blood free fatty acid amount (VT:0001553)serum free fatty acids level (CMO:0000547)7116677010124049952Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
D7Wox44  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,495,002 - 120,495,177 (+)MAPPERmRatBN7.2
Rnor_6.07130,398,861 - 130,399,035NCBIRnor6.0
Rnor_5.07130,083,682 - 130,083,856UniSTSRnor5.0
RGSC_v3.47127,740,778 - 127,740,952UniSTSRGSC3.4
Celera7116,967,617 - 116,967,791UniSTS
Cytogenetic Map7q34UniSTS
Chetk  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,501,074 - 120,501,250 (+)MAPPERmRatBN7.2
Rnor_6.07130,404,933 - 130,405,108NCBIRnor6.0
Rnor_5.07130,089,754 - 130,089,929UniSTSRnor5.0
RGSC_v3.47127,746,850 - 127,747,025UniSTSRGSC3.4
Celera7116,973,689 - 116,973,864UniSTS
RH 3.4 Map7949.5UniSTS
Cytogenetic Map7q34UniSTS
MARC_16689-16690:1017862088:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27120,496,188 - 120,496,842 (+)MAPPERmRatBN7.2
Rnor_6.07130,400,047 - 130,400,700NCBIRnor6.0
Rnor_5.07130,084,868 - 130,085,521UniSTSRnor5.0
RGSC_v3.47127,741,964 - 127,742,617UniSTSRGSC3.4
Celera7116,968,803 - 116,969,456UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000013985   ⟹   ENSRNOP00000013985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7120,491,354 - 120,500,404 (-)Ensembl
Rnor_6.0 Ensembl7130,395,194 - 130,405,347 (-)Ensembl
RefSeq Acc Id: NM_013200   ⟹   NP_037332
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,370,974 - 122,380,024 (-)NCBI
mRatBN7.27120,491,354 - 120,500,404 (-)NCBI
Rnor_6.07130,395,212 - 130,404,262 (-)NCBI
Rnor_5.07130,080,032 - 130,089,314 (-)NCBI
RGSC_v3.47127,737,129 - 127,746,179 (-)RGD
Celera7116,963,968 - 116,973,018 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242180   ⟹   XP_006242242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,370,975 - 122,380,460 (-)NCBI
mRatBN7.27120,491,355 - 120,500,810 (-)NCBI
Rnor_6.07130,395,211 - 130,404,731 (-)NCBI
Rnor_5.07130,080,032 - 130,089,314 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078502   ⟹   XP_038934430
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,370,975 - 122,380,453 (-)NCBI
mRatBN7.27120,491,355 - 120,500,833 (-)NCBI
RefSeq Acc Id: XM_063263066   ⟹   XP_063119136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87122,370,975 - 122,380,473 (-)NCBI
RefSeq Acc Id: NP_037332   ⟸   NM_013200
- UniProtKB: Q63704 (UniProtKB/Swiss-Prot),   A6K7M6 (UniProtKB/TrEMBL),   O70253 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242242   ⟸   XM_006242180
- Peptide Label: isoform X1
- UniProtKB: O70253 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000013985   ⟸   ENSRNOT00000013985
RefSeq Acc Id: XP_038934430   ⟸   XM_039078502
- Peptide Label: isoform X1
- UniProtKB: O70253 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119136   ⟸   XM_063263066
- Peptide Label: isoform X2
- UniProtKB: Q63704 (UniProtKB/Swiss-Prot),   A6K7M6 (UniProtKB/TrEMBL),   O70253 (UniProtKB/TrEMBL)
Protein Domains
Carnitine O-palmitoyltransferase N-terminal   Choline/carnitine acyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63704-F1-model_v2 AlphaFold Q63704 1-772 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695588
Promoter ID:EPDNEW_R6112
Type:multiple initiation site
Name:Cpt1b_1
Description:carnitine palmitoyltransferase 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07130,404,284 - 130,404,344EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2397 AgrOrtholog
BioCyc Gene G2FUF-32435 BioCyc
BioCyc Pathway PWY-6111 [mitochondrial L-carnitine shuttle] BioCyc
BioCyc Pathway Image PWY-6111 BioCyc
Ensembl Genes ENSRNOG00000010438 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013985.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.559.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.1760 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193798 IMAGE-MGC_LOAD
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPT_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25756 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93637 IMAGE-MGC_LOAD
NCBI Gene 25756 ENTREZGENE
PANTHER CARNITINE O-PALMITOYLTRANSFERASE 1, MUSCLE ISOFORM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carn_acyltransf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CPT_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cpt1b PhenoGen
PROSITE ACYLTRANSF_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010438 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229129
UniProt A6K7M6 ENTREZGENE, UniProtKB/TrEMBL
  A6K7M7_RAT UniProtKB/TrEMBL
  B7ZDJ3_RAT UniProtKB/TrEMBL
  CPT1B_RAT UniProtKB/Swiss-Prot
  O70253 ENTREZGENE, UniProtKB/TrEMBL
  Q63704 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Cpt1b  carnitine palmitoyltransferase 1B  Cpt1b  carnitine palmitoyltransferase 1b, muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Cpt1b  carnitine palmitoyltransferase 1b, muscle    carnitine palmitoyltransferase 1b  Name updated 1299863 APPROVED
2002-11-06 Cpt1b  carnitine palmitoyltransferase 1b    Carnitine palmitoyltransferase 1, muscle  Name updated 625702 APPROVED
2001-10-23 Cpt1b  Carnitine palmitoyltransferase 1 beta, muscle isoform      Name withdrawn 68913 WITHDRAWN
2001-10-23 Cpt1b  Carnitine palmitoyltransferase 1, muscle      Name updated to reflect Human and Mouse nomenclature 68913 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease upregulated during the disorders of fatty acid metabolism 628369
gene_drugs Malonyl-CoA inhibits Cpt1 activity 628369
gene_expression expressed in cardiac muscle and heart 628369
gene_expression two splice variants b1 and b2 found in higher levels in red than in white muscles 628369
gene_function transfers long-chain fatty acids to beta-oxidation enzymes 70483
gene_function transfers long-chain fatty acids to beta-oxidation enzymes 628369
gene_other Cpt1b protein more resistant to MalonylCoA inhibition in red than in white muscle 628369
gene_process functions in fatty acid metabolism 70483
gene_process functions in fatty acid metabolism 628369
gene_process controls beta-oxidation of long-chain fatty acids in the heart and skeletal muscle 1298787