Ak4 (adenylate kinase 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ak4 (adenylate kinase 4) Rattus norvegicus
Analyze
Symbol: Ak4
Name: adenylate kinase 4
RGD ID: 2078
Description: Predicted to enable AMP kinase activity; nucleoside diphosphate kinase activity; and nucleoside triphosphate adenylate kinase activity. Involved in liver development and response to xenobiotic stimulus. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Biomarker of acute kidney tubular necrosis. Orthologous to several human genes including AK4 (adenylate kinase 4); PARTICIPATES IN de novo purine biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate kinase 3 alpha-like 1; adenylate kinase 3-like 1; adenylate kinase 3-like 2; adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4; adenylate kinase isoenzyme 4, mitochondrial; AK 4; Ak3l1; Ak3l2; ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4; GTP:AMP phosphotransferase AK4, mitochondrial; MGC93541
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,154,565 - 121,214,403 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5121,154,572 - 121,214,401 (+)EnsemblGRCr8
mRatBN7.25116,039,222 - 116,099,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,039,616 - 116,098,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5118,605,105 - 118,655,660 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,330,473 - 120,381,010 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,381,768 - 120,432,320 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,250,318 - 120,309,153 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,250,616 - 120,305,897 (+)Ensemblrn6Rnor6.0
Rnor_5.05124,129,933 - 124,189,606 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45122,062,872 - 122,119,335 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5114,576,993 - 114,626,919 (+)NCBICelera
RGSC_v3.15122,068,045 - 122,127,564 (+)NCBI
Cytogenetic Map5q33NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
beauvericin  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP,ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
GSK-J4  (ISO)
haloperidol  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
pyrogallol  (ISO)
quercetin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetracycline  (EXP)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA,IEA,ISO)
mitochondrion  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. Dynamics of nucleotide metabolism as a supporter of life phenomena. Noma T J Med Invest. 2005 Aug;52(3-4):127-36.
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
9. Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues. Wu HZ, etal., Anal Bioanal Chem. 2011 Apr;399(10):3431-9. Epub 2010 Dec 9.
10. Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. Yamamoto T, etal., J Toxicol Sci. 2006 Feb;31(1):49-60.
11. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. Yoneda T, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):187-95.
Additional References at PubMed
PMID:11485571   PMID:12477932   PMID:14651853   PMID:15489334   PMID:18614015   PMID:19130895   PMID:19766732   PMID:23376485   PMID:23416111   PMID:23474458   PMID:24767988   PMID:26980435  
PMID:30696468   PMID:37932484  


Genomics

Comparative Map Data
Ak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,154,565 - 121,214,403 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl5121,154,572 - 121,214,401 (+)EnsemblGRCr8
mRatBN7.25116,039,222 - 116,099,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,039,616 - 116,098,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx5118,605,105 - 118,655,660 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,330,473 - 120,381,010 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,381,768 - 120,432,320 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,250,318 - 120,309,153 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,250,616 - 120,305,897 (+)Ensemblrn6Rnor6.0
Rnor_5.05124,129,933 - 124,189,606 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.45122,062,872 - 122,119,335 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera5114,576,993 - 114,626,919 (+)NCBICelera
RGSC_v3.15122,068,045 - 122,127,564 (+)NCBI
Cytogenetic Map5q33NCBI
AK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,147,552 - 65,232,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,146,902 - 65,232,145 (+)Ensemblhg38GRCh38
GRCh37165,613,235 - 65,697,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,385,820 - 65,465,765 (+)NCBIBuild 36Build 36hg18NCBI36
Celera163,903,944 - 63,988,555 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef163,722,163 - 63,806,551 (+)NCBIHuRef
CHM1_1165,729,523 - 65,814,075 (+)NCBICHM1_1
T2T-CHM13v2.0165,025,531 - 65,110,134 (+)NCBIT2T-CHM13v2.0
Ak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,273,675 - 101,324,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,276,474 - 101,324,192 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm384101,416,478 - 101,467,771 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,419,277 - 101,466,995 (+)Ensemblmm10GRCm38
MGSCv374101,091,894 - 101,140,376 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv364100,917,690 - 100,964,927 (+)NCBIMGSCv36mm8
Celera499,759,270 - 99,808,044 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.84NCBI
Ak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,395,836 - 25,427,474 (-)Ensembl
ChiLan1.0NW_00495542325,395,086 - 25,402,324 (-)NCBIChiLan1.0ChiLan1.0
AK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21161,630,069 - 161,714,696 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,780,900 - 160,865,513 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,394,898 - 64,479,536 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,283,102 - 66,367,146 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl166,283,102 - 66,361,230 (+)EnsemblpanPan2panpan1.1
AK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1545,055,294 - 45,119,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,884,283 - 45,120,203 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha545,107,227 - 45,176,810 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0545,230,958 - 45,300,604 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl545,235,891 - 45,300,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1545,196,507 - 45,265,914 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0545,140,926 - 45,210,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,392,014 - 45,461,310 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,277,939 - 78,342,917 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366922,593,349 - 2,658,345 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366922,593,409 - 2,654,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6147,177,029 - 147,257,814 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.16147,177,029 - 147,257,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26135,587,473 - 135,663,801 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12067,840,572 - 67,924,691 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603349,603,493 - 49,717,228 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474229,547,237 - 29,574,160 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ak4
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1153,086,990 - 53,139,905 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ak4
236 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:435
Count of miRNA genes:231
Interacting mature miRNAs:305
Transcripts:ENSRNOT00000070967
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)5102105698152749382Rat
2303586Gluco52Glucose level QTL 522blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)5100826632145826632Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5116702075161702075Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)584630798129630798Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)599905133172190305Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)565089051166764498Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)584630798129630798Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5112142946157142946Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5112142946157142946Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5110770739155770739Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)551657967166600247Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5112142946157142946Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)5104018576124314782Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)592583776137583776Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)598972960143972960Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555124766172190305Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)592583776137583776Rat
2303618Vencon1Ventilatory control QTL 13.8respiration trait (VT:0001943)oxygen consumption (CMO:0002169)5100826632145826632Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5111236572156236572Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584630798129630798Rat
7394710Emca12Estrogen-induced mammary cancer QTL 12mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)594034903139034903Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5114131300159131300Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)595062526133270832Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)560601597137492949Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5112142946157142946Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5116702075161702075Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5112142946157142946Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5116702075161702075Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)574335621156302135Rat
1600362Mcs19Mammary carcinoma susceptibility QTL 192.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)582032155127032155Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5116702075161702075Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)589369373134369373Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)570969494136328156Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5114131300159131300Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)597492524133270832Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)592881678137881678Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)595062526133270832Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)5104262817153890625Rat

Markers in Region
RH134316  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25116,098,765 - 116,098,949 (+)MAPPERmRatBN7.2
Rnor_6.05120,308,853 - 120,309,036NCBIRnor6.0
Rnor_5.05124,189,306 - 124,189,489UniSTSRnor5.0
RGSC_v3.45122,122,486 - 122,122,669UniSTSRGSC3.4
Celera5114,630,069 - 114,630,252UniSTS
RH 3.4 Map5788.2UniSTS
Cytogenetic Map5q33UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 91 59 6 355 191 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000070967   ⟹   ENSRNOP00000065349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl5121,154,572 - 121,214,401 (+)Ensembl
mRatBN7.2 Ensembl5116,039,616 - 116,098,618 (+)Ensembl
Rnor_6.0 Ensembl5120,250,616 - 120,305,897 (+)Ensembl
RefSeq Acc Id: NM_017135   ⟹   NP_058831
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,155,136 - 121,210,955 (+)NCBI
mRatBN7.25116,039,787 - 116,095,614 (+)NCBI
Rnor_6.05120,250,770 - 120,305,703 (+)NCBI
Rnor_5.05124,129,933 - 124,189,606 (+)NCBI
RGSC_v3.45122,062,872 - 122,119,335 (+)RGD
Celera5114,576,993 - 114,626,919 (+)RGD
Sequence:
RefSeq Acc Id: XM_017593196   ⟹   XP_017448685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,154,565 - 121,214,403 (+)NCBI
mRatBN7.25116,039,222 - 116,099,064 (+)NCBI
Rnor_6.05120,250,318 - 120,309,153 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109353   ⟹   XP_038965281
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,155,424 - 121,214,403 (+)NCBI
mRatBN7.25116,040,107 - 116,099,064 (+)NCBI
RefSeq Acc Id: XM_063287246   ⟹   XP_063143316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85121,154,670 - 121,214,403 (+)NCBI
RefSeq Acc Id: NP_058831   ⟸   NM_017135
- UniProtKB: Q9WUS0 (UniProtKB/Swiss-Prot),   A0A8L2QYP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448685   ⟸   XM_017593196
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000065349   ⟸   ENSRNOT00000070967
RefSeq Acc Id: XP_038965281   ⟸   XM_039109353
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143316   ⟸   XM_063287246
- Peptide Label: isoform X1
Protein Domains
Adenylate kinase active site lid

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUS0-F1-model_v2 AlphaFold Q9WUS0 1-223 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693858
Promoter ID:EPDNEW_R4383
Type:initiation region
Name:Ak4_1
Description:adenylate kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05120,250,683 - 120,250,743EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2078 AgrOrtholog
BioCyc Gene G2FUF-40538 BioCyc
BioCyc Pathway PWY-7219 [adenosine ribonucleotides de novo biosynthesis] BioCyc
BioCyc Pathway Image PWY-7219 BioCyc
Ensembl Genes ENSRNOG00000045738 Ensembl
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7107348 IMAGE-MGC_LOAD
InterPro Adenyl_kin_sub UniProtKB/Swiss-Prot
  Adenylat/UMP-CMP_kin UniProtKB/Swiss-Prot
  Adenylat_kinase_CS UniProtKB/Swiss-Prot
  Adenylate_kinase_lid-dom UniProtKB/Swiss-Prot
  AK3/Ak4_mitochondrial UniProtKB/Swiss-Prot
  AK4_mitochondrial UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:29223 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93541 IMAGE-MGC_LOAD
NCBI Gene 29223 ENTREZGENE
PANTHER PTHR23359 UniProtKB/Swiss-Prot
Pfam ADK UniProtKB/Swiss-Prot
  ADK_lid UniProtKB/Swiss-Prot
PhenoGen Ak4 PhenoGen
PRINTS ADENYLTKNASE UniProtKB/Swiss-Prot
PROSITE ADENYLATE_KINASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000045738 RatGTEx
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8L2QYP3 ENTREZGENE, UniProtKB/TrEMBL
  A6JRN4 ENTREZGENE, UniProtKB/TrEMBL
  A6JRN6 ENTREZGENE, UniProtKB/TrEMBL
  KAD4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-29 Ak4  adenylate kinase 4  Ak3l1  adenylate kinase 3-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Ak3l1  adenylate kinase 3-like 1  Ak3l1  adenylate kinase 3 alpha-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-19 Ak3l1  adenylate kinase 3 alpha-like 1  Ak3l1  adenylate kinase 3-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-04-19 Ak3l1  adenylate kinase 3-like 1  Ak3l2  adenylate kinase 3-like 2  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Ak3l2  adenylate kinase 3-like 2  Ak4  adenylate kinase 4  Symbol and Name updated 1299863 APPROVED
2002-06-10 Ak4  adenylate kinase 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may play a role in energy metabolism 632174
gene_product member of a family of adenylate kinase isozymes 632174
gene_protein predicted protein contains 223 amino acid residues 632174