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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | ISO | RGD:2078 | 6480464 | Ethinyl Estradiol results in increased expression of AK4 mRNA | CTD | PMID:12075121 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:2078 | 6480464 | Ethinyl Estradiol results in decreased expression of AK4 mRNA | CTD | PMID:15953391 PMID:17108234 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:2078 | 6480464 | Ethinyl Estradiol results in decreased expression of AK4 mRNA | CTD | PMID:17108234 PMID:15953391 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | EXP | | 6480464 | [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AK4 mRNA | CTD | PMID:15251184 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AK4 mRNA | CTD | PMID:15251184 PMID:20159946 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AK4 mRNA | CTD | PMID:20159946 PMID:15251184 | 2,4-dinitrotoluene | affects expression | ISO | RGD:2078 | 6480464 | 2,4-dinitrotoluene affects the expression of AK4 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | ISO | RGD:2078 | 6480464 | 2,6-dinitrotoluene affects the expression of AK4 mRNA | CTD | PMID:21346803 | 5-aza-2'-deoxycytidine | multiple interactions | EXP | | 6480464 | [decitabine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of AK4 mRNA | CTD | PMID:15251184 | 5-aza-2'-deoxycytidine | decreases expression | EXP | | 6480464 | decitabine results in decreased expression of AK4 mRNA | CTD | PMID:15251184 | all-trans-retinoic acid | affects expression | ISO | RGD:1606591 | 6480464 | Tretinoin affects the expression of AK4 mRNA | CTD | PMID:15498508 | amiodarone | increases expression | ISO | RGD:2078 | 6480464 | Amiodarone results in increased expression of AK4 protein | CTD | PMID:16538043 | ammonium chloride | affects expression | ISO | RGD:2078 | 6480464 | Ammonium Chloride affects the expression of AK4 mRNA | CTD | PMID:16483693 | benzene | affects expression | ISO | RGD:2078 | 6480464 | Benzene affects the expression of AK4 mRNA | CTD | PMID:15878777 | bisphenol A | increases expression | ISO | RGD:2078 | 6480464 | bisphenol A results in increased expression of AK4 mRNA | CTD | PMID:12075121 | clofibrate | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA; more ... | CTD | PMID:17585979 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of AK4 mRNA | CTD | PMID:17585979 | copper(2+) sulfate | decreases expression | ISO | RGD:1606591 | 6480464 | Copper Sulfate results in decreased expression of AK4 mRNA | CTD | PMID:19549813 | diazoxide | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of AK4 mRNA | CTD | PMID:20003209 | doxorubicin | decreases expression | EXP | | 6480464 | Doxorubicin results in decreased expression of AK4 mRNA | CTD | PMID:16243910 | folic acid | affects expression | ISO | RGD:1606591 | 6480464 | Folic Acid affects the expression of AK4 mRNA | CTD | PMID:17320366 | genistein | increases expression | ISO | RGD:2078 | 6480464 | Genistein results in increased expression of AK4 mRNA | CTD | PMID:12075121 | isoprenaline | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of AK4 mRNA | CTD | PMID:20003209 | L-ascorbic acid | decreases expression | EXP | | 6480464 | Ascorbic Acid results in decreased expression of AK4 mRNA | CTD | PMID:15305145 | N-nitrosodiethylamine | decreases expression | ISO | RGD:2078 | 6480464 | Diethylnitrosamine results in decreased expression of AK4 mRNA | CTD | PMID:19638242 | nickel dichloride | increases expression | EXP | | 6480464 | nickel chloride results in increased expression of AK4 mRNA | CTD | PMID:12729255 | nickel dichloride | multiple interactions | EXP | | 6480464 | HIF1A affects the reaction [nickel chloride results in increased expression of AK4 mRNA] | CTD | PMID:12729255 | paracetamol | multiple interactions | EXP | | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of AK4 mRNA; more ... | CTD | PMID:17585979 | paracetamol | increases expression | ISO | RGD:2078 | 6480464 | Acetaminophen results in increased expression of AK4 protein | CTD | PMID:16538043 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of AK4 mRNA | CTD | PMID:17562736 | perfluorooctanoic acid | decreases expression | ISO | RGD:2078 | 6480464 | perfluorooctanoic acid results in decreased expression of AK4 mRNA | CTD | PMID:19162173 | phenobarbital | multiple interactions | EXP | | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of AK4 mRNA] | CTD | PMID:19482888 | phenobarbital | affects expression | EXP | | 6480464 | Phenobarbital affects the expression of AK4 mRNA | CTD | PMID:23091169 | phenobarbital | decreases expression | ISO | RGD:2078 | 6480464 | Phenobarbital results in decreased expression of AK4 mRNA | CTD | PMID:19162173 | phenobarbital | increases expression | EXP | | 6480464 | Phenobarbital results in increased expression of AK4 mRNA | CTD | PMID:19270015 | phenobarbital | decreases expression | EXP | | 6480464 | Phenobarbital results in decreased expression of AK4 mRNA | CTD | PMID:19482888 | phenylephrine | increases expression | ISO | RGD:2078 | 6480464 | Phenylephrine results in increased expression of AK4 mRNA | CTD | PMID:18158353 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of AK4 mRNA | CTD | PMID:18445702 | propiconazole | decreases expression | EXP | | 6480464 | propiconazole results in decreased expression of AK4 mRNA | CTD | PMID:21278054 | quercetin | increases expression | ISO | RGD:1606591 | 6480464 | Quercetin results in increased expression of AK4 mRNA | CTD | PMID:19729006 | quercetin | affects expression | ISO | RGD:2078 | 6480464 | Quercetin affects the expression of AK4 mRNA | CTD | PMID:18178720 | tamibarotene | decreases expression | ISO | RGD:1606591 | 6480464 | Am 80 results in decreased expression of AK4 mRNA; more ... | CTD | PMID:15498508 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of AK4 mRNA | CTD | PMID:15003993 | tetrachloromethane | increases expression | ISO | RGD:2078 | 6480464 | Carbon Tetrachloride results in increased expression of AK4 protein | CTD | PMID:16538043 | tetracycline | increases expression | ISO | RGD:2078 | 6480464 | Tetracycline results in increased expression of AK4 protein | CTD | PMID:16538043 | vancomycin | increases expression | EXP | | 6480464 | Vancomycin results in increased expression of AK4 mRNA | CTD | PMID:18930951 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Purine metabolism | |
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Metabolic pathways |
| Purine metabolism | |
References - curated| 1. |
Kawai J, etal., Nature 2001 Feb 8;409(6821):685-90. |
| 2. |
Ko MS, etal., Development 2000 Apr;127(8):1737-49. |
| 3. |
MGD data from the GO Consortium |
| 4. |
Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40. |
| 5. |
Noma T J Med Invest. 2005 Aug;52(3-4):127-36. |
| 6. |
Okazaki Y, etal., Nature 2002 Dec 5;420(6915):563-73. |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
Wu HZ, etal., Anal Bioanal Chem. 2011 Apr;399(10):3431-9. Epub 2010 Dec 9. |
| 10. |
Yamamoto T, etal., J Toxicol Sci. 2006 Feb;31(1):49-60. |
| 11. |
Yoneda T, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):187-95. |
References - uncurated| PubMed | 10349636 |
| 10922068 | |
| 11042159 | |
| 11076861 | |
| 11485571 | |
| 12446734 | |
| 12477932 | |
| 14681479 | |
| 15489334 | |
| 16141072 | |
| 16141073 | |
| 16602821 | |
| 18614015 | |
| 18799693 | |
| 19521566 | |
| 2034277 | |
| 21267068 | |
| 21677750 | |
| 22516201 | |
| 6375655 | |
| 7774911 | |
| 9338784 |
RGD Disease Portals| Ak4 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Ak4 (Mus musculus) |
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| AK4 (Homo sapiens) |
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| Ak4 (Rattus norvegicus) |
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Nucleotide Sequences| Nucleotide RefSeqs | NM_001177602 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001177604 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001177605 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_009647 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AAHY01038576 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHY01038577 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01038578 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHY01038579 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AB020239 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK004491 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK134600 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK144439 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK154374 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK166975 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL845364 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AV023306 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086663 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC086791 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BY203078 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BY718404 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BY740484 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CJ087385 | (Get FASTA) | Search GEO for Microarray Profiles | |
| D85036 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_009647 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_033777 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001177602 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001171073 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001177605 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001171076 | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001177604 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_001171075 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001171073 | (Get FASTA) |
| NP_001171075 | (Get FASTA) | |
| NP_001171076 | (Get FASTA) | |
| NP_033777 | (Get FASTA) | |
| GenBank Protein | AAH86663 | (Get FASTA) |
| BAA77363 | (Get FASTA) | |
| BAA77760 | (Get FASTA) | |
| BAE22202 | (Get FASTA) | |
| BAE25891 | (Get FASTA) | |
| BAE32544 | (Get FASTA) | |
| BAE39158 | (Get FASTA) | |
| Q9WUR9 | (Get FASTA) |
Promoters| RGD ID: | 6834833 | ||||||||||
| Promoter ID: | MM_KWN:38659 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_4Hour, Brain, ES_Cell, Kidney, Liver | ||||||||||
| Transcripts: | ENSMUST00000030252, ENSMUST00000102780, ENSMUST00000106945, ENSMUST00000106946, ENSMUST00000106947, OTTMUST00000019193, OTTMUST00000019195, UC008TVP.1 | ||||||||||
| Position: |
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| RGD ID: | 6877318 | ||||||||||
| Promoter ID: | EPDNEW_M2110 | ||||||||||
| Type: | preliminary | ||||||||||
| Name: | Ak4_1 | ||||||||||
| Description: | adenylate kinase 4 | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||||
| Position: |
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| RGD ID: | 6834834 | ||||||||||
| Promoter ID: | MM_KWN:38660 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | BoneMarrow_2Hour, BoneMarrow_4Hour, Kidney | ||||||||||
| Transcripts: | OTTMUST00000019196 | ||||||||||
| Position: |
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| RGD ID: | 6834841 | ||||||||||
| Promoter ID: | MM_KWN:38661 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Kidney | ||||||||||
| Transcripts: | OTTMUST00000019197 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000028527 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000099841 | ENTREZGENE |
| ENSMUSP00000102558 | ENTREZGENE | |
| ENSMUSP00000102559 | ENTREZGENE | |
| Ensembl Transcript | ENSMUST00000102780 | ENTREZGENE |
| ENSMUST00000106945 | ENTREZGENE | |
| ENSMUST00000106946 | ENTREZGENE | |
| Entrez Gene | 11639 | ENTREZGENE |
| Germonline | ENSMUSG00000049213 | |
| HomoloGene Group ID | 100316 | ENTREZGENE |
| InterPro | Adenyl_kin_sub | UniProtKB/Swiss-Prot |
| Adenylate_kin | UniProtKB/Swiss-Prot | |
| Adenylate_kinase_lid-dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00125035 | UniProtKB/Swiss-Prot |
| IPI00648501 | UniProtKB/TrEMBL | |
| IPI00649018 | UniProtKB/TrEMBL | |
| IPI00651878 | UniProtKB/TrEMBL | |
| IPI00666165 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:11639 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:87979 | ENTREZGENE |
| PANTHER | Adenylate_kin | UniProtKB/Swiss-Prot |
| Pfam | ADK | UniProtKB/Swiss-Prot |
| ADK_lid | UniProtKB/Swiss-Prot | |
| PRINTS | ADENYLTKNASE | UniProtKB/Swiss-Prot |
| PROSITE | ADENYLATE_KINASE | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Adenylate_kinase_Znf_lid | UniProtKB/Swiss-Prot |
| TIGRFAMs | Adk | UniProtKB/Swiss-Prot |
| UniGene | Mm.42040 | ENTREZGENE |
| UniProt | A2ARF5_MOUSE | UniProtKB/TrEMBL |
| A2ARF6_MOUSE | UniProtKB/TrEMBL | |
| F6TEU8_MOUSE | UniProtKB/TrEMBL | |
| KAD4_MOUSE | UniProtKB/Swiss-Prot | |
| Q3U489_MOUSE | UniProtKB/TrEMBL | |
| Q3UYL0_MOUSE | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-07-27 | Ak4 | adenylate kinase 4 | Ak3l1 | adenylate kinase 3-like 1 | Symbol and/or name change | 39860 | APPROVED |
| More on Ak4 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1551504 |
| Created: | 2005-09-30 |
| Species: | Mus musculus |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




