Ak4 (adenylate kinase 4) - Rat Genome Database

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Gene: Ak4 (adenylate kinase 4) Mus musculus
Analyze
Symbol: Ak4
Name: adenylate kinase 4
RGD ID: 1551504
MGI Page MGI
Description: Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in nucleoside phosphate metabolic process and regulation of oxidative phosphorylation. Predicted to act upstream of or within phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK4 (adenylate kinase 4).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenylate kinase 3 alpha-like 1; adenylate kinase 3-like 1; adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4; adenylate kinase isoenzyme 4, mitochondrial; AK 4; Ak-; Ak-3; Ak-4; Ak3; Ak3l1; ATP-AMP transphosphorylase; D4Ertd274; D4Ertd274e; GTP:AMP phosphotransferase AK4; GTP:AMP phosphotransferase AK4, mitochondrial
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ak3l2-ps  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,273,675 - 101,324,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,276,474 - 101,324,192 (+)EnsemblGRCm39 Ensembl
GRCm384101,416,478 - 101,467,771 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,419,277 - 101,466,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,091,894 - 101,140,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364100,917,690 - 100,964,927 (+)NCBIMGSCv36mm8
Celera499,759,270 - 99,808,044 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (ISO)
aristolochic acid A  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
buspirone  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
epoxiconazole  (EXP)
ethanol  (EXP)
fenofibrate  (ISO)
flavonoids  (ISO)
fluoranthene  (EXP)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
gentamycin  (ISO)
haloperidol  (ISO)
ibuprofen  (ISO)
ifosfamide  (ISO)
indometacin  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
metformin  (ISO)
methoxychlor  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nimesulide  (ISO)
nitrofen  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
propiconazole  (EXP)
pyrogallol  (EXP)
quercetin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP)
Soman  (ISO)
streptozocin  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vorinostat  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA,IDA)
mitochondrion  (HDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Functional annotation of a full-length mouse cDNA collection. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, etal., Cell 2003 Nov 26;115(5):629-40.
5. Dynamics of nucleotide metabolism as a supporter of life phenomena. Noma T J Med Invest. 2005 Aug;52(3-4):127-36.
6. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Proteomics investigation on aristolochic acid nephropathy: a case study on rat kidney tissues. Wu HZ, etal., Anal Bioanal Chem. 2011 Apr;399(10):3431-9. Epub 2010 Dec 9.
10. Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. Yamamoto T, etal., J Toxicol Sci. 2006 Feb;31(1):49-60.
11. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. Yoneda T, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):187-95.
Additional References at PubMed
PMID:2034277   PMID:6375655   PMID:7774911   PMID:9338784   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11485571   PMID:12446734   PMID:12477932   PMID:14681479  
PMID:15489334   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16602821   PMID:18614015   PMID:18799693   PMID:19521566   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22516201  
PMID:29676259   PMID:31202927   PMID:33790902   PMID:34321999  


Genomics

Comparative Map Data
Ak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,273,675 - 101,324,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,276,474 - 101,324,192 (+)EnsemblGRCm39 Ensembl
GRCm384101,416,478 - 101,467,771 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,419,277 - 101,466,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,091,894 - 101,140,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364100,917,690 - 100,964,927 (+)NCBIMGSCv36mm8
Celera499,759,270 - 99,808,044 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.84NCBI
AK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,147,552 - 65,232,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,147,549 - 65,232,145 (+)EnsemblGRCh38hg38GRCh38
GRCh37165,613,235 - 65,697,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,385,820 - 65,465,765 (+)NCBINCBI36Build 36hg18NCBI36
Celera163,903,944 - 63,988,555 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef163,722,163 - 63,806,551 (+)NCBIHuRef
CHM1_1165,729,523 - 65,814,075 (+)NCBICHM1_1
T2T-CHM13v2.0165,025,531 - 65,110,134 (+)NCBIT2T-CHM13v2.0
Ak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,154,565 - 121,214,403 (+)NCBIGRCr8
mRatBN7.25116,039,222 - 116,099,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,039,616 - 116,098,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5118,605,105 - 118,655,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,330,473 - 120,381,010 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,381,768 - 120,432,320 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,250,318 - 120,309,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,250,616 - 120,305,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05124,129,933 - 124,189,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,062,872 - 122,119,335 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15122,068,045 - 122,127,564 (+)NCBI
Celera5114,576,993 - 114,626,919 (+)NCBICelera
Cytogenetic Map5q33NCBI
Ak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,395,836 - 25,427,474 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542325,395,086 - 25,402,324 (-)NCBIChiLan1.0ChiLan1.0
AK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21161,630,069 - 161,714,696 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,780,900 - 160,865,513 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,394,898 - 64,479,536 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,283,102 - 66,367,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl166,283,102 - 66,361,230 (+)Ensemblpanpan1.1panPan2
DNAJC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1545,055,294 - 45,119,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,884,283 - 45,120,203 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha545,107,227 - 45,176,810 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0545,230,958 - 45,300,604 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl545,235,891 - 45,300,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1545,196,507 - 45,265,914 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0545,140,926 - 45,210,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,392,014 - 45,461,310 (-)NCBIUU_Cfam_GSD_1.0
Ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,277,939 - 78,342,917 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366922,593,409 - 2,654,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6147,177,029 - 147,257,814 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16147,177,029 - 147,257,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26135,587,473 - 135,663,801 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12067,840,572 - 67,924,691 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603349,603,493 - 49,717,228 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474229,547,237 - 29,574,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ak4
1710 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6648
Count of miRNA genes:833
Interacting mature miRNAs:1127
Transcripts:ENSMUST00000102780, ENSMUST00000106945, ENSMUST00000106946, ENSMUST00000131397, ENSMUST00000133055, ENSMUST00000151561, ENSMUST00000155749
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314312Syncl2_msynaptonemal complex length 2 (mouse)465718237146584457Mouse
11532700Sluc43d_msusceptibility to lung cancer 43d (mouse)474444699108444983Mouse
11532702Sluc43f_msusceptibility to lung cancer 43f (mouse)474444699108444983Mouse
4141623W6q13_mweight 6 weeks QTL 13 (mouse)Not determined88982069140468203Mouse
13824982Svwq1_mseminal vesicle weight QTL 1 (mouse)489888237118857197Mouse
14696689Gdq2_mgrooming duration QTL 2, females (mouse)4100857197124893793Mouse
4141900Skts-fp1_mskin tumor susceptibility in FVB and PWK 1 (mouse)Not determined453550839124055180Mouse
27226770Tibl11_mtibia length 11, 10 week (mouse)488518237108357197Mouse
4141093W3q17_mweight 3 weeks QTL 17 (mouse)Not determined88982069140468203Mouse
27226746Metcl8_mmetatarsal-calcaneal length 8, 10 week (mouse)487518237107157197Mouse
27095927Pglq7_mpelvic girdle length QTL 7, 10 week (mouse)488118237108357197Mouse
1301823Bmd7_mbone mineral density 7 (mouse)Not determined488982069151654550Mouse
11532714Sluc43_msusceptibility to lung cancer 43 (mouse)446642108123127211Mouse
12904933Edlmmq3_mextensor digitorum longus muscle mass QTL 3 (mouse)481213991115213991Mouse
1300580Lbw2_mlupus NZB x NZW 2 (mouse)Not determined498545539128009280Mouse
1300966Pabr2_mplasma apolipoprotein B (human) regulator 2 (mouse)Not determined446332646105801860Mouse
1301597Anxty_manxiety (mouse)Not determined474137574128009280Mouse
1301847Fecq2_mfecundity QTL 2 (mouse)Not determined4100071971134072206Mouse
27095905Scvln3_msacral vertebrae length 2, 5 week (mouse)455600000128993793Mouse
26884431Zlq8_mzygomatic length QTL 8, 16 week (mouse)474718237108357197Mouse
1301739Pitm2_mprion incubation time 2 (mouse)Not determined471982069105982216Mouse
1300918Stheal4_msoft tissue heal 4 (mouse)Not determined489969627123969747Mouse
1301233Sbw2_msplenomegaly-NZB x NZW 2 (mouse)Not determined494957579128009280Mouse
11532704Sluc43a_msusceptibility to lung cancer 43a (mouse)474444699108444983Mouse
13208562Wght7_mweight 7 (mouse)490888237148084457Mouse
12904002Opfaq9_mopen field activity QTL 9 (mouse)492975790126975790Mouse
27095900Scvln9_msacral vertebrae length 2, 10 week (mouse)468018237107157197Mouse
10412193Plep_mplasma lepin levels (mouse)Not determined474444699108444983Mouse
11532703Sluc43g_msusceptibility to lung cancer 43g (mouse)474444699108444983Mouse
11039506Ltpr4b_mLeishmania tropica response 4b (mouse)479365751113365867Mouse
1302204Spm1_msplenomegaly modifier (mouse)Not determined482244395116244582Mouse
1357726Lnopy1_mlens opacity 1 (mouse)Not determined485428838119429037Mouse
4142047Mvwf3_mmodifier of von Willebrand factor 3 (mouse)Not determined14010457117072206Mouse
1357895Ctrcts_mcataract severity (mouse)Not determined445709925138342753Mouse
11532705Sluc43b_msusceptibility to lung cancer 43b (mouse)474444699108444983Mouse
11532706Sluc43c_msusceptibility to lung cancer 43c (mouse)474444699108444983Mouse
1558948Ath8_matherosclerosis 8 (mouse)Not determined445658442105156995Mouse
39128212Lwq21_mliver weight QTL 21 (mouse)488982069140468203Mouse
11039504Ltpr4a_mLeishmania tropica response 4a (mouse)479365751113365867Mouse
11039505Ltpr4c_mLeishmania tropica response 4c (mouse)479365751113365867Mouse
11039517Ltpr4_mLeishmania tropica response 4 (mouse)479365751113365867Mouse
1301556Cd4vts1_mCD4 virgin T cell subset 1 (mouse)Not determined485428838119429037Mouse
11532708Sluc43i_msusceptibility to lung cancer 43i (mouse)474444699108444983Mouse
27226801Feml6_mfemur length 6, 5 week (mouse)487518237103257197Mouse
4141549W10q10_mweight 10 weeks QTL 10 (mouse)Not determined88982069140468203Mouse
27226760Feml19_mfemur length 19, 16 week (mouse)490888237108457197Mouse
1301815Sles2_msystemic lupus erythmatosus suppressor 2 (mouse)Not determined494957579150676858Mouse
1301106Skts7_mskin tumor susceptibility 7 (mouse)Not determined4100071971134072206Mouse
12880433Fgf23lq1_mFGF23 serum level QTL 1 (mouse)4101157197135157197Mouse
27226724Tibw2_mtibia width 2, proximal, 10 week (mouse)443000000108357197Mouse
26884449Sklq2_mskull length QTL 2, 5 week (mouse)436700000128993793Mouse
26884434Zlq1_mzygomatic length QTL 1, 5 week (mouse)453700000103257197Mouse
1302031Bulb1_mbulb size 1 (mouse)Not determined474033887108034029Mouse
1301118Bbaa23_mB.burgdorferi-associated arthritis 23 (mouse)Not determined485781167119781279Mouse
27226739Metcl14_mmetatarsal-calcaneal length 14, 16 week (mouse)487518237108357197Mouse
15039368Nmrs19_mNAFLD-associated magnetic resonance shift 19 (mouse)490882780124882780Mouse
27226782Tibl2_mtibia length 2, 5 week (mouse)490888237111257197Mouse
27095924Pglq2_mpelvic girdle length QTL 2, 5 week (mouse)469118237130727311Mouse
27095921Pglq12_mpelvic girdle length QTL 12, 16 week (mouse)483118237108357197Mouse
11567249Elorr3_methanol induced loss of righting response 3 (mouse)43722677156268235Mouse
11532707Sluc43h_msusceptibility to lung cancer 43h (mouse)474444699108444983Mouse
27226787Feml14_mfemur length 14, 10 week (mouse)484918237107157197Mouse
27226716Metcl2_mmetatarsal-calcaneal length 2, 5 week (mouse)488118237118557197Mouse
27095939Ulnl9_mulna length 9, 16 week (mouse)465318237118857197Mouse
11532701Sluc43e_msusceptibility to lung cancer 43e (mouse)474444699108444983Mouse
1301545Gauc_mglucose area under curve (mouse)Not determined476763107110763305Mouse
1300697Sle2_msystemic lupus erythmatosus susceptibility 2 (mouse)Not determined477957579111957775Mouse
27226766Tibl17_mtibia length 17, 16 week (mouse)488518237108457197Mouse
14696687Gdq1_mgrooming duration QTL 1, males (mouse)496888237111857197Mouse
1302057Pgia27_mproteoglycan induced arthritis 27 (mouse)Not determined470067227104067464Mouse
1302044Nss1_mNOD Sjogren's syndrome 1 (mouse)Not determined471982069105982216Mouse
26884435Zlq4_mzygomatic length QTL 4, 10 week (mouse)485118237104957197Mouse
27095917Scvln14_msacral vertebrae length 2, 16 week (mouse)468018237130277062Mouse
26884445Sklq7_mskull length QTL 7, 10 week (mouse)468018237150884457Mouse
1301867Idd11_minsulin dependent diabetes susceptibility 11 (mouse)Not determined483604870117605006Mouse
11532738Abd1_mautoimmune biliary disease 1 (mouse)488982069116271120Mouse
26884437Sklq13_mskull length QTL 13, 16 week (mouse)457700000155684457Mouse
12879897Berr4_mberghei resistance locus 4 (mouse)471982069105982216Mouse
1301731Cafq2_mcaffeine metabolism QTL 2 (mouse)Not determined494732255128732454Mouse
1301930Papg1_mpulmonary adenoma progression 1 (mouse)Not determined485781167119781279Mouse
11553870Cmmm_mcarcinoma modifier of MSM (mouse)490590668124590781Mouse


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001177602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001177605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006502685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB020239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK004491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK134600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK144439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK154374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL845364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AV023306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY203078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY718404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BY740484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ087385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D85036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000102780   ⟹   ENSMUSP00000099841
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,276,474 - 101,324,192 (+)Ensembl
GRCm38.p6 Ensembl4101,419,277 - 101,466,995 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106945   ⟹   ENSMUSP00000102558
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,276,516 - 101,324,192 (+)Ensembl
GRCm38.p6 Ensembl4101,419,319 - 101,466,995 (+)Ensembl
RefSeq Acc Id: ENSMUST00000106946   ⟹   ENSMUSP00000102559
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,276,486 - 101,324,192 (+)Ensembl
GRCm38.p6 Ensembl4101,419,289 - 101,466,995 (+)Ensembl
RefSeq Acc Id: ENSMUST00000131397   ⟹   ENSMUSP00000115456
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,276,903 - 101,317,778 (+)Ensembl
GRCm38.p6 Ensembl4101,419,706 - 101,460,581 (+)Ensembl
RefSeq Acc Id: ENSMUST00000133055   ⟹   ENSMUSP00000115454
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,276,930 - 101,320,197 (+)Ensembl
GRCm38.p6 Ensembl4101,419,733 - 101,463,000 (+)Ensembl
RefSeq Acc Id: ENSMUST00000151561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,277,694 - 101,320,877 (+)Ensembl
GRCm38.p6 Ensembl4101,420,497 - 101,463,680 (+)Ensembl
RefSeq Acc Id: ENSMUST00000155749   ⟹   ENSMUSP00000121112
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl4101,304,420 - 101,320,976 (+)Ensembl
GRCm38.p6 Ensembl4101,447,223 - 101,463,779 (+)Ensembl
RefSeq Acc Id: NM_001177602   ⟹   NP_001171073
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,276,486 - 101,324,968 (+)NCBI
GRCm384101,419,289 - 101,467,771 (+)NCBI
MGSCv374101,091,894 - 101,140,376 (+)RGD
Celera499,759,270 - 99,808,044 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177604   ⟹   NP_001171075
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,276,518 - 101,324,968 (+)NCBI
GRCm384101,419,321 - 101,467,771 (+)NCBI
MGSCv374101,091,894 - 101,140,376 (+)RGD
Celera499,759,270 - 99,808,044 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001177605   ⟹   NP_001171076
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,276,509 - 101,324,968 (+)NCBI
GRCm384101,419,312 - 101,467,771 (+)NCBI
MGSCv374101,091,894 - 101,140,376 (+)RGD
Celera499,759,270 - 99,808,044 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_009647   ⟹   NP_033777
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,276,900 - 101,324,968 (+)NCBI
GRCm384101,419,703 - 101,467,771 (+)NCBI
MGSCv374101,091,894 - 101,140,376 (+)RGD
Celera499,759,270 - 99,808,044 (+)RGD
cM Map4 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006502685   ⟹   XP_006502748
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,277,760 - 101,324,194 (+)NCBI
GRCm384101,420,563 - 101,466,997 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319923   ⟹   XP_017175412
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm394101,273,675 - 101,324,194 (+)NCBI
GRCm384101,416,478 - 101,466,997 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_033777   ⟸   NM_009647
- UniProtKB: Q9R1X7 (UniProtKB/Swiss-Prot),   Q9WUR9 (UniProtKB/Swiss-Prot),   Q3U489 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171073   ⟸   NM_001177602
- UniProtKB: Q9R1X7 (UniProtKB/Swiss-Prot),   Q9WUR9 (UniProtKB/Swiss-Prot),   Q3U489 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171076   ⟸   NM_001177605
- UniProtKB: Q9R1X7 (UniProtKB/Swiss-Prot),   Q9WUR9 (UniProtKB/Swiss-Prot),   Q3U489 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001171075   ⟸   NM_001177604
- UniProtKB: Q9R1X7 (UniProtKB/Swiss-Prot),   Q9WUR9 (UniProtKB/Swiss-Prot),   Q3U489 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006502748   ⟸   XM_006502685
- Peptide Label: isoform X2
- UniProtKB: F6TEU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017175412   ⟸   XM_017319923
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000115454   ⟸   ENSMUST00000133055
RefSeq Acc Id: ENSMUSP00000115456   ⟸   ENSMUST00000131397
RefSeq Acc Id: ENSMUSP00000102559   ⟸   ENSMUST00000106946
RefSeq Acc Id: ENSMUSP00000102558   ⟸   ENSMUST00000106945
RefSeq Acc Id: ENSMUSP00000099841   ⟸   ENSMUST00000102780
RefSeq Acc Id: ENSMUSP00000121112   ⟸   ENSMUST00000155749
Protein Domains
Adenylate kinase active site lid

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9WUR9-F1-model_v2 AlphaFold Q9WUR9 1-223 view protein structure

Promoters
RGD ID:6834833
Promoter ID:MM_KWN:38659
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver
Transcripts:ENSMUST00000030252,   ENSMUST00000102780,   ENSMUST00000106945,   ENSMUST00000106946,   ENSMUST00000106947,   OTTMUST00000019193,   OTTMUST00000019195,   UC008TVP.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364101,091,826 - 101,092,557 (+)MPROMDB
RGD ID:6834834
Promoter ID:MM_KWN:38660
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney
Transcripts:OTTMUST00000019196
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364101,092,581 - 101,093,081 (+)MPROMDB
RGD ID:6834841
Promoter ID:MM_KWN:38661
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000019197
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv364101,119,726 - 101,120,226 (+)MPROMDB
RGD ID:6883966
Promoter ID:EPDNEW_M5434
Type:initiation region
Name:Ak4_2
Description:Mus musculus adenylate kinase 4 , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5435  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384101,419,312 - 101,419,372EPDNEW
RGD ID:6883972
Promoter ID:EPDNEW_M5435
Type:initiation region
Name:Ak4_1
Description:Mus musculus adenylate kinase 4 , transcript variant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M5434  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm384101,419,733 - 101,419,793EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:87979 AgrOrtholog
Ensembl Genes ENSMUSG00000028527 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102780 ENTREZGENE
  ENSMUST00000102780.8 UniProtKB/Swiss-Prot
  ENSMUST00000106945 ENTREZGENE
  ENSMUST00000106945.8 UniProtKB/Swiss-Prot
  ENSMUST00000106946 ENTREZGENE
  ENSMUST00000106946.8 UniProtKB/Swiss-Prot
  ENSMUST00000131397.2 UniProtKB/TrEMBL
  ENSMUST00000133055.8 UniProtKB/TrEMBL
  ENSMUST00000155749 ENTREZGENE
  ENSMUST00000155749.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Adenyl_kin_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylat/UMP-CMP_kin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Adenylate_kinase_lid-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADK_active_lid_dom_sf UniProtKB/TrEMBL
  AK3/Ak4_mitochondrial UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AK4_mitochondrial UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11639 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:87979 ENTREZGENE
NCBI Gene 11639 ENTREZGENE
PANTHER ADENYLATE KINASE 4, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23359 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ADK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ADK_lid UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ak4 PhenoGen
PRINTS ADENYLTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57774 UniProtKB/TrEMBL
UniProt A2ARF5_MOUSE UniProtKB/TrEMBL
  A2ARF6_MOUSE UniProtKB/TrEMBL
  F6TEU8 ENTREZGENE, UniProtKB/TrEMBL
  KAD4_MOUSE UniProtKB/Swiss-Prot
  Q3U489 ENTREZGENE, UniProtKB/TrEMBL
  Q3UYL0_MOUSE UniProtKB/TrEMBL
  Q9R1X7 ENTREZGENE
  Q9WUR9 ENTREZGENE
UniProt Secondary Q9R1X7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-27 Ak4  adenylate kinase 4  Ak3l1  adenylate kinase 3-like 1  Symbol and/or name change 5135510 APPROVED