DE NOVO PURINE BIOSYNTHETIC PATHWAY (PW:0000867)

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Description

In addition to their central roles in nucleic acid biosynthesis, purines provide high energy molecules (ATP and GTP) that drive enzymatic reactions, as well as being components of metabolic cofactors such as NAD+, FAD+ and coenzyme A, and serving as signaling molecules operating through purinergic receptors. Purines are synthesized in one of two ways: in a de novo pathway from amino acid and other building blocks or via a salvage pathway from nucleic acid turnover. In de novo synthesis, purines

Pathway Diagram:

Ariadne Genomics Inc. folate mediated one-carbon metabolic pathway FAICAR ---> IMP SAICAR ---> AICAR AICAR ---> FAICAR AIR ---> CAIR CAIR ---> SAICAR Paics PRA ---> GAR L-glycine ---> ADP FGAM ---> AIR Atic FGAM GAR PRA 10-formyl-THF ---> THF 10-formyl-THF FAICAR aspartate glutamate. PRPP ---> PRA Ppat glutamate de novo pyrimidine biosynthetic pathway amino acid metabolic pathway transcription pathway deoxyribonucleotide metabolic pathway folate mediated one-carbon metabolic pathway ---> Gart folate mediated one-carbon metabolic pathway ---> Atic Gart Prps1 XMP adenylosuccinate 5'-GMP AMP 5'-GMP ---> deoxyribonucleotide metabolic pathway 5'-GMP ---> transcription pathway AMP ---> deoxyribonucleotide metabolic pathway AMP ---> transcription pathway PRPP ---> amino acid metabolic pathway PRPP PRPP ---> de novo pyrimidine biosynthetic pathway IMP 5'-GMP ---| Impdh1 AMP ---| Adss 5'-GMP ---| Ppat AMP ---| Ppat PRPP --+> Ppat AICAR SAICAR CAIR AIR HCO3- IMP ---> adenylosuccinate IMP ---> XMP adenylosuccinate ---> AMP XMP ---> 5'-GMP FGAR ---> FGAM GAR ---> FGAR ribose-5-phosphate ---> PRPP ATP ATP ---> AMP. L-glutamine ---> glutamate L-glycine ADP ATP . ---> ADP THF ATP .. ---> ADP . glutamine. ---> glutamate. ATP .. ATP . ADP . ATP ... ADP .. ATP ... ---> ADP .. HCO3- ---> ADP , ATP , ADP , ATP , ---> ADP , aspartate ---> ADP ,, ATP ,, ADP ,, ATP ,, ---> ADP ,, fumarate SAICAR ---> fumarate Prps2 AMP. ribose-5-phosphate L-glutamine glutamine. FGAR Pfas Adsl Adss Adssl1 Impdh2 Impdh1 Gmps
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Genes in Pathway:

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de novo purine biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adsl adenylosuccinate lyase JBrowse link 7 122,157,201 122,192,328 RGD:5135488
G Adss adenylosuccinate synthase JBrowse link 13 95,913,426 95,943,761 RGD:5143930
G Adssl1 adenylosuccinate synthase like 1 JBrowse link 6 137,184,818 137,206,694 RGD:5143930
G Ak1 adenylate kinase 1 JBrowse link 3 11,652,143 11,659,135 RGD:5490520
G Ak2 adenylate kinase 2 JBrowse link 5 147,185,474 147,204,050 RGD:5490520
G Ak3 adenylate kinase 3 JBrowse link 1 247,144,486 247,169,690 RGD:5490520
G Ak4 adenylate kinase 4 JBrowse link 5 120,250,318 120,309,153 RGD:5490520
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase JBrowse link 9 78,862,013 78,882,061 RGD:5135488
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase JBrowse link 11 31,780,477 31,805,728 RGD:1547842
G Gmps guanine monophosphate synthase JBrowse link 2 154,555,967 154,590,662 RGD:5135488
G Impdh1 inosine monophosphate dehydrogenase 1 JBrowse link 4 56,478,383 56,493,987 RGD:5144133
G Impdh2 inosine monophosphate dehydrogenase 2 JBrowse link 8 117,346,983 117,351,619 RGD:5144133
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase JBrowse link 14 33,563,884 33,580,944 RGD:633692
G Pfas phosphoribosylformylglycinamidine synthase JBrowse link 10 55,571,881 55,593,384 RGD:5135276
G Ppat phosphoribosyl pyrophosphate amidotransferase JBrowse link 14 33,580,541 33,614,919 RGD:5135488
G Prps1 phosphoribosyl pyrophosphate synthetase 1 JBrowse link X 111,798,233 111,820,270 RGD:5135488
G Prps1l1 phosphoribosyl pyrophosphate synthetase 1-like 1 JBrowse link 6 54,417,903 54,419,593 RGD:5135488
G Prps2 phosphoribosyl pyrophosphate synthetase 2 JBrowse link X 28,435,275 28,472,882 RGD:5135488
G Taf9 TATA-box binding protein associated factor 9 JBrowse link 2 30,664,407 30,668,414 RGD:5490520

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
Small MoleculeL-glutamine
Small MoleculeL-aspartate
Small Moleculeadenylosuccinate
Small Moleculefumarate
Small MoleculeL-glycine
Small MoleculeL-glutamate
Small Molecule10-formyl-THF10-formyl-tetrahydrofolate
Small MoleculeCAIR4-carboxy-5-aminoimidazole ribonucleotide
Small MoleculeSAICAR5-amino-4-imidazole-N-succinocarboxamide ribonucleotide
Small MoleculeAICAR5-amino-4-imidazolecarboxamide ribonucleotide
Small MoleculeAIR5-aminoimadazole ribonucleotide
Small MoleculeFAICAR5-formamidoimidazole-4-carboxamide ribonucleotide
Small MoleculeFGAM5-phosphoribosyl-N-formylglycineamidine
Small MoleculeADPadenosine diphosphate
Small MoleculeAMPadenosine monophosphate
Small MoleculeATPadenosine triphosphate
Small MoleculeGARglycineamide ribonucleotide
Small MoleculeGMPguanosine monophosphate
Small MoleculeIMPinosine monophosphate
Small MoleculePRPPphosphoribosyl pyrophosphate
Small MoleculeFGARphosphoribosyl-N-formylglycineamide
Small MoleculePRAphosphoribosylamine
Small MoleculeR5Pribose 5-phosphate
Small MoleculeTHFtetrahydrofolate
Small MoleculeXMPxanthosine monophosphate

Pathway Gene Annotations

Disease Annotations Associated with Genes in the de novo purine biosynthetic pathway
Disease TermsGene Symbols
Adenylate Kinase Deficiency, Hemolytic Anemia due toAk1
Adenylosuccinate lyase deficiencyAdsl
AICAR Transformylase Inosine Monophosphate Cyclohydrolase DeficiencyAtic
Aicar Transformylase/Imp Cyclohydrolase DeficiencyAtic
Anemia, HemolyticAk1
Anemia, Hemolytic, Congenital NonspherocyticAk1
Arthritis, ExperimentalAtic
Arthritis, RheumatoidAtic , Gart
Arts SyndromePrps1
Autistic DisorderAdsl
Breast NeoplasmsAdsl
Carcinoma, HepatocellularGmps , Pfas , Ppat
Charcot-Marie-Tooth DiseasePrps1
DeafnessAk2
Deafness, High-Frequency Sensorineural, X-LinkedPrps1
Deafness, X-Linked 1Prps1
Diabetes Mellitus, ExperimentalAdsl , Adssl1 , Gmps , Pfas , Ppat
Diabetes Mellitus, Type 2Ak1
Down SyndromeGart
Drug-Induced Liver InjuryAk4
Drug-Related Side Effects and Adverse ReactionsAtic
Epilepsy, Temporal LobeAk2
Hearing LossPrps1
HIV InfectionsTaf9
Infarction, Middle Cerebral ArteryAk1
Kidney NeoplasmsPpat
Kidney Tubular Necrosis, AcuteAk4
Leber Congenital AmaurosisImpdh1
Leber Congenital Amaurosis 11Impdh1
Leukemia, Myeloid, AcuteGmps
Leukemia, Myelomonocytic, AcuteGmps
Liver Neoplasms, ExperimentalAdsl , Ppat
Lymphoma, Mantle-CellAk1
Myocardial InfarctionAk1
Myocardial IschemiaAk1 , Ppat
Myoclonic Epilepsies, ProgressiveAdsl
MYOPATHY, DISTAL, 5Adssl1
Neoplasms, Second PrimaryGmps
Neurologic ManifestationsPrps1
ObesityAk1
Optic Atrophy Polyneuropathy DeafnessPrps1
OsteoarthritisAk4
OsteoporosisAtic
Phosphoribosylpyrophosphate Synthetase SuperactivityPrps1
Pleomorphic Xanthoastrocytoma Impdh1 , Prps1l1
Prostatic NeoplasmsAdsl
Purine-Pyrimidine Metabolism, Inborn ErrorsAtic
Reticular DysgenesisAk2
Retinal DegenerationImpdh1
Retinitis PigmentosaImpdh1 , Prps1
Retinitis Pigmentosa 10Impdh1
SarcomaAdss , Adssl1
SarcopeniaAk1
SchizophreniaPaics
Severe Combined ImmunodeficiencyAk2
Unverricht-Lundborg SyndromeAdsl
Weight GainPrps1
Pathway Annotations Associated with Genes in the de novo purine biosynthetic pathway
Pathway TermsGene Symbols
2-hydroxyglutaricaciduria disease pathwayGmps , Ppat
adefovir pharmacokinetics pathwayAk1 , Ak2
adenine phoshoribosyltransferase deficiency pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
adenosine monophosphate deaminase deficiency pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
adenylosuccinate lyase deficiency pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
AICA-ribosuria pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
alanine, aspartate and glutamate metabolic pathwayAdsl , Adss , Ppat
azathioprine pharmacodynamics pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
beta-ureidopropionase deficiency pathwayAk3
Canavan disease pathwayAdsl , Adssl1
de novo purine biosynthetic pathwayAdsl , Adss , Adssl1 , Ak1 , Ak2 , Ak3 , Ak4 , Atic , Gart , Gmps , Impdh1 , Impdh2 , Paics , Pfas , Ppat , Prps1 , Prps1l1 , Prps2 , Taf9
dihydropyrimidinase deficiency pathwayAk3
folate mediated one-carbon metabolic pathwayAtic , Gart
folate metabolic pathwayAtic , Gart
glutamic acid/glutamate metabolic pathwayGmps , Ppat
homocarnosinosis disease pathwayGmps , Ppat
Kelley-Seegmiller syndrome pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
Lesch-Nyhan syndrome pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
mercaptopurine pharmacodynamics pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
mercaptopurine pharmacokinetics pathwayGmps , Impdh1 , Ppat
mitochondrial neurogastrointestinal encephalopathy syndrome pathwayAk3
molybdenum cofactor deficiency pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
mycophenolic acid pharmacokinetics pathwayImpdh1 , Impdh2
oroticaciduria 1 disease pathwayAk3
pentose phosphate pathwayPrps1 , Prps1l1 , Prps2
purine metabolic pathwayAdsl , Adss , Ak1 , Ak2 , Atic , Gart , Gmps , Impdh1 , Impdh2 , Paics , Pfas , Ppat , Prps1 , Prps1l1 , Prps2
purine nucleoside phosphorylase deficiency pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
pyrimidine metabolic pathwayAk3
ribose 5-phosphate isomerase deficiency pathwayPrps1l1
ribosome biogenesis pathwayTaf9
RNA polymerase II transcription initiation pathwayTaf9
succinic semialdehyde dehydrogenase deficiency pathwayGmps , Ppat
tenofovir pharmacokinetics pathwayAk1 , Ak2
tioguanine pharmacodynamics pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
transaldolase deficiency pathwayPrps1l1
xanthinuria disease pathwayAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
xanthinuria disease pathway, type IAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1
xanthinuria disease pathway, type IIAdsl , Adss , Ak1 , Atic , Gart , Gmps , Impdh1 , Paics , Pfas , Ppat , Prps1l1

References Associated with the de novo purine biosynthetic pathway:

Ontology Path Diagram:

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