DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6) - Rat Genome Database

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Gene: DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6) Canis lupus familiaris
Analyze
Symbol: DNAJC6 (Ensembl: AK4)
Name: DnaJ heat shock protein family (Hsp40) member C6
RGD ID: 12424640
Description: ENCODES a protein that exhibits adenylate kinase activity (ortholog); nucleoside triphosphate adenylate kinase activity (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); liver development (ortholog); regulation of oxidative phosphorylation (ortholog); PARTICIPATES IN de novo purine biosynthetic pathway; ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Chemical and Drug Induced Liver Injury (ortholog); COVID-19 (ortholog); FOUND IN clathrin-coated vesicle (inferred); cytoplasm (inferred); cytoplasmic vesicle (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adenylate kinase 4; adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4, mitochondrial; AK3L1; AK4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1545,055,294 - 45,119,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,884,283 - 45,120,203 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha545,107,227 - 45,176,810 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0545,230,958 - 45,300,604 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl545,235,891 - 45,300,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1545,196,507 - 45,265,914 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0545,140,926 - 45,210,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,392,014 - 45,461,310 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DNAJC6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1545,055,294 - 45,119,595 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl544,884,283 - 45,120,203 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha545,107,227 - 45,176,810 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0545,230,958 - 45,300,604 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl545,235,891 - 45,300,627 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1545,196,507 - 45,265,914 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0545,140,926 - 45,210,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0545,392,014 - 45,461,310 (-)NCBIUU_Cfam_GSD_1.0
AK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38165,147,552 - 65,232,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl165,147,549 - 65,232,145 (+)EnsemblGRCh38hg38GRCh38
GRCh37165,613,235 - 65,697,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36165,385,820 - 65,465,765 (+)NCBINCBI36Build 36hg18NCBI36
Celera163,903,944 - 63,988,555 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef163,722,163 - 63,806,551 (+)NCBIHuRef
CHM1_1165,729,523 - 65,814,075 (+)NCBICHM1_1
T2T-CHM13v2.0165,025,531 - 65,110,134 (+)NCBIT2T-CHM13v2.0
Ak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394101,273,675 - 101,324,968 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4101,276,474 - 101,324,192 (+)EnsemblGRCm39 Ensembl
GRCm384101,416,478 - 101,467,771 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4101,419,277 - 101,466,995 (+)EnsemblGRCm38mm10GRCm38
MGSCv374101,091,894 - 101,140,376 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364100,917,690 - 100,964,927 (+)NCBIMGSCv36mm8
Celera499,759,270 - 99,808,044 (+)NCBICelera
Cytogenetic Map4C6NCBI
cM Map446.84NCBI
Ak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85121,154,565 - 121,214,403 (+)NCBIGRCr8
mRatBN7.25116,039,222 - 116,099,064 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5116,039,616 - 116,098,618 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5118,605,105 - 118,655,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05120,330,473 - 120,381,010 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05120,381,768 - 120,432,320 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05120,250,318 - 120,309,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5120,250,616 - 120,305,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05124,129,933 - 124,189,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45122,062,872 - 122,119,335 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15122,068,045 - 122,127,564 (+)NCBI
Celera5114,576,993 - 114,626,919 (+)NCBICelera
Cytogenetic Map5q33NCBI
Ak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542325,395,836 - 25,427,474 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542325,395,086 - 25,402,324 (-)NCBIChiLan1.0ChiLan1.0
AK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21161,630,069 - 161,714,696 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11160,780,900 - 160,865,513 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0164,394,898 - 64,479,536 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1166,283,102 - 66,367,146 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl166,283,102 - 66,361,230 (+)Ensemblpanpan1.1panPan2
Ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505878,277,939 - 78,342,917 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366922,593,409 - 2,654,583 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6147,177,029 - 147,257,814 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16147,177,029 - 147,257,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26135,587,473 - 135,663,801 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12067,840,572 - 67,924,691 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603349,603,493 - 49,717,228 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474229,547,237 - 29,574,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DNAJC6
654 total Variants

Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014113708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038476049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038519127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038537234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038601363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038665928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002626714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_002626715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005325774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005325775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005359653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005359654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005394195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005394196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005427256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005427257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00845052318   ⟹   ENSCAFP00845041037
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl545,235,891 - 45,300,627 (-)Ensembl
RefSeq Acc Id: XM_038476049   ⟹   XP_038331977
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1545,196,507 - 45,265,914 (-)NCBI
RefSeq Acc Id: XM_038519127   ⟹   XP_038375055
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha545,107,227 - 45,176,810 (-)NCBI
RefSeq Acc Id: XM_038537234   ⟹   XP_038393162
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0545,392,014 - 45,461,310 (-)NCBI
RefSeq Acc Id: XM_038601363   ⟹   XP_038457291
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0545,140,926 - 45,210,260 (-)NCBI
RefSeq Acc Id: XM_038665928   ⟹   XP_038521856
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0545,230,958 - 45,300,604 (-)NCBI
RefSeq Acc Id: XR_002626714
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1545,055,294 - 45,119,595 (-)NCBI
Dog10K_Boxer_Tasha545,107,227 - 45,176,487 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002626715
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1545,056,190 - 45,119,595 (-)NCBI
Dog10K_Boxer_Tasha545,107,227 - 45,176,499 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005325774
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1545,196,507 - 45,265,591 (-)NCBI
RefSeq Acc Id: XR_005325775
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1545,196,507 - 45,265,603 (-)NCBI
RefSeq Acc Id: XR_005359653
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0545,392,014 - 45,460,978 (-)NCBI
RefSeq Acc Id: XR_005359654
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0545,392,014 - 45,460,990 (-)NCBI
RefSeq Acc Id: XR_005394195
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0545,140,926 - 45,209,928 (-)NCBI
RefSeq Acc Id: XR_005394196
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0545,140,926 - 45,209,940 (-)NCBI
RefSeq Acc Id: XR_005427256
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0545,230,958 - 45,300,281 (-)NCBI
RefSeq Acc Id: XR_005427257
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0545,230,958 - 45,300,293 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_038331977   ⟸   XM_038476049
RefSeq Acc Id: XP_038457291   ⟸   XM_038601363
RefSeq Acc Id: XP_038521856   ⟸   XM_038665928
- UniProtKB: A0A8C0M9K4 (UniProtKB/TrEMBL),   A0A8C0L496 (UniProtKB/TrEMBL),   A0A8I3QJY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038375055   ⟸   XM_038519127
- UniProtKB: A0A8C0M9K4 (UniProtKB/TrEMBL),   A0A8C0L496 (UniProtKB/TrEMBL),   A0A8I3QJY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038393162   ⟸   XM_038537234
- UniProtKB: A0A8C0L496 (UniProtKB/TrEMBL),   A0A8C0M9K4 (UniProtKB/TrEMBL),   A0A8I3QJY0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845041037   ⟸   ENSCAFT00845052318
Protein Domains
Adenylate kinase active site lid   C2 tensin-type   J   Phosphatase tensin-type   Tyrosine specific protein phosphatases


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018607 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00000059289 UniProtKB/TrEMBL
  ENSCAFG00030004228 UniProtKB/TrEMBL
  ENSCAFG00040008562 UniProtKB/TrEMBL
  ENSCAFG00845029543 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029543.5 UniProtKB/TrEMBL
  ENSCAFT00000063149.2 UniProtKB/TrEMBL
  ENSCAFT00030007788.1 UniProtKB/TrEMBL
  ENSCAFT00040015993.1 UniProtKB/TrEMBL
  ENSCAFT00845052318 ENTREZGENE
  ENSCAFT00845052318.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
  2.60.40.1110 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/TrEMBL
InterPro Adenyl_kin_sub UniProtKB/TrEMBL
  Adenylat/UMP-CMP_kin UniProtKB/TrEMBL
  Adenylat_kinase_CS UniProtKB/TrEMBL
  Adenylate_kinase_lid-dom UniProtKB/TrEMBL
  AK3/Ak4_mitochondrial UniProtKB/TrEMBL
  AK4_mitochondrial UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DnaJ_domain UniProtKB/TrEMBL
  J_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  Tensin_C2-dom UniProtKB/TrEMBL
  Tensin_phosphatase UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
NCBI Gene AK4 ENTREZGENE
PANTHER ADENYLATE KINASE 4, MITOCHONDRIAL UniProtKB/TrEMBL
  AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED UniProtKB/TrEMBL
  PTHR23359 UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE AUXILIN-RELATED UniProtKB/TrEMBL
Pfam ADK UniProtKB/TrEMBL
  ADK_lid UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
PRINTS ADENYLTKNASE UniProtKB/TrEMBL
PROSITE ADENYLATE_KINASE UniProtKB/TrEMBL
  C2_TENSIN UniProtKB/TrEMBL
  DNAJ_2 UniProtKB/TrEMBL
  PPASE_TENSIN UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
SMART DnaJ UniProtKB/TrEMBL
  PTEN_C2 UniProtKB/TrEMBL
Superfamily-SCOP (Phosphotyrosine protein) phosphatases II UniProtKB/TrEMBL
  C2 domain (Calcium/lipid-binding domain, CaLB) UniProtKB/TrEMBL
  Chaperone J-domain UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0L496 ENTREZGENE
  A0A8C0M9K4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QJY0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0P0B1_CANLF UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-26 DNAJC6  DnaJ heat shock protein family (Hsp40) member C6  AK4  adenylate kinase 4  Symbol and/or name change 19259463 PROVISIONAL