Agrp (agouti related neuropeptide) - Rat Genome Database

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Gene: Agrp (agouti related neuropeptide) Rattus norvegicus
Analyze
Symbol: Agrp
Name: agouti related neuropeptide
RGD ID: 2068
Description: Predicted to enable neuropeptide hormone activity and type 1 melanocortin receptor binding activity. Involved in several processes, including adult feeding behavior; neuropeptide signaling pathway; and positive regulation of feeding behavior. Located in extracellular space and neuronal cell body. Biomarker of obesity and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human AGRP (agouti related neuropeptide); PARTICIPATES IN altered melanocortin system pathway; melanocortin system pathway; obesity pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; AM-251.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Agouti (mouse) related protein; agouti related protein; agouti related protein homolog (mouse); Agouti-related protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bw130
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,357,899 - 50,396,758 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,357,905 - 50,358,698 (-)EnsemblGRCr8
mRatBN7.21933,447,992 - 33,481,602 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,447,992 - 33,449,584 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,263,577 - 40,265,169 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,916,914 - 40,918,506 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,214,688 - 43,216,280 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,525,941 - 37,584,875 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)Ensemblrn6Rnor6.0
Rnor_5.01948,391,845 - 48,406,659 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,386,682 - 35,388,274 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1932,876,306 - 32,877,927 (-)NCBICelera
RGSC_v3.11935,391,672 - 35,392,244 (-)NCBI
Cytogenetic Map19q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Hyperphagia  (IEP)
obesity  (IEP,ISO)
type 2 diabetes mellitus  (IEP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular region  (IEA)
extracellular space  (IBA,IDA,IEA,ISO,TAS)
Golgi lumen  (IEA,ISO)
neuronal cell body  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A polymorphism in the human agouti-related protein is associated with late-onset obesity. Argyropoulos G, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4198-202.
2. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
3. P2X2 purinoreceptor protein in hypothalamic neurons associated with the regulation of food intake. Collden G, etal., Neuroscience. 2010 Nov 24;171(1):62-78. Epub 2010 Aug 22.
4. Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP)83-132: interaction between AGRP83-132 and melanocortin receptors cannot be influenced by syndecan-3. Creemers JW, etal., Endocrinology. 2006 Apr;147(4):1621-31. Epub 2005 Dec 29.
5. Agouti-related protein has an inhibitory paracrine role in the rat adrenal gland. Dhillo WS, etal., Biochem Biophys Res Commun 2003 Jan 31;301(1):102-7.
6. Immunolesion of norepinephrine and epinephrine afferents to medial hypothalamus alters basal and 2-deoxy-D-glucose-induced neuropeptide Y and agouti gene-related protein messenger ribonucleic acid expression in the arcuate nucleus. Fraley GS and Ritter S, Endocrinology 2003 Jan;144(1):75-83.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Treadmill training enhances rat agouti-related protein in plasma and reduces ghrelin levels in plasma and soleus muscle. Ghanbari-Niaki A, etal., Metabolism. 2009 Dec;58(12):1747-52. Epub 2009 Jul 25.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
11. Plasma levels of agouti-related protein are increased in obese men. Katsuki A, etal., J Clin Endocrinol Metab 2001 May;86(5):1921-4.
12. Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake. Kitamura T, etal., Nat Med. 2006 May;12(5):534-40. Epub 2006 Apr 9.
13. Effects of leptin receptor mutation on Agrp gene expression in fed and fasted lean and obese (LA/N-faf) rats. Korner J, etal., Endocrinology 2000 Jul;141(7):2465-71.
14. Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight. Leibowitz SF, etal., Brain Res. 2005 Mar 2;1036(1-2):180-91.
15. Genetic association analysis of 30 genes related to obesity in a European American population. Li P, etal., Int J Obes (Lond). 2014 May;38(5):724-9. doi: 10.1038/ijo.2013.140. Epub 2013 Jul 31.
16. A role for the Agouti-Related Protein promoter in obesity and type 2 diabetes. Mayfield DK, etal., Biochem Biophys Res Commun. 2001 Sep 21;287(2):568-73.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Mul JD, etal., Obesity (Silver Spring). 2012 Mar;20(3):612-21. doi: 10.1038/oby.2011.81. Epub 2011 Apr 28.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Perinatal nutrient restriction induces long-lasting alterations in the circadian expression pattern of genes regulating food intake and energy metabolism. Orozco-Solis R, etal., Int J Obes (Lond). 2011 Jul;35(7):990-1000. doi: 10.1038/ijo.2010.223. Epub 2010 Nov 9.
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Agouti-related protein is a mediator of diabetic hyperphagia. Qu SY, etal., Regul Pept. 2001 Apr 2;98(1-2):69-75.
24. GOA pipeline RGD automated data pipeline
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Divergent regulation of hypothalamic neuropeptide Y and agouti-related protein by photoperiod in F344 rats with differential food intake and growth. Ross AW, etal., J Neuroendocrinol. 2009 Jul;21(7):610-9. Epub 2009 Apr 13.
28. The critical role of the melanocortin system in the control of energy balance. Seeley RJ, etal., Annu Rev Nutr 2004;24:133-49.
29. Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus. Toshinai K, etal., Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E394-401. Epub 2010 Jun 15.
30. Hyperphagia and central mechanisms for leptin resistance during pregnancy. Trujillo ML, etal., Endocrinology. 2011 Apr;152(4):1355-65. Epub 2011 Feb 8.
31. Glucocorticoids are required for meal-induced changes in the expression of hypothalamic neuropeptides. Uchoa ET, etal., Neuropeptides. 2012 Mar 15.
Additional References at PubMed
PMID:9311920   PMID:12126733   PMID:12213628   PMID:12832105   PMID:12851299   PMID:14636173   PMID:15582725   PMID:15589525   PMID:15616803   PMID:15890775   PMID:15927146   PMID:16046456  
PMID:16087729   PMID:16226323   PMID:16484442   PMID:17289093   PMID:17374702   PMID:17873059   PMID:18384674   PMID:18467436   PMID:18535107   PMID:18583425   PMID:18955035   PMID:19017729  
PMID:19151514   PMID:19255506   PMID:19403567   PMID:19817504   PMID:20335227   PMID:21334429   PMID:21589937   PMID:22450045   PMID:22715380   PMID:23376485   PMID:25509169   PMID:26907996  
PMID:36817590  


Genomics

Comparative Map Data
Agrp
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81950,357,899 - 50,396,758 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1950,357,905 - 50,358,698 (-)EnsemblGRCr8
mRatBN7.21933,447,992 - 33,481,602 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1933,447,992 - 33,449,584 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1940,263,577 - 40,265,169 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01940,916,914 - 40,918,506 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01943,214,688 - 43,216,280 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01937,525,941 - 37,584,875 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)Ensemblrn6Rnor6.0
Rnor_5.01948,391,845 - 48,406,659 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41935,386,682 - 35,388,274 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1932,876,306 - 32,877,927 (-)NCBICelera
RGSC_v3.11935,391,672 - 35,392,244 (-)NCBI
Cytogenetic Map19q12NCBI
AGRP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381667,482,571 - 67,483,547 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1667,482,571 - 67,483,548 (-)Ensemblhg38GRCh38
GRCh371667,516,474 - 67,517,450 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,073,975 - 66,075,217 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341666,073,974 - 66,074,805NCBI
Celera1652,024,676 - 52,025,918 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1653,389,602 - 53,390,844 (-)NCBIHuRef
CHM1_11668,923,856 - 68,925,098 (-)NCBICHM1_1
T2T-CHM13v2.01673,277,343 - 73,278,319 (-)NCBIT2T-CHM13v2.0
Agrp
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,293,327 - 106,306,477 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8106,293,330 - 106,364,025 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm388105,566,695 - 105,579,845 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,566,698 - 105,637,393 (-)Ensemblmm10GRCm38
MGSCv378108,090,598 - 108,092,198 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv368108,455,827 - 108,457,427 (-)NCBIMGSCv36mm8
Celera8109,789,930 - 109,791,530 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Agrp
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,165,120 - 9,166,789 (+)Ensembl
ChiLan1.0NW_0049554849,165,120 - 9,166,789 (+)NCBIChiLan1.0ChiLan1.0
AGRP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21877,011,780 - 77,013,321 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11682,924,427 - 82,925,968 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01647,827,532 - 47,872,727 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11667,216,008 - 67,217,258 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,216,008 - 67,217,258 (-)EnsemblpanPan2panpan1.1
AGRP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,924,249 - 81,926,510 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,925,055 - 81,925,845 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha581,914,032 - 81,915,572 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0582,359,662 - 82,361,202 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl582,360,349 - 82,361,139 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1582,185,812 - 82,187,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0581,866,912 - 81,868,452 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0582,510,362 - 82,511,902 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Agrp
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,652,027 - 41,660,973 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647517,927,985 - 17,937,147 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647517,927,991 - 17,929,377 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGRP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,132,615 - 28,134,900 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1628,132,614 - 28,135,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,399,704 - 25,401,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGRP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,972,728 - 59,974,728 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl559,973,922 - 59,974,660 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604722,722,627 - 22,723,740 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agrp
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,826,545 - 18,827,299 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474618,826,206 - 18,827,453 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Agrp
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11725,297,685 - 25,370,111 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Agrp
152 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:62
Count of miRNA genes:61
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000059628
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)194622677874246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)194438513474246245Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)194172254674246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)194072709254856850Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)194072709254856850Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)194072709254856850Rat

Markers in Region
RH94762  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21933,448,678 - 33,448,781 (+)MAPPERmRatBN7.2
Rnor_6.01937,527,106 - 37,527,208NCBIRnor6.0
Rnor_5.01948,393,005 - 48,393,107UniSTSRnor5.0
RGSC_v3.41935,387,369 - 35,387,471UniSTSRGSC3.4
Celera1932,877,022 - 32,877,124UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 9 58 142 79 78 47 92 47 6 317 175 6 125 77 86 31 13 13

Sequence


Ensembl Acc Id: ENSRNOT00000059628   ⟹   ENSRNOP00000056384
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1950,357,905 - 50,358,698 (-)Ensembl
mRatBN7.2 Ensembl1933,447,992 - 33,449,584 (-)Ensembl
Rnor_6.0 Ensembl1937,526,419 - 37,528,011 (-)Ensembl
RefSeq Acc Id: NM_033650   ⟹   NP_387499
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,357,905 - 50,359,497 (-)NCBI
mRatBN7.21933,447,992 - 33,449,584 (-)NCBI
Rnor_6.01937,526,419 - 37,528,011 (-)NCBI
Rnor_5.01948,391,845 - 48,406,659 (-)NCBI
RGSC_v3.41935,386,682 - 35,388,274 (-)RGD
Celera1932,876,306 - 32,877,927 (-)RGD
Sequence:
RefSeq Acc Id: XM_063277802   ⟹   XP_063133872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,357,899 - 50,396,758 (-)NCBI
RefSeq Acc Id: XM_063277803   ⟹   XP_063133873
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81950,357,899 - 50,373,311 (-)NCBI
Protein Sequences
Protein RefSeqs NP_387499 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133872 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133873 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF20203 (Get FASTA)   NCBI Sequence Viewer  
  EDL92383 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000056384
  ENSRNOP00000056384.3
RefSeq Acc Id: NP_387499   ⟸   NM_033650
- Peptide Label: precursor
- UniProtKB: F1MAG1 (UniProtKB/TrEMBL),   A6IYQ5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000056384   ⟸   ENSRNOT00000059628
RefSeq Acc Id: XP_063133872   ⟸   XM_063277802
- Peptide Label: isoform X1
- UniProtKB: A6IYQ5 (UniProtKB/TrEMBL),   F1MAG1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133873   ⟸   XM_063277803
- Peptide Label: isoform X1
- UniProtKB: A6IYQ5 (UniProtKB/TrEMBL),   F1MAG1 (UniProtKB/TrEMBL)
Protein Domains
Agouti

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAG1-F1-model_v2 AlphaFold F1MAG1 1-129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2068 AgrOrtholog
BioCyc Gene G2FUF-5824 BioCyc
Ensembl Genes ENSRNOG00000039001 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059628 ENTREZGENE
  ENSRNOT00000059628.5 UniProtKB/TrEMBL
Gene3D-CATH 4.10.760.10 UniProtKB/TrEMBL
InterPro Agouti UniProtKB/TrEMBL
  Agouti_dom UniProtKB/TrEMBL
  Agouti_dom_sf UniProtKB/TrEMBL
KEGG Report rno:25582 UniProtKB/TrEMBL
NCBI Gene 25582 ENTREZGENE
PANTHER Agouti UniProtKB/TrEMBL
  AGOUTI-RELATED PROTEIN UniProtKB/TrEMBL
Pfam Agouti UniProtKB/TrEMBL
PhenoGen Agrp PhenoGen
PROSITE AGOUTI_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039001 RatGTEx
SMART Agouti UniProtKB/TrEMBL
Superfamily-SCOP Agouti UniProtKB/TrEMBL
UniProt A6IYQ5 ENTREZGENE, UniProtKB/TrEMBL
  F1MAG1 ENTREZGENE, UniProtKB/TrEMBL
  Q9QXJ3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-07-23 Agrp  agouti related neuropeptide  Agrp  agouti related protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Agrp  agouti related protein homolog (mouse)  Agrp  agouti related protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Agrp  agouti related protein  Agrp  agouti related protein homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Agrp  agouti related protein homolog (mouse)  Agrp  Agouti (mouse) related protein  Name updated 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expression detected in hypothalamus 632165
gene_function may interact with melanocortin receptors 632165
gene_process may play a role in appetite stimulation 632165
gene_regulation expression may be inhibited by leptin 632165
gene_regulation expression increases in response to food deprivation 632165