Rrm2 (ribonucleotide reductase regulatory subunit M2) - Rat Genome Database

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Gene: Rrm2 (ribonucleotide reductase regulatory subunit M2) Rattus norvegicus
Analyze
Symbol: Rrm2
Name: ribonucleotide reductase regulatory subunit M2
RGD ID: 1598310
Description: Predicted to enable ferric iron binding activity; protein homodimerization activity; and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in positive regulation of cell population proliferation and pyrimidine nucleobase metabolic process. Located in nuclear envelope. Used to study endometrial adenocarcinoma. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human RRM2 (ribonucleotide reductase regulatory subunit M2); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC116120; ribonucleoside-diphosphate reductase subunit M2; Ribonucleotide reductase 2; ribonucleotide reductase M2; ribonucleotide reductase M2 (mapped); ribonucleotide reductase M2 polypeptide; ribonucleotide reductase small chain; ribonucleotide reductase small subunit; Rrm2_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,044,755 - 47,075,370 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl647,067,690 - 47,075,370 (+)EnsemblGRCr8
mRatBN7.2641,339,858 - 41,346,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,340,557 - 41,346,773 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx641,660,659 - 41,666,878 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,975,466 - 41,981,683 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,408,612 - 41,414,829 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,884,627 - 43,890,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,884,678 - 43,889,515 (+)Ensemblrn6Rnor6.0
Rnor_5.0660,756,160 - 60,762,351 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4642,350,541 - 42,356,748 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera640,627,438 - 40,633,641 (+)NCBICelera
Cytogenetic Map6q16NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-palmitoylglycerol  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bicalutamide  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
celastrol  (ISO)
chenodeoxycholic acid  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciclopirox  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
dexamethasone  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl maleate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
finasteride  (EXP)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
gedunin  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
glycidol  (EXP)
glycine betaine  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
GW 7647  (ISO)
hydroxyurea  (ISO)
indole-3-methanol  (EXP)
iron atom  (ISO)
iron dichloride  (ISO)
iron(0)  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
ketoconazole  (ISO)
L-methionine  (ISO)
leflunomide  (EXP,ISO)
levofloxacin  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lucanthone  (ISO)
LY294002  (ISO)
lycopene  (ISO)
MeIQx  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
miconazole  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(4)-hydroxycytidine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nimesulide  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paracetamol  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
pinosylvin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
Sunset Yellow FCF  (ISO)
tamibarotene  (ISO)
tebufenpyrad  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-pinosylvin  (ISO)
Tributyltin oxide  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
trovafloxacin  (EXP,ISO)
Tungsten carbide  (ISO)
tunicamycin  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Oncogene amplification in the proximal part of chromosome 6 in rat endometrial adenocarcinoma as revealed by combined BAC/PAC FISH, chromosome painting, zoo-FISH, and allelotyping. Adamovic T, etal., Genes Chromosomes Cancer. 2005 Oct;44(2):139-53.
2. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. Boukovinas I, etal., PLoS One. 2008;3(11):e3695. doi: 10.1371/journal.pone.0003695. Epub 2008 Nov 11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes. Gearhart TL and Bouchard MJ, Virology. 2010 Nov 10;407(1):14-25. Epub 2010 Aug 16.
5. Potent siRNA inhibitors of ribonucleotide reductase subunit RRM2 reduce cell proliferation in vitro and in vivo. Heidel JD, etal., Clin Cancer Res. 2007 Apr 1;13(7):2207-15.
6. Cross-species comparison of orthologous gene expression in human bladder cancer and carcinogen-induced rodent models. Lu Y, etal., Am J Transl Res. 2010 Sep 20;3(1):8-27.
7. The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo. Manjeshwar S, etal., Mol Carcinog. 1999 Mar;24(3):188-96.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. Gemcitabine-based chemogene therapy for pancreatic cancer using Ad-dCK::UMK GDEPT and TS/RR siRNA strategies. Rejiba S, etal., Neoplasia. 2009 Jul;11(7):637-50.
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Immunohistochemical detection of ribonucleotide reductase in human breast-tumors. Saeki T, etal., Int J Oncol. 1995 Mar;6(3):523-9.
15. Evidence that mammalian ribonucleotide reductase is a nuclear membrane associated glycoprotein. Sikorska M, etal., Biochem Cell Biol. 1990 May;68(5):880-8.
16. Changes in the cytoplasmic and nuclear activities of the ribonucleotide reductase holoenzyme and its subunits in regenerating liver cells in normal and thyroparathyroidectomized rats. Youdale T, etal., Can J Biochem Cell Biol. 1984 Sep;62(9):914-9.
Additional References at PubMed
PMID:2684652   PMID:8130196   PMID:8612737   PMID:8876648   PMID:12477932   PMID:12655059   PMID:15489334   PMID:16829694   PMID:16861739   PMID:19176520   PMID:21925507   PMID:26902285  
PMID:34868394  


Genomics

Comparative Map Data
Rrm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8647,044,755 - 47,075,370 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl647,067,690 - 47,075,370 (+)EnsemblGRCr8
mRatBN7.2641,339,858 - 41,346,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl641,340,557 - 41,346,773 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx641,660,659 - 41,666,878 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0641,975,466 - 41,981,683 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0641,408,612 - 41,414,829 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0643,884,627 - 43,890,818 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl643,884,678 - 43,889,515 (+)Ensemblrn6Rnor6.0
Rnor_5.0660,756,160 - 60,762,351 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4642,350,541 - 42,356,748 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera640,627,438 - 40,633,641 (+)NCBICelera
Cytogenetic Map6q16NCBI
RRM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38210,122,568 - 10,211,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl210,120,698 - 10,211,725 (+)Ensemblhg38GRCh38
GRCh37210,262,695 - 10,351,136 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36210,180,184 - 10,188,074 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34210,213,332 - 10,221,220NCBI
Celera210,178,748 - 10,187,595 (+)NCBICelera
Cytogenetic Map2p25.1NCBI
HuRef210,113,982 - 10,122,746 (+)NCBIHuRef
CHM1_1210,192,499 - 10,201,334 (+)NCBICHM1_1
T2T-CHM13v2.0210,151,280 - 10,239,549 (+)NCBIT2T-CHM13v2.0
Rrm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391224,758,253 - 24,764,145 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1224,758,240 - 24,764,145 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381224,708,254 - 24,714,146 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1224,708,241 - 24,714,146 (+)Ensemblmm10GRCm38
MGSCv371225,393,119 - 25,399,011 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361225,297,362 - 25,303,186 (+)NCBIMGSCv36mm8
Celera1226,164,274 - 26,170,181 (+)NCBICelera
Cytogenetic Map12A1.3NCBI
cM Map128.5NCBI
Rrm2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554875,476,954 - 5,483,049 (+)Ensembl
ChiLan1.0NW_0049554875,477,097 - 5,481,422 (+)NCBIChiLan1.0ChiLan1.0
RRM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212116,388,124 - 116,396,941 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A116,392,095 - 116,400,912 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A10,119,508 - 10,128,318 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A10,275,598 - 10,284,640 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A10,275,598 - 10,284,640 (+)EnsemblpanPan2panpan1.1
RRM2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1177,106,515 - 7,113,868 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl177,104,961 - 7,122,939 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha177,033,016 - 7,052,810 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0177,204,147 - 7,223,928 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl177,204,143 - 7,220,570 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1177,095,785 - 7,115,556 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0177,098,343 - 7,118,126 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0177,112,515 - 7,132,291 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rrm2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629251,592,999 - 51,596,629 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365326,348,041 - 6,390,144 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3126,347,819 - 126,365,644 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13126,357,198 - 126,367,145 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RRM2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11497,512,690 - 97,519,734 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1497,512,832 - 97,521,932 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604514,794,522 - 14,803,100 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248654,985,620 - 4,990,120 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248654,984,353 - 4,990,187 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Rrm2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1738,316,854 - 38,323,006 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rrm2
214 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:98
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000011163
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590290Uminl2Urine mineral level QTL 23.960.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)64451097489510974Rat
8693632Alc27Alcohol consumption QTL 272.20.791drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)64005241156848866Rat
634318Bw118Body weight QTL 1183.55abdominal fat pad mass (VT:1000711)abdominal fat pad weight (CMO:0000088)63902865963457441Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
634307Bp141Blood pressure QTL 1414arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)64095756485957564Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)64515378690153786Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
1331779Rf38Renal function QTL 382.876kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)63118500276185002Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)64604735391047353Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
9590140Scort4Serum corticosterone level QTL 414.490.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
9590306Scort18Serum corticosterone level QTL 182.880.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)64451097489510974Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)63332884178328841Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62661831486868070Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)63093763275937632Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)63332884178328841Rat
6893340Cm77Cardiac mass QTL 770.260.57heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)63902865986867923Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
1300143Rf14Renal function QTL 142.92renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)64016318385163183Rat

Markers in Region
RH128375  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,879,602 - 23,879,800 (-)MAPPERmRatBN7.2
mRatBN7.2641,346,372 - 41,346,570 (+)MAPPERmRatBN7.2
Rnor_6.0643,890,417 - 43,890,614NCBIRnor6.0
Rnor_6.01925,393,828 - 25,394,025NCBIRnor6.0
Rnor_5.01936,370,006 - 36,370,203UniSTSRnor5.0
Rnor_5.0660,761,950 - 60,762,147UniSTSRnor5.0
Celera1923,428,502 - 23,428,699UniSTS
Celera640,633,240 - 40,633,437UniSTS
Cytogenetic Map6q16UniSTS
RH137293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2641,345,135 - 41,345,454 (+)MAPPERmRatBN7.2
mRatBN7.21923,880,707 - 23,880,923 (-)MAPPERmRatBN7.2
Rnor_6.0643,889,191 - 43,889,509NCBIRnor6.0
Rnor_6.01925,392,702 - 25,392,917NCBIRnor6.0
Rnor_5.01936,368,880 - 36,369,095UniSTSRnor5.0
Rnor_5.0660,760,724 - 60,761,042UniSTSRnor5.0
Celera1923,429,607 - 23,429,822UniSTS
Celera640,632,004 - 40,632,322UniSTS
Cytogenetic Map6q16UniSTS
PMC207566P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21923,881,059 - 23,881,293 (-)MAPPERmRatBN7.2
Rnor_6.01925,392,332 - 25,392,565NCBIRnor6.0
Rnor_5.01936,368,510 - 36,368,743UniSTSRnor5.0
RGSC_v3.41925,564,412 - 25,564,645UniSTSRGSC3.4
Celera1923,429,959 - 23,430,192UniSTS
Cytogenetic Map6q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 354 192 11 144 79 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000091551   ⟹   ENSRNOP00000073334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl647,067,690 - 47,075,370 (+)Ensembl
mRatBN7.2 Ensembl641,340,557 - 41,346,773 (+)Ensembl
Rnor_6.0 Ensembl643,884,678 - 43,889,515 (+)Ensembl
RefSeq Acc Id: NM_001025740   ⟹   NP_001020911
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8647,069,167 - 47,075,370 (+)NCBI
mRatBN7.2641,340,569 - 41,346,774 (+)NCBI
Rnor_6.0643,884,627 - 43,890,818 (+)NCBI
Rnor_5.0660,756,160 - 60,762,351 (+)NCBI
RGSC_v3.4642,350,541 - 42,356,748 (+)RGD
Celera640,627,438 - 40,633,641 (+)RGD
Sequence:
RefSeq Acc Id: XM_039112489   ⟹   XP_038968417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8647,066,082 - 47,075,370 (+)NCBI
mRatBN7.2641,339,858 - 41,346,774 (+)NCBI
RefSeq Acc Id: XM_063262073   ⟹   XP_063118143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8647,044,755 - 47,075,370 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001020911 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968417 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118143 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99082 (Get FASTA)   NCBI Sequence Viewer  
  EDM03186 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073334
GenBank Protein Q4KLN6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020911   ⟸   NM_001025740
- UniProtKB: Q4KLN6 (UniProtKB/Swiss-Prot),   A6HAY1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073334   ⟸   ENSRNOT00000091551
RefSeq Acc Id: XP_038968417   ⟸   XM_039112489
- Peptide Label: isoform X1
- UniProtKB: A0A8L2R734 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063118143   ⟸   XM_063262073
- Peptide Label: isoform X2
- UniProtKB: Q4KLN6 (UniProtKB/Swiss-Prot),   A6HAY1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4KLN6-F1-model_v2 AlphaFold Q4KLN6 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694523
Promoter ID:EPDNEW_R5046
Type:multiple initiation site
Name:Rrm2_1
Description:ribonucleotide reductase regulatory subunit M2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0643,884,618 - 43,884,678EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1598310 AgrOrtholog
BioCyc Gene G2FUF-38023 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
BioCyc Pathway Image PWY-7184 BioCyc
  PWY-7210 BioCyc
  PWY-7226 BioCyc
  PWY-7227 BioCyc
Ensembl Genes ENSRNOG00000054286 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000091551 ENTREZGENE
Gene3D-CATH 1.10.620.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7443729 IMAGE-MGC_LOAD
InterPro Ferritin-like_SF UniProtKB/Swiss-Prot
  RNR-like UniProtKB/Swiss-Prot
  RNR_small UniProtKB/Swiss-Prot
  RNR_small_AS UniProtKB/Swiss-Prot
  RNR_small_fam UniProtKB/Swiss-Prot
KEGG Report rno:362720 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116120 IMAGE-MGC_LOAD
NCBI Gene 362720 ENTREZGENE
PANTHER PTHR23409 UniProtKB/Swiss-Prot
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2 UniProtKB/Swiss-Prot
Pfam Ribonuc_red_sm UniProtKB/Swiss-Prot
PharmGKB RRM2 RGD
PhenoGen Rrm2 PhenoGen
PROSITE RIBORED_SMALL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000054286 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot
UniProt A0A8L2R734 ENTREZGENE, UniProtKB/TrEMBL
  A6HAY1 ENTREZGENE, UniProtKB/TrEMBL
  Q4KLN6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Rrm2  ribonucleotide reductase regulatory subunit M2  Rrm2  ribonucleotide reductase M2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   ribonucleotide reductase M2  Rrm2  ribonucleotide reductase M2 (mapped)  Name updated 737654 APPROVED
2007-04-12 Rrm2  ribonucleotide reductase M2 (mapped)  Rrm2_mapped  ribonucleotide reductase M2 (mapped)  Data merged from RGD:3605 737654 APPROVED
2006-11-20 Rrm2  ribonucleotide reductase M2 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Rrm2_mapped  ribonucleotide reductase M2 (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Rrm2  Ribonucleotide reductase 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process human homolog is required for formation of deoxyribonucleotides from ribonucleotides 704404