Symbol:
Eng
Name:
endoglin
RGD ID:
1593188
Description:
Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; extracellular matrix constituent secretion; and positive regulation of metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
MGC124909
RGD Orthologs
Alliance Orthologs
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
ENG (endoglin) RGD
RGD
Mus musculus (house mouse):
Eng (endoglin) RGD
RGD
Chinchilla lanigera (long-tailed chinchilla):
Eng (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
ENG (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
ENG (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Eng (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
ENG (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):
ENG (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Eng (endoglin) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
ENG (endoglin)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Mus musculus (house mouse):
Eng (endoglin)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|SonicParanoid)
Danio rerio (zebrafish):
eng (endoglin)
Alliance
DIOPT (Ensembl Compara|PANTHER)
Xenopus tropicalis (tropical clawed frog):
eng
Alliance
DIOPT (Hieranoid|OMA|OrthoFinder|OrthoInspector|SonicParanoid)
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 3 36,332,190 - 36,370,324 (+) NCBI GRCr8 mRatBN7.2 3 15,934,566 - 15,972,618 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 3 15,934,518 - 15,973,230 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 3 19,003,353 - 19,041,237 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 3 27,588,363 - 27,626,245 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 3 25,839,360 - 25,877,319 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 3 11,679,530 - 11,717,486 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 11,679,530 - 11,717,485 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 17,021,673 - 17,058,548 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Celera 3 10,675,660 - 10,713,537 (+) NCBI Celera Cytogenetic Map 3 p11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Only show annotations with direct experimental evidence (0 objects hidden)
Eng Rat (+)-catechin multiple interactions ISO ENG (Homo sapiens) 6480464 [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of ENG mRNA CTD PMID:24763279 Eng Rat (1->4)-beta-D-glucan multiple interactions ISO Eng (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ENG mRNA CTD PMID:36331819 Eng Rat (S)-nicotine decreases expression ISO Eng (Mus musculus) 6480464 Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 Eng Rat 1,1-dichloroethene decreases expression ISO Eng (Mus musculus) 6480464 vinylidene chloride results in decreased expression of ENG mRNA CTD PMID:26682919 Eng Rat 1,2-dimethylhydrazine increases expression ISO Eng (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of ENG mRNA CTD PMID:22206623 Eng Rat 17beta-estradiol affects expression ISO Eng (Mus musculus) 6480464 Estradiol affects the expression of ENG mRNA CTD PMID:15598610 Eng Rat 17beta-estradiol decreases expression ISO Eng (Mus musculus) 6480464 Estradiol results in decreased expression of ENG mRNA CTD PMID:39298647 Eng Rat 17beta-estradiol multiple interactions ISO ENG (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of ENG mRNA CTD PMID:30165855 Eng Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Eng (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of ENG mRNA CTD PMID:21570461 Eng Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of ENG mRNA CTD PMID:34747641 Eng Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of ENG mRNA CTD PMID:24475139 and PMID:32109520 Eng Rat 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO Eng (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of ENG mRNA CTD PMID:26290441 Eng Rat 2-bromohexadecanoic acid multiple interactions ISO ENG (Homo sapiens) 6480464 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of ENG protein] CTD PMID:38195004 Eng Rat 3-chloropropane-1,2-diol increases expression EXP 6480464 alpha-Chlorohydrin results in increased expression of ENG protein CTD PMID:34915118 Eng Rat 4,4'-sulfonyldiphenol increases expression ISO Eng (Mus musculus) 6480464 bisphenol S results in increased expression of ENG mRNA CTD PMID:30951980 Eng Rat 4,4'-sulfonyldiphenol decreases methylation ISO ENG (Homo sapiens) 6480464 bisphenol S results in decreased methylation of ENG gene CTD PMID:31601247 Eng Rat 4,4'-sulfonyldiphenol affects methylation ISO Eng (Mus musculus) 6480464 bisphenol S affects the methylation of ENG exon CTD PMID:33297965 Eng Rat 4,4'-sulfonyldiphenol decreases expression ISO Eng (Mus musculus) 6480464 bisphenol S results in decreased expression of ENG mRNA CTD PMID:39298647 Eng Rat 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2 and 6-dinitrotoluene affects the expression of ENG mRNA CTD PMID:21346803 Eng Rat 4-aminobenzhydrazide multiple interactions ISO ENG (Homo sapiens) 6480464 4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of ENG mRNA] CTD PMID:24530881 Eng Rat 4-hydroxyphenyl retinamide increases expression ISO Eng (Mus musculus) 6480464 Fenretinide results in increased expression of ENG mRNA CTD PMID:28973697 Eng Rat 5-aza-2'-deoxycytidine multiple interactions ISO ENG (Homo sapiens) 6480464 Decitabine inhibits the reaction [tobacco tar results in decreased expression of ENG mRNA] CTD PMID:19559774 Eng Rat 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of ENG mRNA CTD PMID:30047161 Eng Rat aflatoxin B1 increases methylation ISO ENG (Homo sapiens) 6480464 Aflatoxin B1 results in increased methylation of ENG intron CTD PMID:30157460 Eng Rat all-trans-retinoic acid increases expression ISO ENG (Homo sapiens) 6480464 Tretinoin results in increased expression of ENG mRNA CTD PMID:33167477 Eng Rat alpha-Zearalanol multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of ENG mRNA CTD PMID:35163327 Eng Rat amitrole increases expression EXP 6480464 Amitrole results in increased expression of ENG mRNA CTD PMID:30047161 Eng Rat amphetamine increases expression EXP 6480464 Amphetamine results in increased expression of ENG mRNA CTD PMID:30779732 Eng Rat antirheumatic drug decreases expression ISO ENG (Homo sapiens) 6480464 Antirheumatic Agents results in decreased expression of ENG mRNA CTD PMID:24449571 Eng Rat arsenous acid decreases expression ISO ENG (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of ENG mRNA CTD PMID:20458559 Eng Rat benzene-1,2,4-triol decreases expression ISO ENG (Homo sapiens) 6480464 hydroxyhydroquinone results in decreased expression of ENG mRNA CTD PMID:24530881 Eng Rat benzene-1,2,4-triol multiple interactions ISO ENG (Homo sapiens) 6480464 4-aminobenzhydrazide inhibits the reaction [hydroxyhydroquinone results in decreased expression of ENG mRNA] CTD PMID:24530881 Eng Rat benzo[a]pyrene increases expression ISO Eng (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of ENG mRNA CTD PMID:22610609 Eng Rat benzo[a]pyrene increases methylation ISO ENG (Homo sapiens) 6480464 Benzo(a)pyrene results in increased methylation of ENG exon CTD PMID:27901495 Eng Rat benzo[a]pyrene affects methylation ISO ENG (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of ENG intron CTD PMID:30157460 Eng Rat benzo[e]pyrene increases methylation ISO ENG (Homo sapiens) 6480464 benzo(e)pyrene results in increased methylation of ENG intron CTD PMID:30157460 Eng Rat bis(2-ethylhexyl) phthalate increases expression ISO ENG (Homo sapiens) 6480464 Diethylhexyl Phthalate results in increased expression of ENG mRNA CTD PMID:31163220 Eng Rat bis(2-ethylhexyl) phthalate decreases methylation ISO Eng (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased methylation of ENG gene CTD PMID:34319233 Eng Rat bis(2-ethylhexyl) phthalate decreases expression ISO Eng (Mus musculus) 6480464 Diethylhexyl Phthalate results in decreased expression of ENG mRNA CTD PMID:34319233 Eng Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of ENG mRNA CTD PMID:25181051 more ... Eng Rat bisphenol A increases expression ISO Eng (Mus musculus) 6480464 bisphenol A results in increased expression of ENG mRNA CTD PMID:32156529 Eng Rat bisphenol A increases expression ISO ENG (Homo sapiens) 6480464 bisphenol A results in increased expression of ENG mRNA CTD PMID:26546977 Eng Rat bisphenol F increases expression ISO Eng (Mus musculus) 6480464 bisphenol F results in increased expression of ENG mRNA CTD PMID:30951980 Eng Rat bisphenol F decreases expression ISO Eng (Mus musculus) 6480464 bisphenol F results in decreased expression of ENG mRNA CTD PMID:38685157 Eng Rat bleomycin A2 multiple interactions ISO Eng (Mus musculus) 6480464 Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of ENG protein] CTD PMID:30825431 Eng Rat bleomycin A2 increases expression ISO Eng (Mus musculus) 6480464 Bleomycin results in increased expression of ENG protein CTD PMID:30825431 Eng Rat C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of ENG mRNA CTD PMID:19167457 Eng Rat cadmium atom multiple interactions ISO ENG (Homo sapiens) 6480464 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of ENG protein] more ... CTD PMID:35301059 and PMID:38195004 Eng Rat cadmium dichloride multiple interactions ISO ENG (Homo sapiens) 6480464 2-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of ENG protein] more ... CTD PMID:35301059 and PMID:38195004 Eng Rat candesartan multiple interactions EXP 6480464 candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA] and candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 Eng Rat cannabidiol multiple interactions ISO Eng (Mus musculus) 6480464 Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of ENG protein] CTD PMID:30825431 Eng Rat carbon nanotube decreases expression ISO Eng (Mus musculus) 6480464 Nanotubes and Carbon analog results in decreased expression of ENG mRNA CTD PMID:25554681 and PMID:25620056 Eng Rat chlorpyrifos increases expression ISO Eng (Mus musculus) 6480464 Chlorpyrifos results in increased expression of ENG mRNA CTD PMID:37019170 Eng Rat chromium(3+) trichloride increases expression ISO Eng (Mus musculus) 6480464 chromic chloride results in increased expression of ENG mRNA CTD PMID:12128095 Eng Rat clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ENG mRNA CTD PMID:17602206 Eng Rat clotrimazole increases expression EXP 6480464 Clotrimazole results in increased expression of ENG mRNA CTD PMID:30047161 Eng Rat cobalt dichloride decreases expression ISO ENG (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of ENG mRNA CTD PMID:19320972 Eng Rat copper(II) sulfate increases expression ISO ENG (Homo sapiens) 6480464 Copper Sulfate results in increased expression of ENG mRNA CTD PMID:19549813 Eng Rat daunorubicin decreases expression EXP 6480464 Daunorubicin results in decreased expression of ENG mRNA CTD PMID:27090888 Eng Rat deoxynivalenol decreases expression ISO ENG (Homo sapiens) 6480464 deoxynivalenol results in decreased expression of ENG mRNA CTD PMID:31863870 Eng Rat dexamethasone decreases expression ISO ENG (Homo sapiens) 6480464 Dexamethasone results in decreased expression of ENG mRNA CTD PMID:25047013 Eng Rat dextran sulfate decreases expression ISO Eng (Mus musculus) 6480464 Dextran Sulfate results in decreased expression of ENG mRNA CTD PMID:35093514 Eng Rat diarsenic trioxide decreases expression ISO ENG (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of ENG mRNA CTD PMID:20458559 Eng Rat dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of ENG mRNA CTD PMID:21266533 Eng Rat dibutyl phthalate increases expression ISO Eng (Mus musculus) 6480464 Dibutyl Phthalate results in increased expression of ENG mRNA CTD PMID:21266533 Eng Rat dibutyl phthalate decreases expression ISO Eng (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of ENG mRNA CTD PMID:21266533 Eng Rat dicrotophos increases expression ISO ENG (Homo sapiens) 6480464 dicrotophos results in increased expression of ENG mRNA CTD PMID:28302478 Eng Rat dioxygen multiple interactions ISO ENG (Homo sapiens) 6480464 [Oxygen deficiency co-treated with Oxygen] results in increased expression of ENG protein more ... CTD PMID:34995009 Eng Rat dopamine decreases expression EXP 6480464 Dopamine results in decreased expression of ENG mRNA CTD PMID:21983523 Eng Rat doxorubicin increases expression ISO Eng (Mus musculus) 6480464 Doxorubicin results in increased expression of ENG mRNA CTD PMID:15033991 Eng Rat doxorubicin multiple interactions ISO Eng (Mus musculus) 6480464 Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA] CTD PMID:35963316 Eng Rat doxorubicin increases expression ISO ENG (Homo sapiens) 6480464 Doxorubicin results in increased expression of ENG mRNA CTD PMID:29803840 Eng Rat elemental selenium increases expression ISO ENG (Homo sapiens) 6480464 Selenium results in increased expression of ENG mRNA CTD PMID:19244175 Eng Rat enalapril multiple interactions ISO Eng (Mus musculus) 6480464 [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 Eng Rat endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of ENG mRNA CTD PMID:29391264 Eng Rat epoxiconazole decreases expression ISO Eng (Mus musculus) 6480464 epoxiconazole results in decreased expression of ENG mRNA CTD PMID:35436446 Eng Rat ethanol increases expression ISO Eng (Mus musculus) 6480464 Ethanol results in increased expression of ENG mRNA CTD PMID:30319688 Eng Rat fenoldopam increases expression EXP 6480464 Fenoldopam results in increased expression of ENG mRNA CTD PMID:21983523 Eng Rat fenthion increases expression ISO Eng (Mus musculus) 6480464 Fenthion results in increased expression of ENG mRNA CTD PMID:34813904 Eng Rat folic acid decreases expression ISO Eng (Mus musculus) 6480464 Folic Acid results in decreased expression of ENG mRNA CTD PMID:25629700 Eng Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of ENG mRNA CTD PMID:33387578 Eng Rat glafenine increases expression EXP 6480464 Glafenine results in increased expression of ENG mRNA CTD PMID:24136188 Eng Rat harmaline decreases expression ISO Eng (Mus musculus) 6480464 Harmaline results in decreased expression of ENG mRNA CTD PMID:35963316 Eng Rat harmaline multiple interactions ISO Eng (Mus musculus) 6480464 Doxorubicin promotes the reaction [Harmaline results in decreased expression of ENG mRNA] CTD PMID:35963316 Eng Rat iohexol decreases expression ISO ENG (Homo sapiens) 6480464 Iohexol results in decreased expression of ENG protein CTD PMID:29705293 Eng Rat iopamidol decreases expression ISO ENG (Homo sapiens) 6480464 Iopamidol results in decreased expression of ENG protein CTD PMID:29705293 Eng Rat lipopolysaccharide multiple interactions ISO ENG (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of ENG mRNA CTD PMID:35811015 Eng Rat lipopolysaccharide decreases expression ISO ENG (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of ENG mRNA CTD PMID:35811015 Eng Rat losartan multiple interactions EXP 6480464 Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA] and Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 Eng Rat losartan increases expression ISO ENG (Homo sapiens) 6480464 Losartan results in increased expression of ENG mRNA and Losartan results in increased expression of ENG protein CTD PMID:32947957 Eng Rat manganese(II) chloride increases expression ISO Eng (Mus musculus) 6480464 manganese chloride results in increased expression of ENG mRNA CTD PMID:17467022 Eng Rat methapyrilene increases methylation ISO ENG (Homo sapiens) 6480464 Methapyrilene results in increased methylation of ENG intron CTD PMID:30157460 Eng Rat methidathion increases expression ISO Eng (Mus musculus) 6480464 methidathion results in increased expression of ENG mRNA CTD PMID:34813904 Eng Rat methimazole increases expression EXP 6480464 Methimazole results in increased expression of ENG mRNA CTD PMID:30047161 Eng Rat mifepristone multiple interactions ISO Eng (Mus musculus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of ENG mRNA] CTD PMID:20431248 Eng Rat N(gamma)-nitro-L-arginine methyl ester increases expression ISO Eng (Mus musculus) 6480464 NG-Nitroarginine Methyl Ester results in increased expression of ENG protein CTD PMID:34995009 Eng Rat N(gamma)-nitro-L-arginine methyl ester multiple interactions ISO Eng (Mus musculus) 6480464 ALKBH5 protein promotes the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ENG protein] CTD PMID:34995009 Eng Rat N-acetyl-L-cysteine increases expression ISO ENG (Homo sapiens) 6480464 Acetylcysteine results in increased expression of ENG mRNA and Acetylcysteine results in increased expression of ENG protein CTD PMID:32947957 Eng Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of ENG mRNA CTD PMID:17602206 Eng Rat niclosamide increases expression ISO ENG (Homo sapiens) 6480464 Niclosamide results in increased expression of ENG mRNA CTD PMID:36318118 Eng Rat nicotine decreases expression ISO Eng (Mus musculus) 6480464 Nicotine results in decreased expression of ENG mRNA CTD PMID:17456735 Eng Rat nitrofen decreases expression EXP 6480464 nitrofen results in decreased expression of ENG mRNA and nitrofen results in decreased expression of ENG protein CTD PMID:27822781 Eng Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of ENG mRNA CTD PMID:25729387 Eng Rat ozone decreases expression ISO ENG (Homo sapiens) 6480464 Ozone results in decreased expression of ENG mRNA CTD PMID:23033980 Eng Rat ozone multiple interactions ISO Eng (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of ENG mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ENG mRNA CTD PMID:34911549 Eng Rat paracetamol affects expression ISO Eng (Mus musculus) 6480464 Acetaminophen affects the expression of ENG mRNA CTD PMID:17562736 Eng Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of ENG mRNA CTD PMID:33387578 Eng Rat paricalcitol multiple interactions ISO Eng (Mus musculus) 6480464 [Enalapril co-treated with paricalcitol] results in decreased expression of ENG mRNA CTD PMID:25037058 Eng Rat perfluorooctane-1-sulfonic acid multiple interactions ISO Eng (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ENG mRNA CTD PMID:36331819 Eng Rat perfluorooctanoic acid increases expression EXP 6480464 perfluorooctanoic acid results in increased expression of ENG mRNA CTD PMID:35163327 Eng Rat perfluorooctanoic acid decreases expression ISO ENG (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of ENG protein CTD PMID:26879310 Eng Rat perfluorooctanoic acid multiple interactions EXP 6480464 [Zeranol co-treated with perfluorooctanoic acid] results in increased expression of ENG mRNA CTD PMID:35163327 Eng Rat phenobarbital multiple interactions ISO Eng (Mus musculus) 6480464 NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of ENG mRNA] CTD PMID:19482888 Eng Rat phenobarbital decreases expression ISO Eng (Mus musculus) 6480464 Phenobarbital results in decreased expression of ENG mRNA CTD PMID:19482888 Eng Rat progesterone multiple interactions ISO Eng (Mus musculus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of ENG mRNA] CTD PMID:20431248 Eng Rat progesterone increases expression ISO Eng (Mus musculus) 6480464 Progesterone results in increased expression of ENG mRNA CTD PMID:20431248 Eng Rat propiconazole increases expression EXP 6480464 propiconazole results in increased expression of ENG mRNA CTD PMID:30047161 Eng Rat raloxifene increases expression ISO ENG (Homo sapiens) 6480464 Raloxifene Hydrochloride results in increased expression of ENG mRNA and Raloxifene Hydrochloride results in increased expression of ENG protein CTD PMID:20135064 and PMID:32947957 Eng Rat retinyl acetate increases expression ISO Eng (Mus musculus) 6480464 retinol acetate results in increased expression of ENG mRNA CTD PMID:16772331 Eng Rat rotenone increases expression EXP 6480464 Rotenone results in increased expression of ENG mRNA CTD PMID:28374803 Eng Rat S-(1,2-dichlorovinyl)-L-cysteine multiple interactions ISO ENG (Homo sapiens) 6480464 [S-(1 and 2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of ENG mRNA CTD PMID:35811015 Eng Rat Salinomycin decreases expression ISO ENG (Homo sapiens) 6480464 salinomycin results in decreased expression of ENG protein CTD PMID:30273566 Eng Rat selenium atom increases expression ISO ENG (Homo sapiens) 6480464 Selenium results in increased expression of ENG mRNA CTD PMID:19244175 Eng Rat senecionine decreases expression ISO Eng (Mus musculus) 6480464 senecionine results in decreased expression of ENG protein CTD PMID:35357534 Eng Rat serpentine asbestos decreases expression ISO Eng (Mus musculus) 6480464 Asbestos and Serpentine results in decreased expression of ENG mRNA CTD PMID:16251409 Eng Rat sodium arsenite decreases expression ISO ENG (Homo sapiens) 6480464 sodium arsenite results in decreased expression of ENG mRNA CTD PMID:38568856 Eng Rat sodium dichromate decreases expression ISO ENG (Homo sapiens) 6480464 sodium bichromate results in decreased expression of ENG mRNA CTD PMID:17685462 Eng Rat sulfadimethoxine increases expression EXP 6480464 Sulfadimethoxine results in increased expression of ENG mRNA CTD PMID:30047161 Eng Rat temozolomide decreases expression ISO ENG (Homo sapiens) 6480464 Temozolomide results in decreased expression of ENG mRNA CTD PMID:31758290 Eng Rat tert-butyl hydroperoxide increases expression ISO ENG (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of ENG mRNA CTD PMID:15336504 Eng Rat Tesaglitazar increases expression EXP 6480464 tesaglitazar results in increased expression of ENG mRNA CTD PMID:21515302 Eng Rat testosterone enanthate affects expression ISO ENG (Homo sapiens) 6480464 testosterone enanthate affects the expression of ENG mRNA CTD PMID:17440010 Eng Rat tetrachloromethane decreases expression ISO Eng (Mus musculus) 6480464 Carbon Tetrachloride results in decreased expression of ENG mRNA CTD PMID:17484886 Eng Rat thiram decreases expression ISO ENG (Homo sapiens) 6480464 Thiram results in decreased expression of ENG mRNA CTD PMID:38568856 Eng Rat titanium dioxide decreases expression ISO Eng (Mus musculus) 6480464 titanium dioxide results in decreased expression of ENG mRNA CTD PMID:23557971 Eng Rat toluene increases expression EXP 6480464 Toluene results in increased expression of ENG mRNA CTD PMID:22967744 Eng Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of ENG mRNA CTD PMID:25729387 Eng Rat triclosan decreases expression ISO ENG (Homo sapiens) 6480464 Triclosan results in decreased expression of ENG mRNA CTD PMID:30510588 Eng Rat tris(2-butoxyethyl) phosphate affects expression ISO ENG (Homo sapiens) 6480464 tris(2-butoxyethyl) phosphate affects the expression of ENG mRNA CTD PMID:29024780 Eng Rat troglitazone increases expression EXP 6480464 troglitazone results in increased expression of ENG mRNA CTD PMID:21515302 Eng Rat tungsten decreases expression ISO Eng (Mus musculus) 6480464 Tungsten results in decreased expression of ENG mRNA CTD PMID:30912803 Eng Rat urethane decreases expression ISO ENG (Homo sapiens) 6480464 Urethane results in decreased expression of ENG mRNA CTD PMID:28818685 Eng Rat valproic acid affects expression ISO Eng (Mus musculus) 6480464 Valproic Acid affects the expression of ENG mRNA CTD PMID:17292431 Eng Rat valproic acid increases methylation ISO ENG (Homo sapiens) 6480464 Valproic Acid results in increased methylation of ENG gene CTD PMID:29154799 Eng Rat valsartan multiple interactions EXP 6480464 Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA] and Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 Eng Rat vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of ENG mRNA CTD PMID:19015723 Eng Rat Y-27632 decreases expression ISO ENG (Homo sapiens) 6480464 Y 27632 results in decreased expression of ENG mRNA CTD PMID:35388712
Imported Annotations - PID (archival)
acute lymphoblastic leukemia (ISO) arteriovenous malformation (ISO) arteriovenous malformations of the brain (ISO,ISS) breast cancer (ISO) Breast Neoplasms (ISO) Chemical and Drug Induced Liver Injury (IEP) cholestasis (IEP) clear cell renal cell carcinoma (ISO) congenital disorder of glycosylation Iu (ISO) congestive heart failure (IDA,IEP) coronary artery disease (ISO) cystic fibrosis (ISO) developmental and epileptic encephalopathy (ISO) developmental and epileptic encephalopathy 31A (ISO) Diabetic Nephropathies (ISO) diabetic retinopathy (ISO) dystonia (ISO) early infantile epileptic encephalopathy (ISO) Epistaxis (ISO) Experimental Radiation Injuries (IEP,ISO) Galloway-Mowat syndrome 1 (ISO) GNE myopathy (ISO) hepatocellular carcinoma (IEP) hereditary hemorrhagic telangiectasia (ISO,ISS) Hereditary Hemorrhagic Telangiectasia, Type 1 (ISO) Hereditary Hemorrhagic Telangiectasia, Type 2 (ISO) Hypercholesterolemia (ISO) hypertension (IEP) intracranial aneurysm (ISO) juvenile polyposis syndrome (ISO) Kidney Reperfusion Injury (IEP,ISO) Leber congenital amaurosis (ISO) lymphoid leukemia (ISO) melanoma (ISO) middle cerebral artery infarction (ISO) Moyamoya Disease 2 (ISO) multiple myeloma (ISO) pre-eclampsia (IDA,IEP,ISO) Pregnancy in Diabetics (ISO) primary coenzyme Q10 deficiency 7 (ISO) primary pulmonary hypertension 1 (ISO) prostate cancer (ISO) Pulmonary Arterial Hypertension (ISO) Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-Related (ISO) pulmonary hypertension (ISO) renal fibrosis (IDA,IEP,ISO) Right Ventricular Hypertrophy (ISO) secondary hyperparathyroidism (ISO) Stress Fractures (IEP) systemic lupus erythematosus (ISO) Wounds and Injuries (ISO)
(+)-catechin (ISO) (1->4)-beta-D-glucan (ISO) (S)-nicotine (ISO) 1,1-dichloroethene (ISO) 1,2-dimethylhydrazine (ISO) 17beta-estradiol (ISO) 2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO) 2-bromohexadecanoic acid (ISO) 3-chloropropane-1,2-diol (EXP) 4,4'-sulfonyldiphenol (ISO) 4-amino-2,6-dinitrotoluene (EXP) 4-aminobenzhydrazide (ISO) 4-hydroxyphenyl retinamide (ISO) 5-aza-2'-deoxycytidine (ISO) 6-propyl-2-thiouracil (EXP) aflatoxin B1 (ISO) all-trans-retinoic acid (ISO) alpha-Zearalanol (EXP) amitrole (EXP) amphetamine (EXP) antirheumatic drug (ISO) arsenous acid (ISO) benzene-1,2,4-triol (ISO) benzo[a]pyrene (ISO) benzo[e]pyrene (ISO) bis(2-ethylhexyl) phthalate (ISO) bisphenol A (EXP,ISO) bisphenol F (ISO) bleomycin A2 (ISO) C60 fullerene (EXP) cadmium atom (ISO) cadmium dichloride (ISO) candesartan (EXP) cannabidiol (ISO) carbon nanotube (ISO) chlorpyrifos (ISO) chromium(3+) trichloride (ISO) clofibric acid (EXP) clotrimazole (EXP) cobalt dichloride (ISO) copper(II) sulfate (ISO) daunorubicin (EXP) deoxynivalenol (ISO) dexamethasone (ISO) dextran sulfate (ISO) diarsenic trioxide (ISO) dibutyl phthalate (EXP,ISO) dicrotophos (ISO) dioxygen (ISO) dopamine (EXP) doxorubicin (ISO) elemental selenium (ISO) enalapril (ISO) endosulfan (EXP) epoxiconazole (ISO) ethanol (ISO) fenoldopam (EXP) fenthion (ISO) folic acid (ISO) gentamycin (EXP) glafenine (EXP) harmaline (ISO) iohexol (ISO) iopamidol (ISO) lipopolysaccharide (ISO) losartan (EXP,ISO) manganese(II) chloride (ISO) methapyrilene (ISO) methidathion (ISO) methimazole (EXP) mifepristone (ISO) N(gamma)-nitro-L-arginine methyl ester (ISO) N-acetyl-L-cysteine (ISO) N-nitrosodiethylamine (EXP) niclosamide (ISO) nicotine (ISO) nitrofen (EXP) oxaliplatin (EXP) ozone (ISO) paracetamol (EXP,ISO) paricalcitol (ISO) perfluorooctane-1-sulfonic acid (ISO) perfluorooctanoic acid (EXP,ISO) phenobarbital (ISO) progesterone (ISO) propiconazole (EXP) raloxifene (ISO) retinyl acetate (ISO) rotenone (EXP) S-(1,2-dichlorovinyl)-L-cysteine (ISO) Salinomycin (ISO) selenium atom (ISO) senecionine (ISO) serpentine asbestos (ISO) sodium arsenite (ISO) sodium dichromate (ISO) sulfadimethoxine (EXP) temozolomide (ISO) tert-butyl hydroperoxide (ISO) Tesaglitazar (EXP) testosterone enanthate (ISO) tetrachloromethane (ISO) thiram (ISO) titanium dioxide (ISO) toluene (EXP) topotecan (EXP) triclosan (ISO) tris(2-butoxyethyl) phosphate (ISO) troglitazone (EXP) tungsten (ISO) urethane (ISO) valproic acid (ISO) valsartan (EXP) vinclozolin (EXP) Y-27632 (ISO)
1.
Cellular basis of diabetic nephropathy: V. Endoglin expression levels and diabetic nephropathy risk in patients with Type 1 diabetes.
Alvarez-Munoz P, etal., J Diabetes Complications. 2009 Apr 21.
2.
Clinical heterogeneity in hereditary haemorrhagic telangiectasia: are pulmonary arteriovenous malformations more common in families linked to endoglin?
Berg JN, etal., J Med Genet. 1996 Mar;33(3):256-7.
3.
Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype.
Bossler AD, etal., Hum Mutat. 2006 Jul;27(7):667-75.
4.
A murine model of hereditary hemorrhagic telangiectasia.
Bourdeau A, etal., J Clin Invest. 1999 Nov;104(10):1343-51.
5.
Gene expression profiles that segregate patients with childhood acute lymphoblastic leukaemia: an independent validation study identifies that endoglin associates with patient outcome.
Catchpoole D, etal., Leuk Res. 2007 Dec;31(12):1741-7. Epub 2007 Jun 18.
6.
Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II.
Chen K, etal., Circ Res. 2004 Dec 10;95(12):1167-73. Epub 2004 Nov 11.
7.
Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia.
Choi EJ, etal., PLoS One. 2014 Feb 10;9(2):e88511. doi: 10.1371/journal.pone.0088511. eCollection 2014.
8.
Endoglin regulates renal ischaemia-reperfusion injury.
Docherty NG, etal., Nephrol Dial Transplant. 2006 Aug;21(8):2106-19. Epub 2006 Jun 4.
9.
Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment.
Doridot L, etal., Hypertension. 2013 Mar;61(3):662-8. doi: 10.1161/HYPERTENSIONAHA.111.202994. Epub 2013 Jan 28.
10.
Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis.
Dubinski W, etal., Hum Pathol. 2012 Jul;43(7):1037-43. doi: 10.1016/j.humpath.2011.08.012. Epub 2011 Dec 26.
11.
Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer.
Fowler CJ, etal., Biochim Biophys Acta. 2012 Dec 20. pii: S1388-1981(12)00259-4. doi: 10.1016/j.bbalip.2012.12.005.
12.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13.
Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression.
Gilbert JS, etal., Hypertension. 2009 Feb;53(2):399-403. Epub 2008 Dec 15.
14.
Long-term high salt diet causes hypertension and alters renal cytokine gene expression profiles in Sprague-Dawley rats.
Gu JW, etal., Beijing Da Xue Xue Bao. 2009 Oct 18;41(5):505-15.
15.
Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases.
Ikemoto T, etal., Heart Vessels. 2012 Jul;27(4):344-51. doi: 10.1007/s00380-011-0163-z. Epub 2011 Jun 11.
16.
Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling.
Irani RA, etal., Hypertension. 2010 May;55(5):1246-53. doi: 10.1161/HYPERTENSIONAHA.110.150540. Epub 2010 Mar 29.
17.
Magnesium sulfate therapy of preeclampsia: an old tool with new mechanism of action and prospect in management and prophylaxis.
Korish AA Hypertens Res. 2012 Oct;35(10):1005-11. doi: 10.1038/hr.2012.103. Epub 2012 Jul 5.
18.
Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia.
Leanos-Miranda A, etal., Hypertension. 2013 May;61(5):1118-25. doi: 10.1161/HYPERTENSIONAHA.111.00754. Epub 2013 Mar 4.
19.
Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France.
Lesca G, etal., Hum Mutat 2004 Apr;23(4):289-99.
20.
Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1.
Letarte M, etal., Cardiovasc Res. 2005 Oct 1;68(1):155-64.
21.
Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy.
Malik RA, etal., J Cell Mol Med. 2005 Jul-Sep;9(3):692-7.
22.
Evaluation of parathyroid gland angiogenesis in chronic kidney disease associated with secondary hyperparathyroidism.
Martins P, etal., Nephrol Dial Transplant. 2008 Sep;23(9):2889-94. doi: 10.1093/ndt/gfn150. Epub 2008 Apr 8.
23.
Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1.
McAllister KA, etal., Nat Genet. 1994 Dec;8(4):345-51.
24.
Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling.
Meurer SK, etal., Cell Signal. 2011 Apr;23(4):683-99. doi: 10.1016/j.cellsig.2010.12.002. Epub 2010 Dec 10.
25.
Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling.
Meurer SK, etal., J Biol Chem. 2005 Jan 28;280(4):3078-87. Epub 2004 Nov 10.
26.
In vitro and in vivo effects of an anti-mouse endoglin (CD105)-immunotoxin on the early stages of mouse B16MEL4A5 melanoma tumours.
Munoz R, etal., Cancer Immunol Immunother. 2013 Mar;62(3):541-51. doi: 10.1007/s00262-012-1357-7. Epub 2012 Oct 18.
27.
Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment.
Nachtigal P, etal., Can J Physiol Pharmacol. 2007 Aug;85(8):767-73.
28.
OMIM Disease Annotation Pipeline
OMIM Disease Annotation Pipeline
29.
The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage.
Ozbey O, etal., Acta Histochem. 2009 May 28.
30.
Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus.
Ozbey O, etal., Histol Histopathol. 2010 Nov;25(11):1437-45.
31.
Emerging roles of endoglin/CD105 and angiogenic cytokines for disease development and progression in multiple myeloma patients.
Pappa CA, etal., Hematol Oncol. 2013 Dec;31(4):201-5. doi: 10.1002/hon.2044. Epub 2013 Apr 11.
32.
Endoglin haploinsufficiency promotes fibroblast accumulation during wound healing through Akt activation.
Pericacho M, etal., PLoS One. 2013;8(1):e54687. doi: 10.1371/journal.pone.0054687. Epub 2013 Jan 17.
33.
PID Annotation Import Pipeline
Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34.
Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats.
Prieto M, etal., J Physiol Biochem. 2005 Sep;61(3):457-67.
35.
Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal fibrosis induced by renal mass reduction.
Prieto M, etal., Kidney Blood Press Res. 2005;28(1):32-40. Epub 2004 Oct 8.
36.
Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury.
Qiu J, etal., Asia Pac J Clin Oncol. 2011 Dec;7(4):392-8. doi: 10.1111/j.1743-7563.2011.01461.x.
37.
The effect of Kraussianone-2 (Kr2), a natural pyrano-isoflavone from Eriosema kraussianum, in an L-NAME- induced pre-eclamptic rat model.
Ramesar SV, etal., Phytother Res. 2012 Sep;26(9):1375-80. doi: 10.1002/ptr.3697. Epub 2012 Feb 6.
38.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
40.
Comprehensive gene review and curation
RGD comprehensive gene curation
41.
Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy.
Sadlier DM, etal., J Biol Chem. 2004 Jul 9;279(28):29670-80. Epub 2004 Mar 18.
42.
Endoglin (CD105) expression in human renal cell carcinoma.
Sandlund J, etal., BJU Int. 2006 Apr;97(4):706-10.
43.
Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.
Santiago-Sim T, etal., Stroke. 2009 May;40(5):1604-11. doi: 10.1161/STROKEAHA.108.540245. Epub 2009 Mar 19.
44.
Mutation analysis in Spanish patients with hereditary hemorrhagic telangiectasia: deficient endoglin up-regulation in activated monocytes.
Sanz-Rodriguez F, etal., Clin Chem. 2004 Nov;50(11):2003-11. Epub 2004 Sep 16.
45.
The TGF-beta co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney.
Scharpfenecker M, etal., Radiother Oncol. 2012 Dec;105(3):313-20. doi: 10.1016/j.radonc.2012.08.021. Epub 2012 Sep 27.
46.
Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling.
Scherner O, etal., J Biol Chem. 2007 May 11;282(19):13934-43. Epub 2007 Mar 21.
47.
Endoglin deficiency impairs stroke recovery.
Shen F, etal., Stroke. 2014 Jul;45(7):2101-6. doi: 10.1161/STROKEAHA.114.005115. Epub 2014 May 29.
48.
Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia.
Shovlin CL, etal., Am J Hum Genet. 1997 Jul;61(1):68-79.
49.
Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts.
Shyu KG, etal., Eur J Heart Fail. 2010 Mar;12(3):219-26. doi: 10.1093/eurjhf/hfq011.
50.
Mechanical stretch via transforming growth factor-beta1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts.
Shyu KG, etal., Eur J Heart Fail. 2013 Jan;15(1):36-45. doi: 10.1093/eurjhf/hfs143. Epub 2012 Aug 31.
51.
Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide.
Takahashi N, etal., Cancer Res. 2001 Nov 1;61(21):7846-54.
52.
Angiogenesis is required for stress fracture healing in rats.
Tomlinson RE, etal., Bone. 2013 Jan;52(1):212-9. doi: 10.1016/j.bone.2012.09.035. Epub 2012 Oct 5.
53.
Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia.
Toporsian M, etal., Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):509-17. doi: 10.1161/ATVBAHA.109.200121. Epub 2009 Dec 30.
54.
Prognostic relevance of angiopoietin-2, fibroblast growth factor-2 and endoglin mRNA expressions in chronic lymphocytic leukemia.
Vrbacky F, etal., Neoplasma. 2014;61(5):585-92. doi: 10.4149/neo_2014_071.
55.
A hereditary haemorrhagic telangiectasia family with pulmonary involvement is unlinked to the known HHT genes, endoglin and ALK-1.
Wallace GM and Shovlin CL, Thorax. 2000 Aug;55(8):685-90.
56.
Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma.
Wang JY, etal., Chin Med J (Engl). 2010 Mar 20;123(6):730-3.
57.
Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105.
Wood LM, etal., Cancer Immunol Immunother. 2011 Jul;60(7):931-42. doi: 10.1007/s00262-011-1002-x. Epub 2011 Mar 23.
58.
Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women.
Yu Y, etal., Diabetologia. 2009 Jan;52(1):160-8. Epub 2008 Nov 5.
Eng Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 3 36,332,190 - 36,370,324 (+) NCBI GRCr8 mRatBN7.2 3 15,934,566 - 15,972,618 (+) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 3 15,934,518 - 15,973,230 (+) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 3 19,003,353 - 19,041,237 (+) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 3 27,588,363 - 27,626,245 (+) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 3 25,839,360 - 25,877,319 (+) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 3 11,679,530 - 11,717,486 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 3 11,679,530 - 11,717,485 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 3 17,021,673 - 17,058,548 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 Celera 3 10,675,660 - 10,713,537 (+) NCBI Celera Cytogenetic Map 3 p11 NCBI
ENG Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 9 127,815,016 - 127,854,658 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh38.p14 Ensembl 9 127,811,130 - 127,854,773 (-) Ensembl GRCh38 hg38 GRCh38 GRCh37 9 130,577,295 - 130,616,937 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 9 129,617,115 - 129,656,805 (-) NCBI NCBI36 Build 36 hg18 NCBI36 Build 34 9 127,656,849 - 127,696,538 NCBI Celera 9 101,228,133 - 101,267,888 (-) NCBI Celera Cytogenetic Map 9 q34.11 NCBI HuRef 9 100,194,111 - 100,234,515 (-) NCBI HuRef CHM1_1 9 130,728,823 - 130,768,983 (-) NCBI CHM1_1 T2T-CHM13v2.0 9 140,022,435 - 140,062,072 (-) NCBI T2T-CHM13v2.0
Eng Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm39 2 32,536,607 - 32,572,681 (+) NCBI GRCm39 GRCm39 mm39 GRCm39 Ensembl 2 32,536,607 - 32,572,681 (+) Ensembl GRCm39 Ensembl GRCm38 2 32,646,595 - 32,682,669 (+) NCBI GRCm38 GRCm38 mm10 GRCm38 GRCm38.p6 Ensembl 2 32,646,595 - 32,682,669 (+) Ensembl GRCm38 mm10 GRCm38 MGSCv37 2 32,502,115 - 32,538,189 (+) NCBI GRCm37 MGSCv37 mm9 NCBIm37 MGSCv36 2 32,468,604 - 32,504,127 (+) NCBI MGSCv36 mm8 Celera 2 32,353,177 - 32,389,276 (+) NCBI Celera Cytogenetic Map 2 B NCBI cM Map 2 22.09 NCBI
Eng Chinchilla Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChiLan1.0 Ensembl NW_004955419 818,932 - 852,694 (+) Ensembl ChiLan1.0 ChiLan1.0 NW_004955419 818,797 - 853,319 (+) NCBI ChiLan1.0 ChiLan1.0
ENG Bonobo Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl NHGRI_mPanPan1-v2 11 11,500,636 - 11,540,554 (+) NCBI NHGRI_mPanPan1-v2 NHGRI_mPanPan1 9 11,502,983 - 11,542,901 (+) NCBI NHGRI_mPanPan1 Mhudiblu_PPA_v0 9 98,934,080 - 98,973,862 (-) NCBI Mhudiblu_PPA_v0 Mhudiblu_PPA_v0 panPan3 PanPan1.1 9 127,605,608 - 127,644,641 (-) NCBI panpan1.1 PanPan1.1 panPan2 PanPan1.1 Ensembl 9 127,605,608 - 127,644,641 (-) Ensembl panpan1.1 panPan2
ENG Dog Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl CanFam3.1 9 55,558,246 - 55,590,081 (+) NCBI CanFam3.1 CanFam3.1 canFam3 CanFam3.1 CanFam3.1 Ensembl 9 55,558,305 - 55,589,064 (+) Ensembl CanFam3.1 canFam3 CanFam3.1 Dog10K_Boxer_Tasha 9 54,752,221 - 54,783,620 (+) NCBI Dog10K_Boxer_Tasha ROS_Cfam_1.0 9 56,480,195 - 56,511,601 (+) NCBI ROS_Cfam_1.0 ROS_Cfam_1.0 Ensembl 9 56,480,054 - 56,511,589 (+) Ensembl ROS_Cfam_1.0 Ensembl UMICH_Zoey_3.1 9 55,240,157 - 55,271,556 (+) NCBI UMICH_Zoey_3.1 UNSW_CanFamBas_1.0 9 55,554,890 - 55,586,290 (+) NCBI UNSW_CanFamBas_1.0 UU_Cfam_GSD_1.0 9 55,646,354 - 55,677,713 (+) NCBI UU_Cfam_GSD_1.0
Eng Squirrel Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl HiC_Itri_2 NW_024404947 195,698,638 - 195,730,666 (-) NCBI HiC_Itri_2 SpeTri2.0 Ensembl NW_004936487 15,467,835 - 15,477,488 (-) Ensembl SpeTri2.0 SpeTri2.0 Ensembl SpeTri2.0 NW_004936487 15,467,165 - 15,499,180 (-) NCBI SpeTri2.0 SpeTri2.0 SpeTri2.0
ENG Pig Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Sscrofa11.1 Ensembl 1 268,309,400 - 268,343,783 (-) Ensembl Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa11.1 1 268,309,379 - 268,343,861 (-) NCBI Sscrofa11.1 Sscrofa11.1 susScr11 Sscrofa11.1 Sscrofa10.2 1 302,232,063 - 302,266,139 (-) NCBI Sscrofa10.2 Sscrofa10.2 susScr3
ENG Green Monkey Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl ChlSab1.1 12 10,274,705 - 10,315,715 (+) NCBI ChlSab1.1 ChlSab1.1 chlSab2 ChlSab1.1 Ensembl 12 10,275,064 - 10,315,040 (+) Ensembl ChlSab1.1 ChlSab1.1 Ensembl chlSab2 Vero_WHO_p1.0 NW_023666079 5,905,669 - 5,949,288 (-) NCBI Vero_WHO_p1.0 Vero_WHO_p1.0
Eng
.
Predicted Target Of
Count of predictions: 646 Count of miRNA genes: 183 Interacting mature miRNAs: 218 Transcripts: ENSRNOT00000071801, ENSRNOT00000074562 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
1358357 Srcrtb1 Stress Responsive Cort Basal QTL 1 6.36 0.002 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 3 8658162 27494778 Rat 6893355 Bw101 Body weight QTL 101 0.4 0.38 body mass (VT:0001259) body weight (CMO:0000012) 3 10778704 30357018 Rat 10401810 Kidm53 Kidney mass QTL 53 kidney mass (VT:0002707) both kidneys wet weight to body weight ratio (CMO:0000340) 3 8227194 47233430 Rat 1298526 Arunc3 Aerobic running capacity QTL 3 2.2 exercise endurance trait (VT:0002332) maximum distance run on treadmill (CMO:0001406) 3 8227194 33703538 Rat 8693641 Alc30 Alcohol consumption QTL 30 2 0.739 drinking behavior trait (VT:0001422) calculated ethanol drink intake rate (CMO:0001615) 3 10434306 24512004 Rat 2298542 Neuinf11 Neuroinflammation QTL 11 3.9 nervous system integrity trait (VT:0010566) spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126) 3 15005422 76927699 Rat 1558657 Cm43 Cardiac mass QTL 43 6.6 3e-08 heart mass (VT:0007028) heart wet weight (CMO:0000069) 3 10778823 30356773 Rat 631568 Bp92 Blood pressure QTL 92 2.2 0.005 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 3 1 39874793 Rat 6893363 Bw105 Body weight QTL 105 2.6 0.0036 body mass (VT:0001259) body weight (CMO:0000012) 3 10778704 30357018 Rat 61468 Bp15 Blood pressure QTL 15 4.4 blood pressure trait (VT:0000183) pulse pressure (CMO:0000292) 3 1 33278763 Rat 631831 Alc8 Alcohol consumption QTL 8 2.7 consumption behavior trait (VT:0002069) calculated ethanol drink intake rate (CMO:0001615) 3 1 33230976 Rat 1558647 Cm46 Cardiac mass QTL 46 5.4 0.0000055 heart mass (VT:0007028) heart wet weight (CMO:0000069) 3 10778823 30356773 Rat 4889966 Bss95 Bone structure and strength QTL 95 4.4 tibia area (VT:1000281) tibia-fibula cross-sectional area (CMO:0001718) 3 1 36847613 Rat 1558654 Bw56 Body weight QTL 56 4.5 0.0000171 body mass (VT:0001259) body weight (CMO:0000012) 3 10778704 30357018 Rat 1558650 Cm48 Cardiac mass QTL 48 4 0.0001 heart mass (VT:0007028) heart weight to body weight ratio (CMO:0000074) 3 10778823 30356773 Rat 1358905 Hrtrt17 Heart rate QTL 17 5.9 0.000014 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 3 10861912 89878372 Rat 70191 BpQTLcluster4 Blood pressure QTL cluster 4 3 arterial blood pressure trait (VT:2000000) absolute change in systolic blood pressure (CMO:0000607) 3 10778704 50302886 Rat 631545 Bp85 Blood pressure QTL 85 3.1 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 3 1 33278763 Rat 1358885 Bp251 Blood pressure QTL 251 3.8 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 3 14489145 121056321 Rat 631679 Cm10 Cardiac mass QTL 10 7.34 0.0001 heart left ventricle mass (VT:0007031) heart left ventricle weight to body weight ratio (CMO:0000530) 3 1 31158234 Rat 2290452 Scl56 Serum cholesterol level QTL 56 2.26 blood cholesterol amount (VT:0000180) plasma total cholesterol level (CMO:0000585) 3 1 91609953 Rat 70203 Gcr2 Gastric cancer resistance QTL 2 2.6 stomach morphology trait (VT:0000470) stomach tumor susceptibility score (CMO:0002043) 3 8658162 27494778 Rat 70202 Alc19 Alcohol consumption QTL 19 2.5 drinking behavior trait (VT:0001422) ethanol intake volume to total fluid intake volume ratio (CMO:0001591) 3 1 27494778 Rat 2312664 Scl62 Serum cholesterol level QTL 62 0.05 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 3 1 38710544 Rat 1358888 Bp264 Blood pressure QTL 264 4.43 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 3 14489145 121056321 Rat
D3Got2
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 15,952,555 - 15,952,811 (+) MAPPER mRatBN7.2 mRatBN7.2 3 15,952,555 - 15,952,876 (+) MAPPER mRatBN7.2 Rnor_6.0 3 11,697,544 - 11,698,063 NCBI Rnor6.0 Rnor_6.0 3 11,697,544 - 11,697,799 NCBI Rnor6.0 Rnor_5.0 3 17,039,439 - 17,039,958 UniSTS Rnor5.0 Rnor_5.0 3 17,039,439 - 17,039,694 UniSTS Rnor5.0 Celera 3 10,693,503 - 10,693,760 UniSTS RH 3.4 Map 3 68.4 RGD RH 3.4 Map 3 68.4 UniSTS RH 2.0 Map 3 0.0 RGD
RH133417
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 15,972,395 - 15,972,591 (+) MAPPER mRatBN7.2 Rnor_6.0 3 11,717,263 - 11,717,458 NCBI Rnor6.0 Rnor_5.0 3 17,058,326 - 17,058,521 UniSTS Rnor5.0 Celera 3 10,713,315 - 10,713,510 UniSTS RH 3.4 Map 3 72.7 UniSTS
RH134698
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 3 15,972,879 - 15,973,065 (+) MAPPER mRatBN7.2 Rnor_6.0 3 11,717,747 - 11,717,932 NCBI Rnor6.0 Rnor_5.0 3 17,058,810 - 17,058,995 UniSTS Rnor5.0 Celera 3 10,713,799 - 10,713,984 UniSTS RH 3.4 Map 3 70.8 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
9
11
49
113
91
90
59
25
59
6
218
97
93
45
60
31
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Ensembl Acc Id:
ENSRNOT00000071801 ⟹ ENSRNOP00000066355
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 3 15,934,532 - 15,972,619 (+) Ensembl Rnor_6.0 Ensembl 3 11,679,530 - 11,717,485 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000074562 ⟹ ENSRNOP00000066838
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 3 15,934,518 - 15,973,230 (+) Ensembl Rnor_6.0 Ensembl 3 11,679,530 - 11,717,485 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000101522 ⟹ ENSRNOP00000089152
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 3 15,944,396 - 15,973,230 (+) Ensembl
Ensembl Acc Id:
ENSRNOT00000114060 ⟹ ENSRNOP00000094124
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 3 15,942,606 - 15,973,230 (+) Ensembl
RefSeq Acc Id:
NM_001010968 ⟹ NP_001010968
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 3 36,332,279 - 36,370,323 (+) NCBI mRatBN7.2 3 15,934,566 - 15,972,618 (+) NCBI Rnor_6.0 3 11,679,530 - 11,717,485 (+) NCBI Rnor_5.0 3 17,021,673 - 17,058,548 (+) NCBI Celera 3 10,675,660 - 10,713,537 (+) RGD
Sequence:
GTGTCCCGTCCCCAGGCCAGGACCGTCGTCCGCTGCCGTCCCAAAGAGCCCAGTGTCTCTTTCTCACCATCCAGTCAGCTAGAGACCCCTGCCCTGCTTTGAGTCTCCAGCCCACTTCTCCTGACTTC
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RefSeq Acc Id:
XM_063284324 ⟹ XP_063140394
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 3 36,332,190 - 36,370,324 (+) NCBI
RefSeq Acc Id:
NP_001010968 ⟸ NM_001010968
- Peptide Label:
precursor
- UniProtKB:
Q6Q3E8 (UniProtKB/TrEMBL), M0RBA8 (UniProtKB/TrEMBL), A0A9K3Y7N3 (UniProtKB/TrEMBL), A0A8I6GL08 (UniProtKB/TrEMBL)
- Sequence:
MDRSMLPLVITLLLVIYSFVPTSLAERVGCDLQRVDSTRGEVTYTTSQVSEGCVAQVANAAHEVHVLFLNLSRRKSEVELTLQASKQNGTETREVFLVFISNENVLVKLQAPEIPLHLVYNSSLEVFK
hide sequence
Ensembl Acc Id:
ENSRNOP00000066355 ⟸ ENSRNOT00000071801
Ensembl Acc Id:
ENSRNOP00000066838 ⟸ ENSRNOT00000074562
Ensembl Acc Id:
ENSRNOP00000094124 ⟸ ENSRNOT00000114060
Ensembl Acc Id:
ENSRNOP00000089152 ⟸ ENSRNOT00000101522
RefSeq Acc Id:
XP_063140394 ⟸ XM_063284324
- Peptide Label:
isoform X1
- UniProtKB:
Q3KR75 (UniProtKB/TrEMBL), A0A8I6GL08 (UniProtKB/TrEMBL)
RGD ID: 13691990 Promoter ID: EPDNEW_R2515 Type: initiation region Name: Eng_1 Description: endoglin SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 3 11,679,512 - 11,679,572 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2006-11-20
Eng
endoglin
Symbol and Name status set to provisional
70820 PROVISIONAL
