Eng (endoglin) - Rat Genome Database

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Gene: Eng (endoglin) Rattus norvegicus
Analyze
Symbol: Eng
Name: endoglin
RGD ID: 1593188
Description: Enables type II transforming growth factor beta receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of collagen biosynthetic process; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular space. Used to study congestive heart failure; pre-eclampsia; and renal fibrosis. Biomarker of cholestasis; congestive heart failure; hepatocellular carcinoma; hypertension (multiple); and renal fibrosis. Human ortholog(s) of this gene implicated in arteriovenous malformation; arteriovenous malformations of the brain; breast cancer; hereditary hemorrhagic telangiectasia; and intracranial aneurysm. Orthologous to human ENG (endoglin); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC124909
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,332,190 - 36,370,324 (+)NCBIGRCr8
mRatBN7.2315,934,566 - 15,972,618 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,934,518 - 15,973,230 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,003,353 - 19,041,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,588,363 - 27,626,245 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,839,360 - 25,877,319 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,679,530 - 11,717,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,679,530 - 11,717,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,021,673 - 17,058,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,675,660 - 10,713,537 (+)NCBICelera
Cytogenetic Map3p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
arteriovenous malformation  (ISO)
arteriovenous malformations of the brain  (ISO,ISS)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Chemical and Drug Induced Liver Injury  (IEP)
cholestasis  (IEP)
clear cell renal cell carcinoma  (ISO)
congenital disorder of glycosylation Iu  (ISO)
congestive heart failure  (IDA,IEP)
coronary artery disease  (ISO)
cystic fibrosis  (ISO)
developmental and epileptic encephalopathy  (ISO)
developmental and epileptic encephalopathy 31A  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
dystonia  (ISO)
early infantile epileptic encephalopathy  (ISO)
Epistaxis  (ISO)
Experimental Radiation Injuries  (IEP,ISO)
Galloway-Mowat syndrome 1  (ISO)
GNE myopathy  (ISO)
hepatocellular carcinoma  (IEP)
hereditary hemorrhagic telangiectasia  (ISO,ISS)
Hereditary Hemorrhagic Telangiectasia, Type 1  (ISO)
Hereditary Hemorrhagic Telangiectasia, Type 2  (ISO)
Hypercholesterolemia  (ISO)
hypertension  (IEP)
intracranial aneurysm  (ISO)
juvenile polyposis syndrome  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
Leber congenital amaurosis  (ISO)
lymphoid leukemia  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
Moyamoya Disease 2  (ISO)
multiple myeloma  (ISO)
pre-eclampsia  (IDA,IEP,ISO)
Pregnancy in Diabetics  (ISO)
primary coenzyme Q10 deficiency 7  (ISO)
primary pulmonary hypertension 1  (ISO)
prostate cancer  (ISO)
Pulmonary Arterial Hypertension  (ISO)
Pulmonary Arterial Hypertension, Hereditary Hemorrhagic Telangiectasia-Related  (ISO)
pulmonary hypertension  (ISO)
renal fibrosis  (IDA,IEP,ISO)
Right Ventricular Hypertrophy  (ISO)
secondary hyperparathyroidism  (ISO)
Stress Fractures  (IEP)
systemic lupus erythematosus  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-bromohexadecanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
candesartan  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(3+) trichloride  (ISO)
clofibric acid  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
daunorubicin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dopamine  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
enalapril  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fenoldopam  (EXP)
fenthion  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
harmaline  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP,ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methimazole  (EXP)
mifepristone  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP)
niclosamide  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
progesterone  (ISO)
propiconazole  (EXP)
raloxifene  (ISO)
retinyl acetate  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
triclosan  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
Y-27632  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
artery morphogenesis  (ISO)
atrial cardiac muscle tissue morphogenesis  (ISO)
atrioventricular canal morphogenesis  (ISO)
bone development  (IEP)
branching involved in blood vessel morphogenesis  (ISO)
cardiac atrium morphogenesis  (ISO)
cardiac jelly development  (ISO)
cardiac ventricle morphogenesis  (ISO)
cell chemotaxis  (ISO)
cell migration  (IBA,ISO)
cell migration involved in endocardial cushion formation  (ISO)
cell motility  (ISO)
cellular response to mechanical stimulus  (IEP)
central nervous system vasculogenesis  (ISO)
detection of hypoxia  (ISO)
dorsal aorta morphogenesis  (ISO)
endocardial cushion morphogenesis  (ISO)
endocardial cushion to mesenchymal transition  (ISO)
epithelial to mesenchymal transition  (IBA)
epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
extracellular matrix constituent secretion  (IMP)
extracellular matrix disassembly  (ISO)
heart development  (ISO)
heart looping  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
outflow tract septum morphogenesis  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of collagen biosynthetic process  (IMP)
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of systemic arterial blood pressure  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
regulation of cardiac muscle cell apoptotic process  (ISO)
regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  (ISO)
regulation of cell proliferation involved in heart morphogenesis  (ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transforming growth factor beta receptor signaling pathway  (IBA,IDA,ISO)
response to hypoxia  (ISO)
response to transforming growth factor beta  (IEP)
response to xenobiotic stimulus  (IEP)
smooth muscle tissue development  (ISO)
sprouting angiogenesis  (ISO)
transforming growth factor beta receptor signaling pathway  (IBA,ISO)
vascular associated smooth muscle cell development  (ISO)
vasculogenesis  (IBA,ISO)
venous blood vessel morphogenesis  (ISO)
ventricular trabecula myocardium morphogenesis  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cellular basis of diabetic nephropathy: V. Endoglin expression levels and diabetic nephropathy risk in patients with Type 1 diabetes. Alvarez-Munoz P, etal., J Diabetes Complications. 2009 Apr 21.
2. Clinical heterogeneity in hereditary haemorrhagic telangiectasia: are pulmonary arteriovenous malformations more common in families linked to endoglin? Berg JN, etal., J Med Genet. 1996 Mar;33(3):256-7.
3. Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Bossler AD, etal., Hum Mutat. 2006 Jul;27(7):667-75.
4. A murine model of hereditary hemorrhagic telangiectasia. Bourdeau A, etal., J Clin Invest. 1999 Nov;104(10):1343-51.
5. Gene expression profiles that segregate patients with childhood acute lymphoblastic leukaemia: an independent validation study identifies that endoglin associates with patient outcome. Catchpoole D, etal., Leuk Res. 2007 Dec;31(12):1741-7. Epub 2007 Jun 18.
6. Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. Chen K, etal., Circ Res. 2004 Dec 10;95(12):1167-73. Epub 2004 Nov 11.
7. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. Choi EJ, etal., PLoS One. 2014 Feb 10;9(2):e88511. doi: 10.1371/journal.pone.0088511. eCollection 2014.
8. Endoglin regulates renal ischaemia-reperfusion injury. Docherty NG, etal., Nephrol Dial Transplant. 2006 Aug;21(8):2106-19. Epub 2006 Jun 4.
9. Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Doridot L, etal., Hypertension. 2013 Mar;61(3):662-8. doi: 10.1161/HYPERTENSIONAHA.111.202994. Epub 2013 Jan 28.
10. Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis. Dubinski W, etal., Hum Pathol. 2012 Jul;43(7):1037-43. doi: 10.1016/j.humpath.2011.08.012. Epub 2011 Dec 26.
11. Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer. Fowler CJ, etal., Biochim Biophys Acta. 2012 Dec 20. pii: S1388-1981(12)00259-4. doi: 10.1016/j.bbalip.2012.12.005.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Gilbert JS, etal., Hypertension. 2009 Feb;53(2):399-403. Epub 2008 Dec 15.
14. Long-term high salt diet causes hypertension and alters renal cytokine gene expression profiles in Sprague-Dawley rats. Gu JW, etal., Beijing Da Xue Xue Bao. 2009 Oct 18;41(5):505-15.
15. Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases. Ikemoto T, etal., Heart Vessels. 2012 Jul;27(4):344-51. doi: 10.1007/s00380-011-0163-z. Epub 2011 Jun 11.
16. Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling. Irani RA, etal., Hypertension. 2010 May;55(5):1246-53. doi: 10.1161/HYPERTENSIONAHA.110.150540. Epub 2010 Mar 29.
17. Magnesium sulfate therapy of preeclampsia: an old tool with new mechanism of action and prospect in management and prophylaxis. Korish AA Hypertens Res. 2012 Oct;35(10):1005-11. doi: 10.1038/hr.2012.103. Epub 2012 Jul 5.
18. Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia. Leanos-Miranda A, etal., Hypertension. 2013 May;61(5):1118-25. doi: 10.1161/HYPERTENSIONAHA.111.00754. Epub 2013 Mar 4.
19. Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Lesca G, etal., Hum Mutat 2004 Apr;23(4):289-99.
20. Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1. Letarte M, etal., Cardiovasc Res. 2005 Oct 1;68(1):155-64.
21. Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy. Malik RA, etal., J Cell Mol Med. 2005 Jul-Sep;9(3):692-7.
22. Evaluation of parathyroid gland angiogenesis in chronic kidney disease associated with secondary hyperparathyroidism. Martins P, etal., Nephrol Dial Transplant. 2008 Sep;23(9):2889-94. doi: 10.1093/ndt/gfn150. Epub 2008 Apr 8.
23. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. McAllister KA, etal., Nat Genet. 1994 Dec;8(4):345-51.
24. Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. Meurer SK, etal., Cell Signal. 2011 Apr;23(4):683-99. doi: 10.1016/j.cellsig.2010.12.002. Epub 2010 Dec 10.
25. Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling. Meurer SK, etal., J Biol Chem. 2005 Jan 28;280(4):3078-87. Epub 2004 Nov 10.
26. In vitro and in vivo effects of an anti-mouse endoglin (CD105)-immunotoxin on the early stages of mouse B16MEL4A5 melanoma tumours. Munoz R, etal., Cancer Immunol Immunother. 2013 Mar;62(3):541-51. doi: 10.1007/s00262-012-1357-7. Epub 2012 Oct 18.
27. Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment. Nachtigal P, etal., Can J Physiol Pharmacol. 2007 Aug;85(8):767-73.
28. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
29. The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage. Ozbey O, etal., Acta Histochem. 2009 May 28.
30. Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus. Ozbey O, etal., Histol Histopathol. 2010 Nov;25(11):1437-45.
31. Emerging roles of endoglin/CD105 and angiogenic cytokines for disease development and progression in multiple myeloma patients. Pappa CA, etal., Hematol Oncol. 2013 Dec;31(4):201-5. doi: 10.1002/hon.2044. Epub 2013 Apr 11.
32. Endoglin haploinsufficiency promotes fibroblast accumulation during wound healing through Akt activation. Pericacho M, etal., PLoS One. 2013;8(1):e54687. doi: 10.1371/journal.pone.0054687. Epub 2013 Jan 17.
33. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
34. Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats. Prieto M, etal., J Physiol Biochem. 2005 Sep;61(3):457-67.
35. Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal fibrosis induced by renal mass reduction. Prieto M, etal., Kidney Blood Press Res. 2005;28(1):32-40. Epub 2004 Oct 8.
36. Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury. Qiu J, etal., Asia Pac J Clin Oncol. 2011 Dec;7(4):392-8. doi: 10.1111/j.1743-7563.2011.01461.x.
37. The effect of Kraussianone-2 (Kr2), a natural pyrano-isoflavone from Eriosema kraussianum, in an L-NAME- induced pre-eclamptic rat model. Ramesar SV, etal., Phytother Res. 2012 Sep;26(9):1375-80. doi: 10.1002/ptr.3697. Epub 2012 Feb 6.
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Comprehensive gene review and curation RGD comprehensive gene curation
41. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. Sadlier DM, etal., J Biol Chem. 2004 Jul 9;279(28):29670-80. Epub 2004 Mar 18.
42. Endoglin (CD105) expression in human renal cell carcinoma. Sandlund J, etal., BJU Int. 2006 Apr;97(4):706-10.
43. Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm. Santiago-Sim T, etal., Stroke. 2009 May;40(5):1604-11. doi: 10.1161/STROKEAHA.108.540245. Epub 2009 Mar 19.
44. Mutation analysis in Spanish patients with hereditary hemorrhagic telangiectasia: deficient endoglin up-regulation in activated monocytes. Sanz-Rodriguez F, etal., Clin Chem. 2004 Nov;50(11):2003-11. Epub 2004 Sep 16.
45. The TGF-beta co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. Scharpfenecker M, etal., Radiother Oncol. 2012 Dec;105(3):313-20. doi: 10.1016/j.radonc.2012.08.021. Epub 2012 Sep 27.
46. Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling. Scherner O, etal., J Biol Chem. 2007 May 11;282(19):13934-43. Epub 2007 Mar 21.
47. Endoglin deficiency impairs stroke recovery. Shen F, etal., Stroke. 2014 Jul;45(7):2101-6. doi: 10.1161/STROKEAHA.114.005115. Epub 2014 May 29.
48. Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. Shovlin CL, etal., Am J Hum Genet. 1997 Jul;61(1):68-79.
49. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Shyu KG, etal., Eur J Heart Fail. 2010 Mar;12(3):219-26. doi: 10.1093/eurjhf/hfq011.
50. Mechanical stretch via transforming growth factor-beta1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts. Shyu KG, etal., Eur J Heart Fail. 2013 Jan;15(1):36-45. doi: 10.1093/eurjhf/hfs143. Epub 2012 Aug 31.
51. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Takahashi N, etal., Cancer Res. 2001 Nov 1;61(21):7846-54.
52. Angiogenesis is required for stress fracture healing in rats. Tomlinson RE, etal., Bone. 2013 Jan;52(1):212-9. doi: 10.1016/j.bone.2012.09.035. Epub 2012 Oct 5.
53. Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia. Toporsian M, etal., Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):509-17. doi: 10.1161/ATVBAHA.109.200121. Epub 2009 Dec 30.
54. Prognostic relevance of angiopoietin-2, fibroblast growth factor-2 and endoglin mRNA expressions in chronic lymphocytic leukemia. Vrbacky F, etal., Neoplasma. 2014;61(5):585-92. doi: 10.4149/neo_2014_071.
55. A hereditary haemorrhagic telangiectasia family with pulmonary involvement is unlinked to the known HHT genes, endoglin and ALK-1. Wallace GM and Shovlin CL, Thorax. 2000 Aug;55(8):685-90.
56. Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma. Wang JY, etal., Chin Med J (Engl). 2010 Mar 20;123(6):730-3.
57. Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105. Wood LM, etal., Cancer Immunol Immunother. 2011 Jul;60(7):931-42. doi: 10.1007/s00262-011-1002-x. Epub 2011 Mar 23.
58. Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women. Yu Y, etal., Diabetologia. 2009 Jan;52(1):160-8. Epub 2008 Nov 5.
Additional References at PubMed
PMID:1326540   PMID:1537377   PMID:3262645   PMID:8194490   PMID:8294451   PMID:8370410   PMID:9872992   PMID:10348742   PMID:10625534   PMID:12015308   PMID:12477932   PMID:12941632  
PMID:15702480   PMID:17068149   PMID:17628518   PMID:18156205   PMID:18223685   PMID:18974388   PMID:19004009   PMID:19703439   PMID:19736306   PMID:20978343   PMID:21423176   PMID:23868260  
PMID:24392114   PMID:25936493   PMID:26857067   PMID:27466499   PMID:27822781   PMID:28564608   PMID:28590142   PMID:28859090   PMID:29677638   PMID:32972452  


Genomics

Comparative Map Data
Eng
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8336,332,190 - 36,370,324 (+)NCBIGRCr8
mRatBN7.2315,934,566 - 15,972,618 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl315,934,518 - 15,973,230 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx319,003,353 - 19,041,237 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0327,588,363 - 27,626,245 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0325,839,360 - 25,877,319 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0311,679,530 - 11,717,486 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl311,679,530 - 11,717,485 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0317,021,673 - 17,058,548 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera310,675,660 - 10,713,537 (+)NCBICelera
Cytogenetic Map3p11NCBI
ENG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389127,815,016 - 127,854,658 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9127,811,130 - 127,854,773 (-)EnsemblGRCh38hg38GRCh38
GRCh379130,577,295 - 130,616,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369129,617,115 - 129,656,805 (-)NCBINCBI36Build 36hg18NCBI36
Build 349127,656,849 - 127,696,538NCBI
Celera9101,228,133 - 101,267,888 (-)NCBICelera
Cytogenetic Map9q34.11NCBI
HuRef9100,194,111 - 100,234,515 (-)NCBIHuRef
CHM1_19130,728,823 - 130,768,983 (-)NCBICHM1_1
T2T-CHM13v2.09140,022,435 - 140,062,072 (-)NCBIT2T-CHM13v2.0
Eng
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39232,536,607 - 32,572,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl232,536,607 - 32,572,681 (+)EnsemblGRCm39 Ensembl
GRCm38232,646,595 - 32,682,669 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl232,646,595 - 32,682,669 (+)EnsemblGRCm38mm10GRCm38
MGSCv37232,502,115 - 32,538,189 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36232,468,604 - 32,504,127 (+)NCBIMGSCv36mm8
Celera232,353,177 - 32,389,276 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map222.09NCBI
Eng
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955419818,932 - 852,694 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955419818,797 - 853,319 (+)NCBIChiLan1.0ChiLan1.0
ENG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21111,500,636 - 11,540,554 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1911,502,983 - 11,542,901 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0998,934,080 - 98,973,862 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19127,605,608 - 127,644,641 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9127,605,608 - 127,644,641 (-)Ensemblpanpan1.1panPan2
ENG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1955,558,246 - 55,590,081 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl955,558,305 - 55,589,064 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha954,752,221 - 54,783,620 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0956,480,195 - 56,511,601 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl956,480,054 - 56,511,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1955,240,157 - 55,271,556 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0955,554,890 - 55,586,290 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0955,646,354 - 55,677,713 (+)NCBIUU_Cfam_GSD_1.0
Eng
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947195,698,638 - 195,730,666 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648715,467,835 - 15,477,488 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648715,467,165 - 15,499,180 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1268,309,400 - 268,343,783 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11268,309,379 - 268,343,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21302,232,063 - 302,266,139 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11210,274,705 - 10,315,715 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1210,275,064 - 10,315,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660795,905,669 - 5,949,288 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eng
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247607,703,820 - 7,734,457 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247607,703,979 - 7,735,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eng
270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:646
Count of miRNA genes:183
Interacting mature miRNAs:218
Transcripts:ENSRNOT00000071801, ENSRNOT00000074562
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
D3Got2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,952,555 - 15,952,811 (+)MAPPERmRatBN7.2
mRatBN7.2315,952,555 - 15,952,876 (+)MAPPERmRatBN7.2
Rnor_6.0311,697,544 - 11,698,063NCBIRnor6.0
Rnor_6.0311,697,544 - 11,697,799NCBIRnor6.0
Rnor_5.0317,039,439 - 17,039,958UniSTSRnor5.0
Rnor_5.0317,039,439 - 17,039,694UniSTSRnor5.0
Celera310,693,503 - 10,693,760UniSTS
RH 3.4 Map368.4RGD
RH 3.4 Map368.4UniSTS
RH 2.0 Map30.0RGD
RH133417  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,972,395 - 15,972,591 (+)MAPPERmRatBN7.2
Rnor_6.0311,717,263 - 11,717,458NCBIRnor6.0
Rnor_5.0317,058,326 - 17,058,521UniSTSRnor5.0
Celera310,713,315 - 10,713,510UniSTS
RH 3.4 Map372.7UniSTS
RH134698  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,972,879 - 15,973,065 (+)MAPPERmRatBN7.2
Rnor_6.0311,717,747 - 11,717,932NCBIRnor6.0
Rnor_5.0317,058,810 - 17,058,995UniSTSRnor5.0
Celera310,713,799 - 10,713,984UniSTS
RH 3.4 Map370.8UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000071801   ⟹   ENSRNOP00000066355
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,934,532 - 15,972,619 (+)Ensembl
Rnor_6.0 Ensembl311,679,530 - 11,717,485 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000074562   ⟹   ENSRNOP00000066838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,934,518 - 15,973,230 (+)Ensembl
Rnor_6.0 Ensembl311,679,530 - 11,717,485 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101522   ⟹   ENSRNOP00000089152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,944,396 - 15,973,230 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114060   ⟹   ENSRNOP00000094124
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl315,942,606 - 15,973,230 (+)Ensembl
RefSeq Acc Id: NM_001010968   ⟹   NP_001010968
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,332,279 - 36,370,323 (+)NCBI
mRatBN7.2315,934,566 - 15,972,618 (+)NCBI
Rnor_6.0311,679,530 - 11,717,485 (+)NCBI
Rnor_5.0317,021,673 - 17,058,548 (+)NCBI
Celera310,675,660 - 10,713,537 (+)RGD
Sequence:
RefSeq Acc Id: XM_063284324   ⟹   XP_063140394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8336,332,190 - 36,370,324 (+)NCBI
RefSeq Acc Id: NP_001010968   ⟸   NM_001010968
- Peptide Label: precursor
- UniProtKB: Q6Q3E8 (UniProtKB/TrEMBL),   M0RBA8 (UniProtKB/TrEMBL),   A0A9K3Y7N3 (UniProtKB/TrEMBL),   A0A8I6GL08 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066355   ⟸   ENSRNOT00000071801
Ensembl Acc Id: ENSRNOP00000066838   ⟸   ENSRNOT00000074562
Ensembl Acc Id: ENSRNOP00000094124   ⟸   ENSRNOT00000114060
Ensembl Acc Id: ENSRNOP00000089152   ⟸   ENSRNOT00000101522
RefSeq Acc Id: XP_063140394   ⟸   XM_063284324
- Peptide Label: isoform X1
- UniProtKB: Q3KR75 (UniProtKB/TrEMBL)
Protein Domains
ZP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RBA8-F1-model_v2 AlphaFold M0RBA8 1-699 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691990
Promoter ID:EPDNEW_R2515
Type:initiation region
Name:Eng_1
Description:endoglin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0311,679,512 - 11,679,572EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593188 AgrOrtholog
BioCyc Gene G2FUF-50128 BioCyc
Ensembl Genes ENSRNOG00000050190 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071801.3 UniProtKB/TrEMBL
  ENSRNOT00000074562.4 UniProtKB/TrEMBL
  ENSRNOT00000101522.1 UniProtKB/TrEMBL
  ENSRNOT00000114060.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456529 IMAGE-MGC_LOAD
InterPro ZP_dom UniProtKB/TrEMBL
KEGG Report rno:497010 UniProtKB/TrEMBL
MGC_CLONE MGC:124909 IMAGE-MGC_LOAD
NCBI Gene 497010 ENTREZGENE
PANTHER ENDOGLIN UniProtKB/TrEMBL
  ENDOGLIN/TGF-BETA RECEPTOR TYPE III UniProtKB/TrEMBL
Pfam Zona_pellucida UniProtKB/TrEMBL
PhenoGen Eng PhenoGen
RatGTEx ENSRNOG00000050190 RatGTEx
UniProt A0A8I6A813_RAT UniProtKB/TrEMBL
  A0A8I6GL08 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7N3 ENTREZGENE, UniProtKB/TrEMBL
  M0RA19_RAT UniProtKB/TrEMBL
  M0RBA8 ENTREZGENE
  Q3KR75 ENTREZGENE, UniProtKB/TrEMBL
  Q6Q3E8 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary M0RBA8 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-11-20 Eng  endoglin      Symbol and Name status set to provisional 70820 PROVISIONAL